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11 条记录 (耗时 0.015 秒)

    Device incorporating a microfluidic chip for separating analyte from a sample
    1.
    发明申请
    Device incorporating a microfluidic chip for separating analyte from a sample 有权
    装有微流体芯片以用于从样品中分离分析物的装置

    公开(公告)号：US20020055167A1

    公开(公告)日：2002-05-09

    申请号：US10006850

    申请日：2001-11-07

    申请人： Cepheid

    发明人： Farzad Pourahmadi ,  William A. McMillan ,  Jesus Ching ,  Ronald Chang ,  Lee A. Christel ,  Gregory T.A. Kovacs ,  M. Allen Northrup ,  Kurt E. Petersen

    IPC分类号： C12M001/34

    CPC分类号： C12M47/06 ,  B01L2400/0622 ,  B01L2400/0644

    摘要： A device for separating an analyte from a fluid sample comprises a cartridge having a sample port and a first flow path extending from the sample port. A microfluidic chip is positioned in the first flow path. The microfluidic chip includes an extraction chamber having an array of microstructures for capturing the analyte from the sample as the sample flows through the extraction chamber and for subsequently releasing the captured analyte into an elution fluid as the elution fluid flows through the extraction chamber. Each of the microstructures has an aspect ratio of at least 2:1. The cartridge also includes a second flow path for eluting the captured analyte from the microfluidic chip, the second flow path diverging from the first flow path after passing through the chip. At least one flow controller directs the sample into the first flow path and the eluted analyte into the second flow path.

    摘要翻译： 用于从流体样品分离分析物的装置包括具有样品端口和从样品端口延伸的第一流动路径的盒。 微流体芯片位于第一流路中。 微流体芯片包括提取室，其具有用于当样品流过提取室时从样品捕获分析物的微结构阵列，并且随着洗脱流体流过提取室，随后将捕获的分析物释放到洗脱液中。 每个微结构具有至少2:1的纵横比。 盒还包括用于从微流体芯片洗脱捕获的分析物的第二流路，第二流路在通过芯片之后从第一流路发散。 至少一个流量控制器将样品引导到第一流动路径中，并将洗脱的分析物引导到第二流动路径中。

    Device for lysing cells, spores, or microorganisms
    3.
    发明申请
    Device for lysing cells, spores, or microorganisms 有权
    用于裂解细胞，孢子或微生物的装置

    公开(公告)号：US20020045246A1

    公开(公告)日：2002-04-18

    申请号：US10006904

    申请日：2001-11-07

    申请人： Cepheid

    发明人： William A. McMillan ,  Kurt E. Petersen ,  Lee A. Christel ,  Ronald Chang ,  Farzad Pourahmadi ,  Jesus Ching ,  Gregory T.A. Kovacs ,  M. Allen Northrup

    IPC分类号： C12M001/33

    CPC分类号： C12M47/06 ,  B01L2400/0622 ,  B01L2400/0644

    摘要： A device for use with an ultrasonic transducer to lyse components of a fluid sample comprises a cartridge having a lysing chamber, an inlet port in fluid communication with the lysing chamber, and an outlet port for exit of the sample from the lysing chamber. The inlet and outlet ports are positioned to permit flow of the sample through the lysing chamber, and the chamber contains at least one solid phase for capturing the sample components to be lysed as the sample flows through the chamber. The lysing chamber is defined by at least one wall having an external surface for contacting the transducer to effect the transfer of ultrasonic energy to the chamber.

    摘要翻译： 用于与超声换能器一起用于裂解流体样品的组分的装置包括具有裂解室，与裂解室流体连通的入口端口和用于将样品从裂解室排出的出口的筒。 入口端口和出口端口被定位成允许样品流过裂解室，并且室包含至少一个固相，用于在样品流过室时捕获要裂解的样品组分。 裂解室由至少一个具有用于接触换能器的外表面的壁限定，以实现将超声波能量传递到腔室。

    Apparatus and method for cell disruption
    5.
    发明申请
    Apparatus and method for cell disruption 审中-公开
    细胞破裂的装置和方法

    公开(公告)号：US20040200909A1

    公开(公告)日：2004-10-14

    申请号：US10759741

    申请日：2004-01-15

    申请人： Cepheid

    发明人： William A. McMillan ,  Farzad Pourahmadi

    IPC分类号： B02C019/12

    CPC分类号： B01L3/502 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12M47/06

    摘要： An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.

    摘要翻译： 用于破坏细胞或病毒的装置包括具有用于保持细胞或病毒的室的容器。 容器包括限定腔室的至少一个柔性壁。 该装置还包括用于冲击柔性壁的外表面的换能器，以在腔室中产生压力波。 该装置还包括用于增加腔室中的压力的​​压力源。 室的加压确保换能器与柔性壁之间的有效耦合。 该装置还可以包括室中的珠子，用于破裂细胞或病毒。

    CARTRIDGE FOR ANALYZING A FLUID SAMPLE
    9.
    发明申请
    CARTRIDGE FOR ANALYZING A FLUID SAMPLE 有权
    用于分析流体样品的墨盒

    公开(公告)号：US20040166031A1

    公开(公告)日：2004-08-26

    申请号：US09801077

    申请日：2001-03-06

    申请人： Cepheid

    发明人： Michael T. Taylor ,  Farzad Pourahmadi ,  Ronald Chang ,  Douglas B. Dority

    IPC分类号： B01L011/00

    CPC分类号： B01L3/502 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0809 ,  B01L2300/087 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12N1/066 ,  C12N13/00 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/829 ,  Y10T137/87716 ,  Y10T137/88046 ,  Y10T436/255

    摘要： A cartridge for analyzing a fluid sample has a body defining at least first and second channels and a cavity separating the channels. An end of the first channel is positioned on a first side of the cavity, and an end of the second channel is positioned on a second side of the cavity. The cavity is defined by a first curved surface positioned adjacent the end of the first channel, a second curved surface positioned adjacent the end of the second channel, and at least a third surface between the first and second curved surfaces. The cartridge also comprises an elastic membrane for establishing a seal with the first and second curved surfaces to prevent the flow of fluid between the channels. The third surface is recessed from the first and second surfaces to provide a gap between the membrane and the third surface when the membrane is pressed against the first and second surfaces. A cartridge having a conical valve seat is also disclosed.

    摘要翻译： 用于分析流体样品的盒具有至少限定第一和第二通道的主体和分隔通道的空腔。 第一通道的端部位于空腔的第一侧上，并且第二通道的端部位于空腔的第二侧。 空腔由邻近第一通道的端部定位的第一弯曲表面，邻近第二通道的端部定位的第二弯曲表面以及第一和第二弯曲表面之间的至少第三表面限定。 墨盒还包括用于与第一和第二曲面建立密封以防止流体在通道之间流动的弹性膜。 第三表面从第一表面和第二表面凹进，当膜压在第一表面和第二表面上时，在膜和第三表面之间提供间隙。 还公开了一种具有锥形阀座的盒。