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    FLUORINATED FIBERS FOR MULTIMODAL 1H AND 19F MRI, ULTRASOUND, FLUORESCENCE DETECTION AND CONFORMATIONAL AND TEMPERATURE DETECTION BY 19F MRS
    7.
    发明公开
    FLUORINATED FIBERS FOR MULTIMODAL 1H AND 19F MRI, ULTRASOUND, FLUORESCENCE DETECTION AND CONFORMATIONAL AND TEMPERATURE DETECTION BY 19F MRS 审中-公开

    公开(公告)号：US20240115742A1

    公开(公告)日：2024-04-11

    申请号：US18460519

    申请日：2023-09-01

    申请人： New York University

    发明人： Jin Kim Montclare ,  Dustin Britton ,  Youssef Zaim Wadghiri ,  Farbod Mahmoudinobar

    IPC分类号： A61K49/18 ,  A61K49/14 ,  A61K49/22 ,  C07K14/245 ,  G01N24/08 ,  G01N29/34 ,  G16B40/00

    CPC分类号： A61K49/1884 ,  A61K49/14 ,  A61K49/222 ,  C07K14/245 ,  G01N24/08 ,  G01N29/34 ,  G16B40/00 ,  B82Y40/00

    摘要： Provided are proteins/peptides. The proteins or peptides comprise a sequence designed by the methods described herein. The proteins and peptides may have one or more trifluoroleucine (LTF, which may be referred to as TFL or LTF throughout) residues. The proteins may have or contain the following sequence:



    VX1X2X3X4X5X6X7X8X9X10X11X12X13X14X15X16X17X18X19X20X21X22X23X24X25X26X27X28X29X30X31X32X33X34X35X36X37 (SEQ ID NO:1), where X1 is A, E, D, R, H, K, Q, N, or S; X2 is A, E, N, or Q; X3 is A, V, L, I, Q, M, or LT; X4 is A, E, R, D, H, I, L, T, K, Q, N, or LT; X5 is A, F, Q, R, K, H, D, S, or E; X6 is A, L, I, or LTF; X7 is A, K, or E; X8 is A, K, E, D, R, H, Q, or N; X9 is A, T, I, L, Q, or LTF; X10 is A, L, I, or LT; X11 is A, E, D, H, P, I, L, K, Y, N, Q, R, or LT; X12 is A, Q, H, E, D, K, R, or N; X13 is A, M, I, L, Q, T, or LTF; X14 is A, L, D, E, K, I, or LTF; X15 is A, E, D, H, Y, I, L, R, K, Q, N, or Lu; X16 is A, E, or Q; X17 is A, L, M, I, V, or LTF; X18 is A, K, E, D, K, R, H, N, or Q; X19 is A, N, D, K, R, H, Q, or E; X20 is A, L, T, I, M, R, or LTF; X21 is A, N, or Q; X22 is K, A, E, I, L, M, R, H, D, Q, N, S, or LTF; X23 is A, Q, N, I, L, or LTF; X24 is A, L, I, M, T, or LT; X25 is A, H, Q, R, K, D, N, Y, I, E, L, T, or LT; X26 is A, D, E, R, K, Q, H, N, or T; X27 is A, V, I, Q, L, T, or LTF; X28 is A, R, E, D, K, H, N, Q, or T; X29 is A, H, E, R, D, K, I, L, N, Q, T, Y, or LTF; X30 is L, A, D, K, I, N, Q, or LTF; X31 is A, L, Q, I, or LTF; X32 is E, D, K, H, N, Q, A, L, R, I, Y, or LTF; X33 is A, N, Q, D, E, H, K, R, or S; X34 is Q, I, L, A, M, or LT; X35 is S, A, P, or Q; X36 is A, K, T, D, R, H, N, Q, or E; X37 is A, L, I, K, D, N, Q, R, or LTF; where at least one of X3, X4, X6, X9, X10, X11, X13, X14, X15, X16, X17, X20, X22, X23, X24, X25, X27, X29, X30, X31, X32, X34, X37 or any L is replaced with LTF. The proteins and peptides may have desirable self-assembling properties such that they form supramolecular structures (e.g., fibers or fibrils). The supramolecular structures may further gelate water such that a hydrogel is formed. The fibers and/or gels may be used to deliver drugs and/or as theranostic agents.

    Inspection device and inspection method
    10.
    发明授权
    Inspection device and inspection method 有权

    公开(公告)号：US11898991B2

    公开(公告)日：2024-02-13

    申请号：US17410522

    申请日：2021-08-24

    申请人： KABUSHIKI KAISHA TOSHIBA ,  TOSHIBA INFRASTRUCTURE SYSTEMS & SOLUTIONS CORPORATION

    发明人： Yutaka Nakai ,  Tomio Ono ,  Noriko Yamamoto ,  Kazuhiro Itsumi

    IPC分类号： G01N29/04 ,  G01N29/34 ,  G01N29/44

    CPC分类号： G01N29/041 ,  G01N29/343 ,  G01N29/44 ,  G01N2291/011 ,  G01N2291/015

    摘要： According to one embodiment, an inspection device includes a transmitter configured to transmit a first ultrasonic wave, a receiver on which the first ultrasonic wave is incident, and a receiving-side waveguide located between the receiver and an inspection position. The receiver is configured to output a signal corresponding to the incident first ultrasonic wave. The inspection position is between the transmitter and the receiver. The first ultrasonic wave passes through the receiving-side waveguide. An inspection object passes through the inspection position along a second direction crossing a first direction. The first direction is from the transmitter toward the receiver. The receiving-side waveguide includes at least one of a first structure or a second structure. In the first structure, the receiving-side waveguide includes a tubular member and an inner member. The inner member is located inside the tubular member. In the second structure, the receiving-side waveguide includes a tubular member.