公开(公告)号：US20240352413A1

公开(公告)日：2024-10-24

申请号：US18639238

申请日：2024-04-18

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： Jayaraj RAJAGOPAL ,  Hongmei Mou

IPC分类号： C12N5/074 ,  A61K9/00 ,  A61K35/42 ,  A61L27/38 ,  A61L27/56 ,  A61L27/58 ,  C12N5/071 ,  G01N33/68 ,  G03B21/28

CPC分类号： C12N5/0607 ,  A61K35/42 ,  A61L27/3834 ,  A61L27/3882 ,  A61L27/56 ,  A61L27/58 ,  C12N5/0678 ,  C12N5/068 ,  C12N5/0688 ,  C12N5/0689 ,  G01N33/6884 ,  G03B21/28 ,  A61K9/0073 ,  A61L2430/22 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2533/90

摘要： Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells for treatment of lung diseases/disorders or injury to the lung. Whether an adult stem cell can be isolated from human adult lung remains controversial in the art and at present, methods for isolating and using adult lung stem cells from humans lack reproducibility. Thus, the methods and compositions described herein are advantageous over the present state of knowledge in the art and permit the generation of human lung progenitor cells for treatment, tissue engineering, and screening assays.

公开(公告)号：US20240189484A1

公开(公告)日：2024-06-13

申请号：US18177530

申请日：2023-03-02

申请人： Shines Biotechnology Co., Ltd

发明人： Nisi ZHANG ,  Dahong ZHANG ,  Wei WEI ,  Yi HONG ,  Shuai WANG ,  Pu ZHANG ,  Haibo TAN ,  Yidan ZHANG

IPC分类号： A61L27/44 ,  A61L27/36 ,  A61L27/58

CPC分类号： A61L27/44 ,  A61L27/362 ,  A61L27/3629 ,  A61L27/3679 ,  A61L27/3687 ,  A61L27/58 ,  A61L2300/41 ,  A61L2400/02 ,  A61L2420/02 ,  A61L2430/22 ,  A61L2430/40

摘要： The present disclosure provides a composite decellularized matrix membrane and use thereof. The composite decellularized matrix membrane prepared by the present disclosure is prepared by wrapping one layer of a polymer membrane with two layers of decellularized matrix membranes. The decellularized matrix membrane is prepared from at least a biomaterial of a porcine small intestine, a porcine bladder, and porcine skin. The polymer membrane is prepared from at least a polymer material of polycaprolactone, polydimethylsiloxane, polyurethane, polylactic acid-glycolic acid, polyvinyl alcohol, and polyhydroxy fatty acid ester. The composite decellularized matrix membrane prepared by the present disclosure can prevent calculi, makes a patient suffer less, recover faster, live better, and cost less, while medical resources are saved, and hope for treatment is also brought for some patients with a contraindication to an in-situ ileal neobladder surgery.

公开(公告)号：US11975122B2

公开(公告)日：2024-05-07

申请号：US17284579

申请日：2020-03-06

申请人： Telea Biotech S.R.L.

发明人： Gianantonio Pozzato ,  Maurizio Marzaro

IPC分类号： A61L27/36 ,  A61L27/38

CPC分类号： A61L27/3691 ,  A61L27/3679 ,  A61L27/38 ,  A61L2430/22 ,  A61L2430/40

摘要： A method for preparing a biocompatible tissue for revitalization thereof, wherein such tissue has an essentially tubular shape. The method provides inserting a support that mainly extends along a longitudinal extension axis inside the cavity defined by the tissue and performing on the outer and/or inner surface of the tissue a plurality of holes spread out on at least one of the generatrixes of the tissue. Holes are made with a depth which occupies at least a part of the thickness of the tissue.

公开(公告)号：US11932876B2

公开(公告)日：2024-03-19

申请号：US16483095

申请日：2018-02-02

申请人： CORNELL UNIVERSITY

发明人： Shahin Rafii ,  Brisa Palikuqi

IPC分类号： C12N5/071 ,  A61K35/44 ,  A61L27/38 ,  A61L27/50

CPC分类号： C12N5/0691 ,  A61K35/44 ,  A61L27/3808 ,  A61L27/507 ,  A61L2430/22 ,  A61L2430/40 ,  C12N2500/02 ,  C12N2510/00 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90

摘要： The present disclosure provides methods for forming stable three-dimensional vascular structures, such as blood vessels and uses thereof. More specifically, the present disclosure provides methods for culturing differentiated endothelial cells that include an exogenous nucleic acid encoding ETV2 transcription factor on a matrix under conditions that express exogenous ETV2 protein in the endothelial cell to form stable three-dimensional artificial blood vessels without the use of a scaffold, pericytes or perfusion. The present disclosure also provides stable three-dimensional blood vessels that are capable of autonomously forming a functional three-dimensional vascular network, and uses thereof. In addition, the present disclosure includes methods for vascularizing an organoid and a decellularized organ by culturing the organoid or decellularized organ with endothelial cells that include an exogenous nucleic acid encoding ETV2 transcription factor under conditions that express exogenous ETV2 protein in the endothelial cell to vascularize the organoid or decellularized organ.

公开(公告)号：US11890439B2

公开(公告)日：2024-02-06

申请号：US17307082

申请日：2021-05-04

申请人： TARIS Biomedical LLC

发明人： Michael J. Cima ,  Heejin Lee

IPC分类号： A61M31/00 ,  A61K31/167 ,  A61K9/00 ,  A61L31/18 ,  A61K9/20 ,  A61K31/00 ,  A61L31/16 ,  A61F2/04

CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61K9/2072 ,  A61K31/00 ,  A61K31/167 ,  A61L31/16 ,  A61L31/18 ,  A61M31/00 ,  A61F2/042 ,  A61L2300/402 ,  A61L2300/602 ,  A61L2430/22

摘要： Intravesical devices are provided that are wholly deployable within the bladder of a patient in need of treatment and are well tolerated by the patient. The device may include an elastic body having a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. The elastic body may exert a maximum acting force less than 1N when compressed to a shape with a maximum dimension in any dimension of 3 cm. The device may include a drug for controlled release within the bladder, for treatment of the bladder or a regional tissue. Methods of treatment are also provided that include selecting a patient in need of treatment in the bladder where tolerability of the treatment is a primary concern.

公开(公告)号：US20240024538A1

公开(公告)日：2024-01-25

申请号：US17907837

申请日：2022-06-17

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Hyun Woo SHIN ,  Khalmuratova ROZA

IPC分类号： A61L27/38 ,  A61L27/36

CPC分类号： A61L27/3813 ,  A61L27/3691 ,  A61L27/3882 ,  A61L2430/22

摘要： An epithelial cell tube for tracheal transplantation according to an embodiment includes a columnar support, and a whole layer of epithelial cells positioned on an outer peripheral surface of the columnar support. The epithelial cells are oriented so that cilia of the epithelial cells face a lumen side. The epithelial cell tube can be applied to an injured portion to provide an epithelial cell layer which is engrafted in tissues and can induce reduction of stenosis of trachea and inflammation.

公开(公告)号：US20240000558A1

公开(公告)日：2024-01-04

申请号：US18369867

申请日：2023-09-19

申请人： Jiahao JIN

发明人： Jiahao JIN ,  Weiwen YU ,  Dahong ZHANG ,  Gonghui LI ,  Fuqing TAN ,  Jun LU ,  Guohai XIE ,  Xiang HE

IPC分类号： A61F2/04 ,  A61M27/00 ,  A61L27/34

CPC分类号： A61F2/04 ,  A61M27/008 ,  A61L27/34 ,  A61F2002/048 ,  A61F2230/0041 ,  A61M2205/0238 ,  A61M2210/1078 ,  A61L2430/22

摘要： A controllable operation-free take-out ureteral stent with a degradable coating includes a ureteral stent, a traction wire, a discharged body, and a degradable fixture, where the discharged body is fixed on one end of the traction wire, and the degradable fixture fixes the discharged body on the other end of the traction wire and is arranged close to one end of the ureteral stent within a limited period of time; the ureteral stent comprises a nondegradable base layer and a degradable coating which are sequentially arranged from inside to outside; the problem of bacterial adhesion on the surface of the ureteral stent caused by long indwelling time or patients' special allergies can be solved by automatic degradation and peeling off of the degradable coating on the surface of the ureteral stent within a certain period of time.

公开(公告)号：US20190192736A1

公开(公告)日：2019-06-27

申请号：US16260733

申请日：2019-01-29

申请人： MiMedx Group, Inc.

发明人： Brenda S. Morse ,  Somaly Sith ,  Randall Spencer ,  John Daniel

IPC分类号： A61L27/38 ,  A61L27/36 ,  A61K35/50

CPC分类号： A61L27/3891 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3687 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3878 ,  A61L27/3882 ,  A61L2400/18 ,  A61L2430/12 ,  A61L2430/16 ,  A61L2430/22 ,  A61L2430/32 ,  A61L2430/40

摘要： Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.

公开(公告)号：US20180154045A1

公开(公告)日：2018-06-07

申请号：US15652983

申请日：2017-07-18

申请人： Northwestern University

发明人： Arun Sharma ,  Partha Hota ,  Natalie Fuller ,  Derek Matoka ,  Earl Cheng

IPC分类号： A61L27/38 ,  C12N11/08 ,  A61K35/44 ,  C12N5/071 ,  A61K35/28 ,  A61L27/18

CPC分类号： A61L27/3886 ,  A61K35/28 ,  A61K35/44 ,  A61L27/18 ,  A61L2430/22 ,  C12N5/0692 ,  C12N11/08 ,  C12N2502/1352 ,  A61K2300/00

摘要： The present invention provides compositions and methods for the regeneration of tissue. In particular, the present invention provides mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) for bladder regeneration.

公开(公告)号：US20180071074A1

公开(公告)日：2018-03-15

申请号：US15599137

申请日：2017-05-18

申请人： inRegen

发明人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha

IPC分类号： A61F2/04 ,  A61L27/38 ,  A61L27/18 ,  C08L67/04

CPC分类号： A61F2/042 ,  A61L27/18 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3882 ,  A61L2430/22 ,  C08L67/04

摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.