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公开(公告)号：US12105052B2
公开(公告)日：2024-10-01
申请号：US17291504
申请日：2019-11-07
CPC分类号： G01N29/0654 , G01N29/221 , G01N29/348 , G01N2291/02475 , G01N2291/02483 , G01N2291/102
摘要： This disclosure describes systems and methods for ultrasound imaging and targeting. In one example, the systems and methods improve targeting and imaging through a heterogenous medium by using the angular spectrum approach (ASA) alone or in combination with passive acoustic mapping (PAM). In another example, the systems and methods improve the ultrasound imaging of vessels using microbubbles. The imaging of the vessels is also aided by the ASA and PAM. A closed loop controller is described that adjusts the ultrasound pressure provided to a region of interest to a desired pressure based at least in part on the harmonic, ultra-harmonic, sub-harmonic, or broadband frequency ranges for the microbubbles.
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公开(公告)号：US20230211187A1
公开(公告)日：2023-07-06
申请号：US18007562
申请日：2021-06-11
CPC分类号： A61N7/00 , A61B8/4494 , B06B1/0292 , G01S7/5202 , G01S7/52038 , G01S15/899 , G01S15/8925 , G01S15/8929 , A61B8/5261 , A61N2007/0039 , A61N2007/0052
摘要： Multifunctional ultrasound systems and methods for body section registration and mapping of microbubble dynamics. A system is provided that includes one or more micromachined ultrasonic transducer arrays (MUTAs) configured to capture a high-resolution image of at least a portion of a body section using ultrasound and monitor microbubble activity during ultrasound treatment. The system includes an image registration module configured to spatially register the high-resolution image with a reference image. The system includes electronics configured to control one or more of drive signal amplitude, frequency filtering, multiplexing, and DC bias voltage. The system can be configured to control ultrasound treatment based on the monitoring of the microbubble activity during treatment.
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公开(公告)号：US20230183811A1
公开(公告)日：2023-06-15
申请号：US17924765
申请日：2021-05-14
发明人： Costas Arvanitis , Anton Bryksin , Victor Menezes
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： An exemplary embodiment of the present disclosure provides a method for determining the effectiveness of a pharmaceutical drug in effecting a change in a biological specimen of a patient. The method comprises injecting a fluid into the patient, the fluid comprising a plurality of microbubbles; directing an ultrasound signal to the biological specimen of the patient; and detecting a level of cfDNA molecules in the patient.
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4.发明公开公开(公告)号：US20240342511A1
公开(公告)日：2024-10-17
申请号：US18638465
申请日：2024-04-17
IPC分类号： A61N7/00 , B29C64/386 , B29L31/00 , B33Y50/00 , B33Y80/00
CPC分类号： A61N7/00 , B29C64/386 , B33Y50/00 , B33Y80/00 , A61N2007/0026 , A61N2007/0039 , A61N2007/006 , A61N2007/0073 , B29L2031/753
摘要： This disclosure describes systems and methods for producing and registration of an acoustic holographic lens for trans-skull focused ultrasound (FUS). In one example embodiment, the lens is produced using a heterogenous angular spectrum approach that performs computations in the frequency domain, enabling pressure fields created with selected frequencies. In another example embodiment, precise registration of the lens with skull geometry is achieved via use of a nonlinear parametric array effect.
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公开(公告)号：US20220011270A1
公开(公告)日：2022-01-13
申请号：US17291504
申请日：2019-11-07
摘要： This disclosure describes systems and methods for ultrasound imaging and targeting. In one example, the systems and methods improve targeting and imaging through a heterogenous medium by using the angular spectrum approach (ASA) alone or in combination with passive acoustic mapping (PAM). In another example, the systems and methods improve the ultrasound imaging of vessels using microbubbles. The imaging of the vessels is also aided by the ASA and PAM. A closed loop controller is described that adjusts the ultrasound pressure provided to a region of interest to a desired pressure based at least in part on the harmonic, ultra-harmonic, sub-harmonic, or broadband frequency ranges for the microbubbles.
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