公开(公告)号：US20170020419A1

公开(公告)日：2017-01-26

申请号：US15283795

申请日：2016-10-03

申请人： Verily Life Sciences LLC

发明人： Victor Marcel Acosta ,  Vikram Singh Bajaj ,  Andrew Homyk ,  Eric Peeters ,  Jason Donald Thompson

IPC分类号： A61B5/145 ,  G01N21/64 ,  A61K49/00 ,  A61B5/1455 ,  A61B5/00

CPC分类号： A61B5/14546 ,  A61B5/0022 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1477 ,  A61B5/4848 ,  A61B5/681 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/746 ,  A61B5/7475 ,  A61K49/0013 ,  A61K49/0019 ,  A61K49/0093 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  C09K11/59 ,  C23C16/27 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/1746 ,  G01N2021/6439 ,  G01R33/281 ,  G01R33/5601 ,  G02B21/00

摘要： An imaging agent for detecting analytes in a biological environment includes functionalized, silicon vacancy center-containing nanodiamonds. Individual nanodiamonds of the imaging agent include at least one silicon vacancy center. The at least one silicon vacancy center can emit light having a wavelength in a narrow band in response to illumination having any wavelength in a wide range of wavelengths. The nanodiamonds are functionalized to selectively interact with an analyte of interest. The nanodiamonds can additionally include other color centers, and the imaging agent can include a plurality of sets of nanodiamonds having detectably unique ratios of silicon vacancy centers to other color centers. The silicon vacancy centers in the nanodiamonds can have a preferred orientation enabling orientation tracking of individual nanodiamonds or other applications. A method for detecting properties of the analyte of interest by interacting with the imaging agent is also provided.

摘要翻译： 用于检测生物环境中的分析物的成像剂包括具有功能的含空穴中心的纳米金刚石。 成像剂的单个纳米金刚石包括至少一个硅空位中心。 至少一个硅空位中心可以响应于在宽波长范围内具有任何波长的照明而发射具有窄带波长的光。 纳米金刚石被官能化以选择性地与感兴趣的分析物相互作用。 纳米金刚石可以另外包括其它颜色中心，并且成像剂可以包括具有可检测地独特的硅空位中心与其他色心的比例的多组纳米金刚石。 纳米金刚石中的硅空位中心可以具有优选的取向，使得能够对单个纳米金刚石或其它应用进行取向跟踪。 还提供了通过与成像剂相互作用来检测目的分析物的性质的方法。

公开(公告)号：US09442110B2

公开(公告)日：2016-09-13

申请号：US12837308

申请日：2010-07-15

申请人： Suresh M. Menon ,  David E. Newman ,  Terry J. Henderson ,  J. Manuel Perez

发明人： Suresh M. Menon ,  David E. Newman ,  Terry J. Henderson ,  J. Manuel Perez

IPC分类号： G01N33/543 ,  G01N24/08 ,  G01R33/28 ,  G01R33/34 ,  G01R33/38 ,  G01R33/383 ,  G01R33/56

CPC分类号： G01N33/54333 ,  G01N24/08 ,  G01N24/084 ,  G01N33/54373 ,  G01R33/281 ,  G01R33/34053 ,  G01R33/3806 ,  G01R33/383 ,  G01R33/5601 ,  Y10S977/702 ,  Y10S977/773 ,  Y10S977/81 ,  Y10S977/92

摘要： A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the analyte.

公开(公告)号：US20160252532A1

公开(公告)日：2016-09-01

申请号：US15028219

申请日：2014-10-15

申请人： TECHNISCHE UNIVERSITÄT MÜNCHEN

发明人： Franz SCHILLING ,  Steffen GLASER ,  Stephan DÜWEL ,  Malte GERSCH

IPC分类号： G01N33/84 ,  A61B5/00 ,  A61B5/055 ,  A61B5/145 ,  G01N24/08 ,  A61K49/10

CPC分类号： G01N33/84 ,  A61B5/055 ,  A61B5/08 ,  A61B5/14539 ,  A61B5/7278 ,  A61B2576/02 ,  A61K49/10 ,  G01N24/08 ,  G01N24/088 ,  G01N2458/15 ,  G01R33/281 ,  G01R33/465 ,  G01R33/5601

摘要： The present invention relates to the use of compounds with at least one pH-sensitive chemical shift for determining pH and/or measuring pH changes in magnetic resonance. More specifically, the present invention is related to compounds with at least one pH-sensitive chemical shift, such compound being selected from pyruvic acid and its metabolites, compounds produced from pyruvic acid after interaction with acid, and compounds comprising at least one enolic group whose pKa value is lowered through effects of at least one neighboring group into a physiological and/or pathological pH-range, and wherein the compound exhibits at least one pH-sensitive chemical shift in an NMR spectrum. The present invention further relates to biosensors comprising at least one of the compounds. The present invention is furthermore related to in vitro and in vivo methods for determining pH and/or measuring pH changes using the compounds or biosensors. The present invention also relates to methods of diagnosing and/or monitoring treatment of a disease causing changes in pH wherein the compounds or biosensors are applied. The present invention also relates to use of the compounds or biosensors in quality control of food or in the examination of plants and organisms.

摘要翻译： 本发明涉及具有至少一种pH敏感化学位移的化合物用于测定pH和/或测量磁共振中的pH变化的用途。 更具体地说，本发明涉及具有至少一种pH敏感的化学位移的化合物，这种化合物选自丙酮酸及其代谢物，与酸相互作用后由丙酮酸生成的化合物，以及包含至少一个烯醇基团的化合物， pKa值通过至少一个相邻基团的影响降低到生理和/或病理学pH范围内，并且其中所述化合物在NMR光谱中表现出至少一个pH敏感的化学位移。 本发明还涉及包含至少一种化合物的生物传感器。 本发明还涉及使用化合物或生物传感器测定pH和/或测量pH变化的体外和体内方法。 本发明还涉及诊断和/或监测导致pH变化的疾病的治疗方法，其中施用化合物或生物传感器。 本发明还涉及化合物或生物传感器在食品质量控制或植物和生物体检查中的应用。

公开(公告)号：US20150369895A1

公开(公告)日：2015-12-24

申请号：US14739802

申请日：2015-06-15

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETAR ,  THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF COMMERCE

发明人： Gary Zabow ,  Stephen Dodd ,  Alan Koretsky ,  John Moreland

IPC分类号： G01R33/56 ,  A61K49/18

CPC分类号： A61K49/1818 ,  A61B5/0515 ,  A61B5/055 ,  A61K49/18 ,  B82Y5/00 ,  B82Y30/00 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/563 ,  G01R33/56325 ,  G01R33/5635 ,  Y10T428/2982

摘要： The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.

摘要翻译： 本发明涉及一种具有空腔或保留空间的磁共振结构，其提供对比度，以及通过离散和可控的特征频移对诸如水质子的NMR敏感核的频谱特征进行频移的附加能力 独特的MRS设计。 本发明还涉及与相似尺寸的现有MRI造影剂相比具有显着更高磁矩的几乎均匀的固体磁共振T2 *造影剂。

公开(公告)号：US09110068B2

公开(公告)日：2015-08-18

申请号：US14298148

申请日：2014-06-06

申请人： STC.UNM

发明人： Laurel Sillerud

IPC分类号： G01N33/53 ,  G01N33/574 ,  G01N33/543 ,  A61M1/34

CPC分类号： G01N33/57438 ,  A61M1/3486 ,  G01N24/08 ,  G01N33/54306 ,  G01N33/54326 ,  G01N33/54373 ,  G01N33/57488 ,  G01R33/281 ,  G01R33/302 ,  G01R33/448 ,  G01R33/465 ,  Y02A50/58

摘要： A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal. The system and method also include a container having a binding agent therein that has an affinity for the analyte or foreign agent that is used to remove the foreign agent from a patient's blood or plasma. Blood or plasma is shunted through the container to remove or reduce the foreign agent by extracorporeal circulation.

摘要翻译： 用于分析具有NMR信号的液体样品的系统和方法，所述液体具有响应于分析物存在的磁场。 包括具有适于容纳液体并对液体施加磁场的测试部分的NMR装置。 复合物由具有与分析物结合的场梯度的共轭物构成，其在测试部分中具有足够的量级以猝灭液体的NMR信号，由此通过不存在NMR信号来确定复合物的存在。 该系统和方法还包括其中具有粘合剂的容器，其对于用于从患者血液或血浆中除去外来试剂的分析物或外来物质具有亲和力。 血液或血浆通过容器分流，以通过体外循环除去或减少外来物质。

公开(公告)号：US20140330110A1

公开(公告)日：2014-11-06

申请号：US14338385

申请日：2014-07-23

申请人： General Electric Company

发明人： Ralph E. Hurd

IPC分类号： G01R33/56 ,  A61K49/10 ,  A61B5/00

CPC分类号： G01R33/5601 ,  A61B5/055 ,  A61B5/742 ,  A61B5/7475 ,  A61K49/10 ,  G01R33/281 ,  G01R33/4608 ,  G01R33/485 ,  G01R33/5608

摘要： A system and method for improving available signal-to-noise ratio (SNR) and speed of MR imaging of hyperpolarized substances is disclosed. The system and method include decoupling spin effects of hydrogen nuclei from non-hydrogen nuclei of interest during sampling of MR signals therefrom. Though the hydrogen nuclei of the hyperpolarized substance may not be directly bonded to the non-hydrogen nuclei of interest, resonance splitting may still impact SNR. Long range decoupling improves T2* time, and thus preserves signal strength and available SNR.

摘要翻译： 公开了一种用于提高超极化物质的可用信噪比（SNR）和MR成像速度的系统和方法。 该系统和方法包括在从其中的MR信号的采样期间将氢原子的自旋效应从感兴趣的非氢核解耦。 尽管超极化物质的氢核可能不会直接与感兴趣的非氢核结合，但共振分裂仍可能影响SNR。 长距离去耦可提高T2 *时间，从而保持信号强度和可用信噪比。

公开(公告)号：US08862203B2

公开(公告)日：2014-10-14

申请号：US10401227

申请日：2003-03-27

申请人： Jan Weber

发明人： Jan Weber

IPC分类号： A61B5/00 ,  A61B5/055 ,  A61M25/01 ,  G01R33/56 ,  G01R33/28 ,  A61M25/00 ,  A61B19/00

CPC分类号： A61B5/055 ,  A61B90/39 ,  A61B2090/3954 ,  A61F7/12 ,  A61F2007/126 ,  A61M25/0009 ,  A61M25/0045 ,  A61M25/0127 ,  G01R33/281 ,  G01R33/285 ,  G01R33/287 ,  G01R33/5601

摘要： This disclosure employs temperature, magnetism and Curie point transition to construct and use catheters and other medical devices that can be visualized using magnetic resonance imaging (MRI). Accordingly, this disclosure includes, but is not limited to, medical devices, means of constructing medical devices, and methods of imaging medical devices using magnetic resonance and other technologies.

摘要翻译： 本公开采用温度，磁力和居里点过渡来构建和使用可以使用磁共振成像（MRI）可视化的导管和其他医疗装置。 因此，本公开包括但不限于医疗设备，构建医疗设备的手段，以及使用磁共振和其他技术对医疗设备成像的方法。

公开(公告)号：US20140186969A1

公开(公告)日：2014-07-03

申请号：US14066797

申请日：2013-10-30

申请人： Universite D'Aix-Marseille

发明人： Oliver Ouari ,  Hakim Karoui ,  Francois Le Moigne ,  Paul Tordo ,  Robert S. Griffin ,  Yoh Matsuki ,  Thorstep Maly

IPC分类号： G01N1/28

CPC分类号： G01N1/28 ,  C07D471/18 ,  C07D491/22 ,  G01R33/281 ,  G01R33/5601 ,  Y10T436/25

摘要： The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

摘要翻译： 本发明涉及有机化学领域，特别涉及在动态核极化（DNP）技术中用作极化剂的有机自由基，其涉及将电子自旋的极化转移到核磁共振的化合物的核上 （NMR）。 它涉及以硝基氧单元的氨基之间的刚性连接为特征的二氧化氮型双基极化剂。 这种特殊结构使得在低温和高场下，所研究的化合物的极化核的NMR / MAS信号的极化转移和最佳增强是最佳的。

公开(公告)号：US20140039300A1

公开(公告)日：2014-02-06

申请号：US13941652

申请日：2013-07-15

申请人： Kjell-Inge GJESDAL ,  Endre GRØVIK

发明人： Kjell-Inge GJESDAL ,  Endre GRØVIK

IPC分类号： G01R33/48 ,  A61B5/00 ,  G01R33/56 ,  G01R33/28 ,  A61B5/055

CPC分类号： G01R33/5602 ,  A61B5/055 ,  A61B5/4312 ,  A61B5/742 ,  G01R33/281 ,  G01R33/4828 ,  G01R33/5601 ,  G01R33/5608 ,  G01R33/56366

摘要： The present invention encompasses methods, apparatus, and computer based systems for identifying benign and malignant tumors in tissues such as soft tissues and particularly breast tissue using dynamic contrast-enhanced magnetic resonance imagining (DCE-MRI) and dynamic susceptibility contrast-enhanced magnetic resonance (DSC) imagining of the tumors. Some embodiments encompass the use of two dynamic MRI pulse sequences in intercalating mode during parenteral administration of an MR contrast substance, wherein one of said pulse sequences is optimized for spatial information and the other pulse sequence is adjusted for high temporal solution, the high-temporal dissolved sequence further comprising a double echo-collection sensitive towards both DCE and DSC for generating a number of different biomarker data such as pharmacokinetic biomarker data, descriptive DCE biomarkers and descriptive DSC biomarkers, and subsequently normalizing and comparing said data with corresponding data from corresponding benign and malign tumors, respectively.

摘要翻译： 本发明包括使用动态对比增强磁共振想象（DCE-MRI）和动态磁敏度对比度增强磁共振（DCE-MRI）来识别组织（例如软组织，特别是乳腺组织）中的良性和恶性肿瘤的方法，装置和基于计算机的系统 DSC）想象肿瘤。 一些实施方案包括在胃肠外施用MR对比物质期间在插入模式中使用两个动态MRI脉冲序列，其中所述脉冲序列之一针对空间信息进行了优化，另一个脉冲序列被调整用于高时间解，高时间 溶解序列还包含对DCE和DSC两者敏感的双回波收集，用于产生许多不同的生物标志物数据，例如药代动力学生物标志物数据，描述性DCE生物标志物和描述性DSC生物标志物，随后将所述数据与来自相应良性的相应数据进行归一化和比较 和恶性肿瘤。

公开(公告)号：US08624592B2

公开(公告)日：2014-01-07

申请号：US12844708

申请日：2010-07-27

申请人： W. David Lee

发明人： W. David Lee

IPC分类号： G01V3/00

CPC分类号： G01R33/302 ,  G01N24/08 ,  G01N24/088 ,  G01R33/281 ,  G01R33/285 ,  G01R33/34007 ,  G01R33/34053 ,  G01R33/34061 ,  G01R33/34069 ,  G01R33/34084 ,  G01R33/341 ,  G01R33/44 ,  G01R33/465 ,  G01R33/5601

摘要： This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.

摘要翻译： 本发明一般涉及一种具有一个或多个小孔的检测装置，每个小孔由NMR微线圈包围或非常接近，每个孔含有具有磁性纳米颗粒的液体样品，其在目标分析物存在下自组装或分散 ，从而改变液体样品的NMR测定性质。 该装置可以例如用作用于点护理诊断和/或野外使用的便携式单元，或者该装置可被植入用于连续或间歇地监测患者感兴趣的一种或多种生物物种。