公开(公告)号：US20240360116A1

公开(公告)日：2024-10-31

申请号：US18255134

申请日：2021-12-03

Applicant: ELANCO TIERGESUNDHEIT AG

Inventor： Francois PAUTRAT ,  Chouaib TAHTAOUI ,  Pierre DUCRAY ,  Denise RAGEOT

IPC: C07D413/14 ,  A61K31/4709 ,  A61K31/538 ,  A61K31/541 ,  A61K31/69 ,  A61P33/10 ,  C07D265/36 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/107 ,  C07F5/02

CPC classification number: C07D413/14 ,  A61K31/4709 ,  A61K31/538 ,  A61K31/541 ,  A61K31/69 ,  A61P33/10 ,  C07D265/36 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/107 ,  C07F5/02

Abstract: The present invention provides compounds of formula (I′):




which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.

公开(公告)号：US20230355566A1

公开(公告)日：2023-11-09

申请号：US17786438

申请日：2020-12-17

Applicant: Elanco Tiergesundheit AG

Inventor： Peter ROLFE ,  Sarah GEORGE ,  Chouaib TAHTAOUI

IPC: A61K31/277 ,  A61K31/167 ,  A61P33/10

CPC classification number: A61K31/277 ,  A61K31/167 ,  A61P33/10

Abstract: The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of closantel.

公开(公告)号：US20220242857A1

公开(公告)日：2022-08-04

申请号：US17616436

申请日：2020-06-05

Applicant: Elanco Tiergesundheit AG

Inventor： Pierre DUCRAY ,  Francois PAUTRAT ,  Denise RAGEOT ,  Chouaib TAHTAOUI

IPC: C07D413/12 ,  A61P33/10 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/107

Abstract: The present invention provides compounds of formula (I): which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.

公开(公告)号：US11319377B2

公开(公告)日：2022-05-03

申请号：US15685257

申请日：2017-08-24

Applicant: Elanco Tiergesundheit AG

Inventor： Sarah Rue ,  Brendan Eckelman ,  Quinn L. Deveraux ,  Marc Nasoff

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/30 ,  G01N33/574 ,  A61K45/06

Abstract: This disclosure relates to immunogens and monoclonal antibodies useful in the identification and/or treatment of cancer cells, including those of the dog. In one example, chimeric anti-canine CD20 antibodies are provided. The antibodies can be used therapeutically to treat lymphoma in dogs.

公开(公告)号：US20220064160A1

公开(公告)日：2022-03-03

申请号：US17415323

申请日：2019-12-13

Applicant: Elanco Tiergesundheit AG

Inventor： Chouaib Tahtaoui ,  Denise Rageot ,  Francois Pautrat ,  Pierre Ducray

IPC: C07D471/04 ,  C07D495/04 ,  C07D493/04 ,  C07D405/12 ,  C07D311/68 ,  A61P33/10

Abstract: The present invention provides compounds of formula (I): which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.

公开(公告)号：US10537549B2

公开(公告)日：2020-01-21

申请号：US16099590

申请日：2017-05-03

Applicant: Elanco Tiergesundheit AG

Inventor： Chouaib Tahtaoui

IPC: A61K31/381 ,  A23K50/80 ,  A23K20/137 ,  A01N43/80

Abstract: The present invention provides a dihydroisoxazole of formula: or a salt thereof, for use in the control of sea lice in fish.

公开(公告)号：US20180346465A1

公开(公告)日：2018-12-06

申请号：US16055560

申请日：2018-08-06

Applicant: Elanco Tiergesundheit AG

Inventor： Noelle Gauvry ,  Chouaib Tahtaoui ,  Pascal Furet ,  Pierre Ducray

IPC: C07D471/14 ,  C07D239/48 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  C07D239/42 ,  C07D239/46

CPC classification number: C07D471/14 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04

Abstract: The invention relates to a compound of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful as therapeutic agent for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis. Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, inflammatory bowel diseases, Crohn's disease, Alzheimer's disease, leukemia, osteoarthritis, control of pruritus, chronic respiratory disease or keratoconjunctivitis in mammals.

公开(公告)号：US20180319741A1

公开(公告)日：2018-11-08

申请号：US16037396

申请日：2018-07-17

Applicant: ELANCO Tiergesundheit AG

Inventor： Noelle Gauvry ,  Chouaib Tahtaoui

IPC: C07C311/08 ,  C07F7/08 ,  C07D237/26 ,  C07D487/04 ,  C07D215/06 ,  C07D209/08 ,  C07D317/66 ,  C07D275/03 ,  C07D263/50 ,  C07D277/54 ,  C07D277/46 ,  C07D333/78 ,  C07D285/135 ,  C07D277/56 ,  C07D277/60 ,  C07D277/64 ,  C07D249/08 ,  C07D309/06 ,  C07C311/14 ,  C07C311/21 ,  C07D333/28 ,  C07D213/84 ,  C07D277/30 ,  C07D239/26 ,  C07D239/30 ,  C07D213/56 ,  C07D231/56 ,  C07D213/61 ,  C07D231/12 ,  C07D333/24 ,  C07D295/155 ,  C07F5/02

CPC classification number: C07C311/08 ,  C07C235/56 ,  C07C307/10 ,  C07C311/09 ,  C07C311/10 ,  C07C311/14 ,  C07C311/21 ,  C07C311/29 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/40 ,  C07C2602/42 ,  C07D209/08 ,  C07D213/26 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D213/84 ,  C07D215/06 ,  C07D231/12 ,  C07D231/20 ,  C07D231/56 ,  C07D237/26 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D249/08 ,  C07D249/12 ,  C07D263/50 ,  C07D275/03 ,  C07D277/30 ,  C07D277/46 ,  C07D277/54 ,  C07D277/56 ,  C07D277/60 ,  C07D277/62 ,  C07D277/64 ,  C07D279/12 ,  C07D285/135 ,  C07D295/155 ,  C07D295/185 ,  C07D295/26 ,  C07D309/06 ,  C07D317/66 ,  C07D333/24 ,  C07D333/28 ,  C07D333/78 ,  C07D487/04 ,  C07F5/025 ,  C07F7/081 ,  C07F7/0812

Abstract: The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

公开(公告)号：US20240270729A1

公开(公告)日：2024-08-15

申请号：US18569370

申请日：2022-06-15

Applicant: ELANCO TIERGESUNDHEIT AG ,  BAYER ANIMAL HEALTH GMBH

Inventor： Pierre Ducray ,  Denise Rageot ,  Andreas Turberg

IPC: C07D413/04 ,  A61K31/4439 ,  A61P33/14 ,  C07D413/14

CPC classification number: C07D413/04 ,  A61K31/4439 ,  A61P33/14 ,  C07D413/14

Abstract: The present invention provides compounds of formula (I):




which are useful for long-lasting treatment and control of pests, optionally fleas and ticks, in companion animals and livestock, and pharmaceutical compositions and methods of using the same.

公开(公告)号：US11938103B2

公开(公告)日：2024-03-26

申请号：US17281914

申请日：2019-09-30

Applicant: Elanco Tiergesundheit AG

Inventor： Sarah George ,  Peter Rolfe ,  Chouaib Tahtaoui

IPC: A61K31/167 ,  A61K31/63 ,  A61P33/10

CPC classification number: A61K31/167 ,  A61K31/63 ,  A61P33/10

Abstract: The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of clorsulon.