公开(公告)号：US20240360154A1

公开(公告)日：2024-10-31

申请号：US18245167

申请日：2021-09-21

申请人： GENFLEET THERAPEUTICS (SHANGHAI) INC. ,  ZHEJIANG GENFLEET THERAPEUTICS CO., LTD.

发明人： Fusheng ZHOU ,  Tao JIANG ,  Yingtao LIU ,  Chonglan LIN ,  Leitao ZHANG ,  Zhubo LIU ,  Kai MA ,  Wan HE ,  Xiaoming XU ,  Lijian FENG ,  Xiaoling LAN ,  Qian DING ,  Qiang LV ,  Jiong LAN

IPC分类号： C07D498/22 ,  A61K31/4985 ,  A61K31/5386 ,  A61P35/00 ,  C07D471/14 ,  C07D471/22 ,  C07D491/22

CPC分类号： C07D498/22 ,  A61K31/4985 ,  A61K31/5386 ,  A61P35/00 ,  C07D471/14 ,  C07D471/22 ,  C07D491/22

摘要： Disclosed are an aroyl substituted tricyclic compound, a preparation method therefor and use thereof. Specifically, the aroyl substituted tricyclic compound of the present invention has a structure of formula (C), and has, as a BTK inhibitor, the advantages of high activity, good selectivity and low toxic and side effects.

公开(公告)号：US20240327424A1

公开(公告)日：2024-10-03

申请号：US18424022

申请日：2024-01-26

申请人： Shionogi & Co., Ltd.

发明人： Makoto KAWAI ,  Kenji TOMITA ,  Toshiyuki AKIYAMA ,  Azusa OKANO ,  Masayoshi MIYAGAWA

IPC分类号： C07D498/14 ,  A61K31/53 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/553 ,  A61K31/675 ,  A61P31/16 ,  C07D471/14 ,  C07D471/20 ,  C07D491/22 ,  C07D513/14 ,  C07D519/00 ,  C07F7/18 ,  C07F9/6561

CPC分类号： C07D498/14 ,  A61K31/53 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/553 ,  A61K31/675 ,  A61P31/16 ,  C07D471/14 ,  C07D471/20 ,  C07D491/22 ,  C07D513/14 ,  C07D519/00 ,  C07F7/1804 ,  C07F9/6561 ,  C07C2601/08 ,  C07C2601/16

摘要： The present inventon provides the following compounds having anti-viral activity.






A1 is CR1AR1B, S or O;
A2 is CR2AR2B, S or O;
A3 is CR3AR3B, S or O;
A4 is CR4AR4B, S or O;
the number of hetero atoms among atoms constituting the ring which consists of A1, A2, A3, A4, nitrogen atom adjacent to A1 and carbon atom adjacent to A1, is 1 or 2;
R1A and R1B are each independently hydrogen, halogen, alkyl, or the like;
R2A and R2B are each independently hydrogen, halogen, alkyl, or the like;
R3A and R3B are each independently hydrogen, halogen, alkyl, or the like;
R4A and R4B are each independently hydrogen, halogen, alkyl, or the like;
R3A and R3B may be taken together to form non-aromatic carbocycle or non-aromatic heterocycle;
X is CH2, S or O;
R1 is each independently halogen, hydroxy, or the like;
m is any integer of 0 to 2; and
n is any integer of 1 to 2.

公开(公告)号：US12108666B2

公开(公告)日：2024-10-01

申请号：US17278419

申请日：2019-09-26

申请人： IDEMITSU KOSAN CO.,LTD.

发明人： Ryota Takahashi ,  Hidetsugu Ikeda ,  Yuki Nakano ,  Keita Seda

IPC分类号： H10K85/60 ,  C07D403/14 ,  C07D491/22 ,  C07D519/00 ,  C09K11/06 ,  H10K50/11 ,  H10K50/15 ,  H10K50/16 ,  H10K50/17

CPC分类号： H10K85/657 ,  C07D403/14 ,  C07D491/22 ,  C07D519/00 ,  C09K11/06 ,  H10K85/626 ,  H10K85/631 ,  H10K85/654 ,  H10K85/6572 ,  H10K85/6574 ,  C09K2211/1018 ,  H10K50/11 ,  H10K50/15 ,  H10K50/16 ,  H10K50/17 ,  H10K50/171

摘要： A compound having a structure represented by the following formulas (a) and (b):



wherein, in the formulas (a) and (b), a ring A, a ring B, a ring C and a ring D are independently a substituted or unsubstituted aromatic hydrocarbon ring having 6 to 50 ring carbon atoms, or a substituted or unsubstituted heterocyclic ring having 5 to 50 ring atoms; two or more of the ring A, the ring B, the ring C and the ring D are a heterocyclic ring; and each of sites *a, *b, *c and *d in the formula (a) and the formula (b) represents a position of an atom, and the atoms located in the sites *a, *b,*c and *d form one substituted or unsubstituted and saturated or unsaturated six-membered ring including four atoms thereof.

公开(公告)号：US12091418B2

公开(公告)日：2024-09-17

申请号：US18495455

申请日：2023-10-26

申请人： DUALITY BIOLOGICS (SUZHOU) CO., LTD.

发明人： Yu Zhang ,  Zhongyuan Zhu ,  Haiqing Hua ,  Bing Li ,  Jian Li ,  Shengchao Lin ,  Xi Li ,  Hongxia Shen

IPC分类号： C07D491/22 ,  A61K47/65 ,  A61K47/68 ,  A61P35/00

CPC分类号： C07D491/22 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6855 ,  A61P35/00

摘要： The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.

公开(公告)号：US12091417B2

公开(公告)日：2024-09-17

申请号：US17398016

申请日：2021-08-10

申请人： Narodowy Instytut Lekow

发明人： Lech Kozerski ,  Beata Naumczuk ,  Jerzy Sitkowski ,  Elzbieta Bednarek ,  Magdalena Urbanowicz ,  Wojciech Bocian ,  Katarzyna Wiktorska

IPC分类号： C07D491/22

CPC分类号： C07D491/22

摘要： The subject of the present invention are water-soluble derivatives of camptothecin, their synthesis and use. These compounds exhibit preferable biological properties for use in anti-neoplasm therapy.

公开(公告)号：US20240246983A1

公开(公告)日：2024-07-25

申请号：US18556948

申请日：2022-04-27

申请人： Merck Patent GmbH

发明人： Philipp STOESSEL ,  Amir Hossain PARHAM ,  Rouven LINGE

IPC分类号： C07D487/04 ,  C07D487/14 ,  C07D487/22 ,  C07D491/147 ,  C07D491/22 ,  C07D495/14 ,  C07D519/00 ,  C09K11/06 ,  H10K85/30 ,  H10K85/60

CPC分类号： C07D487/04 ,  C07D487/14 ,  C07D487/22 ,  C07D491/147 ,  C07D491/22 ,  C07D495/14 ,  C07D519/00 ,  C09K11/06 ,  H10K85/342 ,  H10K85/626 ,  H10K85/633 ,  H10K85/654 ,  H10K85/6572 ,  H10K85/6574 ,  C09K2211/1022

摘要： The present invention relates to nitrogen-containing heterocyclic compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.

公开(公告)号：US20240114782A1

公开(公告)日：2024-04-04

申请号：US18266832

申请日：2021-12-15

申请人： Merck Patent GmbH

发明人： Philipp STOESSEL

IPC分类号： H10K85/60 ,  C07D471/08 ,  C07D471/16 ,  C07D487/06 ,  C07D487/16 ,  C07D487/18 ,  C07D487/22 ,  C07D491/16 ,  C07D491/20 ,  C07D491/22 ,  C07D495/16 ,  C07D495/22 ,  C07D498/22 ,  C07F7/08 ,  C09K11/02 ,  C09K11/06 ,  H10K85/40

CPC分类号： H10K85/6572 ,  C07D471/08 ,  C07D471/16 ,  C07D487/06 ,  C07D487/16 ,  C07D487/18 ,  C07D487/22 ,  C07D491/16 ,  C07D491/20 ,  C07D491/22 ,  C07D495/16 ,  C07D495/22 ,  C07D498/22 ,  C07F7/0814 ,  C09K11/02 ,  C09K11/06 ,  H10K85/40 ,  H10K85/615 ,  H10K85/624 ,  H10K85/654 ,  H10K85/657 ,  H10K50/11

摘要： The present invention relates to aromatic compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.

公开(公告)号：US11867698B2

公开(公告)日：2024-01-09

申请号：US17027391

申请日：2020-09-21

申请人： Life Technologies Corporation

发明人： Jeffrey Dzubay ,  Kyle Gee ,  Vladimir Martin ,  Aleksey Rukavishnikov ,  Daniel Beacham

IPC分类号： G01N33/58 ,  G01N33/50 ,  G01N33/84 ,  C09B11/24 ,  C09B11/28 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07D209/14 ,  C09K11/06 ,  C07F5/02 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B57/00 ,  C09B69/00 ,  G01N31/22 ,  G01N33/80

CPC分类号： G01N33/582 ,  C07D209/14 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07F5/02 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B11/24 ,  C09B11/28 ,  C09B57/00 ,  C09B69/00 ,  C09K11/06 ,  G01N31/22 ,  G01N33/5005 ,  G01N33/5058 ,  G01N33/5091 ,  G01N33/80 ,  G01N33/84 ,  G01N2333/245 ,  Y10T436/143333

摘要： A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I:






wherein the variables are described throughout the application.

公开(公告)号：US20230406858A1

公开(公告)日：2023-12-21

申请号：US18457070

申请日：2023-08-28

申请人： Ventyx Biosciences, Inc.

发明人： Raju MOHAN ,  John NUSS ,  Jason HARRIS ,  Shendong YUAN

IPC分类号： C07D471/22 ,  C07D491/22 ,  C07D498/18 ,  C07D498/22 ,  C07D513/22 ,  A61P19/02 ,  A61P25/28 ,  A61P37/06 ,  A61P17/06

CPC分类号： C07D471/22 ,  C07D491/22 ,  C07D498/18 ,  C07D498/22 ,  C07D513/22 ,  A61P19/02 ,  A61P25/28 ,  A61P37/06 ,  A61P17/06 ,  C07B2200/05

摘要： Described herein are TYK2 pseudokinase ligands and methods of utilizing TYK2 pseudokinase ligands in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

公开(公告)号：US20230381332A1

公开(公告)日：2023-11-30

申请号：US18030757

申请日：2021-10-09

申请人： Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

发明人： Yi ZHU ,  Weili WAN ,  Shi ZHUO ,  Tianzi YU ,  Guili ZHU ,  Xiujuan YANG

IPC分类号： A61K47/68 ,  C07D491/22 ,  C07K5/103 ,  A61P35/00

CPC分类号： A61K47/68037 ,  C07D491/22 ,  C07K5/1008 ,  A61K47/6855 ,  A61K47/6849 ,  A61K47/6889 ,  A61P35/00 ,  C07B2200/05

摘要： The invention discloses a deuterated camptothecin derivative and its antibody-drug conjugate (ADC), and combines the deuteration technology with camptothecin ADC to discover improved deuterated camptothecin ADC drug, so that it has higher safety and efficacy and can better meet the clinical challenge.