公开(公告)号：US20250060361A1

公开(公告)日：2025-02-20

申请号：US18938922

申请日：2024-11-06

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit AGHVANYAN ,  Eli N. GLEZER ,  John KENTEN ,  George SIGAL ,  Martin STENGELIN

IPC: G01N33/53 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/533 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.

公开(公告)号：US12198922B2

公开(公告)日：2025-01-14

申请号：US17947819

申请日：2022-09-19

Applicant: Applied Materials, Inc.

Inventor： Vilen K. Nestorov

IPC: G01N21/88 ,  C23C16/48 ,  F27B17/00 ,  G01N21/66 ,  H01K1/14 ,  H01K1/16 ,  H01K3/02 ,  H01K7/00 ,  H05B3/00

Abstract: Examples disclosed herein relate to a to a pitch gradient in a lamp filament, and a method of making. In one implementation, a lamp has a bulb filled with a gas. A filament is disposed within the bulb. The filament has a plurality of coils that include a first coil having a first point. The plurality of coils includes a second coil having a second point, and a third coil having a third point. The pitch gradient is defined by a first pitch between the second point and the first point, and a second pitch between the third point and the second point. The second pitch is greater than the first pitch. The second point is 360 degrees away from the first point. The third point is 360 degrees from the second point. A terminal coil is electrically coupled to at least the first coil, the second coil, and the third coil.

公开(公告)号：US20250003963A1

公开(公告)日：2025-01-02

申请号：US18883427

申请日：2024-09-12

Applicant: Meso Scale Technologies, LLC.

Inventor： Mark BILLADEAU ,  Paul FREESE ,  Alan KISHBAUGH ,  Gisbert SPIELES ,  Nicholas FOX-LYON

IPC: G01N33/543 ,  C12Q1/00 ,  G01N21/66 ,  G01N21/69 ,  G01N21/76

Abstract: The specification provides an assay electrode including a composite containing a matrix and a multiplicity of graphene particles dispersed therein.

公开(公告)号：US12006535B2

公开(公告)日：2024-06-11

申请号：US16888368

申请日：2020-05-29

Applicant: Sarmal, Inc.

Inventor： Inanc Ortac

IPC: C12Q1/686 ,  C12Q1/6818 ,  G01N21/66

CPC classification number: C12Q1/686 ,  C12Q1/6818 ,  G01N21/66 ,  C12Q2565/301

Abstract: Provided herein are methods and systems for detecting the presence of absence of a target-nucleic acid sequence, including SARS-COV2.

公开(公告)号：US20240044804A9

公开(公告)日：2024-02-08

申请号：US17405742

申请日：2021-08-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter JOSEL ,  Herbert ANDRES ,  Michaela WINDFUHR ,  Oliver LARBOLETTE ,  Stefan QUINT

IPC: G01N21/76 ,  G01N33/543 ,  C07F15/00 ,  G01N21/66

CPC classification number: G01N21/76 ,  G01N33/5438 ,  C07F15/0033 ,  C07F15/0046 ,  G01N21/66 ,  G01N2458/30 ,  G01N27/308

Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.

公开(公告)号：US11867631B2

公开(公告)日：2024-01-09

申请号：US17527828

申请日：2021-11-16

Applicant: OndaVia, Inc.

Inventor： Mark C. Peterman ,  Merwan Benhabib ,  Samuel Kleinman

IPC: G01N21/65 ,  G01N21/47 ,  G01N21/63 ,  G01N21/66 ,  G01N33/18 ,  G01J3/02 ,  G01J3/18 ,  G01J3/44 ,  B01L3/00 ,  G01N27/447 ,  G01N30/60 ,  G01N21/49 ,  G01N21/68 ,  G01N21/27 ,  G01N30/00 ,  G01J3/28

CPC classification number: G01N21/65 ,  B01L3/502715 ,  B01L3/502761 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/18 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/276 ,  G01N21/47 ,  G01N21/4785 ,  G01N21/49 ,  G01N21/63 ,  G01N21/658 ,  G01N21/66 ,  G01N21/68 ,  G01N27/44704 ,  G01N27/44791 ,  G01N30/6095 ,  G01N33/18 ,  B01L2200/04 ,  B01L2200/0652 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/0867 ,  B01L2400/0418 ,  B01L2400/0421 ,  G01J2003/2866 ,  G01J2003/2879 ,  G01N30/6065 ,  G01N2021/651 ,  G01N2021/656 ,  G01N2030/0095 ,  G01N2201/0221 ,  G01N2201/13

Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge.

公开(公告)号：US11796477B2

公开(公告)日：2023-10-24

申请号：US16044897

申请日：2018-07-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Quint ,  Klaus Bauer-Espindola

IPC: G01N21/66 ,  G01N35/00 ,  G01N27/327 ,  G01N27/416 ,  G01N35/10

CPC classification number: G01N21/66 ,  G01N27/3277 ,  G01N27/4163 ,  G01N35/00623 ,  G01N35/00722 ,  G01N35/1004 ,  G01N2035/00891

Abstract: Described is an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell having a working electrode for detecting the analyte using an electrochemiluminescence measurement cycle, involving

a. carrying out the measurement cycle in a calibration process using a liquid sample without analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode,
b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second EIS being performed using the working electrode,
c. comparing the result of the first EIS and the second EIS,

providing an indication indicating if the comparison results show a deviation between the first EIS and the second EIS exceed a predefined threshold.

公开(公告)号：US11761901B2

公开(公告)日：2023-09-19

申请号：US17947791

申请日：2022-09-19

Applicant: Applied Materials, Inc.

Inventor： Govinda Raj ,  Vilen K. Nestorov

IPC: G01N21/88 ,  G01N21/66 ,  F21V29/10 ,  G01B11/02

CPC classification number: G01N21/8851 ,  G01N21/66 ,  F21V29/10 ,  G01B11/02

Abstract: Examples disclosed herein relate to a method and apparatus for inspecting lamp dimensions. The method includes determining an actual measurement of a lamp. The lamp is configured to heat a substrate in a substrate processing apparatus. A window is generated, the window having a width and a height. The window is based upon a target measurement of the lamp. The method further includes generating a deviation based upon a difference between an image of the actual measurement and the window. The deviation is compared to a first threshold. The lamp is rejected if the deviation is outside the first threshold.

公开(公告)号：US11698399B2

公开(公告)日：2023-07-11

申请号：US16760019

申请日：2018-09-14

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Nao Terasaki ,  Kazuya Kikunaga

IPC: G01R27/02 ,  G01N21/66 ,  G01N23/2254 ,  C09K11/77

CPC classification number: G01R27/02 ,  C09K11/7734 ,  G01N21/66 ,  G01N23/2254

Abstract: [Object] An electric conductivity-measuring material which emits light according to electric conductivity of a measurement object; an electric conductivity-measuring film containing the material; and an electric conductivity-measuring device and an electric conductivity-measuring method using the electric conductivity-measuring film are provided. An electric resistivity-measuring material which emits light according to electric resistivity of a measurement object when electrons are made incident; an electric resistivity-measuring film containing the material; and an electric resistivity-measuring device and an electric resistivity-measuring method using the electric resistivity-measuring film are also provided.
[Solution] An electric conductivity-measuring material is used, which contains at least one of a fluorescent substance, a luminescent substance, an electroluminescent substance, a fractoluminescent substance, a photochromic substance, an afterglow substance, a photostimulated luminescent substance and a mechanoluminescent substance.

公开(公告)号：US20230020070A1

公开(公告)日：2023-01-19

申请号：US17849917

申请日：2022-06-27

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： John KENTEN ,  George SIGAL ,  Alexander K. TUCKER-SCHWARTZ

IPC: G01N21/64 ,  C07F15/00 ,  C12Q1/6816 ,  G01N21/66 ,  G01N33/533 ,  G01N33/58

Abstract: The invention relates to methods, compositions, kits, and assay systems for assay signal amplification. Also provided herein is a signal amplification reagent, wherein the signal amplification reagent is an antibody or antigen-binding fragment thereof.