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    Ultrasound Gel Composition
    4.
    发明申请
    Ultrasound Gel Composition 审中-公开

    公开(公告)号：US20180099058A1

    公开(公告)日：2018-04-12

    申请号：US15719018

    申请日：2017-09-28

    申请人： MYT Enterprises LLC

    发明人： Menachem Treff

    IPC分类号： A61K49/22

    CPC分类号： A61K49/22 ,  A61K49/226

    摘要： A method for conducting an ultrasound session using an ultrasound probe system includes the steps of providing an ultrasound gel for use in combination with the ultrasound probe system, the ultrasound gel defining a composition including 1-10% by weight of Carbopol; 0.001-0.02% by weight of fungistat; 0.001-0.02% by weight of NaOH; 0.001-0.02% by weight of chlorhexidine; 1-5% by weight of glycerin up; 90-95% by weight of purified water; 0.001-0.02% by weight of curacao; 0.1-0.8% by weight of aloe vera leaf juice; 0.01-0.03% by weight of citric acid; 0.001-0.02% by weight of EDTA disodium; 0.001-0.02% by weight of phenoxyethanol; 0.001-0.02% by weight of ethylhexylglycerin; and 0.001-0.02% by weight of methylisothiazolinone; and selectively applying the ultrasound gel on an ultrasound site and operating the ultrasound probe system thereon.

    SMALL MOLECULE DYE FOR MOLECULAR IMAGING AND PHOTOTHERMAL THERAPY
    5.
    发明申请
    SMALL MOLECULE DYE FOR MOLECULAR IMAGING AND PHOTOTHERMAL THERAPY 审中-公开
    用于分子成像和光热治疗的小分子染色体

    公开(公告)号：US20160244614A1

    公开(公告)日：2016-08-25

    申请号：US15051563

    申请日：2016-02-23

    申请人： The Board of Trustees of the Leland Stanford Junior University

    发明人： Zhen CHENG ,  Xuechuan HONG ,  Hongjie DAI ,  Hao CHEN ,  Alexander ANTARIS ,  Kai Cheng

    IPC分类号： C09B49/04 ,  A61K49/00 ,  A61B5/00 ,  A61K49/22 ,  A61M5/00 ,  C07K14/765 ,  A61K41/00

    CPC分类号： A61M5/007 ,  A61B5/0095 ,  A61K31/433 ,  A61K41/0052 ,  A61K47/60 ,  A61K49/0021 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/22 ,  C07K14/765 ,  C09B57/008

    摘要： Disclosed is a small molecule dye for use in imaging in the near-infrared window, namely between 1000 nm-1700 nm wavelength. The present dyes are also useful for photoacoustic imaging and photothermal therapy. The dyes have a structure of a D-A-D (donor-acceptor-donor) fluorescent compound core and side chains rendering the compounds water soluble and easily conjugated to hydrophilic polymers and/or targeting ligands. Further disclosed is compound, CH1055 that can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps utilized to assemble the core structure of the target included a cross-Suzuki coupling reaction, iron reduction and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the donor-acceptor-donor (D-A-D) type fluorescent compound to impart a certain aqueous solubility and to allow facile conjugation to targeting ligands.

    摘要翻译： 公开了用于近红外窗口成像的小分子染料，即在1000nm-1700nm波长之间。 本发明的染料也可用于光声成像和光热疗法。 染料具有D-A-D（供体 - 受体 - 供体）荧光化合物核心和侧链的结构，使得化合物具有水溶性并且容易与亲水性聚合物和/或靶向配体缀合。 进一步公开的是可以聚乙二醇化，缀合至靶向配体或与牛磺酸缀合的化合物CH1055。 用于组装靶核心结构的关键步骤包括交叉Suzuki偶联反应，铁还原和N-亚硫酰苯胺诱导的闭环。 将四个羧酸基团引入供体 - 受体 - 供体（D-A-D）型荧光化合物中以赋予一定的水溶性并允许容易地与靶向配体结合。

    Ruggedized ultrasound hydrogel insert
    8.
    发明授权
    Ruggedized ultrasound hydrogel insert 有权
    坚固的超声水凝胶插入物

    公开(公告)号：US09211107B2

    公开(公告)日：2015-12-15

    申请号：US13671382

    申请日：2012-11-07

    申请人： C. R. Bard, Inc.

    发明人： Jeremy B. Cox ,  Glen E. Southard ,  Shayne Messerly

    IPC分类号： A61K49/00 ,  A61B8/00 ,  B29C39/00 ,  C08J3/075 ,  A61K49/22 ,  C08L5/00

    CPC分类号： A61B8/4281 ,  A61B8/4444 ,  A61K49/22 ,  C08J3/075 ,  C08J2305/00 ,  C08K5/005 ,  C08L5/00

    摘要： A ruggedized hydrogel product that is formulated to withstand the effects of high-energy sterilization procedures, such as gamma beam and electron beam sterilization, without significant structural degradation is disclosed. This enables the hydrogel product to be suitable for use in medical applications where sterile components are required. In one embodiment a ruggedized hydrogel product is disclosed and comprises a gel component, water for hydrating the gel component, and at least one free radical absorber component that is capable of absorbing free radicals produced when the hydrogel product is sterilized via a high-energy sterilization procedure. The free radical absorber component in one embodiment includes potassium metabisulfite and ascorbic acid. The ruggedized hydrogel product can be included with an ultrasound probe to provide an acoustically transparent interface between the probe and the skin of a patient.

    摘要翻译： 公开了一种坚固耐用的水凝胶产品，其被配制成能够承受诸如伽马射线和电子束灭菌等高能灭菌程序的影响，而没有显着的结构退化。 这使得水凝胶产品适用于需要无菌组分的医疗应用。 在一个实施方案中，公开了一种坚固的水凝胶产品，其包含凝胶组分，用于水合凝胶组分的水和至少一种自由基吸收剂组分，其能够吸收当水凝胶产物通过高能灭菌消毒时产生的自由基 程序。 在一个实施方案中，自由基吸收剂组分包括偏亚硫酸氢钾和抗坏血酸。 加固的水凝胶产品可以包含在超声波探头中，以在探针和患者皮肤之间提供声学透明的界面。