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公开(公告)号：US12215148B2
公开(公告)日：2025-02-04
申请号：US16987487
申请日：2020-08-07
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chiayang Lin , Samuel Davis
IPC: C07K16/24 , A61K39/395 , A61K47/68 , C07K16/28 , C07K16/30
Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US12180272B2
公开(公告)日：2024-12-31
申请号：US17666107
申请日：2022-02-07
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chia-Yang Lin , Samuel Davis
Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US20240294627A1
公开(公告)日：2024-09-05
申请号：US18640981
申请日：2024-04-19
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chia-Yang Lin , Samuel Davis
IPC: C07K16/24 , A61K39/395 , A61K47/68 , C07K16/28 , C07K16/30
CPC classification number: C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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4.发明公开
公开(公告)号：US20240167984A1
公开(公告)日：2024-05-23
申请号：US18389370
申请日：2023-11-14
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Michael Rosconi , Nina Liu , Erica Pyles
CPC classification number: G01N30/0005 , G01N33/582 , G01N33/6854 , G01N2030/003
Abstract: The present inventions provide methods for detecting and determining protein structures and stability, including heteromeric protein complexes, in biological fluids, such as serum and other bodily fluids. Systems for performing the methods also are provided.
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公开(公告)号：US11754569B2
公开(公告)日：2023-09-12
申请号：US16553312
申请日：2019-08-28
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Nina Liu , Michael Rosconi , Erica Pyles
CPC classification number: G01N33/6845 , G01N21/49
Abstract: Methods for characterizing protein complexes formed between protein drug products and soluble ligands are provided herein. The disclosed methods can determine the size, heterogeneity, and conformation of protein complexes.
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公开(公告)号：US11965020B2
公开(公告)日：2024-04-23
申请号：US18318871
申请日：2023-05-17
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chia-Yang Lin , Samuel Davis
IPC: C07K16/24 , A61K39/395 , A61K47/68 , C07K16/28 , C07K16/30
CPC classification number: C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US11708407B2
公开(公告)日：2023-07-25
申请号：US17666116
申请日：2022-02-07
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chia-Yang Lin , Samuel Davis
IPC: C07K16/24 , C07K16/28 , C07K16/30 , A61K47/68 , A61K39/395
CPC classification number: C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US20220195030A1
公开(公告)日：2022-06-23
申请号：US17666116
申请日：2022-02-07
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chiayang Lin , Samuel Davis
Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US20210040197A1
公开(公告)日：2021-02-11
申请号：US16987487
申请日：2020-08-07
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chiayang Lin , Samuel Davis
Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US20240168018A1
公开(公告)日：2024-05-23
申请号：US18389375
申请日：2023-11-14
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Michael Rosconi , Nina Liu , Erica Pyles
IPC: G01N33/569 , G01N21/64 , G01N33/58
CPC classification number: G01N33/56983 , G01N21/6428 , G01N33/582 , G01N2021/6439 , G01N2333/015
Abstract: The present inventions provide methods for detecting and evaluating viruses and virus-like particles using A4F combined with Multi-Angle Light Scattering (MALS) and fluorescent (Flr) detectors. Systems for performing the methods also are provided.
