公开(公告)号：US12022832B2

公开(公告)日：2024-07-02

申请号：US17275849

申请日：2019-09-10

申请人： The Governing Council of The University of Toronto

发明人： Peter John Roy ,  Sean Harrington ,  Andrew Burns ,  Jacob Edward Pyche ,  Genna M. Luciani ,  Jessica Knox ,  Mark Lautens ,  Ken Loon Choo

IPC分类号： A01N43/40 ,  A01N43/54 ,  A01N43/60 ,  A01P5/00 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/495 ,  A61K31/505 ,  A61P33/10

CPC分类号： A01N43/40 ,  A01N43/54 ,  A01N43/60 ,  A01P5/00 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/495 ,  A61K31/505 ,  A61P33/10

摘要： The present application relates to the treatment of nematode infections. For example, the application relates to the use of compounds of Formula (III) as defined herein for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection.

公开(公告)号：US20240148800A1

公开(公告)日：2024-05-09

申请号：US18485796

申请日：2023-10-12

申请人： UNIVERSITY OF MASSACHUSETTS

发明人： Raffi Van Aroian ,  Gary R. Ostroff

IPC分类号： A61K35/741 ,  A61K9/48 ,  A61K38/16 ,  A61P33/10

CPC分类号： A61K35/741 ,  A61K9/48 ,  A61K38/164 ,  A61P33/10 ,  A61K45/06

摘要： Compositions and methods for treating or reducing the severity of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a composition comprising isolated native, bioactive nematicidal crystals formed from a single type of nematicidal crystal protein. The isolated native, bioactive nematicidal crystals are substantially free of any bacterial spores or host bacterial proteins, other than nematicidal crystal protein in the form of a crystal. Methods for making isolated native, bioactive nematicidal crystals are also described. The crystal proteins may be full length, truncated, variant, or sub-variant Cry proteins. Examples of crystal proteins include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A.

公开(公告)号：US11938103B2

公开(公告)日：2024-03-26

申请号：US17281914

申请日：2019-09-30

申请人： Elanco Tiergesundheit AG

发明人： Sarah George ,  Peter Rolfe ,  Chouaib Tahtaoui

IPC分类号： A61K31/167 ,  A61K31/63 ,  A61P33/10

CPC分类号： A61K31/167 ,  A61K31/63 ,  A61P33/10

摘要： The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of clorsulon.

公开(公告)号：US20230219974A1

公开(公告)日：2023-07-13

申请号：US18150992

申请日：2023-01-06

申请人： Boehringer Ingelheim Vetmedica GmbH ,  Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： Alan LONG ,  Hannes Fiepko KOOLMAN ,  Hyoung Ik LEE

IPC分类号： C07D495/04 ,  C07D413/14 ,  C07D409/12 ,  C07D407/12 ,  A61P33/10 ,  C07D307/85 ,  C07D519/00 ,  A61K45/06

CPC分类号： C07D495/04 ,  C07D413/14 ,  C07D409/12 ,  C07D407/12 ,  A61P33/10 ,  C07D307/85 ,  C07D519/00 ,  A61K45/06

摘要： This invention provides for compounds of the formula:




wherein the variables are defined herein, or a stereoisomer, tautomer, N-oxide, hydrate, solvate, or salt thereof, compositions comprising these compounds, and method for the treatment, control or prevention of a parasitic infestation or infection in an animal in need thereof by administering an effective amount of these compounds to said animal.

公开(公告)号：US20240173275A1

公开(公告)日：2024-05-30

申请号：US18431308

申请日：2024-02-02

申请人： Elanco Tiergesundheit AG

发明人： Sarah GEORGE ,  Peter ROLFE ,  Chouaib TAHTAOUI

IPC分类号： A61K31/167 ,  A61K31/63 ,  A61P33/10

CPC分类号： A61K31/167 ,  A61K31/63 ,  A61P33/10

摘要： The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of clorsulon.

公开(公告)号：US11964977B2

公开(公告)日：2024-04-23

申请号：US17324288

申请日：2021-05-19

申请人： Boehringer Ingelheim Animal Health USA Inc. ,  BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG

发明人： Hannes Fiepko Koolman ,  Bart Herlé ,  Alan Long

IPC分类号： A61K31/5025 ,  A61P33/10 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61P33/10

摘要： This invention provides for compounds of the formula:






wherein the variables are defined herein, or salt thereof, compositions comprising these compounds, and method for the treatment, control or prevention of a parasitic infestation or infection in an animal in need thereof by administering an effective amount of these compounds to said animal.

公开(公告)号：US20240059680A1

公开(公告)日：2024-02-22

申请号：US18253061

申请日：2021-11-17

申请人： ELANCO TIERGESUNDHEIT AG

发明人： Nils GRIEBENOW ,  Chouaib TAHTAOUI ,  Pierre DUCRAY ,  Denise RAGEOT

IPC分类号： C07D413/12 ,  C07D495/04 ,  C07D487/04 ,  C07D471/04 ,  C07D513/04 ,  A61P33/10

CPC分类号： C07D413/12 ,  C07D495/04 ,  C07D487/04 ,  C07D471/04 ,  C07D513/04 ,  A61P33/10

摘要： The present invention provides compounds of formula (I):




which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.

公开(公告)号：US20230414731A1

公开(公告)日：2023-12-28

申请号：US18173288

申请日：2023-02-23

申请人： New York Blood Center, Inc. ,  The United States of America, as Represented by

发明人： Sara Lustigman ,  Thomas B. Nutman ,  Sasisekhar Bennuru

IPC分类号： A61K39/00 ,  C07K16/18 ,  C07K14/435 ,  A61P33/10 ,  G01N33/53

CPC分类号： A61K39/0003 ,  C07K16/18 ,  C07K14/4354 ,  A61P33/10 ,  G01N33/5308 ,  A61K2039/55505 ,  A61K2039/70 ,  A61K2039/6031 ,  A61K2039/552

摘要： Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.

公开(公告)号：US20240325335A1

公开(公告)日：2024-10-03

申请号：US18616966

申请日：2024-03-26

申请人： Alexander E. Michalow ,  Andrew Michalow

发明人： Alexander E. Michalow ,  Andrew Michalow

IPC分类号： A61K31/20 ,  A61K9/00 ,  A61K31/7012 ,  A61K47/54 ,  A61K47/69 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P33/10

CPC分类号： A61K31/20 ,  A61K9/0014 ,  A61K9/006 ,  A61K9/0078 ,  A61K31/7012 ,  A61K47/544 ,  A61K47/547 ,  A61K47/6951 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P33/10

摘要： A topical aqueous antibiofilm, antimicrobial, and antiviral composition to disrupt biofilm to enhance the killing of microbial and viral particles in a way that prevents and reduces the severity of conditions and infections that are due to such microbial pathogens and viral particles is provided. The composition comprises a fatty acid chosen from saturated and/or unsaturated medium chain fatty acids (MCFAs: C-8 to C-12), saturated and/or unsaturated long chain fatty acids (LCFAs: C-13 to C-26), and/or their derivatives, salts, sugars and esters. The composition also comprises a solubilizing agent, preferably a cyclodextrin, which additionally synergizes the antibiofilm effect, and may be formulated for nebulization/inhalation. The composition further comprises chelating and enhancing agents, and either a neutral, acid or alkaline pH. The composition comprises skin and mucosal permeation enhancers, which improve clinical efficacy. The composition comprises additional antimicrobial and antiviral compounds that can optionally be applied concomitantly.

公开(公告)号：US12060355B2

公开(公告)日：2024-08-13

申请号：US17259795

申请日：2019-07-16

申请人： Merck Patent GmbH

发明人： John Mark Francis Gardner ,  Andrew Simon Bell

IPC分类号： C07D487/04 ,  A61K9/00 ,  A61P33/10 ,  C07D471/04 ,  C07D473/00

CPC分类号： C07D487/04 ,  A61K9/0053 ,  A61P33/10 ,  C07D471/04 ,  C07D473/00

摘要： The present invention relates to compounds and pharmaceutically acceptable salts or solvates thereof for use in the treatment or prevention of fascioliasis. Some of these compounds are novel per se and also have activity as inhibitors of Schistosoma growth. The invention also relates to pharmaceutical compositions comprising such novel compounds, salts or solvates and to the use of such novel compounds as medicaments, in particular in the treatment or prevention of schistosomiasis, also known as bilharzia.