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    In-vivo magnetic detection of magnetic nanoparticles using microneedles
    3.
    发明授权
    In-vivo magnetic detection of magnetic nanoparticles using microneedles 有权

    公开(公告)号：US11039789B2

    公开(公告)日：2021-06-22

    申请号：US16378043

    申请日：2019-04-08

    申请人： Verily Life Sciences LLC

    发明人： James Michael Higbie ,  Victor Marcel Acosta ,  Vikram Singh Bajaj ,  Vasiliki Demas ,  Kimberly Kam

    IPC分类号： A61B5/05 ,  A61B5/00 ,  A61B5/0515

    摘要： Systems and methods are described that enable sensing of magnetic fields within skin tissue. Specifically, a system includes one or more microneedles that include a high magnetic permeability material. The system also includes a magnetic sensor communicatively coupled to the microneedle and configured to detect a magnetic field proximate to the microneedle. The system also includes a controller configured to receive information indicative of a magnetic field proximate to a portion of the microneedle. The controller is further configured to determine a presence of at least one magnetic nanoparticle proximate to the portion of the microneedle based on the received information. Alternatively, other embodiments include a microneedle that includes a nanodiamond material configured to detect a local magnetic field. Such embodiments also include a light source configured to cause the nanodiamond material to emit characteristic emission light that may indicate at least a magnitude of the magnetic field.

    Methods for reducing noise in optical biological sensors
    4.
    发明授权
    Methods for reducing noise in optical biological sensors 有权

    公开(公告)号：US10039491B2

    公开(公告)日：2018-08-07

    申请号：US14319182

    申请日：2014-06-30

    申请人： Verily Life Sciences LLC

    发明人： Jason Donald Thompson ,  Vikram Singh Bajaj ,  Victor Marcel Acosta ,  Tamara Lynn Troy

    IPC分类号： A61B5/1455 ,  A61B5/00

    摘要： Optical measurement of physiological parameters with wearable devices often includes measuring signals in the presence of significant noise sources. These noise sources include, but are not limited to, noise associated with: variable optical coupling to skin or tissue, variations in tissue optical properties with time due to changes in humidity, temperature, hydration, variations in tissue optical properties between individuals, variable coupling of ambient light sources into detectors, and instrument and detector noise, including electrical noise, radio frequency or magnetic interference, or noise caused by mechanical movement of the detector or its components. The present disclosure includes devices and methods configured to produce representations of the raw data in which noise, broadly defined, is separated from the data of interest. The disclosed devices and methods may include subtracting or calibrating out these noise sources and other spurious fluctuations in wearable devices with optical sensors.

    Magnetic Nanoparticle Detection and Separation by Magnetic Relaxation Time
    6.
    发明申请
    Magnetic Nanoparticle Detection and Separation by Magnetic Relaxation Time 审中-公开
    磁性纳米颗粒检测和磁弛豫时间分离

    公开(公告)号：US20170000375A1

    公开(公告)日：2017-01-05

    申请号：US14788882

    申请日：2015-07-01

    申请人： Verily Life Sciences LLC

    发明人： Vasiliki Demas ,  Vikram Singh Bajaj ,  James Michael Higbie ,  Victor Marcel Acosta ,  Michael Brundage ,  Chinmay Belthangady

    IPC分类号： A61B5/05 ,  A61B5/145

    CPC分类号： A61B5/05 ,  A61B5/145 ,  A61B2562/0223

    摘要： Wearable devices configured to detect the presence, concentration, number, or other properties of nanoparticles disposed in subsurface vasculature of a person are provided. The wearable devices are configured to magnetize the nanoparticles at an upstream location of subsurface vasculature and to detect, using a magnetometer, magnetic fields produced by the magnetized nanoparticles at a downstream location of subsurface vasculature. In some embodiments, the nanoparticles are configured to bind to an analyte of interest and detected properties of the magnetized nanoparticles can be used to determine the presence, concentration, or other properties of the analyte. Detecting magnetic fields produced by the magnetized nanoparticles can include detecting the fields directly, detecting an effect of the magnetic fields on nuclear magnetic spins of atoms proximate the magnetized nanoparticles, producing a time-varying magnetic field and detecting a time-varying magnetic field responsively produced by the magnetized nanoparticles, or some other method(s).

    摘要翻译： 提供被配置为检测存在，浓度，数量，或其他设置在人的地下脉管系统的纳米颗粒的性质可穿戴设备。 该可佩戴装置被配置在地下脉管系统的上游位置，以磁化所述的纳米颗粒，并检测，使用磁力计，在地下脉管系统的下游位置由磁化的纳米颗粒产生的磁场。 在一些实施方案中，所述纳米颗粒被配置成结合感兴趣和磁化的纳米颗粒的检测性质的分析物可以被用于确定存在，浓度或所述分析物的其它性能。 检测由磁化的纳米颗粒产生可以包括直接检测字段，检测在原子接近所述磁化的纳米颗粒的核磁自旋的磁场的作用，产生一个随时间变化的磁场，并检测随时间变化的磁场响应产生的磁场 通过磁化纳米颗粒或其它一些方法。

    Methods for Reducing Noise in Optical Biological Sensors
    9.
    发明申请
    Methods for Reducing Noise in Optical Biological Sensors 审中-公开

    公开(公告)号：US20180310880A1

    公开(公告)日：2018-11-01

    申请号：US16026348

    申请日：2018-07-03

    申请人： Verily Life Sciences LLC

    发明人： Jason Donald Thompson ,  Vikram Singh Bajaj ,  Victor Marcel Acosta ,  Tamara Lynn Troy

    IPC分类号： A61B5/00 ,  A61B5/1455

    CPC分类号： A61B5/6801 ,  A61B5/1455 ,  A61B5/681 ,  A61B5/7203 ,  A61B5/7475

    摘要： Optical measurement of physiological parameters with wearable devices often includes measuring signals in the presence of significant noise sources. These noise sources include, but are not limited to, noise associated with: variable optical coupling to skin or tissue, variations in tissue optical properties with time due to changes in humidity, temperature, hydration, variations in tissue optical properties between individuals, variable coupling of ambient light sources into detectors, and instrument and detector noise, including electrical noise, radio frequency or magnetic interference, or noise caused by mechanical movement of the detector or its components. The present disclosure includes devices and methods configured to produce representations of the raw data in which noise, broadly defined, is separated from the data of interest. The disclosed devices and methods may include subtracting or calibrating out these noise sources and other spurious fluctuations in wearable devices with optical sensors.