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公开(公告)号：US10981995B2
公开(公告)日：2021-04-20
申请号：US15749783
申请日：2016-08-05
发明人： Yong Zheng , Jing Li , Zhisheng Chen
摘要： The present disclosure provides monoclonal antibodies against protein programmed cell death 1 ligand (PD-L1), which can block the binding of PD-L1 to PD-1, and therefore block the inhibitory function of PD-L1 on PD-1 expressing T cells. The antibodies of disclosure provide very potent agents for the treatment of multiple cancers via modulating human immune function.
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公开(公告)号：US10696745B2
公开(公告)日：2020-06-30
申请号：US15580281
申请日：2015-06-11
发明人： Yong Zheng , Jing Li , Zhisheng Chen
IPC分类号： C07K16/20 , C07K16/30 , C07K16/40 , C07K16/28 , G01N33/566
摘要： The present disclosure provides monoclonal antibodies against protein programmed cell death 1 ligand (PD-L1), which can block the binding of PD-L1 to PD-1, and therefore block the inhibitory function of PD-L1 on PD-1 expressing T cells. The antibodies of disclosure provide very potent agents for the treatment of multiple cancers via modulating human immune function.
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公开(公告)号：US12054554B2
公开(公告)日：2024-08-06
申请号：US17045561
申请日：2019-04-10
申请人： WUXI Biologics (Shanghai) Co., Ltd. , Wuxi Biologics Ireland Limited , Open Monoclonal Technology, Inc.
发明人： Yong Zheng , Jingjing Liu , Jing Li
CPC分类号： C07K16/2878 , A61P35/00 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/92
摘要： Provided are novel fully human monoclonal antibodies that bind to human 4-1BB. It also provides the methods of hybridoma generation using humanized rats, the nucleic acid molecules encoding the anti-4-1BB antibodies, vectors and host cells used for the expression of anti-4-1BB antibodies. The invention further provides methods for validating the function of antibodies in vitro and the efficacy of antibodies in vivo. The antibodies of invention provide a very potent agent for the treatment of multiple cancers via modulating human immune function.
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