公开(公告)号：US20240360116A1

公开(公告)日：2024-10-31

申请号：US18255134

申请日：2021-12-03

Applicant: ELANCO TIERGESUNDHEIT AG

Inventor： Francois PAUTRAT ,  Chouaib TAHTAOUI ,  Pierre DUCRAY ,  Denise RAGEOT

IPC: C07D413/14 ,  A61K31/4709 ,  A61K31/538 ,  A61K31/541 ,  A61K31/69 ,  A61P33/10 ,  C07D265/36 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/107 ,  C07F5/02

CPC classification number: C07D413/14 ,  A61K31/4709 ,  A61K31/538 ,  A61K31/541 ,  A61K31/69 ,  A61P33/10 ,  C07D265/36 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/107 ,  C07F5/02

Abstract: The present invention provides compounds of formula (I′):




which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.

公开(公告)号：US20240360114A1

公开(公告)日：2024-10-31

申请号：US18293357

申请日：2022-08-09

Applicant: SIRONAX LTD.

Inventor： Jianguang HAN ,  Weijie HOU ,  Zhiyuan ZHANG ,  Yanping XU ,  Yimin JIANG ,  Xingyu XU

IPC: C07D413/04 ,  A61K31/4427 ,  A61K31/47 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/553 ,  C07C211/48 ,  C07D213/74 ,  C07D215/10 ,  C07D215/16 ,  C07D241/04 ,  C07D265/30 ,  C07D401/04 ,  C07D413/14 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107

CPC classification number: C07D413/04 ,  A61K31/4427 ,  A61K31/47 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/553 ,  C07C211/48 ,  C07D213/74 ,  C07D215/10 ,  C07D215/16 ,  C07D241/04 ,  C07D265/30 ,  C07D401/04 ,  C07D413/14 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107

Abstract: This disclosure provides compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating various diseases and conditions, e.g., those involving ferroptosis.

公开(公告)号：US20240343727A1

公开(公告)日：2024-10-17

申请号：US18578677

申请日：2022-08-16

Applicant: InventisBio Co., Ltd. ,  InventisBio LLC

Inventor： Xianhai HUANG ,  Younong YU ,  Haotao NIU ,  Hong YANG ,  Shanshan WANG ,  Jifang WENG ,  Yaolin WANG ,  Xing DAI

IPC: C07D471/04 ,  A61K31/501 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D487/10 ,  C07D491/052 ,  C07D491/107

CPC classification number: C07D471/04 ,  A61K31/501 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D487/10 ,  C07D491/052 ,  C07D491/107

Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), or a pharmaceutically acceptable salt thereof and pharmaceutical compositions comprising the same. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in treating cancer.

公开(公告)号：US12116358B2

公开(公告)日：2024-10-15

申请号：US17268151

申请日：2019-08-14

Applicant: EPIZYME, INC.

Inventor： John Lampe ,  John Campbell ,  Kenneth Duncan ,  Megan Alene Cloonan Foley ,  Darren Martin Harvey ,  Michael John Munchhof ,  Michael Thomenius ,  Lawrence Alan Reiter

IPC: C07D403/12 ,  A61P35/00 ,  C07D209/42 ,  C07D209/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/08 ,  C07D491/107 ,  C07D498/04 ,  C07D498/08 ,  C07D498/10 ,  C07D513/10

CPC classification number: C07D403/12 ,  A61P35/00 ,  C07D209/42 ,  C07D209/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/08 ,  C07D491/107 ,  C07D498/04 ,  C07D498/08 ,  C07D498/10 ,  C07D513/10

Abstract: Compounds of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1e, G1, G2, Q1, Q2, Q3, and (II) are defined as set forth in the specification, as are uses of compounds of Formula I to treat a disease, disorder, or condition such as cancer in a subject.

公开(公告)号：US20240327351A1

公开(公告)日：2024-10-03

申请号：US18276433

申请日：2022-02-09

Applicant: TRIANA BIOMEDICINES, INC.

Inventor： William J. Greenlee ,  Nicholas Calandra ,  Soumya Ray ,  Arthur F. Kluge

IPC: C07D209/30 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/107 ,  C07D498/10

CPC classification number: C07D209/30 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/107 ,  C07D498/10

Abstract: The present application discloses novel compounds, pharmaceutical compositions containing these compounds and methods of inducing degradation of a protein, comprising contacting the protein with an effective amount of a compound of the disclosure. Methods of treating disease and disorders that results from abnormal activity of a target protein in a subject, are also disclosed.

公开(公告)号：US12103926B2

公开(公告)日：2024-10-01

申请号：US17040751

申请日：2019-03-26

Applicant: PTC THERAPEUTICS, INC.

Inventor： Nadiya Sydorenko ,  Suresh Babu ,  Anuradha Bhattacharyya ,  Young-Choon Moon ,  Jana Narasimhan ,  Jigar S. Patel

IPC: C07D401/14 ,  A61P25/28 ,  C07D401/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D493/08 ,  C07D498/04

CPC classification number: C07D471/08 ,  A61P25/28 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D493/08 ,  C07D498/04

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.




In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：US12102633B2

公开(公告)日：2024-10-01

申请号：US18092723

申请日：2023-01-03

Applicant: Quixgen, Inc.

Inventor： Yusheng Xiong ,  Hong-Ping Guan ,  Wenjun Huang

IPC: A61K31/4709 ,  A61K9/00 ,  A61K31/145 ,  A61K31/18 ,  A61K31/192 ,  A61K31/197 ,  A61K31/203 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4164 ,  A61K31/438 ,  A61K31/444 ,  A61K31/575 ,  A61K31/616 ,  A61K31/65 ,  A61K31/7048 ,  A61K31/7056 ,  A61K38/26 ,  A61K47/10 ,  A61K47/32 ,  A61K48/00 ,  A61P1/16 ,  A61P3/04 ,  A61P17/10 ,  C07D491/107 ,  C07D519/00

CPC classification number: A61K31/4709 ,  A61K9/0014 ,  A61K31/145 ,  A61K31/18 ,  A61K31/192 ,  A61K31/197 ,  A61K31/203 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4164 ,  A61K31/438 ,  A61K31/444 ,  A61K31/575 ,  A61K31/616 ,  A61K31/65 ,  A61K31/7048 ,  A61K31/7056 ,  A61K38/26 ,  A61K47/10 ,  A61K47/32 ,  A61K48/005 ,  A61P1/16 ,  A61P3/04 ,  A61P17/10 ,  C07D491/107 ,  C07D519/00

Abstract: Provided herein are spirolactone compounds of Formula I that are useful as inhibitors of ACC1 and/or ACC2. The spirolactone compounds described herein can be used for treating a disease or disorder associated with aberrant ACC1 and/or ACC2 activities, for example, non-alcoholic steatohepatitis (NASH), acne, obesity, diabetes, and cancer. Also provided herein are pharmaceutical compositions comprising the spirolactone compound of Formula I, or pharmaceutically acceptable salt thereof.

公开(公告)号：US20240317721A1

公开(公告)日：2024-09-26

申请号：US18571588

申请日：2022-06-22

Applicant: NOVARTIS AG

Inventor： Claudio BOMIO-CONFAGLIA ,  Saskia Maria BRACHMANN ,  Simona COTESTA ,  Marc GERSPACHER ,  Catherine LEBLANC ,  Fabio LIMA ,  Edwige Liliane Jeanne LORTHIOIS ,  Rainer MACHAUER ,  Robert MAH ,  Sophie RACINE ,  Pascal RIGOLLIER ,  Stefan STUTZ ,  Andrea VAUPEL ,  Nicolas WARIN ,  Rainer WILCKEN ,  Frédéric ZECRI

IPC: C07D403/14 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/499 ,  A61K31/4995 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/547 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/675 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107 ,  C07D495/10 ,  C07D498/04 ,  C07D498/08 ,  C07D498/10 ,  C07D513/08 ,  C07F9/6584

CPC classification number: C07D403/14 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/499 ,  A61K31/4995 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/547 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/675 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107 ,  C07D495/10 ,  C07D498/04 ,  C07D498/08 ,  C07D498/10 ,  C07D513/08 ,  C07F9/6584

Abstract: The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt thereof, and the therapeutic uses of said compound. The present invention further provides a pharmaceutical composition comprising said compound.

公开(公告)号：US12083100B1

公开(公告)日：2024-09-10

申请号：US17938063

申请日：2022-10-05

Applicant: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.

Inventor： Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska

IPC: A61K31/422 ,  A01N43/80 ,  A61K9/00 ,  A61K31/415 ,  A61K31/42 ,  A61K47/10 ,  A61K47/14 ,  C07D261/04 ,  C07D413/04 ,  C07D471/04 ,  C07D491/107 ,  A61K9/08 ,  A61K9/10 ,  A61K9/107

CPC classification number: A61K31/415 ,  A01N43/80 ,  A61K9/0019 ,  A61K31/42 ,  A61K31/422 ,  A61K47/10 ,  A61K47/14 ,  C07D261/04 ,  C07D413/04 ,  C07D471/04 ,  C07D491/107 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/10 ,  A61K9/107

Abstract: This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.

公开(公告)号：US20240277723A1

公开(公告)日：2024-08-22

申请号：US18606903

申请日：2024-03-15

Applicant: Epizyme, Inc.

Inventor： Kevin W. KUNTZ ,  Richard CHESWORTH ,  Kenneth W. DUNCAN ,  Heike KEILHACK ,  Natalie WARHOLIC ,  Christine KLAUS ,  Sarah K. KNUTSON ,  Timothy J.N. WIGLE ,  Masashi SEKI ,  Suji SHIROTORI ,  Satoshi KAWANO

IPC: A61K31/5377 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/551 ,  A61K31/553 ,  C07D213/64 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

CPC classification number: A61K31/5377 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/551 ,  A61K31/553 ,  C07D213/64 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.