公开(公告)号：US20240341618A1

公开(公告)日：2024-10-17

申请号：US18676319

申请日：2024-05-28

申请人： NATIONAL INSTITUTE OF MENTAL HEALTH

发明人： Filip SPANIEL ,  Vaclav CAPEK ,  Antonin SKOCH

IPC分类号： A61B5/055 ,  A61B5/00 ,  A61B5/0515

CPC分类号： A61B5/055 ,  A61B5/0042 ,  A61B5/0515 ,  A61B5/4064

摘要： Methods of categorisation of schizophrenia sufferers into subtypes based on changes in brain morphology, together with associated blood biomarkers are provided. The methods allow for more accurate treatment and diagnosis of schizophrenia.

公开(公告)号：US12117508B1

公开(公告)日：2024-10-15

申请号：US18744685

申请日：2024-06-16

申请人： INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCES

发明人： Jie Tian ,  Zechen Wei ,  Hui Hui ,  Liwen Zhang ,  Xin Yang ,  Tao Zhu

IPC分类号： G01R33/12 ,  A61B5/0515 ,  G06T11/00

CPC分类号： G01R33/1276 ,  A61B5/0515 ,  G06T11/006 ,  G06T2211/441

摘要： A system for reconstructing a magnetic particle image based on adaptive optimization of regularization terms includes: a MPI device for scanning an imaging object to acquire a voltage response signal; a signal processor for constructing a system matrix; and a control processor for reconstructing the magnetic particle image based on an arbitrarily selected regularization term, inputting the reconstructed magnetic particle image to a regularization-term adaptive optimization neural network model for enhancement processing, taking the enhanced magnetic particle image as a first image, and calculating a loss value between the first image and an initial image to acquire a final reconstructed magnetic particle image. The system adopts a neural network model-based automatic learning approach, instead of the approach of manually selecting regularization terms and adjusting parameters, to improve the reconstruction efficiency and quality of the magnetic particle image.

公开(公告)号：US12053268B2

公开(公告)日：2024-08-06

申请号：US18382643

申请日：2023-10-23

申请人： Vanderbilt University

发明人： William A. Grissom ,  Charles F. Caskey

IPC分类号： A61B5/0515 ,  A61B5/00 ,  A61B8/08 ,  G01S15/89

CPC分类号： A61B5/0515 ,  A61B5/0035 ,  A61B8/485 ,  G01S15/8906 ,  A61B2562/0223

摘要： A system and method of magnetic particle imaging (MPI) are disclosed. The system and method use ultrasound to drive magnetic particles (such as nanoparticles) through a magnetic field gradient to generate a signal and map the magnetic particles' distribution or concentration.

公开(公告)号：US11931423B2

公开(公告)日：2024-03-19

申请号：US16691030

申请日：2019-11-21

申请人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Dexing Zeng ,  Di Gao ,  Jiamin Wu

IPC分类号： A61K47/68 ,  A61B5/0515 ,  A61B5/055 ,  A61K47/69 ,  A61P35/00 ,  C07K16/28 ,  C07K16/32

CPC分类号： A61K47/6815 ,  A61B5/0515 ,  A61B5/055 ,  A61K47/6811 ,  A61K47/6851 ,  A61K47/6923 ,  A61P35/00 ,  C07K16/2827 ,  C07K16/2842 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/32

摘要： Bioconjugates and methods of making bioconjugates are provided, wherein the bioconjugates comprise glucose oxidase and nanoparticles that can kill tumor cells. For example, glucose oxidase-iron oxide bioconjugates can produce reactive oxygen species from blood glucose, causing cell death. The use of superparamagnetic iron oxide nanoparticles can provide magnetic resonance imaging guidance to facilitate imaging-guided drug delivery and combine diagnostics with therapy.

公开(公告)号：US11754648B2

公开(公告)日：2023-09-12

申请号：US17156796

申请日：2021-01-25

申请人： UCHICAGO ARGONNE, LLC

发明人： Valentine Novosad ,  Elena A. Rozhkova ,  Maxim Nikitin ,  Petr Nikitin

IPC分类号： A61B5/00 ,  G01R33/12 ,  A61B5/0515 ,  A61K49/18

CPC分类号： G01R33/1269 ,  A61B5/0515 ,  A61K49/1806 ,  A61K49/1818 ,  G01R33/1276

摘要： A significant enhancement of detection capabilities of the room temperature MPQ is seen using optical lithography-defined, ferromagnetic iron-nickel alloy microdisks. Irreversible transitions between strongly non-collinear (vortex) and a collinear single domain states, driven by an ac magnetic field, translate into a nonlinear magnetic response that enables ultrasensitive detection of material at relatively small magnetic fields.

公开(公告)号：US11657916B2

公开(公告)日：2023-05-23

申请号：US16665733

申请日：2019-10-28

申请人： Verily Life Sciences LLC

发明人： Andrew Conrad ,  Eric Peeters

IPC分类号： G16H40/63 ,  A61B5/0205 ,  G16H20/10 ,  A61B5/00 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/1455 ,  A61B5/11 ,  A61B5/145 ,  A61B5/1459 ,  A61N2/00

CPC分类号： G16H40/63 ,  A61B5/0022 ,  A61B5/02055 ,  A61B5/055 ,  A61B5/0515 ,  A61B5/1112 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/14503 ,  A61B5/4848 ,  A61B5/681 ,  A61B5/742 ,  A61B5/7405 ,  A61B5/7455 ,  A61N2/002 ,  G16H20/10

摘要： A method for real-time, high-density physiological data collection includes automatically measuring, by a wearable device, one or more physiological parameters during each of a plurality of measurement periods, and upon conclusion of a measurement period, for each of the plurality of measurement periods, automatically transmitting by the wearable device data representative of the physiological parameters measured during that measurement period, to a server, the server configured to develop a baseline profile based on the data transmitted by the wearable device for the plurality of measurement periods. The measurement periods may extend through a plurality of consecutive days, and each of the consecutive days may include multiple measurement periods. At least some of the physiological parameters are measured by non-invasively detecting one or more analytes in blood circulating in subsurface vasculature proximate to the wearable device.

公开(公告)号：US20190231264A1

公开(公告)日：2019-08-01

申请号：US16378043

申请日：2019-04-08

申请人： Verily Life Sciences LLC

发明人： James Michael Higbie ,  Victor Marcel Acosta ,  Vikram Singh Bajaj ,  Vasiliki Demas ,  Kimberly Kam

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/685 ,  A61B5/0084 ,  A61B5/0515 ,  A61B5/6833 ,  A61B2562/0223

摘要： Systems and methods are described that enable sensing of magnetic fields within skin tissue. Specifically, a system includes one or more microneedles that include a high magnetic permeability material. The system also includes a magnetic sensor communicatively coupled to the microneedle and configured to detect a magnetic field proximate to the microneedle. The system also includes a controller configured to receive information indicative of a magnetic field proximate to a portion of the microneedle. The controller is further configured to determine a presence of at least one magnetic nanoparticle proximate to the portion of the microneedle based on the received information. Alternatively, other embodiments include a microneedle that includes a nanodiamond material configured to detect a local magnetic field. Such embodiments also include a light source configured to cause the nanodiamond material to emit characteristic emission light that may indicate at least a magnitude of the magnetic field.

公开(公告)号：US20180256263A1

公开(公告)日：2018-09-13

申请号：US15905947

申请日：2018-02-27

申请人： COVIDIEN LP

发明人： WILLIAM S. KRIMSKY ,  MICHAEL J. KERN ,  LEV A. KOYRAKH

IPC分类号： A61B34/20 ,  A61B5/06 ,  A61B5/05 ,  G06T17/00 ,  G06T19/00

CPC分类号： A61B34/20 ,  A61B1/00009 ,  A61B1/2676 ,  A61B5/0515 ,  A61B5/062 ,  A61B5/065 ,  A61B2034/2051 ,  A61B2034/2065 ,  G06T17/00 ,  G06T19/003

摘要： A system for monitoring an approach to a target includes a luminal device including a distal portion, a sensor coupled to the distal portion of the luminal device, and a surgical instrument including one or more indicators having a detectable property located along at least a portion of the surgical instrument. The luminal device is configured to be inserted into a patient, and the distal portion of the luminal device is configured to be guided proximate a target. The sensor is configured to sense the detectable property of the one or more indicators. The surgical instrument is configured to be guided through the luminal device.

公开(公告)号：US20180017645A1

公开(公告)日：2018-01-18

申请号：US15714335

申请日：2017-09-25

申请人： Weinberg Medical Physics, Inc.

发明人： Irving N. WEINBERG

IPC分类号： G01R33/48 ,  A61B5/00 ,  A61B5/05 ,  A61B5/055

CPC分类号： G01R33/4806 ,  A61B5/0042 ,  A61B5/0515 ,  A61B5/055

摘要： In accordance with disclosed embodiments, very high magnetic gradients and magnetic slew are applied to magnetizable particle imaging in order to realize high spatial resolution.

公开(公告)号：US20180017639A1

公开(公告)日：2018-01-18

申请号：US15648401

申请日：2017-07-12

申请人： Patrick W. Goodwill

发明人： Patrick W. Goodwill

IPC分类号： G01R33/12 ,  A61B5/05

CPC分类号： G01R33/1276 ,  A61B5/0515 ,  G01N27/72 ,  G01R33/0213 ,  G01R33/10

摘要： A Magnetic Particle Imaging (MPI) system with a magnet configured to generate a magnetic field with a field free line, the magnet integrated with a flux return designed so that a flux path at approximately the center of the field-free line has a first reluctance and a second flux path distal from the center of the field-free line has a second reluctance, and the second reluctance is lower than the first reluctance to facilitate a high fidelity magnetic field and high fidelity field free line.