公开(公告)号：US20240425486A1

公开(公告)日：2024-12-26

申请号：US18699461

申请日：2022-10-07

Applicant: Triana Biomedicines, Inc.

Inventor： William J. Greenlee ,  Nicholas Calandra ,  Soumya Ray

IPC: C07D403/12 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4365 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/517 ,  A61K31/536 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554 ,  C07D209/30 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04 ,  C07D498/04

Abstract: The present application discloses novel compounds, pharmaceutical compositions containing these compounds and methods of inducing degradation of a protein, comprising contacting the protein with an effective amount of a compound of the disclosure. Methods of treating disease and disorders that results from abnormal activity of a target protein in a subject, are also disclosed.

公开(公告)号：US20240190821A1

公开(公告)日：2024-06-13

申请号：US18275382

申请日：2022-02-01

Applicant: Triana Biomedicines, Inc.

Inventor： William J. Greenlee ,  Nicholas Calandra ,  Soumya Ray ,  Arthur F. Kluge

IPC: C07D209/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  C07D471/18 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10

CPC classification number: C07D209/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  C07D471/18 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10

Abstract: The present application discloses novel compounds of formula (I), pharmaceutical compositions containing these compounds and methods of inducing degradation of a protein, comprising contacting the protein with an effective amount of a compound of the disclosure. Methods of treating disease and disorders that results from abnormal activity of a target protein in a subject, are also disclosed.

公开(公告)号：US20240327351A1

公开(公告)日：2024-10-03

申请号：US18276433

申请日：2022-02-09

Applicant: TRIANA BIOMEDICINES, INC.

Inventor： William J. Greenlee ,  Nicholas Calandra ,  Soumya Ray ,  Arthur F. Kluge

IPC: C07D209/30 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/107 ,  C07D498/10

CPC classification number: C07D209/30 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/107 ,  C07D498/10

Abstract: The present application discloses novel compounds, pharmaceutical compositions containing these compounds and methods of inducing degradation of a protein, comprising contacting the protein with an effective amount of a compound of the disclosure. Methods of treating disease and disorders that results from abnormal activity of a target protein in a subject, are also disclosed.

公开(公告)号：US20240145030A1

公开(公告)日：2024-05-02

申请号：US18376729

申请日：2023-10-04

Applicant: Triana Biomedicines, Inc.

Inventor： Johannes Maier

IPC: G16B15/30 ,  G06N3/02

CPC classification number: G16B15/30 ,  G06N3/02

Abstract: Systems and methods to predict protein-protein interaction are provided herein for predicting one or more hot spots on a surface of a protein. An example method can include receiving a 3D model representing a whole structure of a protein. The method can include determining different surface patches associated with the 3D model. The method can include determining for at least one of different surface patches at least one of a geometric property or a chemical property. The method can further include assigning each node of a surface patch input features including chemical features. The method can include processing, with a neural network, at least one of a collection of geometric properties collected from one or more of different surface patches or a collection of the chemical properties collected from one or more of different the surface patches to predict one or more hot spots on the surface of the protein.