公开(公告)号：US12097270B2

公开(公告)日：2024-09-24

申请号：US16780328

申请日：2020-02-03

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Simon P. Robinson ,  Carol Walker ,  David C. Onthank ,  Joel Lazewatsky ,  Nhung Tuyet Nguyen

IPC: A61K49/00 ,  A61B8/08 ,  A61K9/50 ,  A61K49/22 ,  B01F31/20 ,  B01F35/22 ,  G01N29/00 ,  A61B8/13 ,  A61K47/10

CPC classification number: A61K49/22 ,  A61B8/481 ,  A61K9/50 ,  A61K49/227 ,  B01F31/20 ,  B01F31/201 ,  B01F35/2207 ,  B01F35/2209 ,  G01N29/00 ,  A61B8/13 ,  A61K47/10

Abstract: Provided herein are methods and devices for identifying and/or distinguishing UCA formulations and specifically activating such formulations to produce UCA suitable for in vivo use.

公开(公告)号：US11779662B2

公开(公告)日：2023-10-10

申请号：US15713324

申请日：2017-09-22

Applicant: University of Rhode Island Board of Trustees ,  Yale University

Inventor： Yana K. Reshetnyak ,  Oleg A. Andreev ,  Donald M. Engelman

IPC: A61K49/00 ,  C07K19/00 ,  C07K14/00 ,  A61B5/00 ,  G01N33/58 ,  A61K49/04 ,  A61K49/22 ,  C09B69/10 ,  C09K11/06

CPC classification number: A61K49/0056 ,  A61B5/0082 ,  A61K49/0034 ,  A61K49/04 ,  A61K49/221 ,  A61K49/227 ,  C07K14/001 ,  C07K19/00 ,  C09B69/107 ,  C09K11/06 ,  G01N33/582 ,  A61B5/0071 ,  C09K2211/1466

Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.

公开(公告)号：US20230293733A1

公开(公告)日：2023-09-21

申请号：US18321714

申请日：2023-05-22

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Simon P. Robinson ,  Robert W. Siegler ,  Nhung Tuyet Nguyen ,  David C. Onthank ,  Tarakeshwar Vishwanath Anklekar ,  Charles Chester Van Kirk

IPC: A61K49/22 ,  A61B8/08 ,  C07F9/09

CPC classification number: A61K49/223 ,  A61B8/481 ,  C07F9/09 ,  A61K49/226 ,  A61K49/227 ,  C07F9/106

Abstract: Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.

公开(公告)号：US11738096B2

公开(公告)日：2023-08-29

申请号：US16334734

申请日：2017-09-22

Applicant: University of Rhode Island Board of Trustees ,  Yale University

Inventor： Yana K. Reshetnyak ,  Oleg A. Andreev ,  Donald M. Engelman

IPC: A61K49/00 ,  C07K19/00 ,  C07K14/00 ,  A61B5/00 ,  G01N33/58 ,  A61K49/22 ,  C09B69/10 ,  C09K11/06 ,  A61K49/04

CPC classification number: A61K49/0056 ,  A61B5/0082 ,  A61K49/0034 ,  A61K49/04 ,  A61K49/221 ,  A61K49/227 ,  C07K14/001 ,  C07K19/00 ,  C09B69/107 ,  C09K11/06 ,  G01N33/582 ,  A61B5/0071 ,  C09K2211/1466

Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.

公开(公告)号：US20190201559A1

公开(公告)日：2019-07-04

申请号：US16264176

申请日：2019-01-31

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Simon P. Robinson ,  Robert W. Siegler ,  Nhung Tuyet Nguyen ,  David C. Onthank ,  Tarakeshwar Vishwanath Anklekar ,  Charles Chester Van Kirk

IPC: A61K49/22

CPC classification number: A61K49/223 ,  A61K49/226 ,  A61K49/227

Abstract: Provided herein are improve methods for preparing phospholipid formulations including phospholipid UCA formulations.

公开(公告)号：US20180271788A1

公开(公告)日：2018-09-27

申请号：US15781940

申请日：2016-12-09

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv

Inventor： Xiaoyuan Chen ,  Jibin Song

IPC: A61K9/127 ,  A61K51/12 ,  A61K41/00 ,  A61P35/00 ,  A61K49/22 ,  B01J13/12 ,  A61N5/06

CPC classification number: A61K9/1272 ,  A61K9/1278 ,  A61K9/5115 ,  A61K41/0052 ,  A61K49/225 ,  A61K49/227 ,  A61K51/1237 ,  A61K51/1244 ,  A61N5/0625 ,  A61P35/00 ,  B01J13/12

Abstract: Disclosed is a method of producing a vesicle containing a metallic nanoparticle that is covalently bound to at least one hydrophilic polymer and at least one hydrophobic polymer, wherein the method involves dispersing the polymer-bound metallic nanoparticle in an organic solvent, adding an aqueous solution containing a dispersing aid to form a mixed solution, sonicating the mixed solution to form an emulsion; and removing the organic solvent from the emulsion until the vesicle forms. Using this method, the formed vesicle has a diameter of 20-150 nm, which is useful for a method of conducting photothermal therapy (PTT) for killing cells, such as cancer cells.

公开(公告)号：US09814672B2

公开(公告)日：2017-11-14

申请号：US12044189

申请日：2008-03-07

Applicant: Susan T. Laing ,  Shaoling Huang ,  David D. McPherson ,  Christy K. Holland ,  Melvin E. Klegerman

Inventor： Susan T. Laing ,  Shaoling Huang ,  David D. McPherson ,  Christy K. Holland ,  Melvin E. Klegerman

IPC: A61K9/127 ,  A61K9/00 ,  A61K47/48 ,  A61K49/22

CPC classification number: A61K9/0009 ,  A61K9/127 ,  A61K47/6911 ,  A61K47/6913 ,  A61K49/227

Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.

公开(公告)号：US20170142967A1

公开(公告)日：2017-05-25

申请号：US15380754

申请日：2016-12-15

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION

Inventor： Jess Dreher Reed ,  Christian Gerald Krueger ,  Sergio Madrigal-Carballo

IPC: A01N43/16 ,  A61K9/20 ,  A61K9/51 ,  A61K9/00 ,  A61K9/12 ,  A61K9/06 ,  A61K39/00 ,  A61K39/39 ,  A61K31/722 ,  A61K31/353 ,  A61K31/366 ,  A61K31/351 ,  A01N43/24 ,  A01N25/16 ,  A61K9/127

CPC classification number: A01N43/16 ,  A01N25/16 ,  A01N43/24 ,  A23V2250/21166 ,  A61F2013/00523 ,  A61F2013/00676 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/008 ,  A61K9/06 ,  A61K9/12 ,  A61K9/122 ,  A61K9/1273 ,  A61K9/19 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/5123 ,  A61K9/5161 ,  A61K9/7007 ,  A61K31/351 ,  A61K31/353 ,  A61K31/366 ,  A61K31/715 ,  A61K31/722 ,  A61K39/0005 ,  A61K39/39 ,  A61K45/06 ,  A61K47/36 ,  A61K47/55 ,  A61K49/227 ,  A61K2039/542 ,  A61K2039/55583 ,  A61L29/085 ,  A61L31/10 ,  C08H6/00 ,  A01N25/28 ,  A01N2300/00 ,  A61K2300/00 ,  C08L5/08

Abstract: The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.

公开(公告)号：US09629935B2

公开(公告)日：2017-04-25

申请号：US14654709

申请日：2013-12-20

Applicant: James Shue-Min Yeh

Inventor： James Shue-Min Yeh

IPC: G06K9/00 ,  A61K49/22 ,  A61B8/06 ,  G01R33/56 ,  A61B6/00 ,  A61B8/08 ,  G06T7/00 ,  A61K49/00 ,  A61K49/16 ,  A61K49/18 ,  A61B5/055 ,  A61B5/02 ,  G06F19/00

CPC classification number: A61K49/227 ,  A61B5/02028 ,  A61B5/055 ,  A61B6/481 ,  A61B6/486 ,  A61B6/5217 ,  A61B8/06 ,  A61B8/481 ,  A61B8/5223 ,  A61B2576/023 ,  A61K49/0017 ,  A61K49/0034 ,  A61K49/0058 ,  A61K49/0082 ,  A61K49/16 ,  A61K49/1809 ,  A61K49/221 ,  A61K49/223 ,  G01R33/5601 ,  G06F19/321 ,  G06T7/0016 ,  G06T2207/10088 ,  G06T2207/10132 ,  G06T2207/30104

Abstract: The method comprises: a) receiving a plurality of imaging signals of the object over a period of time; b) measuring the signal intensity in each of the plurality of imaging signals corresponding to a point on the object; and c) curve fitting the measured signal intensity of the point on the object to a bi-exponential function comprising a first and a second exponential term, the first exponential term representing the decrease in concentration of the contrast agent which is free over time and the second exponential term representing a decrease in concentration of the contrast agent which is retained on the object over time.

公开(公告)号：US20160263254A1

公开(公告)日：2016-09-15

申请号：US15170220

申请日：2016-06-01

Applicant: Bracco Suisse S.A.

Inventor： Philippe BUSSAT ,  Samir Cherkaoui ,  Hong Fan ,  Bernard Lamy ,  Palaniappa Nanjappan ,  Radhakrishna K. Pillai ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

IPC: A61K49/22 ,  A61K47/48

CPC classification number: A61K49/223 ,  A61K38/00 ,  A61K47/544 ,  A61K47/60 ,  A61K47/62 ,  A61K49/227 ,  C07K7/08 ,  C07K14/001 ,  C07K14/52 ,  C07K14/71 ,  C07K2319/00 ,  Y02A50/58

Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.