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    Methods for spectrally resolving fluorophores of a sample and systems for same
    1.
    发明授权
    Methods for spectrally resolving fluorophores of a sample and systems for same 有权

    公开(公告)号：US12038326B2

    公开(公告)日：2024-07-16

    申请号：US17975243

    申请日：2022-10-27

    Applicant: Becton, Dickinson and Company

    Inventor： Peter Mage ,  Keegan Owsley

    IPC: G01J3/44 ,  G01N21/64

    CPC classification number: G01J3/4406 ,  G01N21/6428 ,  G01N21/6486

    Abstract: Aspects of the present disclosure include methods for spectrally resolving light from fluorophores having overlapping fluorescence spectra in a sample. Methods according to certain embodiments include detecting light with a light detection system from a sample having a plurality of fluorophores having overlapping fluorescence spectra and spectrally resolving light from each fluorophore in the sample. In some embodiments, methods include estimating the abundance of one or more of the fluorophores in the sample, such as on a particle. In certain instances, methods include identifying the particle in the sample based on the abundance of each fluorophore and sorting the particle. Methods according to some embodiments includes spectrally resolving the light from each fluorophore by calculating a spectral unmixing matrix for the fluorescence spectra of each fluorophore. Systems and integrated circuit devices (e.g., a field programmable gate array) for practicing the subject methods are also provided.

    Multi-wavelength laser inspection
    3.
    发明授权
    Multi-wavelength laser inspection 有权

    公开(公告)号：US11860093B2

    公开(公告)日：2024-01-02

    申请号：US17681650

    申请日：2022-02-25

    Applicant: The Boeing Company

    Inventor： Keith D. Humfeld ,  Morteza Safai

    IPC: G01N21/64 ,  G01J3/44 ,  G01J3/02 ,  H01S5/10 ,  G01J3/06 ,  G01J3/28

    CPC classification number: G01N21/6402 ,  G01J3/0232 ,  G01J3/4406 ,  G01J3/2889 ,  G01J2003/064 ,  G01N2021/6419 ,  G01N2021/6421 ,  H01S5/1092

    Abstract: An example system for inspecting a surface includes a laser, an optical system, a gated camera, and a control system. The laser is configured to emit pulses of light, with respective wavelengths of the pulses of light varying over time. The optical system includes at least one optical element, and is configured to direct light emitted by the laser to points along a scan line one point at a time. The gated camera is configured to record a fluorescent response of the surface from light having each wavelength of a plurality of wavelengths at each point along the scan line. The control system is configured to control the gated camera such that an aperture of the gated camera is open during fluorescence of the surface but closed during exposure of the surface to light emitted by the laser.

    SYSTEM AND METHOD FOR DETERMINING SUCCESSIVE SINGLE MOLECULAR DECAY
    5.
    发明公开
    SYSTEM AND METHOD FOR DETERMINING SUCCESSIVE SINGLE MOLECULAR DECAY 审中-公开

    公开(公告)号：US20230251133A1

    公开(公告)日：2023-08-10

    申请号：US18130867

    申请日：2023-04-04

    Applicant: MIFTEK CORPORATION

    Inventor： Masanobu Yamamoto ,  Keegan Hernandez ,  J. Paul Robinson ,  John Jaiber González Murillo

    IPC: G01J3/44 ,  G01J3/02

    CPC classification number: G01J3/4406 ,  G01J3/0218 ,  G01J3/0227

    Abstract: A flow cytometry measurement system is disclosed which includes a flow chamber configured to flow particles of interest in a flow stream, one or more optical sources configured to excite the particles of interest by an excitation light activated and deactivated according to a pulse train thus causing particles of interest emitting emission light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the particles of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the particles of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.

    OPTICAL RAMAN SYSTEM
    8.
    发明申请
    OPTICAL RAMAN SYSTEM 审中-公开

    公开(公告)号：US20190242752A1

    公开(公告)日：2019-08-08

    申请号：US16333192

    申请日：2017-09-13

    Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS

    Inventor： Kishan DHOLAKIA ,  Mingzhou CHEN

    IPC: G01J3/44 ,  G01J3/02 ,  G01N21/65

    CPC classification number: G01J3/4412 ,  G01J3/0218 ,  G01J3/0262 ,  G01J3/0272 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/65 ,  G01N2021/651

    Abstract: A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer, and an optical system for coupling light from the optical source to a sample and for coupling light from the sample to the spectrometer and a further spectrometer. A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer and an optical system for coupling light from the optical source and a further optical source to a sample and for coupling light from the sample to the spectrometer. The optical system may be configured for coupling light from the optical source and the further optical source to the sample and for coupling light from the sample to the spectrometer and the further spectrometer. The Raman system may be portable and/or may be configured to be transported and/or carried and/or may be handheld.

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