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    GLUTATHIONE-DETECTING FLUORESCENT PROBE
    7.
    发明申请
    GLUTATHIONE-DETECTING FLUORESCENT PROBE 审中-公开
    荧光检测荧光探针

    公开(公告)号：US20170045525A1

    公开(公告)日：2017-02-16

    申请号：US15116661

    申请日：2015-02-24

    申请人： THE UNIVERSITY OF TOKYO

    发明人： Yasuteru URANO ,  Mako KAMIYA ,  Keitaro UMEZAWA ,  Masafumi YOSHIDA

    IPC分类号： G01N33/68 ,  C09K11/07 ,  C09B19/00 ,  G01N33/58 ,  G01N21/64 ,  C09B11/24

    CPC分类号： G01N33/68 ,  C07F7/081 ,  C07F7/0812 ,  C09B11/08 ,  C09B11/24 ,  C09B11/28 ,  C09B19/00 ,  C09K11/06 ,  C09K11/07 ,  C09K2211/1007 ,  C09K2211/1033 ,  C09K2211/1055 ,  C09K2211/1088 ,  C09K2211/1096 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/582 ,  G01N33/6815 ,  G01N2021/6439 ,  G01N2021/6441

    摘要： [Problem] To provide the following: a novel fluorescent probe for detecting a compound, such as glutathione, that contains a —SH group; a detection method using said fluorescent probe; and a detection kit containing said probe.[Solution] A fluorescent probe for detecting a compound containing an —SH group, wherein the fluorescent probe comprises a compound represented by formula (I) or a salt thereof (In the formula, X represents Si(Ra)(Rb), Ge(Ra)(Rb), Sn(Ra)(Rb), C(Ra)(Rb), or O (wherein Ra and Rb each independently represent a hydrogen atom or alkyl group); R1 represents a hydrogen atom, or 1-4 identical or different substituents independently selected from the group consisting of a cyano group, alkyl group, carboxyl group, ester group, alkoxy group, amide group, and azide group, each of which may be optionally substituted; R2 represents a hydrogen atom, halogen atom, hydroxyl group, cyano group, or an alkyl group, alkynyl group, alkoxy group, aryl, or heteroaryl, each of which may be optionally substituted; R3 and R4 each independently represent a hydrogen atom or 1-3 identical or different substituents independently selected from the group consisting of a hydroxyl group, halogen atom, or an alkyl group, sulfo group, carboxyl group, ester group, amide group and azide group, each of which may be optionally substituted; R5, R6, R7 and R8 each independently represent a hydrogen atom or alkyl group, wherein, R5 or R6, respectively together with R3, may form a ring structure including the nitrogen atoms bonded thereto, or R7 or R8, respectively together with R4, may form a ring structure including the nitrogen atoms bonded thereto).

    摘要翻译： [解决方案]用于检测含有-SH基团的化合物的荧光探针，其中所述荧光探针包含由式（I）表示的化合物或其盐（在该式中，X表示Si（Ra）（Rb），Ge Ra）（Rb），Sn（Ra）（Rb），C（Ra）（Rb）或O（其中Ra和Rb各自独立地表示氢原子或烷基）; R1表示氢原子或1-4 相同或不同的取代基，其独立地选自氰基，烷基，羧基，酯基，烷氧基，酰胺基和叠氮基，其各自可以被任选取代; R 2表示氢原子，卤素原子 ，羟基，氰基或烷基，炔基，烷氧基，芳基或杂芳基，其各自可以被任选取代; R 3和R 4各自独立地表示氢原子或1-3个相同或不同的独立选择的取代基 由羟基，卤素原子或烷基基团组成的组 p，磺基，羧基，酯基，酰胺基和叠氮基，其各自可以任选被取代; R 5，R 6，R 7和R 8各自独立地表示氢原子或烷基，其中，R 5或R 6分别与R 3一起形成包含与其结合的氮原子的环结构，或者R 7或R 8与R 4， 可以形成包括与其结合的氮原子的环结构）。

    Compound, and method for measuring iron concentration by using novel compound as chelate color former
    9.
    发明授权
    Compound, and method for measuring iron concentration by using novel compound as chelate color former 有权
    化合物和通过使用新型化合物作为螯合色素测量铁浓度的方法

    公开(公告)号：US09448244B2

    公开(公告)日：2016-09-20

    申请号：US14433311

    申请日：2013-10-15

    申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD.

    发明人： Yoshikazu Fujita ,  Toshinari Ohashi ,  Naoyuki Yamamoto ,  Takashi Takagaki ,  Satoshi Hasaba

    IPC分类号： C09B11/28 ,  G01N33/20 ,  G01N33/84 ,  C09B11/24 ,  G01N31/00 ,  C09B49/12 ,  G01N33/90 ,  G01N31/22

    CPC分类号： G01N33/84 ,  C09B11/24 ,  C09B11/28 ,  C09B49/12 ,  G01N31/00 ,  G01N31/22 ,  G01N33/20 ,  G01N33/90

    摘要： The present invention addresses the problem of providing a chelate color former which can measure the concentration of iron with high sensitivity and with low blank values when measuring the concentration of iron, and an iron concentration measurement method and kit that use this chelate color former. The present invention relates to: a compound represented by following formula [1] or a salt thereof wherein, R1 and R2 each independently represent —SO3H or —CO2H; an iron concentration measurement method in which the compound is used as a chelate color former, the compound is brought into contact with iron in a sample, and the concentration of iron in the sample is measured on the basis of the degree of resulting color development; and a kit to be used therein.

    摘要翻译： 本发明解决了提供一种螯合成色剂的问题，其可以测量铁的浓度时可以高灵敏度和低空白值测量铁的浓度，以及使用该螯合色素的铁浓度测量方法和试剂盒。 本发明涉及：由下式[1]表示的化合物或其盐，其中R 1和R 2各自独立地表示-SO 3 H或-CO 2 H; 使用化合物作为螯合色素的铁浓度测定方法，使化合物与样品中的铁接触，并且根据得到的显色程度测量样品中的铁浓度; 和其中使用的试剂盒。