公开(公告)号：US20180303394A1

公开(公告)日：2018-10-25

申请号：US16017668

申请日：2018-06-25

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Peter C. Simpson ,  Robert J. Boock ,  Monica Rixman Swinney ,  Mark C. Brister

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  C12Q1/00 ,  G01N33/543

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/411 ,  A61B5/418 ,  A61B5/6848 ,  A61B2562/08 ,  C12Q1/006 ,  G01N33/54366 ,  G01N33/66 ,  Y02A50/55 ,  Y02A50/58

Abstract: The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

公开(公告)号：US20180242894A1

公开(公告)日：2018-08-30

申请号：US15967338

申请日：2018-04-30

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Robert J. Boock ,  Monica A. Rixman ,  Peter C. Simpson ,  Mark C. Brister ,  Mark C. Shults

IPC: A61B5/1486 ,  G01N33/66 ,  A61B5/145 ,  C12Q1/00 ,  A61B5/00 ,  G01N33/543 ,  A61B5/1473

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/411 ,  A61B5/418 ,  A61B5/6848 ,  A61B2562/08 ,  C12Q1/006 ,  G01N33/54366 ,  G01N33/66 ,  Y02A50/55 ,  Y02A50/58

Abstract: Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.

公开(公告)号：US20180238902A1

公开(公告)日：2018-08-23

申请号：US15805437

申请日：2017-11-07

Applicant: ICB INTERNATIONAL, INC.

Inventor： Ram S. Bhatt ,  Rishi Bhatt

IPC: G01N33/68 ,  G01N33/569 ,  G01N33/574

CPC classification number: G01N33/6857 ,  C07K2317/20 ,  C07K2317/22 ,  C07K2317/569 ,  G01N33/56966 ,  G01N33/574 ,  G01N33/6893 ,  G01N2800/387 ,  Y02A50/57 ,  Y02A50/58 ,  Y02A50/59

Abstract: Camelid and shark single-domain heavy chain antibodies lacking the light chains, and their analogs are disclosed. Methods for using the antibodies and their analogs to detect antigens are disclosed. Methods to derivatize such antibodies and analogs to develop diagnostic assays are described. Also provided are kits, and methods of using such diagnostics assays.

公开(公告)号：US20180171393A1

公开(公告)日：2018-06-21

申请号：US15571153

申请日：2016-05-02

Applicant: VANDERBILT UNIVERSITY ,  BioVentures, Inc.

Inventor： Frederick R. Haselton ,  Nicholas M. Adams ,  Steven J. Simmons ,  Elliott P. Dawson

IPC: C12Q1/6818 ,  C12Q1/686 ,  B01L7/00

CPC classification number: C12Q1/6818 ,  B01L7/52 ,  C12N2310/122 ,  C12N2310/32 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q2525/101 ,  C12Q2525/113 ,  C12Q2531/113 ,  C12Q2537/143 ,  C12Q2561/113 ,  Y02A50/58

Abstract: Systems, methods, and compositions for monitoring and analyzing nucleic acid hybridization state using L-DNA probes are described. The methods include adding L-DNA probes that can be fluorescently detected to a system including D-DNA. The L-DNA probes include primer, target, and antisense nucleotide sequences, and fluorescent dye compounds. The L-DNA probes are particularly useful for monitoring and analyzing various parameters during DNA amplification using the polymerase chain reaction.

公开(公告)号：US09986942B2

公开(公告)日：2018-06-05

申请号：US11503367

申请日：2006-08-10

Applicant: James H. Brauker ,  Robert Boock ,  Monica Rixman ,  Peter C. Simpson ,  Mark Brister ,  Mark Shults

Inventor： James H. Brauker ,  Robert Boock ,  Monica Rixman ,  Peter C. Simpson ,  Mark Brister ,  Mark Shults

IPC: A61B5/1486 ,  A61B5/1473 ,  G01N33/66 ,  A61B5/145 ,  A61B5/00 ,  C12Q1/00 ,  G01N33/543

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/411 ,  A61B5/418 ,  A61B5/6848 ,  A61B2562/08 ,  C12Q1/006 ,  G01N33/54366 ,  G01N33/66 ,  Y02A50/55 ,  Y02A50/58

Abstract: Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.

公开(公告)号：US20180086823A1

公开(公告)日：2018-03-29

申请号：US15566176

申请日：2016-04-11

Applicant: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.

Inventor： Rolf Fendel ,  Stefan Barth ,  Rainer Fischer ,  Andreas Reimann ,  Dominika Maskus ,  Torsten Klockenbring

IPC: C07K16/20

CPC classification number: C07K16/205 ,  A61K2039/507 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/58

Abstract: The technology provided herein relates to novel human antibodies against Plasmodium parasites, in particular against the malaria parasite Plasmodium falciparum. The present disclosure pertains to antibodies against apical membrane antigen 1 (AMA-1). These antibodies have high affinity e.g. to Plasmodium falciparum schizonts and merozoites, inhibit the reinvasion of merozoites into erythrocytes and thereby neutralize parasitic multiplication.

公开(公告)号：US20170336412A1

公开(公告)日：2017-11-23

申请号：US15653949

申请日：2017-07-19

Applicant: Institut Pasteur

Inventor： Jean-Claude MANUGUERRA ,  Jessica VANHOMWEGEN ,  Philippe DESPRES ,  Sylvie PAULOUS

IPC: G01N33/569 ,  G01N33/543

CPC classification number: G01N33/56983 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54353 ,  G01N33/564 ,  G01N33/6845 ,  G01N2333/18 ,  G01N2333/185 ,  G01N2469/20 ,  Y02A50/51 ,  Y02A50/53 ,  Y02A50/56 ,  Y02A50/58 ,  Y02A50/60

Abstract: The present invention provides kits and assay methods for the early detection of pathogens, precise identification of the etiologic agent, and improved disease surveillance. More specifically, the present invention discloses an immunoassay leading to the rapid and simultaneous detection of antibodies to a wide range of infectious pathogens in biological fluids of infected patients. This immunoassay involves the covalent and oriented coupling of fusion proteins comprising an AGT enzyme and a viral antigen on an identifiable solid support (e.g. fluorescent microspheres), said support being previously coated with an AGT substrate. This coupling is mediated by the irreversible reaction of the AGT enzyme on its substrate. The thus obtained antigen-coupled microspheres show enhanced capture of specific antibodies as compared to antigen-coupled microspheres produced by standard amine coupling procedures. The methods of the invention possess the ability to multiplex, minimize the amount of biological sample, and have enhanced sensitivity and specificity toward target antibodies as compared with classical ELISA or Radio-Immunoprecipitation assays.

公开(公告)号：US20170333568A1

公开(公告)日：2017-11-23

申请号：US15522631

申请日：2015-10-31

Applicant: Igor C. ALMEIDA ,  Katja MICHAEL ,  Nathaniel SCHOCKER

Inventor： Igor C. ALMEIDA ,  Katja MICHAEL ,  Nathaniel SCHOCKER

IPC: A61K47/64 ,  G01N33/569

CPC classification number: A61K47/643 ,  A61K47/646 ,  G01N33/56905 ,  G01N2400/02 ,  Y02A50/55 ,  Y02A50/58

Abstract: Certain embodiments are directed to method for synthesizing and using glycoconjugates on the immunodominant epitope Galα(1,3)Galβ(3(1,4)GlcNAcα (Galα3LNα).

公开(公告)号：US09759721B2

公开(公告)日：2017-09-12

申请号：US14161117

申请日：2014-01-22

Applicant: IMICROQ, S.L.

Inventor： Pablo Lozano Sánchez ,  Gemma Freixes Prous ,  Sergio Martinez Montequín ,  Anna Pallares Lleo ,  Cristina Perez Girona ,  Katia Uliaque Cugat

IPC: G01N33/569 ,  C12Q1/04 ,  C12Q1/68

CPC classification number: C12Q1/10 ,  C12Q1/04 ,  C12Q1/045 ,  C12Q1/6888 ,  G01N33/52 ,  G01N33/569 ,  G01N33/56916 ,  G01N33/66 ,  G01N2333/255 ,  Y02A50/451 ,  Y02A50/52 ,  Y02A50/56 ,  Y02A50/57 ,  Y02A50/58 ,  Y02A50/59 ,  Y02A50/60

Abstract: The present specification discloses methods of detecting a pathogen of interest and components useful in carrying out these methods, including a pre-enrichment media, and enrichment media and a detection solution.

公开(公告)号：US20170233787A1

公开(公告)日：2017-08-17

申请号：US15501807

申请日：2015-08-04

Applicant: Becton, Dickinson and Company

Inventor： David Sebba ,  Adam Curry ,  Kara Birchfield ,  Kristin Weidemaier ,  Erin Carruthers

IPC: C12Q1/32 ,  G01N33/569

CPC classification number: C12Q1/32 ,  G01N33/569 ,  G01N2333/445 ,  G01N2333/904 ,  Y02A50/58

Abstract: Methods and compositions for the detection of glucose-6-phosphate dehydrogenase (G6PD) enzyme activity in blood samples are described. Some embodiments disclosed herein provide methods for detecting G6PD activity in undiluted or minimally diluted blood samples, including obtaining a blood sample, and detecting G6PD activity present in the undiluted or minimally diluted blood sample by epifluorescence. Also provided are methods for detecting G6PD activity and detecting a bloodborne microorganism as two parts of a single test.