公开(公告)号：US20240201085A1

公开(公告)日：2024-06-20

申请号：US18554145

申请日：2022-03-15

Applicant: Ushio Denki Kabushiki Kaisha

Inventor： Toshikazu NAGASHIMA

IPC: G01N21/49 ,  G01N21/25 ,  G01N21/84

CPC classification number: G01N21/49 ,  G01N21/255 ,  G01N21/84 ,  G01N2021/845 ,  G01N2201/0636 ,  G01N2201/0638 ,  G01N2201/0697 ,  G01N2201/1042

Abstract: A conveyance device supports and conveys an object. The conveyance device has a support portion in which an opening narrower than the object is provided at a position where the object is supported. A lighting device irradiates a first surface of the object with measurement light having a wavelength changing over time through the opening of the support portion. A light receiving device detects object light that is diffusely transmitted light emitted from a second surface of the object.

公开(公告)号：US11960131B2

公开(公告)日：2024-04-16

申请号：US17575326

申请日：2022-01-13

Applicant: Apple Inc.

Inventor： Michael J. Bishop ,  Vijay M. Iyer ,  Jason S. Pelc ,  Mario J. Costello

IPC: G02B6/42 ,  G01N21/47 ,  G01N21/49

CPC classification number: G02B6/4268 ,  G01N21/4785 ,  G01N21/49 ,  G02B6/4214 ,  G02B6/4251

Abstract: Described herein is an integrated photonics device including a light emitter, integrated edge outcoupler(s), optics, and a detector array. The device can include a hermetically sealed enclosure. The hermetic seal can reduce the amount of moisture and/or contamination that may affect the measurement, analysis, and/or the function of the individual components within the sealed enclosure. Additionally or alternatively, the hermetic seal can be used to protect the components within the enclosure from environmental contamination induced during the manufacturing, packaging, and/or shipping process. The outcoupler(s) can be formed by creating one or more pockets in the layers of a die. Outcoupler material can be formed in the pocket and, optionally, subsequent layers can be deposited on top. The edge of the die can be polished until a targeted polish plane is achieved. Once the outcoupler is formed, the die can be flipped over and other components can be formed.

公开(公告)号：US11829013B2

公开(公告)日：2023-11-28

申请号：US17186634

申请日：2021-02-26

Applicant: INTERFACE TECHNOLOGY (CHENGDU) CO., LTD. ,  INTERFACE OPTOELECTRONICS (SHENZHEN) CO., LTD. ,  INTERFACE OPTOELECTRONICS (WUXI) CO., LTD. ,  GENERAL INTERFACE SOLUTION LIMITED

Inventor： Che Wen Chiang

IPC: G02F1/13 ,  G01N21/21 ,  G01N21/49

CPC classification number: G02F1/1309 ,  G01N21/21 ,  G01N21/49 ,  G01N2201/0231 ,  G01N2201/121

Abstract: An optical environment oscillation detection system and an optical measurement method using the same are provided. This system includes a laser light source, a polarizer, a liquid crystal (LC) element, an analyzer, and an optical sensor arranged in sequence. A polarization axis of the polarizer and that of the analyzer are respectively parallel to a first and a second axis direction being perpendicular to each other. When there is no environmental disturbance, the alignment of LC cells in the LC element has an original pretilt angle, and the optical sensor senses a first scattered light intensity of the laser beam outputted from the analyzer. When there is environmental disturbance, the alignment of the LC cells has a changed pretilt angle in relative to the original pretilt angle, and the optical sensor senses a second scattered light intensity of the laser beam outputted from the analyzer.

公开(公告)号：US20230371852A1

公开(公告)日：2023-11-23

申请号：US18322418

申请日：2023-05-23

Applicant: Northeastern University

Inventor： Qianqian Fang ,  Miguel Adrian Mireles Nunez ,  Edward Xu

IPC: A61B5/1455 ,  G01N21/49 ,  G01N21/31 ,  G01N33/483

CPC classification number: A61B5/1455 ,  G01N21/49 ,  G01N21/31 ,  G01N33/4833 ,  G01N2201/061 ,  A61B2562/0238

Abstract: Methods and systems for performing optical imaging are provided. An optical imaging system includes a light source configured to generate a spatially-distributed illumination beam of temporally-varying light and a detector configured to detect light resulting from an interaction between the illumination beam and a sample. The system further includes a processor configured to determine spatial and temporal characteristics of the detected light and generate a representation of the sample based on the determined spatial and temporal characteristics.

公开(公告)号：US11754569B2

公开(公告)日：2023-09-12

申请号：US16553312

申请日：2019-08-28

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Nina Liu ,  Michael Rosconi ,  Erica Pyles

IPC: G01N33/68 ,  G01N21/49

CPC classification number: G01N33/6845 ,  G01N21/49

Abstract: Methods for characterizing protein complexes formed between protein drug products and soluble ligands are provided herein. The disclosed methods can determine the size, heterogeneity, and conformation of protein complexes.

公开(公告)号：US11726036B2

公开(公告)日：2023-08-15

申请号：US17346390

申请日：2021-06-14

Applicant: Apple Inc.

Inventor： Mark Alan Arbore ,  Matthew A. Terrel

IPC: G01N21/59 ,  G01N21/49 ,  G01N21/17 ,  G01N21/47

CPC classification number: G01N21/59 ,  G01N21/49 ,  G01N2021/1782 ,  G01N2021/4709 ,  G01N2021/4711 ,  G01N2201/066 ,  G01N2201/0691 ,  G01N2201/0696 ,  G01N2201/12

Abstract: An illuminator/collector assembly can deliver incident light to a sample and collect return light returning from the sample. A sensor can measure ray intensities as a function of ray position and ray angle for the collected return light. A ray selector can select a first subset of rays from the collected return light at the sensor that meet a first selection criterion. In some examples, the ray selector can aggregate ray intensities into bins, each bin corresponding to rays in the collected return light that traverse within the sample an estimated optical path length within a respective range of optical path lengths. A characterizer can determine a physical property of the sample, such as absorptivity, based on the ray intensities, ray positions, and ray angles for the first subset of rays. Accounting for variations in optical path length traversed within the sample can improve accuracy.

公开(公告)号：US20230204497A1

公开(公告)日：2023-06-29

申请号：US18111740

申请日：2023-02-20

Applicant: Apple Inc.

Inventor： Miikka M. Kangas ,  Mark Alan Arbore ,  David I. Simon ,  Michael J. Bishop ,  James W. Hillendahl ,  Robert Chen

IPC: G01N21/27 ,  G01N21/35 ,  G01N21/47 ,  G01J3/32 ,  G01J3/36 ,  G01J3/433 ,  G01J3/447 ,  G01J3/02 ,  G01J3/42

CPC classification number: G01N21/276 ,  G01N21/35 ,  G01N21/474 ,  G01N21/4785 ,  G01J3/32 ,  G01J3/36 ,  G01J3/433 ,  G01J3/447 ,  G01J3/0286 ,  G01J3/42 ,  G01N2021/4709 ,  G01N2201/0221 ,  G01N2201/12723 ,  G01N21/49

Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.

公开(公告)号：US20190234852A1

公开(公告)日：2019-08-01

申请号：US16340881

申请日：2017-09-22

Applicant: Malvern Panalytical Limited

Inventor： Richard SCULLION ,  Jason CORBETT

IPC: G01N15/02 ,  G01N15/14 ,  G01N21/49

CPC classification number: G01N15/0211 ,  G01N15/1434 ,  G01N15/1456 ,  G01N21/49 ,  G01N2015/0222 ,  G01N2015/1454 ,  G01N2021/4707 ,  G01N2021/4709 ,  G01N2201/063 ,  G01N2201/0635

Abstract: A particle characterisation instrument, comprising a light source, a sample cell, an optical element between the light source and sample cell and a detector. The optical element is configured to modify light from the light source to create a modified beam, the modified beam: a) interfering with itself to create an effective beam in the sample cell along an illumination axis and b) diverging in the far field to produce a dark region along the illumination axis that is substantially not illuminated at a distance from the sample cell. The detector is at the distance from the sample cell, and is configured to detect light scattered from the effective beam by a sample in the sample cell, the detector positioned to detect forward or back scattered light along a scattering axis that is at an angle of 0° to 10° from the illumination axis.

公开(公告)号：US20180356406A1

公开(公告)日：2018-12-13

申请号：US16107721

申请日：2018-08-21

Applicant: i-calQ, LLC

Inventor： Joel R.L. Ehrenkranz ,  Pamela J. Turbeville ,  Jeong-Yeol Yoon ,  David J. You

IPC: G01N33/53 ,  G01N33/78 ,  G01N33/558 ,  G01N21/49

CPC classification number: G01N33/5302 ,  G01N21/49 ,  G01N33/558 ,  G01N33/78 ,  Y10S435/805 ,  Y10S435/97 ,  Y10S436/81

Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.

公开(公告)号：US20180356231A1

公开(公告)日：2018-12-13

申请号：US15906342

申请日：2018-02-27

Applicant: Wartsila North America, Inc.

Inventor： Heink Steffens ,  Claus Oltrogge ,  Andreas Kohler ,  Richard Dixon ,  Christian Sellin

IPC: G01C21/00 ,  G01N21/49 ,  G01N21/21 ,  G01W1/14 ,  G05D1/02 ,  G08G3/02

CPC classification number: G01C21/005 ,  B63B45/04 ,  B63B2213/02 ,  B63C9/0005 ,  B63J2099/008 ,  G01N21/21 ,  G01N21/49 ,  G01W1/14 ,  G05D1/0206 ,  G08B5/36 ,  G08G3/02 ,  H05B33/086 ,  H05B37/029

Abstract: Systems and methods for displaying a communication from a vessel in a first location to a person or second vessel in a second location are described. The communication system alerts persons and other nearby vessels to the presence of the vessel during fog and other low visibility conditions on a body of water. The communication is displayed by the system in the form of a light display routine that can be a text communication, an image, an animation, a video, or a combination of them. The system includes a computer and a network to communicatively connect the computer to at least one splitter, at least control unit, and at least one light fixture, which can be an array of light emitting diodes. The computer commences the light display routine based on detection of a trigger event by analyzing data received from onboard sensor devices, an external source, or both.