公开(公告)号：US12053778B2

公开(公告)日：2024-08-06

申请号：US17529498

申请日：2021-11-18

申请人： LUMICKS CA HOLDING B.V.

发明人： Andrea Candelli ,  Felix Oswald ,  Gerrit Sitters

IPC分类号： B01L3/00 ,  B01L7/00 ,  G01N15/1429 ,  G01N21/03 ,  G01N21/17 ,  G01N29/036 ,  G01N29/22 ,  G01N29/24 ,  G01N29/34 ,  G01N21/64

CPC分类号： B01L3/502761 ,  B01L3/50273 ,  B01L7/00 ,  G01N15/1429 ,  G01N21/0332 ,  G01N29/036 ,  G01N29/222 ,  G01N29/2437 ,  G01N29/2462 ,  G01N29/346 ,  G01N29/348 ,  B01L2200/0652 ,  B01L2300/0663 ,  B01L2300/163 ,  B01L2300/1822 ,  B01L2400/0436 ,  G01N2021/177 ,  G01N21/6458 ,  G01N2291/014 ,  G01N2291/02466 ,  G01N2291/02475 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0257 ,  G01N2291/02809 ,  G01N2291/0423 ,  G01N2291/0426

摘要： A method of manipulating and/or investigating cellular bodies (9) is provided. The method comprises the steps of: providing a sample holder (3) comprising a holding space (5) for holding a fluid medium (11); providing a sample (7) comprising one or more cellular bodies (9) in a fluid medium (11) in the holding space (5); generating an acoustic wave in the holding space exerting a force (F) on the sample (7) in the holding space (5). The method further comprises providing the holding space (5) with a functionalised wall surface portion (17) to be contacted by the sample (7) and the sample (7) is in contact with the functionalised wall surface portion (17) during at least part of the step of application of the acoustic wave. A system and a sample holder (3) are also provided.

公开(公告)号：US20240219398A1

公开(公告)日：2024-07-04

申请号：US18407278

申请日：2024-01-08

申请人： Seer, Inc.

发明人： William Manning ,  Young Kim ,  Brandon Kwan-Leong ,  Hope Liou ,  Xiaoyan Zhao ,  Daniel Hornburg ,  Martin Goldberg

IPC分类号： G01N33/68 ,  B01L3/00 ,  B01L7/00 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01N1/34 ,  G01N1/44 ,  G01N33/543

CPC分类号： G01N33/6848 ,  B01L3/5085 ,  B01L7/00 ,  G01N1/34 ,  G01N1/44 ,  G01N33/54326 ,  G01N33/54346 ,  B01L2400/043 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

摘要： Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.

公开(公告)号：US20240181461A1

公开(公告)日：2024-06-06

申请号：US18550717

申请日：2022-03-17

申请人： DH Technologies Development Pte. Ltd.

发明人： Wayne Wei Kang SNG

IPC分类号： B01L7/00

CPC分类号： B01L7/00 ,  B01L2300/0829 ,  B01L2300/1827

摘要： A well plate includes a body including a plurality of well walls and an outer wall. A glass plate is disposed below the plurality of well walls so as to form a bottom of each of a plurality of wells defined by the plurality of well walls. A plurality of electrical heat trace wires are disposed on the glass plate. A plurality of contacts are disposed proximate an exterior surface of the body. A plurality of conductors connect the plurality of contacts to the plurality of heat trace wires.

公开(公告)号：US11959844B2

公开(公告)日：2024-04-16

申请号：US17389653

申请日：2021-07-30

申请人： JEOL Ltd.

发明人： Takashi Yaginuma ,  Kiyohiro Ishikawa ,  Yusuke Yamanaka

IPC分类号： B01L3/00 ,  B01L7/00 ,  G01N1/34 ,  G01N1/42 ,  G01N35/00 ,  G01N35/10

CPC分类号： G01N1/42 ,  B01L3/505 ,  B01L3/52 ,  B01L7/00 ,  B01L13/02 ,  G01N1/34 ,  G01N35/00584 ,  G01N35/10 ,  B01L2300/042 ,  B01L2300/069 ,  B01L2300/105 ,  B01L2300/1894 ,  G01N2035/00435

摘要： There is provided a cool box for use in an automatic analyzer. The cool box has a box body and an air circulator. The box body has a receiving space capable of accommodating therein receptacles for analytes or reagents. The circulator has an intake portion, a fan, and an exhaust portion and operates to circulate air in the receiving space by rotation of the fan. The circulator further includes an inhibitor removing agent retaining portion on which a pouch is set. The pouch contains an analysis inhibitor removing agent for removing components (analysis inhibitor) which adversely affect or inhibit analysis of the analytes.

公开(公告)号：US20240091770A1

公开(公告)日：2024-03-21

申请号：US18520005

申请日：2023-11-27

申请人： First Light Biosciences, Inc.

发明人： Bruce Walsh ,  Boris Blanter ,  Matthew Barra ,  Brian Connolly ,  Greg Yantz ,  Paul Gervasio ,  Don Straus

IPC分类号： B01L3/00 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157 ,  G01N21/03 ,  G01N21/25 ,  G01N21/64 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02

CPC分类号： B01L3/502715 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150274 ,  A61B5/150305 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150786 ,  A61B5/15113 ,  A61B5/15186 ,  A61B5/157 ,  B01L3/5027 ,  B01L3/502738 ,  B01L3/502761 ,  B01L3/5029 ,  B01L3/5082 ,  G01N21/03 ,  G01N21/253 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/54373 ,  G01N35/0098 ,  G01N35/02 ,  G01N35/025 ,  A61B5/151 ,  B01L7/00

摘要： The invention provides analyzers that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient and specific selection and sensitive imaging detection of individual microscopic targets at low magnification. Automated embodiments allow efficient walk-away, on-demand, random-access high-throughput testing. The analyzers perform tests without requiring wash steps thus streamlining engineering and lowering costs. Thus, the invention provides analyzers that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests for analytes.

公开(公告)号：US11927513B2

公开(公告)日：2024-03-12

申请号：US17557636

申请日：2021-12-21

申请人： LCTech GmbH

发明人： Martin Brandlhuber ,  Uwe Aulwurm

IPC分类号： B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N1/40

CPC分类号： G01N1/40 ,  B01L3/502 ,  B01L7/00 ,  B01L9/50 ,  B01L2200/0689 ,  B01L2300/0832 ,  B01L2300/14 ,  B01L2300/18

摘要： The extraction system according to the invention for extracting analytes from a sample comprises



an extraction cell for receiving the sample, which has at least one first fluid connector for the supply or discharge of a fluid, and
a clamping device for clamping the extraction cell, and
a fluid connection device for establishing a fluid connection with the at least one first fluid connector of the extraction cell,

wherein an extraction cell holder is provided for receiving the extraction cell, and the clamping device has a guiding and positioning arrangement for linearly inserting the extraction cell holder, together with the extraction cell, in order to position the extraction cell in an insertion position.

公开(公告)号：US11906526B2

公开(公告)日：2024-02-20

申请号：US18365674

申请日：2023-08-04

申请人： Seer, Inc.

发明人： William Manning ,  Young Kim ,  Brandon Kwan-Leong ,  Hope Liou ,  Xiaoyan Zhao ,  Daniel Hornburg ,  Martin Goldberg

IPC分类号： G01N1/34 ,  G01N1/44 ,  G01N33/543 ,  B01L3/00 ,  B01L7/00 ,  G01N33/68 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

CPC分类号： G01N33/6848 ,  B01L3/5085 ,  B01L7/00 ,  G01N1/34 ,  G01N1/44 ,  G01N33/54326 ,  G01N33/54346 ,  B01L2400/043 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

摘要： Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.

公开(公告)号：US11906454B2

公开(公告)日：2024-02-20

申请号：US16462059

申请日：2017-11-13

申请人： President and Fellows of Harvard College

发明人： Jinhye Bae ,  Joost J Vlassak

IPC分类号： G01N25/48 ,  B01L7/00

CPC分类号： G01N25/4846 ,  B01L7/00 ,  B01L2300/023 ,  B01L2300/0663 ,  B01L2300/0848 ,  B01L2300/12 ,  B01L2300/1805

摘要： A microcalorimeter device capable of measuring cellular bioenergetics and systems that are limited in analytic volume. The microcalorimeter device provides sub-nWatt resolution and even tens of pico-Watt resolution, thus enabling resolution of the metabolic rate of a single cell.

公开(公告)号：US11892205B2

公开(公告)日：2024-02-06

申请号：US17989938

申请日：2022-11-18

申请人： Bio-Rad Laboratories, Inc.

发明人： Amir Sadri ,  Nenad Kircanski ,  Thanh-Vi Tran ,  Carl Marlowe ,  Brian David Wilson

IPC分类号： F25B21/04 ,  B01L7/00 ,  H10N10/10 ,  H10N10/80

CPC分类号： F25B21/04 ,  B01L7/00 ,  B01L7/52 ,  H10N10/10 ,  H10N10/80 ,  B01L2300/08 ,  B01L2300/123 ,  B01L2300/1805

摘要： A heat pump that includes a thermoelectric device(s) and a heat sink having a raised portion with a top surface for thermally coupling with a planar face of the thermoelectric device(s). The raised portion of the heat sink includes an outer periphery and a raised central region surrounded by a void region to provide more uniform thermal conductivity when clamped within an assembly. The raised central region is shaped in an any shape corresponding to a shape of uneven thermal conductivity due to clamping pressure applied to the heat sink. The void region can be substantially contiguous and entirely circumscribe the central raised region. The device can optionally include discrete supports formed of a less thermally-conductive material within the void region. The supports can be elastomeric, such as O-rings, and disposed within pockets defined within the void region.

公开(公告)号：US11890620B2

公开(公告)日：2024-02-06

申请号：US16755505

申请日：2018-10-12

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： Kirsty A. McFarland ,  Charles A. Lissandrello ,  Andrew P. Magyar ,  Erin Rosenberger

IPC分类号： B01L3/00 ,  B01L7/00 ,  B04B3/00 ,  B04B5/04 ,  C12Q1/6837 ,  C12Q1/6874

CPC分类号： B01L3/50853 ,  B01L3/502715 ,  B01L3/502746 ,  B01L7/00 ,  B04B3/00 ,  B04B5/0414 ,  C12Q1/6837 ,  C12Q1/6874 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/168

摘要： Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency.