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    CARTRIDGE FOR ANALYZING A FLUID SAMPLE
    3.
    发明申请
    CARTRIDGE FOR ANALYZING A FLUID SAMPLE 有权
    用于分析流体样品的墨盒

    公开(公告)号：US20040166031A1

    公开(公告)日：2004-08-26

    申请号：US09801077

    申请日：2001-03-06

    Applicant: Cepheid

    Inventor： Michael T. Taylor ,  Farzad Pourahmadi ,  Ronald Chang ,  Douglas B. Dority

    IPC: B01L011/00

    CPC classification number: B01L3/502 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0809 ,  B01L2300/087 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12N1/066 ,  C12N13/00 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/829 ,  Y10T137/87716 ,  Y10T137/88046 ,  Y10T436/255

    Abstract: A cartridge for analyzing a fluid sample has a body defining at least first and second channels and a cavity separating the channels. An end of the first channel is positioned on a first side of the cavity, and an end of the second channel is positioned on a second side of the cavity. The cavity is defined by a first curved surface positioned adjacent the end of the first channel, a second curved surface positioned adjacent the end of the second channel, and at least a third surface between the first and second curved surfaces. The cartridge also comprises an elastic membrane for establishing a seal with the first and second curved surfaces to prevent the flow of fluid between the channels. The third surface is recessed from the first and second surfaces to provide a gap between the membrane and the third surface when the membrane is pressed against the first and second surfaces. A cartridge having a conical valve seat is also disclosed.

    Abstract translation: 用于分析流体样品的盒具有至少限定第一和第二通道的主体和分隔通道的空腔。 第一通道的端部位于空腔的第一侧上，并且第二通道的端部位于空腔的第二侧。 空腔由邻近第一通道的端部定位的第一弯曲表面，邻近第二通道的端部定位的第二弯曲表面以及第一和第二弯曲表面之间的至少第三表面限定。 墨盒还包括用于与第一和第二曲面建立密封以防止流体在通道之间流动的弹性膜。 第三表面从第一表面和第二表面凹进，当膜压在第一表面和第二表面上时，在膜和第三表面之间提供间隙。 还公开了一种具有锥形阀座的盒。

    Container for holding cells or viruses for disruption
    5.
    发明申请
    Container for holding cells or viruses for disruption 有权
    用于控制细胞或病毒的容器用于中断

    公开(公告)号：US20020187547A1

    公开(公告)日：2002-12-12

    申请号：US10208976

    申请日：2002-07-30

    Applicant: Cepheid

    Inventor： Michael T. Taylor ,  Phillip Belgrader ,  Farzad Pourahmadi ,  William A. McMillan ,  Ronald Chang ,  Douglas B. Dority

    IPC: C12M001/33

    CPC classification number: B01L3/502 ,  B01L3/50825 ,  B01L7/52 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/14 ,  B01L2400/0439 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12M47/06

    Abstract: A container for holding cells or viruses for disruption comprises a chamber defined by two spaced apart, opposing major walls and side walls connecting the major walls to each other. At least one of the major walls has an external surface to which the transducer may be coupled and is sufficiently flexible to flex in response to vibratory motion of the transducer. The container also has at least one port for introducing the cells or viruses into the chamber. In some embodiments, the chamber contains beads for aiding the disruption of the cells or viruses.

    Abstract translation: 用于保持细胞或病毒用于破坏的容器包括由两个间隔开的相对的主壁和连接主壁彼此连接的侧壁限定的室。 主壁中的至少一个具有外部表面，换能器可以连接到该外表面，并且响应于换能器的振动运动而具有足够的柔性以弯曲。 容器还具有用于将细胞或病毒引入腔室中的至少一个端口。 在一些实施方案中，室包含用于帮助细胞或病毒破坏的珠。

    Fluid processing and control
    6.
    发明申请
    Fluid processing and control 有权
    流体加工和控制

    公开(公告)号：US20030162304A1

    公开(公告)日：2003-08-28

    申请号：US10084409

    申请日：2002-02-25

    Applicant: Cepheid

    Inventor： Douglas B. Dority ,  Ronald Chang

    IPC: G01N001/10

    CPC classification number: B01L3/502715 ,  B01L3/502 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/06 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0848 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2400/0421 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0644 ,  G01N1/18 ,  G01N1/28 ,  G01N1/405 ,  Y10T436/255 ,  Y10T436/2575

    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers. One or more of the chambers may be a processing chamber which includes two ports configured to selectively engage the at least one external port of the body, and a fluid processing material such as an enrichment material or a depletion material. In some embodiments, one or more chambers may include a separation channel, and an electric field may be applied across the separation channel.

    Abstract translation: 用于控制多个室之间的流体流动的流体控制和处理系统包括主体，其包括与流体位移区域流体连续耦合的流体处理区域。 流体位移区域是可减压的，以将流体吸入流体移动区域并且可加压以从流体位移区域排出流体。 身体至少包括一个外部端口。 流体处理区域与至少一个外部端口流体耦合。 流体位移区域与主体的至少一个外部端口流体耦合。 主体相对于多个室可调节以将至少一个外部端口选择性地与多个室流体连通。 一个或多个室可以是处理室，其包括构造成选择性地接合主体的至少一个外部端口的两个端口，以及诸如富集材料或耗尽材料的流体处理材料。 在一些实施例中，一个或多个腔室可以包括分离通道，并且可以跨越分离通道施加电场。

    Reaction vessel and temperature control system
    7.
    发明申请
    Reaction vessel and temperature control system 有权
    反应容器和温度控制系统

    公开(公告)号：US20020168299A1

    公开(公告)日：2002-11-14

    申请号：US10167898

    申请日：2002-06-11

    Applicant: Cepheid

    Inventor： Ronald Chang ,  Douglas B. Dority ,  Lee A. Christel ,  Kurt E. Petersen

    IPC: B01L003/00

    CPC classification number: B01L3/502 ,  B01L3/50825 ,  B01L7/52 ,  B01L2200/026 ,  B01L2200/0642 ,  B01L2200/0684 ,  B01L2300/0654 ,  B01L2300/14 ,  B01L2400/049 ,  B01L2400/0644 ,  G01N2035/0405 ,  Y10T436/2575

    Abstract: A reaction vessel has a reaction chamber, a loading reservoir connected to the reaction chamber via a first channel, and an aspiration port connected to the chamber via a second channel. To load the sample into the reaction chamber, the sample is dispensed into the loading reservoir and then drawn into the chamber by application of a vacuum to the aspiration port. A system for controlling the temperature of the sample in the reaction vessel includes one or more thermal elements for heating or cooling the sample and optionally optics for detecting one or more analytes in the sample.

    Abstract translation: 反应容器具有反应室，经由第一通道连接到反应室的装载容器和经由第二通道连接到室的抽吸口。 为了将样品加载到反应室中，将样品分配到装载容器中，然后通过向抽吸端口施加真空而将其吸入室中。 用于控制反应容器中的样品的温度的系统包括用于加热或冷却样品的一个或多个热元件，以及用于检测样品中的一种或多种分析物的任选的光学元件。

    Multi-channel optical detection system
    8.
    发明申请
    Multi-channel optical detection system 有权
    多通道光学检测系统

    公开(公告)号：US20020109844A1

    公开(公告)日：2002-08-15

    申请号：US10119228

    申请日：2002-04-08

    Applicant: Cepheid

    Inventor： Lee A. Christel ,  M. Allen Northrup ,  Kurt E. Petersen ,  William A. McMillan ,  Gregory T.A. Kovacs ,  Steven J. Young ,  Ronald Chang ,  Douglas B. Dority ,  Raymond T. Herbert ,  Gregory J. Kintz

    IPC: G01N021/64

    CPC classification number: B01L3/508 ,  B01J19/0093 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/042 ,  B01L2300/0809 ,  B01L2300/0858 ,  B01L2300/168 ,  B01L2300/1805 ,  F28D2021/0077 ,  F28F3/12 ,  F28F21/04 ,  F28F2280/10 ,  G01N21/0303 ,  G01N21/0332 ,  G01N2035/00326

    Abstract: An apparatus for thermally controlling and optically interrogating a reaction mixture includes a vessel null2null having a chamber null10null for holding the mixture. The apparatus also includes a heat-exchanging module null37null having a pair of opposing thermal plates null34A, 34Bnull for receiving the vessel null2null between them and for heating/and or cooling the mixture contained in the vessel. The module null37null also includes optical excitation and detection assemblies null46,48null positioned to optically interrogate the mixture. The excitation assembly null46null includes multiple light sources null100null and a set of filters for sequentially illuminating labeled analytes in the mixture with excitation beams in multiple excitation wavelength ranges. The detection assembly null48null includes multiple detectors null102null and a second set of filters for detecting light emitted from the chamber null10null in multiple emission wavelength ranges. The optics assemblies null46,48null thus provide a multi-channel system for detecting a plurality of different target analytes in the mixture.

    Abstract translation: 用于热控制和光学询问反应混合物的装置包括具有用于保持混合物的室[10]的容器[2]。 该装置还包括具有一对相对的热板[34A，34B]的热交换模块[37]，用于在它们之间接收容器[2]并用于加热和/或冷却容纳在容器中的混合物。 模块[37]还包括定位成光学询问混合物的光学激发和检测组件[46,48]。 激发组件[46]包括多个光源[100]和一组用于在多个激发波长范围内用激发光束顺序地照射混合物中的标记分析物的滤光器。 检测组件[48]包括多个检测器[102]和第二组滤波器，用于在多个发射波长范围内检测从腔室[10]发射的光。 因此，光学组件[46,48]提供用于检测混合物中的多个不同目标分析物的多通道系统。

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