公开(公告)号：US12150735B2

公开(公告)日：2024-11-26

申请号：US17668971

申请日：2022-02-10

Applicant: Bioventures, LLC

Inventor： Vladimir Pavlovich Zharov

IPC: A61B5/00 ,  A61B5/02 ,  A61B8/08 ,  A61B18/00 ,  A61B18/20 ,  A61K49/22 ,  G01N15/14 ,  G01N15/1434 ,  G01N21/17 ,  G01N21/39

Abstract: A photoacoustic flow cytometry (PAFC) device for the in vivo detection of cells circulating in blood or lymphatic vessels is described. Ultrasound transducers attached to the skin of an organism detect the photoacoustic ultrasound waves emitted by target objects in response to their illumination by at least one pulse of laser energy delivered using at least one wavelength. The wavelengths of the laser light pulse may be varied to optimize the absorption of the laser energy by the target object. Target objects detected by the device may be unlabelled biological cells or cell products, contrast agents, or biological cells labeled with one or more contrast agents.

公开(公告)号：US12102693B1

公开(公告)日：2024-10-01

申请号：US18456300

申请日：2023-08-25

Applicant: NANOMEDTRIX, LLC

Inventor： Joe G. Assouline ,  Sean K. Sweeney

IPC: A61K9/51 ,  A61K9/00 ,  A61K31/00 ,  A61K31/337 ,  A61K31/407 ,  A61K31/704 ,  A61K31/7068 ,  A61K49/00 ,  A61K49/08 ,  A61K49/22 ,  A61P35/00

CPC classification number: A61K49/0002 ,  A61K9/0053 ,  A61K9/5115 ,  A61K31/337 ,  A61K31/407 ,  A61K31/658 ,  A61K31/704 ,  A61K31/7068 ,  A61K49/0093 ,  A61K49/085 ,  A61K49/225 ,  A61P35/00

Abstract: A mesoporous silica nanoparticle (“MSN”); a bioactive agent loaded into the MSN; and an enteric coating encapsulating the surface of the MSN for oral administration or combination with more than one other pharmaceutical composition each having distinct bioactive agents.

公开(公告)号：US20240262942A1

公开(公告)日：2024-08-08

申请号：US18624492

申请日：2024-04-02

Applicant: Celanese International Corporation

Inventor： Christina Schmid ,  Rainer Walkenhorst

IPC: C08F10/02 ,  A61B17/122 ,  A61B90/98 ,  A61C8/00 ,  A61F5/00 ,  A61F6/14 ,  A61J15/00 ,  A61K47/32 ,  A61K49/12 ,  A61K49/22 ,  A61L27/16 ,  A61L29/04 ,  A61L31/04 ,  A61M25/10 ,  A61N1/36 ,  B29C45/00 ,  B29K23/00 ,  B29K105/00 ,  B29L31/00

CPC classification number: C08F10/02 ,  A61K47/32 ,  A61K49/126 ,  A61K49/22 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  B29C45/0001 ,  A61B17/122 ,  A61B90/98 ,  A61C8/0016 ,  A61F5/005 ,  A61F6/14 ,  A61J15/00 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/20 ,  A61L2430/22 ,  A61L2430/24 ,  A61L2430/30 ,  A61L2430/38 ,  A61M25/10 ,  A61N1/36038 ,  A61N1/3605 ,  B29K2023/0675 ,  B29K2105/0052 ,  B29L2031/753 ,  B29L2031/7532

Abstract: A high molecular weight polyethylene polymer is formulated so that the polymer is capable of being injection molded. The polyethylene polymer has a Viscosity Number of greater than about 400 ml/g and has a melt flow rate of greater than about 0.9 g/10 min. The polyethylene polymer is of high purity and is particularly well suited for producing medical products.

公开(公告)号：US12042772B2

公开(公告)日：2024-07-23

申请号：US18370462

申请日：2023-09-20

Applicant: Devicor Medical Products, Inc.

Inventor： Timothy Zimmer ,  Michelle Louise Johnson ,  Stephen D. Stallard

IPC: B01F31/00 ,  A61B90/00 ,  A61K49/22 ,  B01F23/23 ,  B01F31/65 ,  B01F35/22 ,  A47K5/12 ,  A61B8/08 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61L31/14 ,  A61L31/18 ,  B01F101/00 ,  C08J9/30

CPC classification number: B01F31/65 ,  A61B90/39 ,  A61K49/226 ,  B01F23/2319 ,  B01F35/2206 ,  A47K5/1217 ,  A61B8/481 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61B2090/3987 ,  A61K49/006 ,  A61K49/04 ,  A61K49/1803 ,  A61L31/145 ,  A61L31/146 ,  A61L31/148 ,  A61L31/18 ,  B01F2101/2202 ,  C08J9/30 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2300/16

Abstract: A method and system are used to enhance a marker material to include a plurality of air bubbles. The method of manufacturing a marker includes enhancing a marker material to include a plurality of air bubbles using at least a first EFD and a second EFD. The method may include cycling repeatedly through a transfer process between a first container and a second container. A system for enhancing a marker material includes a transfer apparatus configured to receive a marker material and a selected amount of air. The system comprises a first EFD coupled to a first end of the transfer apparatus and a second EFD coupled to a second end of the transfer apparatus.

公开(公告)号：US11981757B2

公开(公告)日：2024-05-14

申请号：US16826475

申请日：2020-03-23

Applicant: Celanese International Corporation

Inventor： Christina Schmid ,  Rainer Walkenhorst

IPC: C08F10/02 ,  A61K47/32 ,  A61K49/12 ,  A61K49/22 ,  A61L27/16 ,  A61L29/04 ,  A61L31/04 ,  B29C45/00 ,  A61B17/122 ,  A61B90/98 ,  A61C8/00 ,  A61F5/00 ,  A61F6/14 ,  A61J15/00 ,  A61M25/10 ,  A61N1/36 ,  B29K23/00 ,  B29K105/00 ,  B29L31/00

CPC classification number: C08F10/02 ,  A61K47/32 ,  A61K49/126 ,  A61K49/22 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  B29C45/0001 ,  A61B17/122 ,  A61B90/98 ,  A61C8/0016 ,  A61F5/005 ,  A61F6/14 ,  A61J15/00 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/20 ,  A61L2430/22 ,  A61L2430/24 ,  A61L2430/30 ,  A61L2430/38 ,  A61M25/10 ,  A61N1/36038 ,  A61N1/3605 ,  B29K2023/0675 ,  B29K2105/0052 ,  B29L2031/753 ,  B29L2031/7532

Abstract: A high molecular weight polyethylene polymer is formulated so that the polymer is capable of being injection molded. The polyethylene polymer has a Viscosity Number of greater than about 400 ml/g and has a melt flow rate of greater than about 0.9 g/10 min. The polyethylene polymer is of high purity and is particularly well suited for producing medical products.

公开(公告)号：US11904068B2

公开(公告)日：2024-02-20

申请号：US17651509

申请日：2022-02-17

Applicant: University of Virginia Patent Foundation

Inventor： John C. Herr ,  Alexander L. Klibanov ,  Kevin Simon Eisenfrats

IPC: A61B17/34 ,  A61F6/22 ,  A61L24/00 ,  A61L24/06 ,  A61L27/52 ,  A61L27/54 ,  A61K49/22 ,  A61B8/08 ,  A61B17/12 ,  A61B17/42

CPC classification number: A61L24/06 ,  A61B8/085 ,  A61B8/0833 ,  A61B8/0841 ,  A61B17/12 ,  A61B17/12022 ,  A61B17/12186 ,  A61B17/3403 ,  A61F6/22 ,  A61K49/223 ,  A61K49/226 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0036 ,  A61L27/52 ,  A61L27/54 ,  A61B8/0891 ,  A61B8/481 ,  A61B8/488 ,  A61B17/42 ,  A61B2017/3413 ,  A61L2300/626 ,  A61L2400/06 ,  A61L2430/36

Abstract: Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.

公开(公告)号：US20240042043A1

公开(公告)日：2024-02-08

申请号：US18256143

申请日：2021-11-29

Applicant: IMGT CO, LTD.

Inventor： Daehyun KIM ,  Yoon-Seok KIM ,  Hyun Ryoung KIM ,  Eun Ah JUNG

IPC: A61K47/54 ,  A61K49/22 ,  C07K16/28 ,  A61P35/00

CPC classification number: A61K47/546 ,  A61K49/221 ,  C07K16/2827 ,  A61P35/00 ,  A61K2121/00

Abstract: The present invention relates to an immune checkpoint inhibitor conjugated with an sonosensitizer, a use thereof, and the like. The immune checkpoint inhibitor conjugate conjugated with an sonosensitizer according to the present invention has selectivity for tumors with respect to targeted therapy and specifically responds to ultrasonic waves, and thus can be used to produce drugs for diagnosing and treating cancer. Particularly, the conjugate of the present invention exhibits excellent solubility and stability in an aqueous solution, and provides excellent anticancer effects as compared with simple immune checkpoint inhibitors, and therefore, is expected to be useful as a novel drug for treating cancer.

公开(公告)号：US11872092B2

公开(公告)日：2024-01-16

申请号：US17095121

申请日：2020-11-11

Applicant: Board of Regents, The University of Texas System

Inventor： Baohong Yuan

IPC: A61B90/00 ,  A61B5/00 ,  A61B8/08 ,  A61K49/00 ,  A61K49/22

CPC classification number: A61B90/39 ,  A61B5/0071 ,  A61B8/481 ,  A61K49/0089 ,  A61K49/223 ,  A61K49/225 ,  A61B2090/3908 ,  A61B2090/3941 ,  A61B2090/3954 ,  A61B2090/3979

Abstract: A tissue implantation device comprises a capsule; and a population of ultrasound-switchable fluorophores incorporated in the capsule. A method of imaging a tissue implantation device in a biological environment comprises disposing the tissue implantation device in a biological environment, the population of ultrasound-switchable fluorophores having a switching threshold in the biological environment; exposing the biological environment to an ultrasound beam to form an activation region within the biological environment; switching the ultrasound-switchable fluorophores in the activation region from an off state to an on state; exciting the ultrasound-switchable fluorophores in the activation region with a beam of electromagnetic radiation; and detecting light emitted by the ultrasound-switchable fluorophores.

公开(公告)号：US20230389888A1

公开(公告)日：2023-12-07

申请号：US18131349

申请日：2023-04-05

Applicant: Agitated Solutions Inc.

Inventor： Morgan Evans ,  Micah Eimer ,  Jennifer Chmura ,  Ryan Kruchten

IPC: A61B8/06 ,  A61B8/08 ,  A61B17/00 ,  A61K49/22

CPC classification number: A61B8/06 ,  A61B8/481 ,  A61B17/0057 ,  A61B8/5223 ,  A61K49/223 ,  A61B8/12

Abstract: A method may include intravenously directing first bubbles into a patient's venous circulatory system and to a right side of the patient's heart. The first bubbles may have sizes that fall within a first range. The method may further include monitoring the patient's heart, with ultrasound imaging, to detect presence of the first bubbles on a left side of the patient's heart. Upon detecting the first bubbles on the left side of the patient's heart, the method may further include intravenously directing second bubbles into the patient's venous circulatory system and to the right side of the patient's heart. The second bubbles may have sizes that fall within a second range that is different than the first range. Upon detecting the second bubbles on the left side of the patient's heart, the method may further include initiating treatment to minimize risk of stroke in the patient.

公开(公告)号：US11801374B2

公开(公告)日：2023-10-31

申请号：US16329862

申请日：2017-09-01

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： Li Li ,  Guillermo J. Tearney

IPC: A61M37/00 ,  A61K49/22 ,  A61K41/00 ,  A61B8/08 ,  A61B5/055 ,  A61N2/00 ,  A61K38/00

CPC classification number: A61M37/0092 ,  A61B5/055 ,  A61B8/0833 ,  A61K41/0028 ,  A61K49/223 ,  A61N2/004

Abstract: The present disclosure includes system, methods, and kits relating to creating a second structure with a plurality of first structures at a target site inside or adjacent to a host object. The methods include the step of generating a field that non-invasively penetrates into the host object. The methods further include the step of positioning a first portion of the plurality of first structures at the target site using a force corresponding to the field. Additionally, the methods include the step of linking the first portion of the plurality of first structures with one another and/or the host object at the target site to form the second structure.