公开(公告)号：US20240238456A1

公开(公告)日：2024-07-18

申请号：US18291677

申请日：2022-07-29

Applicant: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  UNIVERSITE DE CAEN NORMANDIE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE CAEN NORMANDIE

Inventor： Maxime GAUBERTI ,  Sara MARTINEZ DE LIZARRONDO ,  Thomas BONNARD ,  Charlène JACQMARCQ ,  Denis VIVIEN

IPC: A61K49/18 ,  A61K49/16

CPC classification number: A61K49/1857 ,  A61K49/16 ,  A61K49/1887

Abstract: The present invention relates to a biocompatible particle comprising nanoparticles of iron oxide embedded in a polycathecolamine or polyserotonine matrix, a suspension of said particles, a process for preparing said suspension of particles, a conjugate comprising said particle and the use of said particle and said conjugate in imaging techniques.

公开(公告)号：US11786613B2

公开(公告)日：2023-10-17

申请号：US17497119

申请日：2021-10-08

Applicant: Ferronova Pty Ltd

Inventor： Stewart Gavin Bartlett ,  Melanie Ruth Maria Nelson ,  Benjamin Thierry ,  Aidan Cousins ,  Thi Hanh Nguyen Pham ,  Brian Stanley Hawkett

IPC: A61K49/18

CPC classification number: A61K49/1854 ,  A61K49/1857

Abstract: Disclosed herein are pharmacologically acceptable magnetic nanoparticles suitable for administration to a subject.

公开(公告)号：US20230241255A1

公开(公告)日：2023-08-03

申请号：US17588458

申请日：2022-01-31

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Wei XU ,  Leisha MARTIN

IPC: A61K49/18 ,  A61B5/055

CPC classification number: A61K49/183 ,  A61B5/055 ,  A61K49/1857 ,  A61K49/1875

Abstract: The present disclosure provides contrast agent compositions comprises a plurality of nanoparticles, such as nanoparticles comprises an iron nanoparticle such as an iron nitride. The disclosure also provides methods for magnetic resonance imaging of the contrast agent compositions as well as other methods of performing magnetic resonance imaging. Further, the disclosure provides kits comprising a contrast agent composition.

公开(公告)号：US09687569B2

公开(公告)日：2017-06-27

申请号：US13969362

申请日：2013-08-16

Applicant: University of Washington through its Center for Commercialization

Inventor： Miqin Zhang ,  Chen Fang

IPC: A61B5/055 ,  A61K49/18 ,  A61K9/51 ,  A61K49/00 ,  A61K47/48

CPC classification number: A61K49/1857 ,  A61K47/6923 ,  A61K47/6935

Abstract: Nanoparticle having a poly(beta-amino ester) coating. The poly(beta-amino ester) coating includes one or more therapeutic agents that can be delivered by the particle and one or more anchoring groups that couple the polymer to the nanoparticle's core surface. In certain embodiments, the poly(beta-amino ester) includes one or more polyalkylene oxide groups. The poly(beta-amino ester) can further include a targeting agent to target the nanoparticle to a site of interest and a diagnostic agent that allows for imaging of the particle. Methods for making and using the nanoparticles are also provided.

公开(公告)号：US09555136B2

公开(公告)日：2017-01-31

申请号：US15043313

申请日：2016-02-12

Applicant: University of Washington through its Center for Commercialization

Inventor： Amit P. Khandhar ,  Kannan M. Krishnan ,  R. Matthew Ferguson ,  Scott Kemp

IPC: A61K49/18 ,  A61K41/00 ,  A61N2/00 ,  A61B5/05

CPC classification number: A61K49/1857 ,  A61B5/05 ,  A61B5/0515 ,  A61K41/0052 ,  A61N2/004

Abstract: Disclosed herein are polymer-coated iron oxide magnetic nanoparticles and methods of their manufacture and use. The nanoparticles are coated with a copolymer of poly(maleic anhydride alt-H2C═CH—R1)-polyethylene glycol (PMAR-PEG), wherein R1 is a hydrophobic moiety. The molecular weights of the PMAR and PEG portions of the copolymer, as well as the core diameter of the nanoparticles are selected in order to produce optimal performance for specific applications. Representative applications of the nanoparticles include magnetic particle imaging, magnetic sentinel lymph node biopsy, and magnetic fluid hyperthermia. The disclosed nanoparticles are tools for these methods that provide previously unachieved levels of stability (e.g., via reduced agglomeration) and customizability (e.g., tuned blood circulation half-life in vivo).

Abstract translation: 本文公开了聚合物涂覆的氧化铁磁性纳米颗粒及其制造和使用的方法。 纳米颗粒用聚（马来酸酐alt-H2C = CH-R1） - 聚乙二醇（PMAR-PEG）的共聚物涂覆，其中R1是疏水部分。 选择共聚物的PMAR和PEG部分的分子量以及纳米颗粒的芯直径以便为特定应用产生最佳性能。 纳米颗粒的代表性应用包括磁粉成像，磁哨淋巴结活检和磁流体热疗。 所公开的纳米颗粒是提供以前未达到的稳定水平（例如通过减少的聚集）和定制性（例如，体内调节的血液循环半衰期）的这些方法的工具。

公开(公告)号：US20160367489A1

公开(公告)日：2016-12-22

申请号：US14931872

申请日：2015-11-04

Applicant: NATIONAL TSING HUA UNIVERSITY

Inventor： HSIN-CHENG CHIU ,  WEN-HSUAN CHIANG ,  CHIA-CHIAN HUNG ,  TING-WEI YU

IPC: A61K9/51 ,  G01N33/84 ,  A61K31/704

CPC classification number: A61K9/5153 ,  A61K9/0019 ,  A61K9/5146 ,  A61K31/704 ,  A61K41/0052 ,  A61K45/06 ,  A61K49/0034 ,  A61K49/0093 ,  A61K49/1857 ,  A61K49/186 ,  A61P35/00 ,  G01N33/84 ,  A61K2300/00

Abstract: A pH-responsive nanoparticle made of a pH-responsive polymer and a poly(lactic-co-glycolic acid) by self-assembly includes a polyethylene glycol derivative and a R-Histidine derivative that are subjected to a chemical reaction to form the pH-responsive polymer, wherein the surface electric potential of the pH-responsive nanoparticle is −25 to 10 mV, such that when a pH value of the pH-responsive nanoparticle is changed from 7.4 to 5.0 depending upon an external environment, a surface zeta potential of the pH-responsive nanoparticle is converted from negative charge to positive charge.

Abstract translation: 通过自组装由pH响应性聚合物和聚（乳酸 - 共 - 乙醇酸）制成的pH响应性纳米颗粒包括聚乙二醇衍生物和R-组氨酸衍生物，其经受化学反应以形成pH- 响应性聚合物，其中所述pH响应性纳米颗粒的表面电势为-25至10mV，使得当pH响应性纳米颗粒的pH值根据外部环境从7.4变为5.0时，表面ζ电位 pH响应纳米颗粒从负电荷转化为正电荷。

公开(公告)号：US20160331850A1

公开(公告)日：2016-11-17

申请号：US15110189

申请日：2015-01-07

Applicant: COLOROBBIA ITALIA S.P.A.

Inventor： Giovanni BALDI ,  Costanza RAVAGLI ,  Mauro COMES FRANCHINI ,  Mario Milco D'ELIOS ,  Marisa BENAGIANO ,  Marco BITOSSI

IPC: A61K49/18 ,  H01F1/00 ,  A61K9/107 ,  A61K41/00 ,  A61K9/50 ,  A61K9/20

CPC classification number: A61K49/186 ,  A61K9/1075 ,  A61K9/20 ,  A61K9/5031 ,  A61K9/5089 ,  A61K41/0052 ,  A61K49/1857 ,  H01F1/0054 ,  H01F1/0063

Abstract: There are described magnetic nanoparticles the surface of which is functionalized with catechol and constructs comprising a plurality of said nanoparticles encapsulated in a biocompatible polymer matrix, wherein a molecule with therapeutic action is optionally dispersed, said polymer matrix optionally being in turn further functionalized; there are further described cells of the immune system incorporating said polymeric constructs giving rise to their engineering.

Abstract translation: 描述了磁性纳米颗粒，其表面用邻苯二酚和包含多个包封在生物相容性聚合物基质中的所述纳米颗粒的构建体功能化，其中具有治疗作用的分子任选地分散，所述聚合物基质任选进一步官能化; 进一步描述包含所述聚合物构建体的免疫系统的细胞产生其工程化。

公开(公告)号：US09439978B2

公开(公告)日：2016-09-13

申请号：US14346330

申请日：2012-09-28

Applicant: Subhra Mohapatra ,  Chunyan Wang

Inventor： Subhra Mohapatra ,  Chunyan Wang

IPC: A61K48/00 ,  A61K47/48 ,  A61K49/18 ,  C12N15/88 ,  C12N15/85

CPC classification number: A61K48/0041 ,  A61K47/48192 ,  A61K47/4823 ,  A61K47/48907 ,  A61K47/48923 ,  A61K47/59 ,  A61K47/61 ,  A61K47/6935 ,  A61K47/6939 ,  A61K48/0033 ,  A61K49/1809 ,  A61K49/1857 ,  A61K49/1863 ,  A61K49/1875 ,  C12N15/85 ,  C12N15/88 ,  C12N2800/107 ,  C12N2810/859

Abstract: Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide.

Abstract translation: 本文提供了包含具有疏水超磁性氧化铁纳米颗粒（SPION）芯的胶束，包含阳离子聚合物的第一涂层和包含多核苷酸的第二涂层的组合物。 还提供了使用组合物用于与多核苷酸转染和/或转化细胞的方法。 还提供了用多核苷酸检测细胞转染的方法。

公开(公告)号：US20160089455A1

公开(公告)日：2016-03-31

申请号：US14670805

申请日：2015-03-27

Applicant: SNU R&DB FOUNDATION ,  Institute for Basic Science ,  The Catholic University of Korea Industry-Academic Cooperation Foundation

Inventor： Taeghwan Hyeon ,  Kun NA ,  Daishun LING ,  Wooram PARK

IPC: A61K49/12 ,  A61K49/18 ,  C08G69/40 ,  C08G81/00

CPC classification number: C08G69/40 ,  A61K49/1857 ,  C08G69/08 ,  C08G81/00

Abstract: The present invention relates to MRI contrasting agent for contrasting cancer cell which contains ultrafine nanoparticles. More particularly, the present invention is directed to a self-assembled ligand composition comprising a ligand A, which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range, MRI contrast agent for contrasting cancer cell comprising said ligand composition and MRI contrasting nanoparticles, and the methods for preparing them.

Abstract translation: 本发明涉及用于对比含有超细纳米颗粒的癌细胞的MRI对比剂。 更具体地，本发明涉及包含在特定pH范围分离的配体A和在特定pH范围内表面电荷变化的配体B的自组装配体组合物，用于对比癌症的MRI造影剂 包含所述配体组合物和MRI对比纳米颗粒的细胞及其制备方法。

公开(公告)号：US20150359910A1

公开(公告)日：2015-12-17

申请号：US14763815

申请日：2013-10-14

Applicant: Pengke YAN

Inventor： Pengke YAN

IPC: A61K49/18 ,  A61K49/08

CPC classification number: A61K49/1848 ,  A61K49/085 ,  A61K49/1851 ,  A61K49/1857 ,  C12N15/115 ,  C12N2310/16 ,  G01R33/5601

Abstract: Disclosed are a targeting aptamer for atherosclerosis and a preparation method and application thereof. The targeting aptamer is a targeting aptamer fragment for atherosclerosis obtained through screening of macrophage-derived foam cells together with reverse screening of smooth muscle cells, endothelial cells, and THP-1 cells using a SELEX method; and the use of the targeting aptamer in preparation of an MRI targeting nano-contrast agent for atherosclerosis allows the specific binding of the MRI targeting nano-contrast agent for atherosclerosis only with the macrophage-derived foam cells, and allows high specific binding thereof with vascular tissues with AS lesion, this improving targeting effect of the MRI targeting nano-contrast agent for atherosclerosis and realizing early specific diagnosis of arterial sclerosis.

Abstract translation: 公开了用于动脉粥样硬化的靶向适体及其制备方法和应用。 靶向适体是通过筛选巨噬细胞衍生的泡沫细胞获得的动脉粥样硬化的靶向适体片段，以及使用SELEX方法反向筛选平滑肌细胞，内皮细胞和THP-1细胞; 并且靶向适体在制备用于动脉粥样硬化的MRI靶向纳米造影剂中的使用允许MRI靶向纳米造影剂用于动脉粥样硬化的特异性结合仅与巨噬细胞衍生的泡沫细胞结合，并且允许其与血管的高度特异性结合 具有AS损伤的组织，这提高了MRI靶向纳米造影剂用于动脉粥样硬化的靶向效应，并实现了动脉硬化症的早期特异性诊断。