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    Chemical and biomedical nanosensors
    3.
    发明授权
    Chemical and biomedical nanosensors 有权

    公开(公告)号：US09995718B1

    公开(公告)日：2018-06-12

    申请号：US14824311

    申请日：2015-08-12

    Applicant: Vlad Joseph Novotny

    Inventor： Vlad Joseph Novotny

    IPC: G01N29/036 ,  G01N29/24 ,  G01N29/02

    CPC classification number: G01N29/2437 ,  B82Y15/00 ,  G01N29/022 ,  G01N2291/014 ,  G01N2291/02416 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0257

    Abstract: The electrostatic sensors of bridge or cantilever type with multiple electrodes, the electrostatic sensors of comb type and piezoelectric sensors are used for the single molecule detection of ligands. The electrical driving of sensors is separated in some cases from the sensing for increased sensitivity. The large arrays of sensors with individual or common sensing circuits are employed to further improve detection sensitivity. The fabrication of the sensors, their functionalization for detection of many chemical and biological species and electrical circuitry, packaging, microfluidic subsystem and the system architecture are also disclosed. The individual, specific sensing of single species or simultaneous detection of multiple species is realized. The freeze drying or critical point drying after exposure of sensors to ligands present in liquids and detection in reduced pressure or vacuum is employed for increased sensitivity, down to the single molecule.

    CANTILEVERED PROBE DETECTOR WITH PIEZOELECTRIC ELEMENT
    4.
    发明申请
    CANTILEVERED PROBE DETECTOR WITH PIEZOELECTRIC ELEMENT 有权
    具有压电元件的检测探头

    公开(公告)号：US20150177216A1

    公开(公告)日：2015-06-25

    申请号：US14643641

    申请日：2015-03-10

    Applicant: Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada

    Inventor： Jesse D. Adams ,  Todd A. Sulchek ,  Stuart C. Feigin

    IPC: G01N33/22 ,  G01N29/02

    CPC classification number: G01N33/227 ,  G01N25/00 ,  G01N27/007 ,  G01N29/022 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/0057 ,  G01N2291/0257

    Abstract: A disclosed chemical detection system for detecting a target material, such as an explosive material, can include a cantilevered probe, a probe heater coupled to the cantilevered probe, and a piezoelectric element disposed on the cantilevered probe. The piezoelectric element can be configured as a detector and/or an actuator. Detection can include, for example, detecting a movement of the cantilevered probe or a property of the cantilevered probe. The movement or a change in the property of the cantilevered probe can occur, for example, by adsorption of the target material, desorption of the target material, reaction of the target material and/or phase change of the target material. Examples of detectable movements and properties include temperature shifts, impedance shifts, and resonant frequency shifts of the cantilevered probe. The overall chemical detection system can be incorporated, for example, into a handheld explosive material detection system.

    Abstract translation: 用于检测目标材料（例如爆炸材料）的公开的化学检测系统可以包括悬臂式探针，耦合到悬臂式探针的探针加热器和设置在悬臂式探针上的压电元件。 压电元件可以被配置为检测器和/或致动器。 检测可以包括例如检测悬臂式探针的移动或悬臂式探针的性质。 悬臂式探头的运动或性质的变化可以例如通过吸附目标材料，目标材料的解吸，目标材料的反应和/或目标材料的相变而发生。 可检测的运动和性质的实例包括悬臂式探头的温度偏移，阻抗偏移和谐振频率偏移。 整体化学检测系统可以例如并入到手持炸药材料检测系统中。

    ENHANCED DETECTION SENSITIVITY WITH PIEZOELECTRIC MICROCANTILEVER SENSORS
    5.
    发明申请
    ENHANCED DETECTION SENSITIVITY WITH PIEZOELECTRIC MICROCANTILEVER SENSORS 审中-公开
    用压电微型传感器增强检测灵敏度

    公开(公告)号：US20140315284A1

    公开(公告)日：2014-10-23

    申请号：US14259439

    申请日：2014-04-23

    Applicant: WAN Y. SHIH ,  WEI-HENG SHIH ,  QING ZHU

    Inventor： WAN Y. SHIH ,  WEI-HENG SHIH ,  QING ZHU

    IPC: G01N33/543 ,  G01N29/24

    CPC classification number: G01N29/2437 ,  G01N29/036 ,  G01N33/54373 ,  G01N2291/0257

    Abstract: A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's modulus during detection of a species of interest. The change in the Young's modulus may be induced or enhanced by the application of a DC bias electric field to the piezoelectric layer that enhances non-180° polarization domain switching of the piezoelectric layer. The change in the Young's modulus may also result from binding of the species of interest to the piezelectric microcantilever sensor or a combination of binding and application of a DC bias electric field. Significantly enhanced detection sensitity results from the changed Young's modulus of the piezoelectric layer.

    Abstract translation: 一种提高压电微悬臂梁传感器检测灵敏度的方法。 该方法可以包括提供压电微悬臂梁并在感兴趣的物种的检测期间引起杨氏模量的变化。 杨氏模量的变化可以通过向压电层施加直流偏压电场而引起或增强，这增强了压电层的非180°极化域切换。 杨氏模量的变化也可以由感兴趣的物质与压电式微悬臂梁传感器的结合或DC偏置电场的结合和施加的组合引起。 由压电层的杨氏模量的变化引起的显着增强的检测敏感度。

    Biosensor and Method of Manufacturing Such a Biosensor
    6.
    发明申请
    Biosensor and Method of Manufacturing Such a Biosensor 有权
    生物传感器和制造这种生物传感器的方法

    公开(公告)号：US20130327649A1

    公开(公告)日：2013-12-12

    申请号：US14000957

    申请日：2012-02-14

    Applicant: Jérôme Polesel Maris ,  Thomas Berthelot

    Inventor： Jérôme Polesel Maris ,  Thomas Berthelot

    IPC: G01N27/327

    CPC classification number: G01N27/327 ,  B82Y15/00 ,  B82Y40/00 ,  G01N29/022 ,  G01N29/036 ,  G01N2291/0255 ,  G01N2291/0257 ,  G01N2291/0427

    Abstract: A method of manufacturing a biosensor having a microbeam linked to a support, at least one electrode a biological molecule A grafted onto the microbeam in a different zone from the zone where the electrode is embedded, and a mechanoelectrical transducer for converting variations of the mechanical properties of the microbeam into an electrical signal, when the biological molecule A is placed in contact with a biological molecule B to be detected and/or quantified. The method includes: formation of an electrode on fluoropolymer material sheet, passivation of the electrode(s), creation of the form of the biosensor in the sheet of polymer material and separation of this form from the sheet, functionalization either of a prefunctionalized zone or of a zone of the microbeam, this zone being different from the zone wherein the electrode is embedded, and grafting of a biological molecule A onto the functionalized zone.

    Abstract translation: 一种制造具有与载体连接的微束的生物传感器的方法，至少一个电极，在与嵌入电极的区域不同的区域中接枝到微束上的生物分子A和用于转换机械性能变化的机械电传感器 当将生物分子A与待检测和/或定量的生物分子B接触时，将微束束转化为电信号。 该方法包括：在含氟聚合物材料片上形成电极，使电极钝化，在聚合物材料片中形成生物传感器的形式并将该形式与片材分离，将功能化前的功能化区域 的微波束的区域，该区域不同于电极被嵌入的区域，并且将生物分子A接枝到官能化区域上。

    CANTILEVERED PROBE DETECTOR WITH PIEZOELECTRIC ELEMENT
    9.
    发明申请
    CANTILEVERED PROBE DETECTOR WITH PIEZOELECTRIC ELEMENT 有权
    具有压电元件的检测探头

    公开(公告)号：US20100288015A1

    公开(公告)日：2010-11-18

    申请号：US12748788

    申请日：2010-03-29

    Applicant: Jesse D. Adams ,  Todd A. Sulchek ,  Stuart C. Feigin

    Inventor： Jesse D. Adams ,  Todd A. Sulchek ,  Stuart C. Feigin

    IPC: G01N29/02 ,  B05D5/12

    CPC classification number: G01N33/227 ,  G01N25/00 ,  G01N27/007 ,  G01N29/022 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/0057 ,  G01N2291/0257

    Abstract: A disclosed chemical detection system for detecting a target material, such as an explosive material, can include a cantilevered probe, a probe heater coupled to the cantilevered probe, and a piezoelectric element disposed on the cantilevered probe. The piezoelectric element can be configured as a detector and/or an actuator. Detection can include, for example, detecting a movement of the cantilevered probe or a property of the cantilevered probe. The movement or a change in the property of the cantilevered probe can occur, for example, by adsorption of the target material, desorption of the target material, reaction of the target material and/or phase change of the target material. Examples of detectable movements and properties include temperature shifts, impedance shifts, and resonant frequency shifts of the cantilevered probe. The overall chemical detection system can be incorporated, for example, into a handheld explosive material detection system.

    Abstract translation: 用于检测目标材料（例如爆炸材料）的公开的化学检测系统可以包括悬臂式探针，耦合到悬臂式探针的探针加热器和设置在悬臂式探针上的压电元件。 压电元件可以被配置为检测器和/或致动器。 检测可以包括例如检测悬臂式探针的移动或悬臂式探针的性质。 悬臂式探头的运动或性质的变化可以例如通过吸附目标材料，目标材料的解吸，目标材料的反应和/或目标材料的相变而发生。 可检测的运动和性质的实例包括悬臂式探头的温度偏移，阻抗偏移和谐振频率偏移。 整体化学检测系统可以例如并入到手持炸药材料检测系统中。

    Cantilevered probe detector with piezoelectric element
    10.
    发明授权
    Cantilevered probe detector with piezoelectric element 有权
    带有压电元件的悬臂式探头探测器

    公开(公告)号：US07694346B2

    公开(公告)日：2010-04-06

    申请号：US11576443

    申请日：2005-09-30

    Applicant: Jesse D. Adams ,  Todd A. Sulchek ,  Stuart C. Feigin

    Inventor： Jesse D. Adams ,  Todd A. Sulchek ,  Stuart C. Feigin

    IPC: H01J49/00

    CPC classification number: G01N33/227 ,  G01N25/00 ,  G01N27/007 ,  G01N29/022 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/0057 ,  G01N2291/0257

    Abstract: A disclosed chemical detection system for detecting a target material, such as an explosive material, can include a cantilevered probe, a probe heater coupled to the cantilevered probe, and a piezoelectric element disposed on the cantilevered probe. The piezoelectric element can be configured as a detector and/or an actuator. Detection can include, for example, detecting a movement of the cantilevered probe or a property of the cantilevered probe. The movement or a change in the property of the cantilevered probe can occur, for example, by adsorption of the target material, desorption of the target material, reaction of the target material and/or phase change of the target material. Examples of detectable movements and properties include temperature shifts, impedance shifts, and resonant frequency shifts of the cantilevered probe. The overall chemical detection system can be incorporated, for example, into a handheld explosive material detection system.

    Abstract translation: 用于检测目标材料（例如爆炸材料）的公开的化学检测系统可以包括悬臂式探针，耦合到悬臂式探针的探针加热器和设置在悬臂式探针上的压电元件。 压电元件可以被配置为检测器和/或致动器。 检测可以包括例如检测悬臂式探针的移动或悬臂式探针的性质。 悬臂式探头的运动或性质的变化可以例如通过吸附目标材料，目标材料的解吸，目标材料的反应和/或目标材料的相变而发生。 可检测的运动和性质的实例包括悬臂式探头的温度偏移，阻抗偏移和谐振频率偏移。 整体化学检测系统可以例如并入到手持炸药材料检测系统中。

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