公开(公告)号：US12078634B2

公开(公告)日：2024-09-03

申请号：US17819784

申请日：2022-08-15

Applicant: Promega Corporation

Inventor： Cesear Corona ,  Poncho Meisenheimer ,  Matthew Robers ,  James Vasta

IPC: C07D239/48 ,  G01N1/34 ,  G01N33/543 ,  G01N33/573 ,  G01N21/64 ,  G01R33/56 ,  G01T1/164

CPC classification number: G01N33/54353 ,  C07D239/48 ,  G01N1/34 ,  G01N33/573 ,  G01N21/6428 ,  G01N2021/6439 ,  G01R33/5601 ,  G01T1/1642

Abstract: Provided herein are compounds that are broad-spectrum protein kinase binding agents, detectable tracers comprising such compounds, and method of use thereof for the detection of protein kinases.

公开(公告)号：US20240241202A1

公开(公告)日：2024-07-18

申请号：US18391962

申请日：2023-12-21

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Sotaro TAKI ,  Sadanori TOMIHA ,  Masao YUI

IPC: G01R33/56 ,  G01R33/48 ,  G01R33/565

CPC classification number: G01R33/5601 ,  G01R33/4804 ,  G01R33/56563

Abstract: An MRI apparatus according to one embodiment includes processing circuitry that obtains information about a contrast agent containing substances with different chemical shifts, and determines, based on the information, a frequency band related to decrease in a MR signal due to the chemical shifts; and sequence control circuitry that acquires, before contrast enhancement using the contrast agent, a first MR signal group in the frequency band by CEST imaging under different saturation pulse conditions, and acquires, after contrast enhancement using the contrast agent, a second MR signal group in the frequency band by CEST imaging under different saturation pulse conditions. The processing circuitry calculates a difference between a first Z-spectrum generated based on the first MR signal group and a second Z-spectrum generated based on the second MR signal group, and detects, from the difference, peaks indicating the decrease in the MR signal due to the chemical shifts of the substances.

公开(公告)号：US12029494B2

公开(公告)日：2024-07-09

申请号：US17241282

申请日：2021-04-27

Applicant: HeartFlow, Inc.

Inventor： Charles A. Taylor

IPC: G06T7/11 ,  A61B5/00 ,  A61B5/02 ,  A61B5/021 ,  A61B5/024 ,  A61B5/026 ,  A61B5/029 ,  A61B5/055 ,  A61B5/107 ,  A61B5/11 ,  A61B5/22 ,  A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  A61B8/02 ,  A61B8/04 ,  A61B8/06 ,  A61B8/08 ,  A61B34/00 ,  A61B34/10 ,  A61M5/00 ,  G01R33/56 ,  G01R33/563 ,  G06F17/10 ,  G06F18/10 ,  G06F18/22 ,  G06F18/24 ,  G06F30/20 ,  G06F30/23 ,  G06F30/28 ,  G06G7/60 ,  G06T7/00 ,  G06T7/12 ,  G06T7/13 ,  G06T7/149 ,  G06T7/20 ,  G06T7/60 ,  G06T7/62 ,  G06T7/70 ,  G06T7/73 ,  G06T11/00 ,  G06T11/20 ,  G06T11/60 ,  G06T15/10 ,  G06T17/00 ,  G06T17/20 ,  G06V10/40 ,  G06V10/42 ,  G06V10/44 ,  G06V20/69 ,  G16B5/00 ,  G16B45/00 ,  G16H10/40 ,  G16H10/60 ,  G16H30/20 ,  G16H30/40 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70 ,  G16H70/00 ,  A61B90/00 ,  G06T7/10 ,  G06V10/46

CPC classification number: A61B34/10 ,  A61B5/0035 ,  A61B5/004 ,  A61B5/0044 ,  A61B5/02 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/024 ,  A61B5/026 ,  A61B5/0263 ,  A61B5/029 ,  A61B5/055 ,  A61B5/1075 ,  A61B5/1118 ,  A61B5/22 ,  A61B5/4848 ,  A61B5/6852 ,  A61B5/7246 ,  A61B5/7275 ,  A61B5/7278 ,  A61B5/745 ,  A61B6/03 ,  A61B6/032 ,  A61B6/481 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5205 ,  A61B6/5217 ,  A61B6/5229 ,  A61B8/02 ,  A61B8/04 ,  A61B8/06 ,  A61B8/065 ,  A61B8/481 ,  A61B8/5223 ,  A61B8/5261 ,  A61B34/25 ,  A61M5/007 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56366 ,  G06F17/10 ,  G06F18/10 ,  G06F18/22 ,  G06F18/24 ,  G06F30/20 ,  G06F30/23 ,  G06F30/28 ,  G06G7/60 ,  G06T7/0012 ,  G06T7/0014 ,  G06T7/11 ,  G06T7/12 ,  G06T7/13 ,  G06T7/149 ,  G06T7/20 ,  G06T7/60 ,  G06T7/62 ,  G06T7/70 ,  G06T7/73 ,  G06T7/74 ,  G06T11/00 ,  G06T11/001 ,  G06T11/008 ,  G06T11/20 ,  G06T11/60 ,  G06T15/10 ,  G06T17/00 ,  G06T17/005 ,  G06T17/20 ,  G06V10/40 ,  G06V10/42 ,  G06V10/44 ,  G06V20/698 ,  G16B5/00 ,  G16B45/00 ,  G16H10/40 ,  G16H10/60 ,  G16H30/20 ,  G16H30/40 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70 ,  G16H70/00 ,  A61B5/6868 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/108 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/3764 ,  A61B2576/00 ,  A61B2576/023 ,  G06T7/10 ,  G06T2200/04 ,  G06T2207/10012 ,  G06T2207/10072 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/20036 ,  G06T2207/20124 ,  G06T2207/30016 ,  G06T2207/30048 ,  G06T2207/30104 ,  G06T2210/41 ,  G06T2211/404 ,  G06V10/467 ,  Y02A90/10 ,  G06T7/0012 ,  G06T2207/30048

Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

公开(公告)号：US12023644B2

公开(公告)日：2024-07-02

申请号：US16895721

申请日：2020-06-08

Applicant: Xemed LLC

Inventor： F. William Hersman ,  Iulian C. Ruset

IPC: B01J19/12 ,  C01B23/00 ,  G01R33/28 ,  G01R33/56

CPC classification number: B01J19/121 ,  C01B23/00 ,  G01R33/282 ,  G01R33/5601 ,  B01J2219/0871 ,  B01J2219/0875 ,  B01J2219/12

Abstract: An apparatus, system, and methods for polarizing nuclei of a noble gas are disclosed. The disclosed system may include a polarization apparatus configured to polarize a noble gas mixture including xenon-129. The disclosed system also may include separate volumes for (1) saturating the polarizable noble gas mixture with alkali metal vapor, (2) desaturating said noble gas mixture from its alkali metal vapor after polarization is completed, (3) intermediate storage of the resultant polarized noble gas mixture, and (4) transfer of said polarized noble gas mixture to a storage vessel (e.g., a delivery bag). The disclosed system further may include separate reservoirs for (1) the noble gas(es) to be polarized, (2) lightweight gas(es) to displace the noble gas(es), and (3) a heavy inert gas (e.g., such as natural xenon) to push the polarized noble gas(es) into a storage vessel.

公开(公告)号：US20240168117A1

公开(公告)日：2024-05-23

申请号：US18425964

申请日：2024-01-29

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Darin OKUDA

IPC: G01R33/56 ,  G01R33/48 ,  G06N20/00 ,  G06T7/11

CPC classification number: G01R33/5608 ,  G01R33/4822 ,  G01R33/5601 ,  G06N20/00 ,  G06T7/11 ,  G06T2207/10088 ,  G06T2207/30016 ,  G06T2207/30096

Abstract: 3D MRI images of the brain may be created and acquired. After administration of contrast, brain lesions and other abnormalities may be identified and isolated from the 3D MRI images, with each lesion serving as a region of interest (ROI). 3D region of contrast enhancement images may be created from segmented 3D MRI images and different regions of contrast enhancement of the brain lesion may be depicted. Saved regions of contrast enhancement may be converted into stereolithography format, maximum intensity projection (MIP) images, and/or orthographic projection images. Data corresponding to these resulting 3D region of contrast enhancement images may be used to create 3D printed models of the isolated region of contrast enhancement. Analysis of the 3D brain region of contrast enhancement images and the 3D printed region of contrast enhancement models may enable a more efficient and accurate way of determining brain lesion risk factors and effective treatment regimens.

公开(公告)号：US20240161256A1

公开(公告)日：2024-05-16

申请号：US18508403

申请日：2023-11-14

Applicant: Subtle Medical, Inc.

Inventor： Dayang WANG ,  Srivathsa Pasumarthi VENKATA

IPC: G06T5/00 ,  G01R33/56 ,  G06N3/08 ,  G06T5/50

CPC classification number: G06T5/009 ,  G01R33/5601 ,  G01R33/5608 ,  G06N3/08 ,  G06T5/50 ,  G06T2207/10088 ,  G06T2207/20081 ,  G06T2207/30016 ,  G06T2207/30096

Abstract: Methods and systems are provided for simulating images with different dosages. The method comprises: learning a mapping relationship from a post-contrast image to a low-dose image using an iterative method, where learning the mapping comprises generating a plurality of images with intermediate dosages; and applying the mapping relationship to an input images with a higher dose level and a lower dose level to generate one or more simulated images with intermediate dose levels between the higher dose level and the lower dose level.

公开(公告)号：US11933866B2

公开(公告)日：2024-03-19

申请号：US16992160

申请日：2020-08-13

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Yael Mardor ,  Leor Zach ,  David Guez ,  David Last ,  Dianne Daniels Elmakias

IPC: G01R33/28 ,  A61B5/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/56 ,  G06T7/00 ,  G16H30/40 ,  G16H40/40 ,  G16H40/63 ,  A61K31/166 ,  A61K31/555 ,  A61K31/7068

CPC classification number: G01R33/281 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4842 ,  A61B5/4848 ,  A61B5/7275 ,  G01R33/4806 ,  G01R33/5601 ,  G01R33/5608 ,  G06T7/0016 ,  G16H30/40 ,  G16H40/40 ,  G16H40/63 ,  A61B2576/026 ,  A61K31/166 ,  A61K31/555 ,  A61K31/7068 ,  A61K2300/00 ,  G06T2207/10096 ,  G06T2207/30016 ,  G06T2207/30096

Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.

公开(公告)号：US20230400544A1

公开(公告)日：2023-12-14

申请号：US18329632

申请日：2023-06-06

Applicant: Siemens Healthcare GMBH

Inventor： Karl-Philipp KUNZE ,  Radhouene NEJI

IPC: G01R33/56 ,  G01R33/48 ,  G01R33/565

CPC classification number: G01R33/5608 ,  G01R33/4818 ,  G01R33/56509 ,  G01R33/5601

Abstract: One or more example embodiments discloses a computer-implemented method of reconstructing a dynamic series of magnetic resonance images of a patient, comprising acquiring first and second k-space data of the patient; reconstructing at least one proton density weighted image based on the first k-space data; generating a dynamic series of processing images based on the second k-space data and temporal regularization; applying a motion correction to processing image based on an estimated motion; registering the proton density weighted image to the motion corrected image; and applying a signal intensity correction to the dynamic series of motion corrected images based on the proton density weighted image.

公开(公告)号：US11835610B2

公开(公告)日：2023-12-05

申请号：US17866069

申请日：2022-07-15

Applicant: The General Hospital Corporation

Inventor： Matthew S. Rosen ,  Zdenka Kuncic ,  David Waddington

IPC: G01R33/561 ,  G01R33/56 ,  G01R33/44 ,  A61B5/055

CPC classification number: G01R33/5614 ,  A61B5/055 ,  G01R33/445 ,  G01R33/5601 ,  G01R33/5602 ,  G01R33/5608

Abstract: Systems and methods are provided for susceptibility contrast imaging of nanoparticles at low magnetic fields. A susceptibility-based MRI technique, such as imaging with a balanced steady-state free precession (bSSFP) pulse sequence, may be used for imaging a contrast agent such as biocompatible superparamagnetic nanoparticles at ultra-low fields. The contrast agent and imaging technique may be used to improving the visibility of anatomical structures and detecting diseases, such as cancer, with low-field MRI.

公开(公告)号：US11717247B2

公开(公告)日：2023-08-08

申请号：US14910288

申请日：2014-10-14

Applicant: Andreas Gutzeit

Inventor： Andreas Gutzeit

IPC: A61B6/00 ,  A61B8/06 ,  A61B5/055 ,  A61B5/08 ,  G01R33/563 ,  A61B8/08 ,  G01R33/565 ,  A61B6/03 ,  G01R33/56 ,  A63B23/18 ,  A63B21/008

CPC classification number: A61B6/507 ,  A61B5/055 ,  A61B5/08 ,  A61B6/032 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61B8/481 ,  G01R33/56509 ,  A63B21/0088 ,  A63B23/18 ,  G01R33/5601 ,  G01R33/563

Abstract: A method of and device for acquiring in-vivo images or quantitative/qualitative data (perfusion, blood flow, vascularization, contrast enhancement, selective blood supply management) of interior parts of the human body (20) is described, using an imaging system (21) and including the steps of positioning the body (20) relatively to the imaging system (21), applying a respiratory resistance device (10) to the respiratory system of the body (20), and performing an image acquisition step during or concomitantly an inhalation/inspiration/suction or exhalation/Valsalva/expiration phase, during which the body provides suction or exhalation against a resistance as provided by the respiratory resistance device (10).