公开(公告)号：US20120253099A1

公开(公告)日：2012-10-04

申请号：US13523336

申请日：2012-06-14

Applicant: John MON ,  Alan J. FENN

Inventor： John MON ,  Alan J. FENN

IPC: A61M37/00

CPC classification number: A61B18/18 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/00274 ,  A61B2017/22051 ,  A61B2017/22069 ,  A61B2018/00023 ,  A61B2018/00214 ,  A61B2018/00285 ,  A61B2018/00547 ,  A61B2018/046 ,  A61K9/0004 ,  A61K9/127 ,  A61K9/1272 ,  A61K9/1277 ,  A61N5/045 ,  A61N7/022 ,  Y10S436/829 ,  Y10S514/866 ,  Y10T428/2984

Abstract: A method and apparatus (100) of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source (110) heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source (110) activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.

Abstract translation: 一种使用热疗法在身体导管附近处理组织的方法和装置（100），同时防止由于水肿导致的身体导管的障碍，包括将药物包封在热敏载体（例如脂质体）内部的区域内 的待处理组织。 由能量发射源（110）产生的热将身体导管周围的组织的一部分加热至约43℃的温度足以破坏组织的加热部分。 此外，由能量发射源（110）产生的热激活热敏载体以激活封装药物的释放，并且药物靶向待加热的组织。 能量发射源的聚焦能量与作用在目标区域上的压缩有助于将药物输送到目标区域，使得天然支架具有长期功效。

公开(公告)号：US07951453B2

公开(公告)日：2011-05-31

申请号：US11981439

申请日：2007-10-31

Applicant: Benoit Dubertret ,  Vincent Noireaux ,  Albert Libchaber

Inventor： Benoit Dubertret ,  Vincent Noireaux ,  Albert Libchaber

IPC: A61K9/50

CPC classification number: B82Y30/00 ,  A61K49/0067 ,  B82Y5/00 ,  B82Y25/00 ,  H01F1/0054 ,  H01F1/0063 ,  H01F1/36 ,  H01F1/37 ,  Y10S436/829 ,  Y10T428/2989 ,  Y10T428/2991

Abstract: The invention provides a water soluble complex comprising an inner core of a metal or semi-conductor nanoparticle. The nanoparticle is coated with a hydrophobic ligand, which is encapsulated in a micelle. In an aqueous medium, the micelle comprises a hydrophilic shell and a hydrophobic core, the hydrophilic shell comprising a plurality of hydrophilic moieties, the hydrophobic core comprising a plurality of hydrophobic moieties, each hydrophobic moiety comprising at least one chain, each chain comprising a minimum of 8 atoms; wherein the total number of atoms in all chains for each moiety comprises at least 24 atoms. The micelle has a minimum average diameter of approximately 5 nm and a maximum average diameter of approximately 45 nm.

公开(公告)号：US07867723B2

公开(公告)日：2011-01-11

申请号：US10866163

申请日：2004-06-14

Applicant: Maria Isabel Baeza-Ramirez ,  José Leopoldo Aguilr-Faisal ,  Carlos Wong-Ramirez ,  Miguel Angel Ibáñez Hernández ,  Mónica Lara-Uc

Inventor： Maria Isabel Baeza-Ramirez ,  José Leopoldo Aguilr-Faisal ,  Carlos Wong-Ramirez ,  Miguel Angel Ibáñez Hernández ,  Mónica Lara-Uc

IPC: G01N33/53 ,  G01N21/00

CPC classification number: G01N33/92 ,  Y10S435/975 ,  Y10S436/811 ,  Y10S436/815 ,  Y10S436/829

Abstract: Methods for detecting anti-lipidic particle antibodies and lipidic particles in cellular membranes for the diagnosis of diseases associated with antiphospholipid syndrome are disclosed. Kits or sets to put these methods of diagnosis into practice are disclosed. Methods for the therapeutic treatment of diseases associated with antiphospholipid syndrome are disclosed as well. In addition, methods for the detection of the diverse physiologic states of cells and kits useful for this are also disclosed.

Abstract translation: 公开了用于检测细胞膜中抗脂质颗粒抗体和脂质颗粒以诊断与抗磷脂综合征有关的疾病的方法。 披露了将这些诊断方法付诸实践的套件或套件。 还公开了治疗与抗磷脂综合征有关的疾病的方法。 此外，还公开了用于检测细胞的不同生理状态的方法和可用于此的试剂盒。

公开(公告)号：US07723056B1

公开(公告)日：2010-05-25

申请号：US09529342

申请日：1998-10-14

Applicant: David J. Clarke ,  Michael H. Harrison ,  Harmesh S. Aojula

Inventor： David J. Clarke ,  Michael H. Harrison ,  Harmesh S. Aojula

IPC: G01N33/554

CPC classification number: G01N33/586 ,  A61K9/1271 ,  G01N33/569 ,  Y10S436/829

Abstract: Lipid vesicle particles capable of being targeted to a cell type of interest, said particle incorporating a peptide which is responsive to a predetermined metabolic signal from the targeted cell so as to modulate the permeability of the particle, said particle further incorporating a species to be targeted to the cell which is activated on said modulation of permeability. The particles may be used in methods for detecting cells, methods of treating cells and also therapeutically.

Abstract translation: 能够靶向感兴趣的细胞类型的脂质囊泡颗粒，所述颗粒掺入肽，其对来自靶细胞的预定代谢信号有反应，以调节颗粒的渗透性，所述颗粒进一步掺入待靶向物种 通过所述调节透过性被活化的细胞。 该颗粒可用于检测细胞的方法，治疗细胞的方法以及治疗性的方法。

公开(公告)号：US20090291454A1

公开(公告)日：2009-11-26

申请号：US12317954

申请日：2008-12-31

Applicant: Sang Jun Sim ,  Jun-Pyo Kim ,  Cheol-Hee Park

Inventor： Sang Jun Sim ,  Jun-Pyo Kim ,  Cheol-Hee Park

IPC: G01N33/53 ,  G01N33/543 ,  G01N21/76 ,  C12M1/00

CPC classification number: G01N33/5432 ,  Y10S435/808 ,  Y10S436/829 ,  Y10S436/905

Abstract: Provided are a method for detecting biomaterials, a method for fabricating a chip for biomaterial detection and a chip for biomaterial detection. The method for detecting biomaterials is characterized by comprising the steps of: (S1) immobilizing polydiacetylene liposomes onto a substrate; (S2) linking the polydiacetylene liposomes together and layering them on the substrate; (S3) immobilizing a material which forms a complementary binding with a subject biomaterial to be detected onto the polydiacetylene liposomes; (S4) exposing the resulted polydiacetylene liposome to UV light so as to form a chip for biomaterial detection; (S5) applying the subject biomaterial to be detected to the chip for biomaterial detection for reaction; and (S6) measuring a fluorescent signal from the chip for biomaterial detection.

Abstract translation: 提供了生物材料检测方法，生物材料检测用芯片的制造方法以及生物材料检测用芯片。 检测生物材料的方法的特征在于包括以下步骤：（S1）将聚二乙炔脂质体固定在基材上; （S2）将聚二乙炔脂质体连接在一起并将它们层叠在基材上; （S3）将与要检测的受试生物材料形成互补结合的材料固定在聚二乙炔脂质体上; （S4）将得到的聚二乙炔脂质体暴露于紫外光，形成用于生物材料检测的芯片; （S5）将要检测的对象生物材料应用于用于反应的生物材料检测用芯片; 和（S6）测量来自用于生物材料检测的芯片的荧光信号。

公开(公告)号：US20090028904A1

公开(公告)日：2009-01-29

申请号：US12148942

申请日：2008-04-23

Applicant: Leila Zarif ,  Tuo Jin ,  Ignacio Segarra ,  Raphael J. Mannino

Inventor： Leila Zarif ,  Tuo Jin ,  Ignacio Segarra ,  Raphael J. Mannino

IPC: A61K9/00 ,  A61K31/70 ,  A61K38/02 ,  A61K39/00 ,  A61K31/7048 ,  A61K31/704 ,  A61K38/13 ,  A61K31/472 ,  A61K31/496 ,  A61K47/12 ,  A61K31/07 ,  A61K39/145 ,  A61K31/20 ,  A61K33/30 ,  A61K33/26 ,  A61K33/00 ,  A61K36/54

CPC classification number: A61K9/1274 ,  A61K31/07 ,  A61K31/11 ,  A61K31/20 ,  A61K31/472 ,  A61K31/496 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/713 ,  A61K36/54 ,  A61K38/13 ,  Y10S436/829 ,  Y10S514/966 ,  Y10S514/967 ,  Y10T428/2984

Abstract: A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.

Abstract translation: 一种生产小型，基于脂质的耳蜗的方法。 耳蜗源自脂质体，其悬浮在水性两相聚合物溶液中，使得能够通过相分离差异分配极性分子基结构。 用带正电荷的分子如Ca2 +或Zn2 +处理的含脂质体的两相聚合物溶液形成粒度小于1微米的耳蜗沉淀物。 该方法可用于产生含有生物相关分子的耳蜗细胞。

公开(公告)号：US07422902B1

公开(公告)日：2008-09-09

申请号：US09431594

申请日：1999-11-01

Applicant: Jeffery J. Wheeler ,  Marcel B. Bally ,  Yuan-Peng Zhang ,  Dorothy L. Reimer ,  Michael Hope ,  Pieter R. Cullis ,  Peter Scherrer

Inventor： Jeffery J. Wheeler ,  Marcel B. Bally ,  Yuan-Peng Zhang ,  Dorothy L. Reimer ,  Michael Hope ,  Pieter R. Cullis ,  Peter Scherrer

IPC: C12N15/88 ,  C12Q1/68 ,  A61K9/127 ,  C07H21/04 ,  A01N43/04

CPC classification number: A61K9/1272 ,  A61K47/6911 ,  C12N15/88 ,  Y10S436/829

Abstract: Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. Upon removal of a solubilizing component (i.e., detergent or an organic solvent) the lipid-nucleic acid complexes form particles wherein the nucleic acid is serum-stable and is protected from degradation. The particles thus formed have access to extravascular sites and target cell populations and are suitable for the therapeutic delivery of nucleic acids.

Abstract translation: 描述了可用于体外或体内基因转移的新型脂质 - 核酸颗粒复合物。 可以使用洗涤剂透析方法或利用有机溶剂的方法形成颗粒。 在除去增溶组分（即洗涤剂或有机溶剂）后，脂质 - 核酸复合物形成其中核酸是血清稳定的并且被保护免于降解的颗粒。 由此形成的颗粒可以进入血管外部位和靶细胞群，并且适合于治疗性递送核酸。

公开(公告)号：US07208322B2

公开(公告)日：2007-04-24

申请号：US10116013

申请日：2002-04-02

Applicant: Mark L. Stolowitz ,  Jean P. Wiley ,  Guisheng Li ,  Kevin Lund

Inventor： Mark L. Stolowitz ,  Jean P. Wiley ,  Guisheng Li ,  Kevin Lund

IPC: G01N33/553 ,  G01N27/00 ,  G01N33/567 ,  G01N33/566

CPC classification number: G01N33/54373 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/553 ,  G01N33/54353 ,  G01N33/553 ,  G01N2610/00 ,  Y10S436/806 ,  Y10S436/829 ,  Y10T436/143333

Abstract: The present invention provides a sensor surface comprising: a substrate coated with a free electron metal; and a matrix layer disposed on the free electron metal, wherein the matrix layer comprises an organic compound having a boronic acid complexing moiety. The matrix is preferably a self-assembled monolayer (SAM), a mixed self-assembled monolayer (mSAM), or combinations thereof.

Abstract translation: 本发明提供了一种传感器表面，包括：涂覆有自由电子金属的基底; 以及设置在所述自由电子金属上的基质层，其中所述基质层包含具有硼酸络合部分的有机化合物。 基质优选为自组装单层（SAM），混合自组装单层（mSAM）或其组合。

公开(公告)号：US20040166031A1

公开(公告)日：2004-08-26

申请号：US09801077

申请日：2001-03-06

Applicant: Cepheid

Inventor： Michael T. Taylor ,  Farzad Pourahmadi ,  Ronald Chang ,  Douglas B. Dority

IPC: B01L011/00

CPC classification number: B01L3/502 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0809 ,  B01L2300/087 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12N1/066 ,  C12N13/00 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/829 ,  Y10T137/87716 ,  Y10T137/88046 ,  Y10T436/255

Abstract: A cartridge for analyzing a fluid sample has a body defining at least first and second channels and a cavity separating the channels. An end of the first channel is positioned on a first side of the cavity, and an end of the second channel is positioned on a second side of the cavity. The cavity is defined by a first curved surface positioned adjacent the end of the first channel, a second curved surface positioned adjacent the end of the second channel, and at least a third surface between the first and second curved surfaces. The cartridge also comprises an elastic membrane for establishing a seal with the first and second curved surfaces to prevent the flow of fluid between the channels. The third surface is recessed from the first and second surfaces to provide a gap between the membrane and the third surface when the membrane is pressed against the first and second surfaces. A cartridge having a conical valve seat is also disclosed.

Abstract translation: 用于分析流体样品的盒具有至少限定第一和第二通道的主体和分隔通道的空腔。 第一通道的端部位于空腔的第一侧上，并且第二通道的端部位于空腔的第二侧。 空腔由邻近第一通道的端部定位的第一弯曲表面，邻近第二通道的端部定位的第二弯曲表面以及第一和第二弯曲表面之间的至少第三表面限定。 墨盒还包括用于与第一和第二曲面建立密封以防止流体在通道之间流动的弹性膜。 第三表面从第一表面和第二表面凹进，当膜压在第一表面和第二表面上时，在膜和第三表面之间提供间隙。 还公开了一种具有锥形阀座的盒。

公开(公告)号：US06777193B1

公开(公告)日：2004-08-17

申请号：US09632735

申请日：2000-08-04

Applicant: María Isabel Baeza-Ramirez ,  José Leopoldo Aguilar-Faisal ,  Carlos Wong Ramirez ,  Miguel Angel Ibáñez Hernández ,  Mónica Lara Uc

Inventor： María Isabel Baeza-Ramirez ,  José Leopoldo Aguilar-Faisal ,  Carlos Wong Ramirez ,  Miguel Angel Ibáñez Hernández ,  Mónica Lara Uc

IPC: G01N3353

CPC classification number: G01N33/92 ,  Y10S435/975 ,  Y10S436/811 ,  Y10S436/815 ,  Y10S436/829

Abstract: Methods for detecting anti-lipidic particles antibodies and lipidic particles in cellular membranes for the diagnosis of diseases associated to the antiphospholipid syndrome are disclosed. Kits or sets to put these methods of diagnosis into practice are also disclosed. Methods for the therapeutically treatment of diseases associated to the antiphospholipid syndrome are disclosed as well. In addition, methods for the detection of the diverse physiologic states of cells, and those kits useful for this are also disclosed.

Abstract translation: 公开了用于检测细胞膜中的抗脂质颗粒抗体和脂质颗粒以诊断与抗磷脂综合征有关的疾病的方法。 还披露了将这些诊断方法付诸实践的套件或套件。 还公开了用于治疗治疗与抗磷脂综合征有关的疾病的方法。 此外，还公开了用于检测细胞的不同生理状态的方法，以及可用于此的试剂盒。