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    Chelate nanoemulsion for MRI
    1.
    发明授权
    Chelate nanoemulsion for MRI 有权

    公开(公告)号：US09770520B2

    公开(公告)日：2017-09-26

    申请号：US13995732

    申请日：2011-12-20

    申请人： Marc Port ,  Caroline Robic ,  Fernando Leal Calderon ,  Samy Chadel

    发明人： Marc Port ,  Caroline Robic ,  Fernando Leal Calderon ,  Samy Chadel

    IPC分类号： A61K49/18

    CPC分类号： A61K49/1809 ,  A61K49/1806

    摘要： The present invention relates to an oil-in-water nanoemulsion composition for MRI, comprising: an aqueous phase, representing 70% to 90% by weight of the composition, advantageously 75% to 85% and more advantageously from 78% to 82% a lipid phase comprising an oil, representing 9.5% to 29.5% by weight of the composition, advantageously 14% to 25% and more advantageously 17% to 21%, a surfactant at the interface between the aqueous and lipid phases, the surfactant comprising at least one amphiphilic paramagnetic metal chelate and optionally an amphiphilic lipid; the total content of surfactant by weight relative to the oil being between 4% and 10% and advantageously between 5% and 8%; the total content of surfactant by weight relative to the composition being between 0.35% and 2.95% and advantageously between 0.5% and 2%; the oil comprising at least 70%, advantageously at least 80%, advantageously at least 95% by weight and especially at least 97% of saturated C6-C18, advantageously C6-C14 and more advantageously C6-C10 fatty acids.

    BIODEGRADABLE ORGANIC RADICAL-FUNCTIONALIZED POLYCARBONATES FOR MEDICAL APPLICATIONS
    4.
    发明申请
    BIODEGRADABLE ORGANIC RADICAL-FUNCTIONALIZED POLYCARBONATES FOR MEDICAL APPLICATIONS 有权
    用于医疗应用的可生物降解的有机功能化的聚碳酸酯

    公开(公告)号：US20160220705A1

    公开(公告)日：2016-08-04

    申请号：US14609778

    申请日：2015-01-30

    申请人： International Business Machines Corporation ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    发明人： Julian M. W. Chan ,  James L. Hedrick ,  Ashlynn L. Z. Lee ,  Rudy J. Wojtecki ,  Yi Yan Yang

    IPC分类号： A61K49/00 ,  C08G64/18 ,  C08L69/00 ,  C08G64/02

    CPC分类号： C08L69/00 ,  A61K49/085 ,  A61K49/126 ,  A61K49/1809 ,  A61K49/20 ,  C08G64/0241 ,  C08G64/183

    摘要： Paramagnetic, amphiphilic, biocompatible polymers were prepared comprising a carbonate repeat unit bearing a paramagnetic organic radical, more specifically a nitroxyl radical. The radical polymers can be produced in one step from a precursor polymer bearing an active ester side chain by treating the precursor polymer with a radical-bearing nucleophile. The precursor polymer can be prepared by organocatalyzed catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The radical polymers can be non-toxic and partially biodegradable. The radical polymers have utility as contrast enhancing agents in a medical imaging application and/or as therapeutic agents for treating a medical condition. The radical polymers can also serve as carriers for therapeutic agents (e.g., drugs) and/or medical image enhancing agents (e.g., NIRF dyes).

    摘要翻译： 制备包含具有顺磁性有机基团，更具体地为硝酰基的碳酸酯重复单元的顺磁性，两亲性的生物相容性聚合物。 自由基聚合物可以通过用带有自由基的亲核试剂处理前体聚合物，从一个带有活性酯侧链的前体聚合物一步制备。 前体聚合物可以通过具有活性酯侧链的环状碳酸酯单体的有机催化的开环聚合（ROP）来制备。 自由基聚合物可以是无毒的，部分可生物降解的。 自由基聚合物在医学成像应用中可用作对比增强剂，和/或作为用于治疗医疗状况的治疗剂。 自由基聚合物还可以用作治疗剂（例如药物）和/或医用图像增强剂（例如NIRF染料）的载体。

    LANTHANOID COMPLEX CAPSULE AND PARTICLE CONTRAST AGENTS, METHODS OF MAKING AND USING THEREOF
    7.
    发明申请
    LANTHANOID COMPLEX CAPSULE AND PARTICLE CONTRAST AGENTS, METHODS OF MAKING AND USING THEREOF 有权
    兰萨诺复合胶囊和颗粒对比剂，其制备和使用方法

    公开(公告)号：US20150071863A1

    公开(公告)日：2015-03-12

    申请号：US14492749

    申请日：2014-09-22

    申请人： New York University

    发明人： Marc Anton WALTERS

    IPC分类号： A61K49/10 ,  A61K49/12 ,  A61K9/51 ,  A61K49/18 ,  C07D257/02 ,  C07F5/00

    CPC分类号： A61K49/106 ,  A61K9/5153 ,  A61K9/5176 ,  A61K49/108 ,  A61K49/124 ,  A61K49/1809 ,  A61K49/1818 ,  A61K49/1881 ,  C07D257/02 ,  C07F5/003

    摘要： The invention relates to compositions of DOTA derivative compounds, lanthanoid-DOTA derivative molecular complex, and lanthanoid-complex encapsulated solid lipid particles or capsules, and methods of making and using the compositions. The solid lipid particles or capsules contain micelle cores stabilized by a hyperbranched polymer shell based from a crosslinked DOTA derivative compound or crosslinked lanthanoid-DOTA derivative complex. These solid lipid particles or capsules can be used in various applications, such as contrast agents or drug delivery vehicles.

    摘要翻译： 本发明涉及DOTA衍生物化合物，镧系元素-DTA衍生物分子复合物和镧系元素复合物包封的固体脂质颗粒或胶囊的组合物，以及制备和使用该组合物的方法。 固体脂质颗粒或胶囊含有由交联的DOTA衍生物化合物或交联的镧系元素-DTA衍生物复合物形成的超支化聚合物壳稳定的胶束核。 这些固体脂质颗粒或胶囊可用于各种应用，例如造影剂或药物递送载体。

    SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS
    8.
    发明申请
    SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS 审中-公开
    在酸性肿瘤微环境中累积的自组装分子

    公开(公告)号：US20140363378A1

    公开(公告)日：2014-12-11

    申请号：US14372567

    申请日：2013-02-01

    申请人： The Ohio State University

    发明人： Joshua E. Goldberger ,  Michael F. Tweedle

    IPC分类号： A61K51/12 ,  A61K49/18 ,  A61K49/00 ,  A61K49/22 ,  A61K49/04

    CPC分类号： A61K51/1227 ,  A61K49/0082 ,  A61K49/0414 ,  A61K49/14 ,  A61K49/1809 ,  A61K49/227

    摘要： Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles in the circulation into cylindrical nanofibers in the acidic extracellular environment of tumors which can be used to achieve a higher relative concentration of imaging, drug delivery, or radiotherapeutic agents at the tumor site compared to non-tumor tissues. This transition is rapid and reversible, indicating the system is in thermodynamic equilibrium.

    摘要翻译： 公开了包含多个生物相容性自组装分子的组合物，其从循环中的分离分子或球形胶束转变成在肿瘤的酸性细胞外环境中的圆柱形纳米纤维，其可用于实现更高的成像，药物递送相对浓度， 或放射治疗剂在肿瘤部位与非肿瘤组织相比。 这种转变是快速和可逆的，表明系统处于热力学平衡状态。

    Lanthanoid complex capsule and particle contrast agents, methods of making and using thereof
    9.
    发明授权
    Lanthanoid complex capsule and particle contrast agents, methods of making and using thereof 有权
    镧系元素复合物胶囊和颗粒造影剂，其制备和使用方法

    公开(公告)号：US08865129B2

    公开(公告)日：2014-10-21

    申请号：US13464718

    申请日：2012-05-04

    申请人： Marc Anton Walters

    发明人： Marc Anton Walters

    IPC分类号： A61K49/00 ,  A61K49/18 ,  A61K49/10 ,  A61K9/51 ,  A61K49/12 ,  C07D257/02

    CPC分类号： A61K49/106 ,  A61K9/5153 ,  A61K9/5176 ,  A61K49/108 ,  A61K49/124 ,  A61K49/1809 ,  A61K49/1818 ,  A61K49/1881 ,  C07D257/02 ,  C07F5/003

    摘要： The invention relates to compositions of DOTA derivative compounds, lanthanoid-DOTA derivative molecular complex, and lanthanoid-complex encapsulated solid lipid particles or capsules, and methods of making and using the compositions. The solid lipid particles or capsules contain micelle cores stabilized by a hyperbranched polymer shell based from a crosslinked DOTA derivative compound or crosslinked lanthanoid-DOTA derivative complex. These solid lipid particles or capsules can be used in various applications, such as contrast agents or drug delivery vehicles.

    摘要翻译： 本发明涉及DOTA衍生物化合物，镧系元素-DTA衍生物分子复合物和镧系元素复合物包封的固体脂质颗粒或胶囊的组合物，以及制备和使用该组合物的方法。 固体脂质颗粒或胶囊含有由交联的DOTA衍生物化合物或交联的镧系元素-DTA衍生物复合物形成的超支化聚合物壳稳定的胶束核。 这些固体脂质颗粒或胶囊可用于各种应用，例如造影剂或药物递送载体。