公开(公告)号：US20240352413A1

公开(公告)日：2024-10-24

申请号：US18639238

申请日：2024-04-18

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： Jayaraj RAJAGOPAL ,  Hongmei Mou

IPC分类号： C12N5/074 ,  A61K9/00 ,  A61K35/42 ,  A61L27/38 ,  A61L27/56 ,  A61L27/58 ,  C12N5/071 ,  G01N33/68 ,  G03B21/28

CPC分类号： C12N5/0607 ,  A61K35/42 ,  A61L27/3834 ,  A61L27/3882 ,  A61L27/56 ,  A61L27/58 ,  C12N5/0678 ,  C12N5/068 ,  C12N5/0688 ,  C12N5/0689 ,  G01N33/6884 ,  G03B21/28 ,  A61K9/0073 ,  A61L2430/22 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2533/90

摘要： Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells for treatment of lung diseases/disorders or injury to the lung. Whether an adult stem cell can be isolated from human adult lung remains controversial in the art and at present, methods for isolating and using adult lung stem cells from humans lack reproducibility. Thus, the methods and compositions described herein are advantageous over the present state of knowledge in the art and permit the generation of human lung progenitor cells for treatment, tissue engineering, and screening assays.