公开(公告)号：US12178557B2

公开(公告)日：2024-12-31

申请号：US16241573

申请日：2019-01-07

Applicant: HeartFlow, Inc.

Inventor： Leo Grady ,  Charles A. Taylor

IPC: A61B5/024 ,  A61B5/00 ,  A61B5/02 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/055 ,  A61B6/00 ,  A61B6/50 ,  A61B8/08 ,  G06T19/00 ,  G16B45/00 ,  G16H50/20 ,  G16H50/50

Abstract: Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving one or more vascular models associated with either the patient or with a plurality of individuals; receiving observed perfusion information associated with the patient; and estimating, using one or more computer processors, one or more blood flow characteristics or one or more pathological characteristics of the patient based on the observed perfusion information and the one or more vascular models.

公开(公告)号：US12016635B2

公开(公告)日：2024-06-25

申请号：US17330521

申请日：2021-05-26

Applicant: HeartFlow, Inc.

Inventor： Charles A. Taylor

IPC: G06T7/00 ,  A61B5/00 ,  A61B5/02 ,  A61B5/021 ,  A61B5/024 ,  A61B5/026 ,  A61B5/029 ,  A61B5/055 ,  A61B5/107 ,  A61B5/11 ,  A61B5/22 ,  A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  A61B8/02 ,  A61B8/04 ,  A61B8/06 ,  A61B8/08 ,  A61B34/00 ,  A61B34/10 ,  A61M5/00 ,  G01R33/56 ,  G01R33/563 ,  G06F17/10 ,  G06F18/10 ,  G06F18/22 ,  G06F18/24 ,  G06F30/20 ,  G06F30/23 ,  G06F30/28 ,  G06G7/60 ,  G06T7/11 ,  G06T7/12 ,  G06T7/13 ,  G06T7/149 ,  G06T7/20 ,  G06T7/60 ,  G06T7/62 ,  G06T7/70 ,  G06T7/73 ,  G06T11/00 ,  G06T11/20 ,  G06T11/60 ,  G06T15/10 ,  G06T17/00 ,  G06T17/20 ,  G06V10/40 ,  G06V10/42 ,  G06V10/44 ,  G06V20/69 ,  G16B5/00 ,  G16B45/00 ,  G16H10/40 ,  G16H10/60 ,  G16H30/20 ,  G16H30/40 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70 ,  G16H70/00 ,  A61B90/00 ,  G06T7/10 ,  G06V10/46

CPC classification number: A61B34/10 ,  A61B5/0035 ,  A61B5/004 ,  A61B5/0044 ,  A61B5/02 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/024 ,  A61B5/026 ,  A61B5/0263 ,  A61B5/029 ,  A61B5/055 ,  A61B5/1075 ,  A61B5/1118 ,  A61B5/22 ,  A61B5/4848 ,  A61B5/6852 ,  A61B5/7246 ,  A61B5/7275 ,  A61B5/7278 ,  A61B5/745 ,  A61B6/03 ,  A61B6/032 ,  A61B6/481 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5205 ,  A61B6/5217 ,  A61B6/5229 ,  A61B8/02 ,  A61B8/04 ,  A61B8/06 ,  A61B8/065 ,  A61B8/481 ,  A61B8/5223 ,  A61B8/5261 ,  A61B34/25 ,  A61M5/007 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56366 ,  G06F17/10 ,  G06F18/10 ,  G06F18/22 ,  G06F18/24 ,  G06F30/20 ,  G06F30/23 ,  G06F30/28 ,  G06G7/60 ,  G06T7/0012 ,  G06T7/0014 ,  G06T7/11 ,  G06T7/12 ,  G06T7/13 ,  G06T7/149 ,  G06T7/20 ,  G06T7/60 ,  G06T7/62 ,  G06T7/70 ,  G06T7/73 ,  G06T7/74 ,  G06T11/00 ,  G06T11/001 ,  G06T11/008 ,  G06T11/20 ,  G06T11/60 ,  G06T15/10 ,  G06T17/00 ,  G06T17/005 ,  G06T17/20 ,  G06V10/40 ,  G06V10/42 ,  G06V10/44 ,  G06V20/698 ,  G16B5/00 ,  G16B45/00 ,  G16H10/40 ,  G16H10/60 ,  G16H30/20 ,  G16H30/40 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70 ,  G16H70/00 ,  A61B5/6868 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/108 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/3764 ,  A61B2576/00 ,  A61B2576/023 ,  G06T7/10 ,  G06T2200/04 ,  G06T2207/10012 ,  G06T2207/10072 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/20036 ,  G06T2207/20124 ,  G06T2207/30016 ,  G06T2207/30048 ,  G06T2207/30104 ,  G06T2210/41 ,  G06T2211/404 ,  G06V10/467 ,  Y02A90/10 ,  G06T7/0012 ,  G06T2207/30048

Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

公开(公告)号：US11918293B2

公开(公告)日：2024-03-05

申请号：US17106987

申请日：2020-11-30

Applicant: HeartFlow, Inc.

Inventor： Leo Grady ,  Charles A. Taylor ,  Christopher Zarins

IPC: A61B34/10 ,  A61B5/026 ,  A61B6/00 ,  A61B6/03 ,  A61B8/06 ,  G06F30/20 ,  G06T7/00 ,  G06T7/11 ,  G09B9/00 ,  G09B23/30 ,  G16H50/50

CPC classification number: A61B34/10 ,  A61B5/0263 ,  A61B6/032 ,  A61B6/503 ,  A61B6/504 ,  A61B8/06 ,  G06F30/20 ,  G06T7/0012 ,  G06T7/11 ,  G09B9/00 ,  G09B23/303 ,  G16H50/50 ,  A61B2034/104 ,  A61B2034/105 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10132 ,  G06T2207/30048 ,  G06T2207/30056 ,  G06T2207/30084 ,  G06T2207/30104 ,  G06T2211/404

Abstract: Systems and methods are disclosed for assessing organ and/or tissue transplantation by estimating blood flow through a virtual transplant model by receiving a patient-specific anatomical model of the intended transplant recipient; receiving a patient-specific anatomical model of the intended transplant donor, the model including the vasculature of the organ or tissue that is intended to be transplanted to the recipient; constructing a unified model of the connected system post transplantation, the connected system including the transplanted organ or tissue from the intended transplant donor and the vascular system of the intended transplant recipient; receiving one or more blood flow characteristics of the connected system; assessing the suitability for an actual organ or tissue transplantation using the received blood flow characteristics; and outputting the assessment into an electronic storage medium or display.

公开(公告)号：US11854704B2

公开(公告)日：2023-12-26

申请号：US17812935

申请日：2022-07-15

Applicant: HeartFlow, Inc.

Inventor： Leo Grady ,  Charles A. Taylor ,  Campbell Rogers ,  Christopher K. Zarins ,  Gilwoo Choi

IPC: G16H50/50

CPC classification number: G16H50/50

Abstract: Systems and methods are disclosed herein for anatomical modeling using information obtained during a medical procedure, whereby an initial anatomical model is generated or obtained, a correspondence is determined between the initial model and additional data and/or measurements from an invasive or noninvasive procedure, and, if a discrepancy is found between the initial model and the additional data, the anatomical model is updated to incorporate the additional data and reduce the discrepancy.

公开(公告)号：US11504019B2

公开(公告)日：2022-11-22

申请号：US15708980

申请日：2017-09-19

Applicant: HeartFlow, Inc.

Inventor： Timothy A. Fonte ,  Leo Grady ,  Charles A. Taylor

IPC: A61B5/026 ,  A61B5/11 ,  G06F16/00 ,  G16H50/50 ,  A61B5/00 ,  A61B5/02 ,  G16H50/30 ,  G16H50/70 ,  G16H10/40 ,  A61B8/06

Abstract: Systems and methods are disclosed for informing and monitoring blood flow calculations with user-specific activity data, including sensor data. One method includes receiving or accessing a user-specific anatomical model and a first set of physiological characteristics of a user; calculating a first value of a blood flow metric of the user based on the user-specific anatomical model and the first set of physiological characteristics; receiving or calculating a second set of physiological characteristics of the user by accessing or receiving sensor data of the user's blood flow and/or sensor data of the user's physiological characteristics; and calculating second value of the blood flow metric of the user based on the user-specific anatomical model and the second set of physiological characteristics of the user.

公开(公告)号：US11017904B2

公开(公告)日：2021-05-25

申请号：US15421832

申请日：2017-02-01

Applicant: HeartFlow, Inc.

Inventor： Sethuraman Sankaran ,  Leo J. Grady ,  Charles A. Taylor ,  Christopher K. Zarins

IPC: G16H50/50 ,  G16H20/40 ,  G16H40/67 ,  G06F17/18 ,  G06F19/00

Abstract: Systems and methods are disclosed for simulation of occluded arteries and/or optimization of occlusion-based treatments. One method includes obtaining a patient-specific anatomic model of a patient's vasculature; obtaining an initial computational model of blood flow through the patient's vasculature based on the patient-specific anatomic model; obtaining a post-treatment computational model by modifying portions of the initial computational model based on an occlusion-based treatment; generating a pre-treatment blood flow characteristic using the initial computational model or computing a post-treatment blood flow using the post-treatment computational model; and outputting a representation of the pre-treatment blood flow characteristic or the post-treatment blood flow characteristic.

公开(公告)号：US10978210B2

公开(公告)日：2021-04-13

申请号：US15434578

申请日：2017-02-16

Applicant: HeartFlow, Inc.

Inventor： Leo Grady ,  Charles A. Taylor ,  Christopher K. Zarins

IPC: G16H50/50 ,  A61B5/02 ,  A61B5/026 ,  G16H50/20 ,  A61B5/00 ,  G16H20/10 ,  G16H20/40

Abstract: Systems and methods are disclosed for using vessel reactivity to guide diagnosis or treatment for cardiovascular disease. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at a first physiological state; determining a second vessel size at the one or more locations of the vessel of the patient-specific vascular model at a second physiological state using a simulation or learned information; comparing the first vessel size to the corresponding second vessel size; and estimating a characteristic of the vessel of the patient-specific vascular model based on the comparison.

公开(公告)号：US10881465B2

公开(公告)日：2021-01-05

申请号：US16680005

申请日：2019-11-11

Applicant: HeartFlow, Inc.

Inventor： Leo Grady ,  Charles A. Taylor ,  Christopher Zarins

IPC: A61B34/10 ,  G09B23/30 ,  G16H50/50 ,  A61B5/026 ,  A61B6/03 ,  A61B6/00 ,  A61B8/06 ,  G06T7/00 ,  G09B9/00 ,  G06T7/11

Abstract: Systems and methods are disclosed for assessing organ and/or tissue transplantation by estimating blood flow through a virtual transplant model by receiving a patient-specific anatomical model of the intended transplant recipient; receiving a patient-specific anatomical model of the intended transplant donor, the model including the vasculature of the organ or tissue that is intended to be transplanted to the recipient; constructing a unified model of the connected system post transplantation, the connected system including the transplanted organ or tissue from the intended transplant donor and the vascular system of the intended transplant recipient; receiving one or more blood flow characteristics of the connected system; assessing the suitability for an actual organ or tissue transplantation using the received blood flow characteristics; and outputting the assessment into an electronic storage medium or display.

公开(公告)号：US10702340B2

公开(公告)日：2020-07-07

申请号：US15183341

申请日：2016-06-15

Applicant: HeartFlow, Inc.

Inventor： Charles A. Taylor

IPC: A61B34/10 ,  G06T7/11 ,  G06T7/12 ,  G06T7/13 ,  G06T7/149 ,  G06T7/62 ,  A61B5/02 ,  G16H50/50 ,  A61B5/026 ,  A61B5/00 ,  G06F17/10 ,  A61B34/00 ,  G16B5/00 ,  G16B45/00 ,  G06T7/70 ,  G06T7/73 ,  A61B6/00 ,  G16H10/60 ,  G16H50/30 ,  G06G7/60 ,  A61B5/029 ,  A61B6/03 ,  A61B8/06 ,  A61B8/08 ,  G01R33/563 ,  A61B5/107 ,  G06T7/00 ,  G06T17/00 ,  G06K9/00 ,  G06K9/62 ,  A61B5/021 ,  G06F17/50 ,  A61B5/024 ,  A61B5/22 ,  G06F19/00 ,  G06K9/46 ,  G06T7/20 ,  G06T11/00 ,  G06T11/20 ,  A61M5/00 ,  G06K9/52 ,  A61B5/055 ,  A61B5/11 ,  G06T17/20 ,  G06T15/10 ,  G06T11/60 ,  G06T7/60 ,  A61B8/02 ,  A61B8/04 ,  G01R33/56 ,  G16H30/20 ,  G16H30/40 ,  G16H10/40 ,  G16H50/70 ,  A61B90/00

Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

公开(公告)号：US10702339B2

公开(公告)日：2020-07-07

申请号：US14276394

申请日：2014-05-13

Applicant: HeartFlow, Inc.

Inventor： Charles A. Taylor

IPC: A61B34/10 ,  G06F17/10 ,  A61B34/00 ,  G16B5/00 ,  G16B45/00 ,  G06T7/70 ,  G06T7/73 ,  G06T7/11 ,  G06T7/12 ,  G06T7/13 ,  G06T7/149 ,  G06T7/62 ,  A61B5/02 ,  A61B6/00 ,  G16H10/60 ,  G16H50/30 ,  G16H50/50 ,  G06F30/20 ,  G06F30/23 ,  A61B5/026 ,  G06G7/60 ,  A61B5/00 ,  A61B5/029 ,  A61B6/03 ,  A61B8/06 ,  A61B8/08 ,  G01R33/563 ,  A61B5/107 ,  G06T7/00 ,  G06T17/00 ,  G06K9/00 ,  G06K9/62 ,  A61B5/021 ,  A61B5/024 ,  A61B5/22 ,  G06K9/46 ,  G06T7/20 ,  G06T11/00 ,  G06T11/20 ,  A61M5/00 ,  G06K9/52 ,  A61B5/055 ,  A61B5/11 ,  G06T17/20 ,  G06T15/10 ,  G06T11/60 ,  G06T7/60 ,  A61B8/02 ,  A61B8/04 ,  G01R33/56 ,  G16H30/20 ,  G16H30/40 ,  G16H10/40 ,  G16H50/70 ,  A61B90/00

Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.