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公开(公告)号：US11857643B2
公开(公告)日：2024-01-02
申请号：US16816015
申请日：2020-03-11
发明人： Surbhi Desai , Marie Christine Nlend , Kyle Gee , Matthew Baker , Robert Aggeler , Scott Sweeney , Aleksey Rukavishnikov , Shih-Jung Huang
CPC分类号： A61K49/0015 , A61K47/10 , A61K47/18 , A61K49/0058 , G01N33/533 , G01N33/582 , G01N33/68
摘要： This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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公开(公告)号：US20150218379A1
公开(公告)日：2015-08-06
申请号：US14402358
申请日：2013-03-14
发明人： Kyle Gee , Upinder Singh , Aleksey Rukavishnikov , Daniel Beacham , Shih-Jung Huang , Michael Janes , Wenjun Zhou
CPC分类号： C09B11/24 , A61K49/0041 , C07D311/90 , G01N33/5005 , G01N33/582 , G01N33/84
摘要： Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.
摘要翻译： 本文公开了使用pH敏感荧光染料检测样品中的pH的化合物，组合物，方法和试剂盒。 本文公开的化合物是包含具有一个或多个给电子基团的苯胺部分的新型呫吨衍生物染料，该染料用于在体外或体内检测样品中的pH。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的所述染料的方法。
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公开(公告)号：US09645153B2
公开(公告)日：2017-05-09
申请号：US14829346
申请日：2015-08-18
IPC分类号： G01N33/58 , C07D311/18 , C07D495/22 , C07D493/14 , C07D209/18 , C07F5/02 , C09B11/26 , C09B45/00 , C07D311/82 , G01N33/532 , C07D401/10 , C07D209/14
CPC分类号： G01N33/58 , C07D209/14 , C07D209/18 , C07D311/18 , C07D311/82 , C07D401/10 , C07D493/14 , C07D495/22 , C07F5/022 , C09B11/24 , C09B11/26 , C09B23/04 , C09B23/08 , C09B45/00 , C09B56/16 , G01N33/532 , G01N33/582
摘要： The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.
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公开(公告)号：US09599622B2
公开(公告)日：2017-03-21
申请号：US14402358
申请日：2013-03-14
发明人： Kyle Gee , Upinder Singh , Aleksey Rukavishnikov , Daniel Beacham , Shih-Jung Huang , Michael Janes , Wenjun Zhou
CPC分类号： C09B11/24 , A61K49/0041 , C07D311/90 , G01N33/5005 , G01N33/582 , G01N33/84
摘要： Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.
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公开(公告)号：US20150241438A1
公开(公告)日：2015-08-27
申请号：US14402375
申请日：2013-03-14
发明人： Kyle Gee , Upinder Singh , Aleksey Rukavishnikov , Daniel Beacham , Shih-Jung Huang , Michael Janes , Wenjun Zhou , Judith Berlier
IPC分类号： G01N33/58 , C07D311/90
CPC分类号： C09B11/24 , A61K49/0041 , C07D311/90 , G01N33/5005 , G01N33/582 , G01N33/84
摘要： Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.
摘要翻译： 本文公开了使用pH敏感荧光染料检测样品中的pH的化合物，组合物，方法和试剂盒。 本文公开的化合物是包含具有一个或多个给电子基团的苯胺部分的新型呫吨衍生物染料，该染料用于在体外或体内检测样品中的pH。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的所述染料的方法。
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公开(公告)号：US11865191B2
公开(公告)日：2024-01-09
申请号：US16882271
申请日：2020-05-22
发明人： Surbhi Desai , Marie Christine Nlend , Kyle Gee , Matthew Baker , Robert Aggeler , Scott Sweeney , Aleksey Rukavishnikov , Shih-Jung Huang
CPC分类号： A61K49/0015 , A61K47/10 , A61K47/18 , A61K49/0058 , G01N33/533 , G01N33/582 , G01N33/68
摘要： This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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公开(公告)号：US20210041465A1
公开(公告)日：2021-02-11
申请号：US17027391
申请日：2020-09-21
IPC分类号： G01N33/84 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07D209/14 , C09K11/06 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/28 , C09B57/00 , C09B69/00 , G01N31/22 , G01N33/50 , C09B11/24 , G01N33/58 , G01N33/80
摘要： A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.
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公开(公告)号：US20180362766A1
公开(公告)日：2018-12-20
申请号：US15955332
申请日：2018-04-17
发明人： Kyle Gee , Upinder Singh , Aleksey Rukavishnikov , Daniel Beacham , Shih-Jung Huang , Michael Janes , Wenjun Zhou , Judith Berlier
摘要： Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.
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公开(公告)号：US20180238912A1
公开(公告)日：2018-08-23
申请号：US15899021
申请日：2018-02-19
IPC分类号： G01N33/84 , C09B11/24 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/28 , C09B57/00 , G01N31/22 , G01N33/50 , G01N33/58 , C09K11/06 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07D209/14 , C07F5/02 , C09B69/00 , G01N33/80
CPC分类号： G01N33/84 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/582 , G01N33/80 , G01N2333/245 , Y10T436/143333
摘要： A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.
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公开(公告)号：US11867698B2
公开(公告)日：2024-01-09
申请号：US17027391
申请日：2020-09-21
IPC分类号： G01N33/58 , G01N33/50 , G01N33/84 , C09B11/24 , C09B11/28 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07D209/14 , C09K11/06 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B57/00 , C09B69/00 , G01N31/22 , G01N33/80
CPC分类号： G01N33/582 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/80 , G01N33/84 , G01N2333/245 , Y10T436/143333
摘要： A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I:
wherein the variables are described throughout the application.
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