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2315 条记录 (耗时 0.03 秒)

    Method for producing bilayer membrane and planar bilayer membrane
    6.
    发明授权
    Method for producing bilayer membrane and planar bilayer membrane 有权
    双层膜和平面双层膜的制备方法

    公开(公告)号：US08961898B2

    公开(公告)日：2015-02-24

    申请号：US12450517

    申请日：2008-03-28

    申请人： Takasi Nisisako ,  Takahiro Baba

    发明人： Takasi Nisisako ,  Takahiro Baba

    IPC分类号： B01L3/00 ,  G01N33/487 ,  G01N27/447 ,  C12M3/06

    CPC分类号： B01L3/502784 ,  B01L3/5027 ,  B01L3/502753 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  C12M23/16 ,  G01N27/44791 ,  G01N33/48728 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/25

    摘要： The present invention provides a bilayer membrane produced using a microchannel capable of easily forming bilayer membranes such as planar lipid bilayer membranes in large quantities, and a production method thereof. A process for producing a bilayer membrane of the present invention comprises forming a state where two liquid phases or liquid and gaseous phases each containing amphipathic molecules are alternately arranged in a microchannel, discharging one of the two liquid phases or the gaseous phase of the liquid and gaseous phases through branch minichannels formed in the wall on one side or in the walls on both sides to contact the remaining liquid phases adjacent to each other, and thereby forming a side-by-side arrangement of bilayer membranes comprising the amphipathic molecules.

    摘要翻译： 本发明提供一种使用能够容易地形成大量双平面脂质双层膜等双层膜的微通道的双层膜及其制造方法。 本发明的双层膜的制造方法包括：形成两个液相或含有两亲性分子的液相和气相在微通道中交替排列的状态，排出两液相或液相中的一个， 气相通过在一侧或两侧的壁上形成的分支微通道与彼此相邻的剩余液相接触，从而形成包含两亲性分子的双层膜的并排排列。

    Methods for Forming a Channel Through a Polymer Layer Using One or More Photoresist Layers
    7.
    发明申请
    Methods for Forming a Channel Through a Polymer Layer Using One or More Photoresist Layers 有权
    通过使用一个或多个光刻胶层的聚合物层形成通道的方法

    公开(公告)号：US20150004058A1

    公开(公告)日：2015-01-01

    申请号：US13931086

    申请日：2013-06-28

    申请人： Google Inc.

    发明人： Huanfen Yao ,  Jeffrey George Linhardt ,  Babak Parviz

    IPC分类号： G03F7/16

    CPC分类号： G03F7/16 ,  B29D11/00826 ,  G02B1/04 ,  G02C7/04 ,  G02C11/10 ,  G03F7/425 ,  Y10S435/808 ,  Y10S436/805 ,  Y10T436/25

    摘要： A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.

    摘要翻译： 方法可以包括在位于结构上的传感器上形成一个或多个光致抗蚀剂层，使得传感器被一个或多个光致抗蚀剂层覆盖。 传感器被配置为检测分析物。 该方法可以包括形成第一聚合物层。 此外，该方法可以包括将结构定位在第一聚合物层上。 此外，该方法可以包括在第一聚合物层和结构上形成第二聚合物层，使得该结构被第一聚合物层，第二聚合物层和一个或多个光致抗蚀剂层完全包围。 该方法还可以包括去除一个或多个光致抗蚀剂层以形成通过第二聚合物层的通道，其中传感器经配置以经由通道接收分析物。

    Gradient injection for biosensing
    9.
    发明授权
    Gradient injection for biosensing 有权
    梯度注射用于生物传感

    公开(公告)号：US08906672B2

    公开(公告)日：2014-12-09

    申请号：US12674290

    申请日：2008-01-16

    申请人： John Gerard Quinn

    发明人： John Gerard Quinn

    IPC分类号： C12M1/34 ,  G01N35/10 ,  G01N21/55 ,  G01N33/53 ,  G01N35/08 ,  G01N21/05

    CPC分类号： G01N35/1097 ,  B01L2300/0636 ,  G01N21/55 ,  G01N21/553 ,  G01N33/53 ,  G01N35/08 ,  G01N35/085 ,  G01N2021/058 ,  Y10S435/808 ,  Y10S436/805 ,  Y10T436/117497

    摘要： A single injection gradient with a biosensor, both structural and methodological, achieves the binding of analyte to immobilized ligand over a wide concentration range without the necessity of regeneration of the sensing area. A gradient of concentrations adjacent to or within a flow cell facilitates kinetic analysis of interactions without requiring multiple discrete volumes or injections to achieve a range of concentrations. A continuous gradient fluid is preferably formed directly adjacent to the flow cell inlet or a region of sample/buffer dispersion at an injection point into a flow channel of a flow cell. The analyte gradient may be flowed through the flow cell from a low analyte concentration. Multiple component gradients are also provided.

    摘要翻译： 具有结构和方法学的生物传感器的单次注射梯度实现了在宽浓度范围内分析物与固定化配体的结合，而不需要再生感测区域。 与流动池相邻或相邻的浓度梯度促进了相互作用的动力学分析，而不需要多个离散的体积或注射来达到一定范围的浓度。 连续梯度流体优选直接邻近流动池入口或在注入点处的流动池的流动通道中的样品/缓冲液分散区域形成。 分析物梯度可以从低分析物浓度流过流动池。 还提供了多组分梯度。