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公开(公告)号：US11024444B1
公开(公告)日：2021-06-01
申请号：US15945860
申请日：2018-04-05
发明人： Andrew Homyk , Saurabh Vyawahare
摘要： Disclosed herein are liquid conductive wires and methods for making and using the same. Liquid conductive wires can be used in flexible, reconfigurable, dynamic and transparent electronic devices. Liquid conductive wires can be used in a variety of systems including, but not limited to, soft robotics.
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公开(公告)号：US10292631B1
公开(公告)日：2019-05-21
申请号：US14957840
申请日：2015-12-03
发明人： Andrew Homyk , Jerrod Joseph Schwartz , Alberto Clemente Vitari , Joshua Simon Klein , Mark Audeh
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/145
摘要： Body-mountable devices are provided to detect the presence or status of a tumor in a body by detecting one or more properties of a probe located in subsurface vasculature of the body. A wearable body-mountable device can be worn for a protracted period of time to detect a probe in the vasculature at low concentrations and/or at low rates. A body-mountable device can detect properties of the probe that are indicative of whether the probe has interacted with a tumor of the body and determine the presence or status of a tumor in the body based on such detected properties. Additionally or alternatively, the probe could be introduced into the body as a probe aggregate and released from if the probe aggregate is absorbed by a tumor. The presence of released probes could be detected to determine a presence or status of a tumor in the body.
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公开(公告)号：US20170196455A1
公开(公告)日：2017-07-13
申请号：US15469921
申请日：2017-03-27
IPC分类号： A61B5/00
CPC分类号： A61B5/00 , A61B5/0022 , A61B5/0059 , A61B5/02427 , A61B5/489 , A61B5/6801 , A61B5/6802 , A61B5/681 , A61B5/70 , A61B2562/043 , G01B11/14
摘要： Wearable devices are described herein including at least two photodetectors and a mount configured to mount the at least two photodetectors to an external surface of a wearer. The at least two photodetectors are configured to detect alignment between the wearable device and a target on or in the body of the wearer (e.g., to detect the location of vasculature within the body of the wearer relative to the at least two photodetectors). Alignment of the at least two photodetectors relative to the target could enable detection of one or more physiological properties of the wearer. For example, the wearable device could include a sensor configured to detect a property of the target when the sensor is above the target, and alignment of the target relative to the at least two photodetectors could include the sensor being located above the target.
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公开(公告)号：US09603569B2
公开(公告)日：2017-03-28
申请号：US14329341
申请日：2014-07-11
CPC分类号： A61B5/00 , A61B5/0022 , A61B5/0059 , A61B5/02427 , A61B5/489 , A61B5/6801 , A61B5/6802 , A61B5/681 , A61B5/70 , A61B2562/043 , G01B11/14
摘要： Wearable devices are described herein including at least two photodetectors and a mount configured to mount the at least two photodetectors to an external surface of a wearer. The at least two photodetectors are configured to detect alignment between the wearable device and a target on or in the body of the wearer (e.g., to detect the location of vasculature within the body of the wearer relative to the at least two photodetectors). Alignment of the at least two photodetectors relative to the target could enable detection of one or more physiological properties of the wearer. For example, the wearable device could include a sensor configured to detect a property of the target when the sensor is above the target, and alignment of the target relative to the at least two photodetectors could include the sensor being located above the target.
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5.发明申请公开(公告)号：US20170020419A1
公开(公告)日：2017-01-26
申请号：US15283795
申请日：2016-10-03
发明人： Victor Marcel Acosta , Vikram Singh Bajaj , Andrew Homyk , Eric Peeters , Jason Donald Thompson
IPC分类号： A61B5/145 , G01N21/64 , A61K49/00 , A61B5/1455 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/0022 , A61B5/0071 , A61B5/0075 , A61B5/14532 , A61B5/1455 , A61B5/14558 , A61B5/1459 , A61B5/1468 , A61B5/1477 , A61B5/4848 , A61B5/681 , A61B5/7282 , A61B5/742 , A61B5/746 , A61B5/7475 , A61K49/0013 , A61K49/0019 , A61K49/0093 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C09K11/59 , C23C16/27 , G01N21/6428 , G01N21/6458 , G01N2021/1746 , G01N2021/6439 , G01R33/281 , G01R33/5601 , G02B21/00
摘要： An imaging agent for detecting analytes in a biological environment includes functionalized, silicon vacancy center-containing nanodiamonds. Individual nanodiamonds of the imaging agent include at least one silicon vacancy center. The at least one silicon vacancy center can emit light having a wavelength in a narrow band in response to illumination having any wavelength in a wide range of wavelengths. The nanodiamonds are functionalized to selectively interact with an analyte of interest. The nanodiamonds can additionally include other color centers, and the imaging agent can include a plurality of sets of nanodiamonds having detectably unique ratios of silicon vacancy centers to other color centers. The silicon vacancy centers in the nanodiamonds can have a preferred orientation enabling orientation tracking of individual nanodiamonds or other applications. A method for detecting properties of the analyte of interest by interacting with the imaging agent is also provided.
摘要翻译： 用于检测生物环境中的分析物的成像剂包括具有功能的含空穴中心的纳米金刚石。 成像剂的单个纳米金刚石包括至少一个硅空位中心。 至少一个硅空位中心可以响应于在宽波长范围内具有任何波长的照明而发射具有窄带波长的光。 纳米金刚石被官能化以选择性地与感兴趣的分析物相互作用。 纳米金刚石可以另外包括其它颜色中心，并且成像剂可以包括具有可检测地独特的硅空位中心与其他色心的比例的多组纳米金刚石。 纳米金刚石中的硅空位中心可以具有优选的取向，使得能够对单个纳米金刚石或其它应用进行取向跟踪。 还提供了通过与成像剂相互作用来检测目的分析物的性质的方法。
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公开(公告)号：US10945620B2
公开(公告)日：2021-03-16
申请号：US16375504
申请日：2019-04-04
发明人： Andrew Homyk
摘要： Disclosed methods and systems may be operable to obtain non-contact diagnostic information about movements of scattering objects such as fluids in subsurface vasculature in tissue. As an example, a method may include causing a light source to illuminate the tissue with at least a first portion of the emitted light and illuminate an optical modulator with at least a second portion of the emitted light. The second portion of the emitted light may be modulated by the optical modulator. An offset source is configured to provide an offset frequency signal. An image sensor may receive optical information from the sample. A heterodyne signal based on the reference frequency signal and the offset frequency signal may be used as a gain input of each detector element of the image sensor. Based on the received information, a movement of a portion of the sample may be determined.
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公开(公告)号：US10194808B1
公开(公告)日：2019-02-05
申请号：US14583861
申请日：2014-12-29
摘要： Wearable devices are described herein including at least two sensors configured to detect hemodynamic properties of a wearer. A first sensor is configured to detect a hemodynamic property of a portion of vasculature, where the operation of the first sensor is based on a hemodynamic property detected by a second sensor. A timing of operation, a value of one or more controlled operational parameters, a filter setting, or some other aspect of the operation of the first sensor could be controlled based on the hemodynamic property detected by the second sensor. Hemodynamic properties could include blood flow rate, volume, and/or pressure in one or more portions of vasculature, a timing, rate, delay, or other information about heartbeats, an oxygenation level of blood, a velocity of blood cells in blood, or some other information about a wearer's blood, heart, and/or cardiovascular system.
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公开(公告)号：US20180064352A1
公开(公告)日：2018-03-08
申请号：US15808555
申请日：2017-11-09
发明人： Andrew Homyk , Jason D. Thompson
IPC分类号： A61B5/026 , A61B5/00 , A61B5/1455
CPC分类号： A61B5/0261 , A61B5/14551 , A61B5/489 , A61B5/742
摘要： Systems are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with a coherent light source and detecting time-varying patterns of constructive and destructive interference in light received from portions of the biological tissue by an imager. The movement of blood cells and other light-scattering elements in the biological tissue causes transient, short-duration changes in light emitted from portions of the biological tissue proximate to the moving blood cells or other scatterers. High-frequency sampling or other high-bandwidth processing of light intensities detected by an imager could be used to determine the flow of blood or other fluids at a plurality of points in the biological tissue, to detect and/or localize a tumor in the biological tissue, to determine the location, pattern, width, or other properties of vasculature in the biological tissue, or to provide information for some other application(s).
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公开(公告)号：US09839365B1
公开(公告)日：2017-12-12
申请号：US14551480
申请日：2014-11-24
IPC分类号： A61B5/1455 , A61B5/026 , A61B5/00
CPC分类号： A61B5/0261 , A61B5/14551 , A61B5/489 , A61B5/742
摘要： Systems are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with a coherent light source and detecting time-varying patterns of constructive and destructive interference in light received from portions of the biological tissue by an imager. The movement of blood cells and other light-scattering elements in the biological tissue causes transient, short-duration changes in light emitted from portions of the biological tissue proximate to the moving blood cells or other scatterers. High-frequency sampling or other high-bandwidth processing of light intensities detected by an imager could be used to determine the flow of blood or other fluids at a plurality of points in the biological tissue, to detect and/or localize a tumor in the biological tissue, to determine the location, pattern, width, or other properties of vasculature in the biological tissue, or to provide information for some other application(s).
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公开(公告)号：US20220388004A1
公开(公告)日：2022-12-08
申请号：US17658781
申请日：2022-04-11
摘要： The present disclosure is related to a method of producing a microfluidic sorting apparatus. The method includes providing an injection-molded substrate comprising a network of channels; bonding an insulating film to an upper surface of the substrate to cover the network of channels; and depositing a conductive film on the insulating film. The substrate can be separated from the conductive film.
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