公开(公告)号：US20230324341A1

公开(公告)日：2023-10-12

申请号：US18003244

申请日：2021-07-12

申请人： LUMICKS CA HOLDING B.V.

发明人： Felix OSWALD ,  Douwe KAMSMA ,  Amanda Caroline FRANKLIN

IPC分类号： G01N29/036 ,  G01N29/22

CPC分类号： G01N29/036 ,  G01N29/222 ,  G01N2291/014 ,  G01N2291/02466

摘要： The disclosure relates to methods and systems for manipulating a particle, in particular for studying small particles and/or biological cellular bodies. A disclosed method comprises the steps of: providing a sample holder (3) comprising a holding space (5) for holding a sample comprising a particle (9) in a fluid medium (11); providing a driving signal, having a signal frequency, a signal amplitude and a signal power, to the sample holder generating an acoustic wave in the sample holder (3) for applying an acoustic force to the particle (9), the wave having a frequency; determining an acoustic resonance frequency of the sample holder and determining a quality factor for the sample holder with respect to the resonance frequency. An associated system (1) is also disclosed.

公开(公告)号：US20240359182A1

公开(公告)日：2024-10-31

申请号：US18765527

申请日：2024-07-08

申请人： LUMICKS CA HOLDING B.V.

发明人： Andrea CANDELLI ,  Felix OSWALD ,  Gerrit SITTERS

IPC分类号： B01L3/00 ,  B01L7/00 ,  G01N15/1429 ,  G01N21/03 ,  G01N21/17 ,  G01N21/64 ,  G01N29/036 ,  G01N29/22 ,  G01N29/24 ,  G01N29/34

CPC分类号： B01L3/502761 ,  B01L3/50273 ,  B01L7/00 ,  G01N15/1429 ,  G01N21/0332 ,  G01N29/036 ,  G01N29/222 ,  G01N29/2437 ,  G01N29/2462 ,  G01N29/346 ,  G01N29/348 ,  B01L2200/0652 ,  B01L2300/0663 ,  B01L2300/163 ,  B01L2300/1822 ,  B01L2400/0436 ,  G01N2021/177 ,  G01N21/6458 ,  G01N2291/014 ,  G01N2291/02466 ,  G01N2291/02475 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0257 ,  G01N2291/02809 ,  G01N2291/0423 ,  G01N2291/0426

摘要： A method of manipulating and/or investigating cellular bodies (9) is provided. The method comprises the steps of: providing a sample holder (3) comprising a holding space (5) for holding a fluid medium (11); providing a sample (7) comprising one or more cellular bodies (9) in a fluid medium (11) in the holding space (5); generating an acoustic wave in the holding space exerting a force (F) on the sample (7) in the holding space (5). The method further comprises providing the holding space (5) with a functionalised wall surface portion (17) to be contacted by the sample (7) and the sample (7) is in contact with the functionalised wall surface portion (17) during at least part of the step of application of the acoustic wave. A system and a sample holder (3) are also provided.