公开(公告)号：US20240118297A1

公开(公告)日：2024-04-11

申请号：US18542235

申请日：2023-12-15

申请人： BiopTek, Inc.

发明人： Nanetta Rapuano ,  Michael Peter Mikulasovich

IPC分类号： G01N35/00 ,  G01N35/04

CPC分类号： G01N35/00732 ,  G01N35/04 ,  G01N2035/00752 ,  G01N2035/00772 ,  G01N2035/00831 ,  G01N35/0099 ,  G01N2035/0405

摘要： Automated systems for processing a biopsy sample are disclosed herein, as well as methods for automating the processing of a biopsy sample. A benefit to the automated systems and methods herein can be the efficient and cost-effective processing of large numbers of biopsy samples. Another benefit to the automated systems and methods herein can be increased personnel safety for processing biopsy samples. Additional benefits to the automated systems and methods herein can be greater patient safety by increasing accuracy in biopsy sample processing, and preventing errors in biopsy sample processing that may lead to misdiagnosis and improper treatments.

公开(公告)号：US11892455B2

公开(公告)日：2024-02-06

申请号：US17061095

申请日：2020-10-01

申请人： Meso Scale Technologies, LLC

发明人： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

IPC分类号： G01N35/10 ,  B67B7/00 ,  G01N33/58 ,  G01N21/64 ,  G01N21/66 ,  G01N33/53 ,  G01N35/02 ,  B01L3/00 ,  G01N35/04

CPC分类号： G01N33/582 ,  B01L3/5085 ,  B01L3/50255 ,  B67B7/24 ,  G01N21/6452 ,  G01N21/66 ,  G01N33/5302 ,  G01N35/028 ,  G01N35/1011 ,  G01N35/1079 ,  G01N35/1081 ,  G01N35/1002 ,  G01N35/109 ,  G01N2035/0405 ,  G01N2035/0425 ,  G01N2035/1025 ,  Y10T83/9314

摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US11885823B2

公开(公告)日：2024-01-30

申请号：US17320955

申请日：2021-05-14

申请人： BD KIESTRA B.V.

发明人： Martijn Kleefstra ,  Martijn Xander Berntsen ,  Jan Bart Van Der Vijver ,  Tsjerk Nauta ,  Andrej Girgenson

IPC分类号： C12M1/00 ,  C12M1/36 ,  C12M3/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/02

CPC分类号： G01N35/04 ,  C12M23/44 ,  C12M41/14 ,  C12M41/48 ,  G01N35/0099 ,  G01N35/00732 ,  G01N35/0092 ,  G01N35/028 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00316 ,  G01N2035/00356 ,  G01N2035/00831 ,  G01N2035/00851 ,  G01N2035/0405 ,  G01N2035/0427 ,  G01N2035/0441 ,  G01N2035/0465 ,  G01N2035/0493 ,  G01N2035/0496

摘要： The present invention describes an integrated incubator and image capture module that regulates the incubator atmosphere and obtains high-resolution digital images of sample specimens. The incubator has a cabinet type enclosure that enables the provision of a controlled environment to the contents of the incubator by having at least three ports on one face of the cabinet for the passage of sample containers. Additionally, an image capture module is located immediately adjacent to the incubator. In this regard, using at least three separate access/egress points for the sample containers streamlines operation of the system and enhances preservation of the incubator environment. Furthermore, locating the image capture module directly adjacent to the incubator reduces the amount of time a sample container is exposed to the external environment, thereby reducing the extent to which samples are exposed to potential contaminants and reducing the exchange of the lab and ambient atmospheres.

公开(公告)号：US20230324428A1

公开(公告)日：2023-10-12

申请号：US18010005

申请日：2021-02-05

申请人： HITACHI HIGH-TECH CORPORATION

发明人： Tsukasa SUENARI ,  Takenori OKUSA ,  Taichiro YAMASHITA

IPC分类号： G01N35/10 ,  G01N35/02

CPC分类号： G01N35/1002 ,  G01N35/025 ,  G01N2035/0405

摘要： Provided is an automatic analyzer capable of reliably closing an openable lid provided in an opening for accessing a region covered by a cover. An automatic analyzer includes an incubator cover disposed to cover a preprocessing region provided on an operation surface on a housing, an openable lid disposed to openably cover an opening portion provided in the incubator cover in order to access the inside from the outside of the preprocessing region, and a safety cover disposed to cover upper portions of the operation surface and the preprocessing region, and the openable lid is moved to a closed position in association with movement of the safety cover from an opened position to the closed position in a case where the openable lid is at the opened position and the safety cover is at the opened position.

公开(公告)号：US11761971B2

公开(公告)日：2023-09-19

申请号：US16725881

申请日：2019-12-23

申请人： Joachim Gerstel

发明人： Joachim Gerstel

IPC分类号： G01N35/02 ,  G01N35/10 ,  G01N1/28 ,  B01L3/02 ,  B01D35/02 ,  B04B5/04 ,  B01F25/10 ,  B04B11/04 ,  G01N35/00 ,  G01N35/04 ,  B01F101/23

CPC分类号： G01N35/025 ,  B01D35/02 ,  B01F25/10 ,  B01L3/0275 ,  B04B5/0414 ,  B04B5/0421 ,  B04B11/043 ,  G01N1/286 ,  G01N35/00732 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1011 ,  G01N35/1079 ,  B01F2101/23 ,  B01L2300/0681 ,  B04B2011/046 ,  G01N35/1097 ,  G01N2001/2873 ,  G01N2035/0405 ,  G01N2035/0449 ,  G01N2035/103 ,  G01N2035/1025 ,  G01N2035/1053

摘要： The invention relates to an arrangement for preparing a plurality of samples for an analytical method, comprising a carousel with a solid housing and moveable receiving parts for the sample containers; a control for controlling the receiving parts in the carousel; and a sample receiving device for providing the sample for the analytical method. Said arrangement is characterized in that one or more stations for preparing samples are provided on the carousel, the receiving parts for the sample containers of the carousel can be positioned on said stations. Said arrangement also comprises a centrifuge with pairs of opposite lying receiving parts provided for the sample containers, and said receiving parts are arranged such that they can move on the centrifuge for the sample holder such that a transfer of a sample holder between a receiving part in the carousel and a receiving part in the centrifuge can be carried out. The control takes place by the same control which is also provided for controlling the carousel.

公开(公告)号：US20230160801A1

公开(公告)日：2023-05-25

申请号：US17997067

申请日：2021-04-27

申请人： HORIBA, LTD.

发明人： Tetsuji YAMAGUCHI

IPC分类号： G01N9/30 ,  G01N35/04 ,  G01N35/10 ,  B04B1/08

CPC分类号： G01N9/30 ,  G01N35/04 ,  G01N35/1009 ,  B04B1/08 ,  G01N2035/0405

摘要： To improve the measurement accuracy of a particle size distribution measuring device that performs a particle size distribution measurement in a line start mode. A measurement cell used in a line start mode of a centrifugal sedimentation type particle size distribution measuring device includes: a cell main body that has an opening provided on one end and stores therein a density gradient liquid WDGS; and a cell cap that closes the opening of the cell main body and has an internal passage R provided therein for holding a sample liquid WSS. When an application of a centrifugal force is received, the sample liquid WSS is introduced from the internal passage R into the density gradient liquid WDGS.

公开(公告)号：US20190194765A1

公开(公告)日：2019-06-27

申请号：US16287275

申请日：2019-02-27

申请人： GeneWeave Biosciences, Inc.

发明人： Diego Ariel REY ,  Shaunak ROY ,  Leonardo Maestri TEIXEIRA ,  Ryan C. GRISWOLD ,  Kenneth G. OLSON ,  Bruce J. RICHARDSON ,  Victor H. YEE ,  Werner FREI

IPC分类号： C12Q1/6897 ,  B01L3/00 ,  G01N21/13 ,  B01L7/00 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/10 ,  C12Q1/14 ,  C12Q1/66 ,  G01N21/76 ,  G01N21/03 ,  G01N21/01 ,  G01J1/00

CPC分类号： C12Q1/6897 ,  B01L3/502 ,  B01L3/50825 ,  B01L3/52 ,  B01L3/523 ,  B01L3/54 ,  B01L3/545 ,  B01L7/00 ,  B01L2200/028 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2300/0672 ,  B01L2400/0478 ,  B01L2400/06 ,  B01L2400/0683 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/10 ,  C12Q1/14 ,  C12Q1/66 ,  G01J1/00 ,  G01N21/01 ,  G01N21/03 ,  G01N21/13 ,  G01N21/76 ,  G01N21/763 ,  G01N2035/00346 ,  G01N2035/0405 ,  G01N2333/195

摘要： Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

公开(公告)号：US20180229240A1

公开(公告)日：2018-08-16

申请号：US15950620

申请日：2018-04-11

申请人： Roche Diagnostics Operations, Inc.

发明人： Reinhold Kraemer ,  Stephan Sattler

IPC分类号： B01L3/00 ,  B29C45/44 ,  B29C45/33

CPC分类号： B01L3/523 ,  B01L3/52 ,  B01L2300/0809 ,  B01L2300/0848 ,  B01L2300/0851 ,  B01L2300/0858 ,  B29C45/2624 ,  B29C45/332 ,  B29C45/4421 ,  B29K2023/06 ,  B29K2023/12 ,  B29L2031/752 ,  G01N2035/0405

摘要： A reagent vessel, an apparatus and a method for manufacturing a lower part of a reagent vessel for an analytical instrument are disclosed. The reagent vessel is configured to store a liquid reagent. The reagent vessel comprises a cover and a lower part. The lower part comprises a bottom wall, a front wall, a rear wall, two opposing side walls and at least one connection wall. The cover, bottom wall, front wall, rear wall and two opposing side walls define at least one internal volume for storing at least one liquid reagent. The two opposing side walls are at least partially connected to one another by the at least one connection wall located within the at least one internal volume. The connection wall is spaced apart from the bottom wall. The connection wall and at least the two opposing side walls can be injection-molded and are monolithically formed.

公开(公告)号：US20180188275A1

公开(公告)日：2018-07-05

申请号：US15740028

申请日：2016-07-08

申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION

发明人： Kazuhiro NODA ,  Yukinori SAKASHITA ,  Takushi MIYAKAWA ,  Katsuhiro KAMBARA

IPC分类号： G01N35/04

CPC分类号： G01N35/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/025 ,  G01N2035/00435 ,  G01N2035/0405

摘要： The purpose of the present invention is to stably hold the lid of a reagent container in an open state without being influenced by reagent container lid opening and closing operations. An automated analyzer is provided with reagent containers 116-118, a cassette 100, a reagent container lid opening and closing mechanism, and a lid holding mechanism 131. The reagent containers 116-118 accommodate the reagent and have lids 101a-101c that pivot about a pivot point. The reagent containers 116-118 are mounted on the cassette 100. The reagent container lid opening and closing mechanism opens and closes the lids 101a-101c. The lid holding mechanism 131 holds the lids 101a opened by the reagent container lid opening and closing mechanism.

公开(公告)号：US09993824B2

公开(公告)日：2018-06-12

申请号：US14694365

申请日：2015-04-23

申请人： TECAN TRADING AG

发明人： Friedrich Menges ,  Harald Gebetsroither ,  Gyoergy Wenczel

IPC分类号： B01L9/00 ,  B01L1/00 ,  B01L99/00 ,  G01N35/02 ,  G01N35/04 ,  G01N21/01 ,  G01N35/00 ,  G01N21/03

CPC分类号： B01L9/523 ,  B01L1/00 ,  B01L99/00 ,  B01L2300/0663 ,  B01L2300/12 ,  B01L2300/16 ,  G01N21/0303 ,  G01N35/028 ,  G01N35/04 ,  G01N2021/036 ,  G01N2035/00287 ,  G01N2035/0405 ,  Y10S436/807

摘要： A microplate reader comprises a housing; at least one optical measuring/detection device; a microplate support; a moving unit; and an integrated lid holding apparatus. The lid holding apparatus is arranged to move the microplate lid and/or the microplate support is arranged to move the microplate in one respective, in an at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electromagnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material.