公开(公告)号：US20240269309A1

公开(公告)日：2024-08-15

申请号：US18562049

申请日：2022-05-27

申请人： ZYMEWORKS INC.

发明人： Mark Edmund Petersen ,  Michael Brant ,  Raffaele Colombo ,  james R. Rich ,  Manuel Michel Auguste Lasalle ,  Stuart Barnscher ,  Samir Das

IPC分类号： A61K47/68 ,  A61K31/4745 ,  A61P35/00 ,  C07D491/22

CPC分类号： A61K47/68037 ,  A61K31/4745 ,  A61K47/6851 ,  A61K47/6889 ,  A61P35/00 ,  C07D491/22

摘要： Camptothecin analogues of Formula (I) and conjugates comprising the camptothecin analogues are described. The camptothecin analogues and conjugates may be used as therapeutic agents, particularly in the treatment of cancer, an autoimmune disease or a viral infection.

公开(公告)号：US20240246992A1

公开(公告)日：2024-07-25

申请号：US18548231

申请日：2022-03-17

申请人： LES LABORATOIRES SERVIER ,  ONCODESIGN PRECISION MEDICINE (OPM)

发明人： Audrey DUMOULIN ,  Petra Marcella BLOM ,  Alain DAUGAN ,  Maxime LAUGEOIS ,  Christopher Gaétan HOUSSEMAN ,  Alexis DENIS ,  Yann LAMOTTE ,  Arnaud LE TIRAN ,  Kenneth CHRISTENSEN

IPC分类号： C07D491/16 ,  A61K9/20 ,  A61K31/4162 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/429 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  C07D491/06 ,  C07D491/22 ,  C07D498/06 ,  C07D498/16

CPC分类号： C07D491/16 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/4162 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/429 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  C07D491/06 ,  C07D491/22 ,  C07D498/06 ,  C07D498/16

摘要： Compounds of formula (I) are useful as LRRK2 kinase inhibitors.

公开(公告)号：US20240246975A1

公开(公告)日：2024-07-25

申请号：US18527967

申请日：2023-12-04

申请人： Gilead Sciences, Inc.

发明人： Hang Chu ,  Hongyan Guo ,  Lan Jiang ,  Jiayao Li ,  David W. Lin ,  Hyung-Jung Pyun ,  Qiaoyin Wu ,  Hong Yang ,  Adam D. Zajdlik ,  Jennifer R. Zhang

IPC分类号： C07D471/18 ,  A61P31/18 ,  C07D491/22

CPC分类号： C07D471/18 ,  A61P31/18 ,  C07D491/22

摘要： Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):




including stereoisomers and pharmaceutically acceptable salts thereof. Methods associated with the preparation and use of the disclosed compounds, as well as pharmaceutical compositions comprising such compounds are also disclosed.

公开(公告)号：US12029736B2

公开(公告)日：2024-07-09

申请号：US17185012

申请日：2021-02-25

申请人： MediBoston Limited

发明人： Wei Li

IPC分类号： A61K31/4745 ,  A61K47/54 ,  A61K47/65 ,  A61K47/68 ,  A61P35/00 ,  C07D491/22

CPC分类号： A61K31/4745 ,  A61K47/545 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6855 ,  A61K47/6889 ,  A61P35/00 ,  C07D491/22

摘要： The invention provides, camptothecins, camptothecin payloads, and camptothecin conjugates, methods of preparing and using, and intermediates useful in the preparation thereof. Also provided herein are methods of treating cancer and autoimmune diseases with the camptothecin conjugates described herein.

公开(公告)号：US12024528B2

公开(公告)日：2024-07-02

申请号：US18334611

申请日：2023-06-14

申请人： Gilead Sciences, Inc.

发明人： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Xiaochun Han ,  Anna E. Hurtley ,  Lan Jiang ,  Jiayao Li ,  Gregg M. Schwarzwalder ,  Devleena M. Shivakumar ,  Matthew J. Von Bargen ,  Qiaoyin Wu ,  Hong Yang

IPC分类号： C07D498/20 ,  A61K45/06 ,  A61P31/18 ,  C07D471/22 ,  C07D491/22 ,  C07D497/22 ,  C07D498/22 ,  C07D513/22 ,  C07D515/22

CPC分类号： C07D498/20 ,  A61K45/06 ,  A61P31/18 ,  C07D471/22 ,  C07D491/22 ,  C07D497/22 ,  C07D498/22 ,  C07D513/22 ,  C07D515/22 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds, of Formula I:




Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

公开(公告)号：US20240208988A1

公开(公告)日：2024-06-27

申请号：US18562605

申请日：2022-06-14

申请人： NAPO PHARMACEUTICALS, INC.

发明人： Steven King ,  Karen Brunke ,  Elaine Elisabetsky ,  Maurice M. Iwu

IPC分类号： C07D491/22 ,  A61K31/4375 ,  A61K45/06 ,  A61P25/18

CPC分类号： C07D491/22 ,  A61K31/4375 ,  A61K45/06 ,  A61P25/18

摘要： The present disclosure is concerned with alstonine, alstonine analogs, and salts thereof for the treatment of various disorders where changes in 5-HT2A/5-HT2C receptor signaling and/or dopamine transporter activity may be beneficial such as, for example, psychotic disorders, epilepsy, and anxiety disorders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11998610B2

公开(公告)日：2024-06-04

申请号：US17173498

申请日：2021-02-11

申请人： Flagship Pioneering Innovations V, Inc.

发明人： Spencer Cory Peck ,  Steven John Taylor ,  Elijah Lane Bogart ,  Devin Forest Reed Doud ,  Joo Hyun Im ,  Dervla Tamara Isaac ,  Jenny Liu ,  Ferdinand Edward Massari ,  Robert Walter Myers ,  John Robert Proudfoot ,  Cheri Ross ,  John Patrick Casey, Jr. ,  David Arthur Berry

IPC分类号： A61K47/65 ,  A61K47/54 ,  A61P31/04 ,  A61P35/00 ,  C07D239/553 ,  C07D311/16 ,  C07D491/22 ,  C07H19/06 ,  C07K5/02 ,  C07K5/062 ,  C07K5/065 ,  C07K5/068 ,  C07K5/078

CPC分类号： A61K47/65 ,  A61K47/542 ,  A61P31/04 ,  A61P35/00 ,  C07D239/553 ,  C07D311/16 ,  C07D491/22 ,  C07H19/06 ,  C07K5/0205 ,  C07K5/06017 ,  C07K5/06034 ,  C07K5/06078 ,  C07K5/06086 ,  C07K5/06139

摘要： Disclosed are conjugates including a recognition element covalently bonded to or linked through a linker to a payload. The payload is a pharmaceutical agent (e.g., an antineoplastic agent, anti-infective agent, or anti-inflammatory agent) or a diagnostic agent. Also disclosed are methods of using the conjugates.

公开(公告)号：US20240132516A1

公开(公告)日：2024-04-25

申请号：US18495455

申请日：2023-10-26

申请人： DUALITY BIOLOGICS (SUZHOU) CO., LTD.

发明人： Yu ZHANG ,  Zhongyuan ZHU ,  Haiqing HUA ,  Bing LI ,  Jian LI ,  Shengchao LIN ,  Xi LI ,  Hongxia SHEN

IPC分类号： C07D491/22 ,  A61K47/65 ,  A61K47/68 ,  A61P35/00

CPC分类号： C07D491/22 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6855 ,  A61P35/00

摘要： The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.

公开(公告)号：US20240116945A1

公开(公告)日：2024-04-11

申请号：US18240392

申请日：2023-08-31

申请人： Merck Sharp & Dohme LLC

发明人： Vlad Bacauanu ,  Manoj B. Charati ,  Rebecca Elizabeth Johnson ,  Simon B. Lang ,  Ryan Quiroz ,  W. Michael Seganish ,  Song Yang ,  Nancy S. Zepeda

IPC分类号： C07D491/22 ,  A61P35/00

CPC分类号： C07D491/22 ,  A61P35/00

摘要： The present disclosure is directed to alcohol and amine containing exatecan derivatives, and pharmaceutically acceptable salts or solvates thereof, comprising a structure of formula I:




wherein X is defined in the disclosure. The disclosure is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of cancers and/or tumors.

公开(公告)号：US11951188B2

公开(公告)日：2024-04-09

申请号：US16979017

申请日：2019-03-07

申请人： LUMIPHORE, INC.

发明人： David Tatum ,  Jide Xu ,  Darren Magda ,  Nathaniel Butlin

IPC分类号： A61K51/04 ,  A61K51/08 ,  C07D471/18 ,  C07D491/22 ,  C07F5/00

CPC分类号： A61K51/0482 ,  A61K51/082 ,  C07D471/18 ,  C07D491/22 ,  C07F5/003

摘要： The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.