公开(公告)号：US20240219307A1

公开(公告)日：2024-07-04

申请号：US18429280

申请日：2024-01-31

Applicant: Meso Scale Technologies, LLC.

Inventor： Charles M. CLINTON ,  Eli N. GLEZER ,  Sharon WEST ,  George SIGAL ,  Carl STEVENS ,  Michael L. VOCK

IPC: G01N21/76 ,  G01N21/69 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N21/76 ,  G01N21/69 ,  G01N35/0092 ,  G01N35/028 ,  G01N2035/00524 ,  G01N2035/0425 ,  G01N35/1079 ,  Y10T436/114165

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US11940385B2

公开(公告)日：2024-03-26

申请号：US16270062

申请日：2019-02-07

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Charles M. Clinton ,  Eli N. Glezer ,  Sharon West ,  George Sigal ,  Carl Stevens ,  Michael L. Vock

IPC: G01N35/00 ,  G01N21/69 ,  G01N21/76 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N21/76 ,  G01N21/69 ,  G01N35/0092 ,  G01N35/028 ,  G01N2035/00524 ,  G01N2035/0425 ,  G01N35/1079 ,  Y10T436/114165

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US11598727B1

公开(公告)日：2023-03-07

申请号：US17406594

申请日：2021-08-19

Applicant: 2S Water Incorporated

Inventor： Joseph John Cheramy ,  Anders Jacques Palmgren ,  Avro Anthony Sargeaunt Nelson ,  Neil Wallace Johnson ,  Howard Andrew Suissa ,  Anthony Brent Nelson

IPC: H01J61/02 ,  G01N21/67 ,  G01N21/69 ,  H01J61/30 ,  H01J61/64

Abstract: An aspect of some embodiments of the present invention relates to a plasma chamber for containing a solution electrode glow discharge (SEGD) apparatus, the plasma chamber comprising a hollow body and a lens. The hollow body is configured to enclose a plasma generated between a solid electrode and a solution electrode, and includes at least one viewing port for letting light generated from the plasma leave the hollow body. The lens is disposed at or near the viewing port, the lens being configured to collect light from the plasma and direct the light onto a light receiving unit.

公开(公告)号：US11099182B2

公开(公告)日：2021-08-24

申请号：US15637957

申请日：2017-06-29

Applicant: Sysmex Corporation

Inventor： Kazuyoshi Horii ,  Tomoyuki Nose ,  Takao Fujiwara ,  Sayuri Tomoda ,  Yusuke Miida ,  Yasunori Maekawa ,  Noriaki Sasaki

IPC: G01N33/543 ,  G01N35/00 ,  G01N21/76 ,  B01L3/00 ,  G01N21/69 ,  G01N35/10 ,  G01N33/58 ,  B03C1/28

Abstract: Disclosed is a detection apparatus that transfers magnetic particles through a plurality of chambers in a cartridge which includes the plurality of chambers and a channel connecting between the plurality of chambers, and that causes the magnetic particles to carry a complex of a test substance and a labelling substance, to detect the test substance on the basis of the labelling substance in the complex. The detection apparatus includes: a rotation mechanism configured to rotate the cartridge about a rotation shaft; a magnet configured to collect the magnetic particles in the chambers; a movement mechanism configured to move the magnet in a direction different from a circumferential direction of a circle in which the rotation shaft is centered; a detector configured to detect the test substance; and a controller programmed to control the rotation mechanism and the movement mechanism so as to transfer the magnetic particles from one of the chambers to another one of the chambers.

公开(公告)号：US20200116642A1

公开(公告)日：2020-04-16

申请号：US16626898

申请日：2018-06-29

Applicant: Aleksandr Nikolaevich ZABRODIN ,  Sergei Aleksandrovich ZABRODIN

Inventor： Aleksandr Nikolaevich ZABRODIN ,  Sergei Aleksandrovich ZABRODIN

IPC: G01N21/69 ,  G01J3/443 ,  G01J3/02 ,  G01N21/71 ,  G01N21/85 ,  G01N21/67

Abstract: The invention relates to the field of spectral analysis of the chemical composition of ferrous and non-ferrous metals and can be used in metallurgical factories to monitor the ongoing production of molten (liquid) electrically conductive materials directly in the melting units.A method for optical emission spectral analysis of the chemical composition of an electrically conductive metal melt includes the following steps: immersion of a refractory probe with a sampler into a container with a metal melt at an angle to its surface, ingress of the metal melt into the sampler due to the ferrostatic pressure and stabilization of its level due to an inert gas flow, excitation of plasma torch using electric spark from an electrode located inside the sampler, transfer of the plasma glow through the optical channel to the input of the spectrometer, receiving a spectrum of the chemical elements in the metal, processing this spectrum in the computer to evaluate composition and the mass fraction of the chemical elements in the melt, wherein when measuring the level of the liquid sample in the sampler is stabilized and maintained at the level of the lateral opening in the wall of the sampler due to the flow of inert gas, which is continuously fed into the probe and comes out as bubbles through the hole directly into the melt medium. The technical effect: increase in sensitivity and accuracy of spectral analysis of electrically conductive melts, increase in reliability and simplification of the device for plasma excitation.

公开(公告)号：US10184884B2

公开(公告)日：2019-01-22

申请号：US12959952

申请日：2010-12-03

Applicant: Nicholas Anderson ,  Jeffery Debad ,  Eli N. Glezar ,  Sudeep Kumar ,  Noel Lawrence ,  Kenneth Page ,  George Sigal ,  Sharon West

Inventor： Nicholas Anderson ,  Jeffery Debad ,  Eli N. Glezar ,  Sudeep Kumar ,  Noel Lawrence ,  Kenneth Page ,  George Sigal ,  Sharon West

IPC: G01N21/05 ,  G01N21/69 ,  G01N21/76 ,  G01N21/03 ,  G01F23/02 ,  G01F23/292 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00

Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20180275058A1

公开(公告)日：2018-09-27

申请号：US15756938

申请日：2016-09-02

Applicant: SeLux Diagnostics, Inc.

Inventor： Eric STERN ,  Aleksandar VACIC ,  Nathan B. PURMORT

IPC: G01N21/64 ,  B01L3/00 ,  G01J3/44 ,  G01N21/69 ,  G01N21/76

CPC classification number: G01N21/6428 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0605 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0688 ,  B82Y15/00 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/03 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6489 ,  G01N21/69 ,  G01N21/76 ,  G01N2021/0321 ,  G01N2021/0328 ,  G01N2021/0346 ,  G01N2021/6482 ,  G01N2201/0245

Abstract: In some aspects, reader systems for optically detecting binding agents or analyte complexes in a sample as a result of performing biochemical assays can include: a housing defining a positioning receptacle to receive the sample; an excitation source to generate incident light directed at the sample; at least one solid-state photomultiplier detector configured to: i) receive a light emitted by at least one label associated with the binding agents and/or analyte complexes within the sample; and ii) produce a signal in response to receiving the light emitted by the at least one label or substrate solution that is physically or chemically modified by the said label, the at least one detector being connected to integrated signal processing electronics to process the signal; and a user interface in communication with the signal processing electronics for conveying one or more results of the one or more biochemical as says.

公开(公告)号：US09891165B2

公开(公告)日：2018-02-13

申请号：US15255036

申请日：2016-09-01

Applicant: University of Virginia Patent Foundation

Inventor： Brooks Hart Pate ,  Kevin K. Lehmann

IPC: G01J3/30 ,  G01N21/3586 ,  G01N22/00 ,  G01N21/31 ,  G01N21/62 ,  G01N21/69 ,  G01J3/44 ,  G01N21/67

CPC classification number: G01N21/3586 ,  G01J3/10 ,  G01J3/4338 ,  G01J3/44 ,  G01N21/31 ,  G01N21/62 ,  G01N21/67 ,  G01N21/69 ,  G01N22/00 ,  H01S3/0057

Abstract: A pulse train comprising chirped pulses can be used to excite a sample, such as for spectroscopic analysis. The respective chirped pulses can include a frequency sweep to establish a first frequency-domain comb. A width of frequency-domain comb peaks can be established at least in part by a total duration of the pulse train, and a bandwidth of the first frequency-domain comb can be determined at least in part by a bandwidth of the frequency sweep of the respective chirped pulses. A free-space or enclosed sample interaction region can be used.

公开(公告)号：US20180039885A1

公开(公告)日：2018-02-08

申请号：US15228753

申请日：2016-08-04

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Conrad M. Albrecht ,  Josephine B. Chang ,  Levente Klein ,  Siyuan Lu ,  Fernando J. Marianno

IPC: G06N3/08 ,  G01N33/22 ,  G01N33/00 ,  G01N21/69

CPC classification number: G06N3/08 ,  G01N21/3504 ,  G01N33/0047 ,  G01N33/0062 ,  G01N33/0075 ,  G01N33/225 ,  G01N2021/3531 ,  G01V8/02

Abstract: Methods and systems for detecting emission sites include identifying a set of known emitters having visible features and a spectroscopic signature that correspond to sites that emit a substance to form a training set. A classifier is generated based on the training set. New emitters are identified based on the classifier, a spectroscopic signature map, and a map of visible features. An alert is provided responsive to the identification of a new emitter.

公开(公告)号：US09505619B2

公开(公告)日：2016-11-29

申请号：US11385277

申请日：2006-03-20

Applicant: Richard J. Massey ,  Mark T. Martin ,  Liwen Dong ,  Ming Lu ,  Alan Fischer ,  Fabian Jameison ,  Pam Liang ,  Robert Hoch ,  Jonathan K. Leland

Inventor： Richard J. Massey ,  Mark T. Martin ,  Liwen Dong ,  Ming Lu ,  Alan Fischer ,  Fabian Jameison ,  Pam Liang ,  Robert Hoch ,  Jonathan K. Leland

IPC: G01N33/573 ,  C12Q1/32 ,  C01B31/02 ,  B82Y30/00 ,  B82Y40/00 ,  C07K17/06 ,  D01F9/12 ,  D01F11/14 ,  G01N33/543 ,  G01N33/58 ,  H01M4/60 ,  G01N21/69 ,  G01N21/76 ,  G01N30/88 ,  G11C13/02

CPC classification number: C01B31/0213 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/152 ,  C01B32/174 ,  C01B2202/34 ,  C01B2202/36 ,  C07K17/06 ,  D01F9/12 ,  D01F11/14 ,  G01N21/69 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/582 ,  G01N2030/8863 ,  G11C13/025 ,  H01M4/60 ,  Y10S435/968 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S977/737 ,  Y10S977/742

Abstract: Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.

Abstract translation: 石墨纳米管，其包括通过化学取代官能化的管状富勒烯（通常称为“buckytubes”）和原纤维，被用作电致化学发光测定中的固体支持物。 石墨纳米管在用于测定之前用官能团生物分子进行化学修饰。 电化学发光钌络合物与官能团生物分子修饰的纳米管的关联允许通过多种形式检测包括核酸，抗原，酶和酶底物的分子。