公开(公告)号：US20240287166A1

公开(公告)日：2024-08-29

申请号：US18564951

申请日：2022-05-27

申请人： David Weiner ,  Nicholas Tursi ,  Ami Patel

发明人： David Weiner ,  Nicholas Tursi ,  Ami Patel

IPC分类号： C07K16/20 ,  A61K39/00 ,  A61K48/00 ,  A61P33/06

CPC分类号： C07K16/205 ,  A61P33/06 ,  A61K2039/505 ,  A61K48/00 ,  C07K2317/24 ,  C07K2317/76

摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Plasmodium parasitic antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a Plasmodium parasitic infection in a subject using said composition and method of generation.

公开(公告)号：US11692026B2

公开(公告)日：2023-07-04

申请号：US17146423

申请日：2021-01-11

申请人： Rhode Island Hospital

发明人： Jonathan Kurtis ,  Dipak K. Raj ,  Alok Das Mohapatra ,  Jenna Zuromski

IPC分类号： A61K39/395 ,  C07K16/20 ,  A61K45/06 ,  A61P33/06 ,  A61K39/00

CPC分类号： C07K16/205 ,  A61K45/06 ,  A61P33/06 ,  A61K2039/505

摘要： Provided herein are methods, compositions and kits for preventing and treating malaria. Also included herein are kits for preventing and treating malaria.

公开(公告)号：US11655290B2

公开(公告)日：2023-05-23

申请号：US17842351

申请日：2022-06-16

申请人： Atreca, Inc.

发明人： Daniel Eric Emerling ,  Randal R. Ketchem ,  Shaun M. Lippow ,  Wayne Volkmuth ,  Katherine L. Williams

IPC分类号： C07K16/00 ,  A61K39/395 ,  C07K16/20 ,  A61P33/06 ,  A61K39/00

CPC分类号： C07K16/205 ,  A61P33/06 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/92

摘要： The present disclosure provides anti-circumsporozoite (CSP) antibodies, compositions comprising such antibodies. Also disclosed are methods of producing the disclosed antibodies and methods of treating or preventing malaria using the same.

公开(公告)号：US20230015910A1

公开(公告)日：2023-01-19

申请号：US17784690

申请日：2020-12-17

申请人： Intervet Inc.

发明人： Markus Hendrikus Van Roosmalen ,  Koen Gevers

IPC分类号： C07K14/44 ,  A61K39/002 ,  A61P33/02 ,  A61P1/12 ,  C12P21/02 ,  A61K39/39 ,  C07K16/20 ,  A61K35/20

摘要： The invention is based on the finding that incubating a Cryptosporidium gp40 protein with an aziridine, significantly increases its immunogenicity. When used as a vaccine, this allows a reduction of the dose, which improves economic feasibility and safety. Consequently the aziridine-treated gp40 can now be used as a safe and effective subunit-vaccine for humans or non-human-animals against Cryptosporidiosis. Specifically for new-born ruminants a vaccination by way of colostral transfer was found to be very effective in reducing clinical signs of Cryptosporidiosis, especially diarrhoea.

公开(公告)号：US20220233667A1

公开(公告)日：2022-07-28

申请号：US17284617

申请日：2019-10-10

申请人： Oxford University Innovation Limited

发明人： Simon DRAPER ,  Matthew HIGGINS ,  Daniel G.W. ALANINE

IPC分类号： A61K39/015 ,  C07K16/20 ,  A61K39/395 ,  A61P33/06 ,  C12N15/115

摘要： There are provided antibodies and combination thereof, and other binding proteins against malarial antigens, as well as said antigens and vectors encoding the antibodies and antigens. The invention also provides the use of such compounds and combinations thereof in the prevention or treatment of malaria. In particular, synergistic combinations of non-neutralising antibodies directed towards an epitope on Reticulocyte-binding protein Homologue 5 (PfRH5) and neutralising antibodies directed towards Plasmodium merozoite antigens are provided.

公开(公告)号：US20220227853A1

公开(公告)日：2022-07-21

申请号：US17608381

申请日：2020-05-04

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Robert Seder ,  Lawrence Wang ,  Rachel Vistein ,  Joseph Francica

IPC分类号： C07K16/20 ,  A61K47/68 ,  G01N33/569 ,  A61P33/06

摘要： Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.

公开(公告)号：US20220072115A1

公开(公告)日：2022-03-10

申请号：US17289133

申请日：2019-11-04

申请人： Rhode Island Hospital

发明人： Ian Charles Michelow ,  Jonathan Kurtis

IPC分类号： A61K39/015 ,  C07K16/20 ,  A61P37/04 ,  A61P33/06

摘要： Provided herein are compositions and methods for treating and preventing malaria. The vaccine of the invention is directed to the protein encoded by the PF3D7_1134300 gene, or fragments of the protein, which are Pf Erythrocyte Membrane and Merozoite Antigenl (PfEMMAI). Exemplary fragments include Fragment 1, Fragment 2, or a C-terminal fragment of PfEMMAI.

公开(公告)号：US10787518B2

公开(公告)日：2020-09-29

申请号：US15623314

申请日：2017-06-14

申请人： Xencor, Inc.

发明人： Matthew Bernett ,  Gregory Moore ,  John Desjarlais ,  Michael Hedvat ,  Christine Bonzon ,  Alex Nisthal

IPC分类号： C07K16/20 ,  C07K16/30 ,  C07K16/40 ,  C07K16/28 ,  C07K14/735 ,  C12N15/861 ,  A61K39/00 ,  A61P35/00

摘要： The present invention is directed to compositions that include programmed cell death 1 (PD-1) binding domains and antibodies that include such PD-1 binding domains. Also provided are nucleic acid compositions that encode the binding domains and antibodies, expression vector compositions that include the nucleic acids, and host cells that include the expression vector compositions.

公开(公告)号：US10781477B2

公开(公告)日：2020-09-22

申请号：US16254926

申请日：2019-01-23

申请人： ARATOME, LLC

发明人： Jay Trautman ,  Gordon Wang ,  David Lenzi

IPC分类号： C12Q1/68 ,  C07H21/00 ,  G01N33/53 ,  C12Q1/6827 ,  G01N33/58 ,  G01N33/533 ,  C12Q1/44 ,  G01N33/532 ,  C12Q1/6816 ,  C07K16/20 ,  C12Q1/6818 ,  C12Q1/6823 ,  C12Q1/6886 ,  C12Q1/6888 ,  G01N1/36 ,  C12Q1/6809

摘要： Disclosed herein are compositions, kits, methods, and systems for detecting a target molecule in a sample using a detection molecule.

公开(公告)号：US10696745B2

公开(公告)日：2020-06-30

申请号：US15580281

申请日：2015-06-11

申请人： WUXI BIOLOGICS (SHANGHAI) CO. LTD.

发明人： Yong Zheng ,  Jing Li ,  Zhisheng Chen

IPC分类号： C07K16/20 ,  C07K16/30 ,  C07K16/40 ,  C07K16/28 ,  G01N33/566

摘要： The present disclosure provides monoclonal antibodies against protein programmed cell death 1 ligand (PD-L1), which can block the binding of PD-L1 to PD-1, and therefore block the inhibitory function of PD-L1 on PD-1 expressing T cells. The antibodies of disclosure provide very potent agents for the treatment of multiple cancers via modulating human immune function.