公开(公告)号：US20240033381A1

公开(公告)日：2024-02-01

申请号：US18227049

申请日：2023-07-27

申请人： ARTHREX, INC.

发明人： Michael Dominik Steiner ,  Efrain O. Morales Correa

IPC分类号： A61K49/00 ,  A61B5/0275 ,  A61B5/02 ,  A61B5/00

CPC分类号： A61K49/0034 ,  A61B5/0275 ,  A61B5/02007 ,  A61B5/0071

摘要： A method for fluorescent imaging of a subject, the method having the steps of: placing an illuminator in a surgical area of a subject, the illuminator having an emission band substantially similar to an fluorescence imaging agent; administering the fluorescence imaging agent to the subject; acquiring a plurality of images of the surgical area of the subject showing fluorescence intensity over a predetermined time period; and analyzing the plurality of images to determine changes in sensed fluorescence from the fluorescence imaging agent; wherein an exposure gain is applied to the images based on changes in detected intensity of the fluorescence from the illuminator.

公开(公告)号：US11832924B2

公开(公告)日：2023-12-05

申请号：US16482190

申请日：2018-02-01

申请人： The Regents of the University of California

发明人： Shanglei Liu ,  Santiago Horgan ,  David Owens

IPC分类号： A61B5/0275 ,  A61B5/00 ,  A61B1/00 ,  A61B1/04 ,  A61K49/00

CPC分类号： A61B5/0275 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/725 ,  A61B5/742 ,  A61B1/00096 ,  A61B1/043 ,  A61K49/0034

摘要： Methods for dynamically evaluating blood flow are provided. The method may include injecting Indocyanine Green (ICG) into the bloodstream of a patient, such that the ICG perfuses into a tissue of the patient. ICG images of the tissue may be recorded and stored, such that a user may select a range of stored ICG images. Data indicative of the selected range of stored ICG images is automatically normalized and background-filtering, and a dynamic representation of the ICG perfusion may be generated as a function of time based on the normalized and filtered data. As such, a clinical decision may be made based on the dynamic representation of the ICG perfusion.

公开(公告)号：US20230346324A1

公开(公告)日：2023-11-02

申请号：US18342207

申请日：2023-06-27

申请人： The General Hospital Corporation

发明人： Nathaniel Alpert ,  Georges El Fakhri

IPC分类号： A61B6/03 ,  A61B6/00 ,  A61B5/0275 ,  A61K51/04 ,  A61B5/00

CPC分类号： A61B6/037 ,  A61B6/481 ,  A61B5/02755 ,  A61B6/508 ,  A61B6/507 ,  A61B6/503 ,  A61K51/0459 ,  A61B5/4884

摘要： The present invention provides a system and method for performing a single-scan rest-stress cardiac measurement. In one aspect, the system includes a positron emission tomography (PET) imaging system, a source of a first PET radiotracer for administration to a subject, a source of a second PET radiotracer for administration to a subject, and a processor. The processor has non-transient computer readable media programmed with instructions to obtain PET images of the subject administered with the radiotracer. Furthermore, the computer readable media is programmed with instructions to process the PET images with a non-steady-state, multi-compartment parametric model. An output of the non-steady-state, multi-compartment parametric model is a measure of myocardial blood flow for both a rest state and a stress state of the subject.

公开(公告)号：US11605466B2

公开(公告)日：2023-03-14

申请号：US15991097

申请日：2018-05-29

申请人： HeartFlow, Inc.

发明人： Leo Grady ,  Charles A. Taylor

IPC分类号： G16H50/50 ,  A61B5/02 ,  A61B5/026 ,  A61B5/055 ,  A61B5/00 ,  G06T7/00 ,  G16H10/60 ,  A61B5/0275 ,  A61B5/053 ,  A61B5/11 ,  A61B5/22

摘要： Systems and methods are disclosed for assessing tissue function based on vascular disease. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's tissue; receiving a patient-specific vascular model generated from patient-specific imaging of at least a portion of a patient's vasculature; receiving an estimate of blood supplied to a portion of the patient-specific anatomic model; and determining a characteristic of the function of the patient's tissue using the estimate of blood supplied to the portion of the patient-specific anatomic model.

公开(公告)号：US11517198B2

公开(公告)日：2022-12-06

申请号：US17159616

申请日：2021-01-27

申请人： Siemens Healthcare Limited ,  King's College London

发明人： Giulio Ferrazzi ,  Amedeo Chiribiri ,  Karl-Philipp Kunze ,  Sarah McElroy ,  Radhouene Neji ,  Sebastien Roujol

IPC分类号： A61B5/05 ,  A61B5/00 ,  A61B5/026 ,  A61B5/0275 ,  G01R33/567

摘要： The present techniques relate to a techniques for performing cardiac perfusion imaging in order to detect perfusion defects in the myocardium. The present techniques relate to methods for performing cardiac perfusion imaging by performing at least two image acquisitions using different, customizable saturation delay times, which improves the ability to detect defects.

公开(公告)号：US20220378294A1

公开(公告)日：2022-12-01

申请号：US17815745

申请日：2022-07-28

申请人： Cilag GmbH International

发明人： Joshua D. Talbert ,  Donald M. Wichern

IPC分类号： A61B5/00 ,  H04N5/225 ,  H04N9/64 ,  H04N5/235 ,  H04N13/15 ,  A61B5/0275 ,  A61B1/04

摘要： Hyperspectral, fluorescence, and laser mapping imaging with a minimal area image sensor are disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation, wherein the pixel array comprises active pixels and optical black pixels. The system includes a black clamp circuit providing offset control for data generated by the pixel array. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of: electromagnetic radiation having a wavelength from about 513 nm to about 545 nm; electromagnetic radiation having a wavelength from about 565 nm to about 585 nm; electromagnetic radiation having a wavelength from about 900 nm to about 1000 nm; an excitation wavelength of electromagnetic radiation that causes a reagent to fluoresce; or a laser mapping pattern.

公开(公告)号：US11363954B2

公开(公告)日：2022-06-21

申请号：US16150473

申请日：2018-10-03

申请人： Visionsense LTD.

发明人： Nadav Horesh ,  Alex Chanin ,  Ofer Braude

IPC分类号： A61B5/00 ,  A61B1/04 ,  A61B5/1455 ,  H04N5/52 ,  A61B5/0275 ,  A61B5/026

摘要： A device and method for fluorescent imaging may include an imaging unit including a fluorescent camera with an optical detector that is configured to acquire a fluorescent image of a fluorescing sample, the image including raw pixel values. A user interface may display an image formed from display image pixels derived from the raw image pixels. A distance sensor may measure a distance to the fluorescing sample. A distance between the optical detector and fluorescing sample may be determined from the measured distance. A processing unit may obtain a gain value, match the determined distance to a distance value associated a respective gain range, and impose limits of the gain values range onto the gain value, to determine a limited gain value. The limited gain value may be applied to the raw image pixels, thereby deriving display image pixels.

公开(公告)号：US11284823B2

公开(公告)日：2022-03-29

申请号：US16233488

申请日：2018-12-27

申请人： Oregon Health & Science University

发明人： Theodore Hobbs ,  Ravikant Samatham ,  Steven L. Jacques

IPC分类号： A61B5/1455 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/00 ,  A61B5/02

摘要： Disclosed are a method, device and system for determining total circulating blood volume (BV) using a minimally invasive technique.

公开(公告)号：US11170890B2

公开(公告)日：2021-11-09

申请号：US16153746

申请日：2018-10-06

申请人： KONINKLIJKE PHILIPS N.V.

发明人： John Unser

IPC分类号： G16H30/40 ,  A61B6/03 ,  A61B6/00 ,  G16H50/50 ,  G16H50/20 ,  A61B5/0275 ,  G06T7/00 ,  G06T7/20 ,  G06T11/20 ,  G06T11/60 ,  A61B5/00

摘要： Devices, systems, and methods for evaluating blood flow with vascular perfusion imaging are disclosed. In an embodiment, a medical system is disclosed. One embodiment of the medical system comprises a perfusion imaging system configured to obtain perfusion imaging data associated with movement of contrast through a vessel of a patient, a graphical user interface, and a medical processing unit in communication with the perfusion imaging system and the graphical user interface. The medical processing unit is configured to receive a first set of perfusion imaging data from the perfusion imaging system, determine at least one parameter representative of the movement of the contrast through the vessel of the patient, generate a first graphical representation of the first set of perfusion imaging data and the at least one parameter determined based on the first set of perfusion imaging data, and output the first graphical representation to the graphical user interface.

公开(公告)号：US20210308285A1

公开(公告)日：2021-10-07

申请号：US17349723

申请日：2021-06-16

申请人： Memorial Sloan Kettering Cancer Center

发明人： Mark Dunphy ,  Gabriela Chiosis

IPC分类号： A61K51/04 ,  A61P35/00 ,  A61K49/00 ,  A61B5/318 ,  A61B5/0275 ,  A61B5/08 ,  A61B5/00 ,  A61B6/03 ,  A61B6/00 ,  A61K31/52 ,  A61K49/18

摘要： The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.