公开(公告)号：US10047040B2

公开(公告)日：2018-08-14

申请号：US15502512

申请日：2015-08-27

Applicant: Elanco Tiergesundheit AG

Inventor： Noelle Gauvry ,  Chouaib Tahtaoui

IPC: C07C311/08 ,  C07F7/08 ,  C07F5/02 ,  C07D295/155 ,  C07D333/24 ,  C07D231/12 ,  C07D213/61 ,  C07D231/56 ,  C07D213/56 ,  C07D239/30 ,  C07D239/26 ,  C07D277/30 ,  C07D213/84 ,  C07D333/28 ,  C07C311/21 ,  C07C311/14 ,  C07D309/06 ,  C07D249/08 ,  C07D277/64 ,  C07D277/60 ,  C07D277/56 ,  C07D285/135 ,  C07D333/78 ,  C07D277/46 ,  C07D277/54 ,  C07D263/50 ,  C07D275/03 ,  C07D317/66 ,  C07D209/08 ,  C07D215/06 ,  C07D487/04 ,  C07D237/26

CPC classification number: C07C311/08 ,  C07C235/56 ,  C07C307/10 ,  C07C311/09 ,  C07C311/10 ,  C07C311/14 ,  C07C311/21 ,  C07C311/29 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/40 ,  C07C2602/42 ,  C07D209/08 ,  C07D213/26 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D213/84 ,  C07D215/06 ,  C07D231/12 ,  C07D231/20 ,  C07D231/56 ,  C07D237/26 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D249/08 ,  C07D249/12 ,  C07D263/50 ,  C07D275/03 ,  C07D277/30 ,  C07D277/46 ,  C07D277/54 ,  C07D277/56 ,  C07D277/60 ,  C07D277/62 ,  C07D277/64 ,  C07D279/12 ,  C07D285/135 ,  C07D295/155 ,  C07D295/185 ,  C07D295/26 ,  C07D309/06 ,  C07D317/66 ,  C07D333/24 ,  C07D333/28 ,  C07D333/78 ,  C07D487/04 ,  C07F5/025 ,  C07F7/081 ,  C07F7/0812

Abstract: The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

公开(公告)号：US20220064159A1

公开(公告)日：2022-03-03

申请号：US17415309

申请日：2019-12-13

Applicant: Elanco Tiergesundheit AG

Inventor： Chouaib Tahtaoui ,  Denise Rageot ,  Francois Pautrat ,  Pierre Ducray

IPC: C07D471/04 ,  C07D405/12 ,  C07D215/42 ,  C07D311/74

Abstract: The present invention provides compounds of formula (I): which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.

公开(公告)号：US20220008366A1

公开(公告)日：2022-01-13

申请号：US17281914

申请日：2019-09-30

Applicant: Elanco Tiergesundheit AG

Inventor： Sarah George ,  Peter Rolfe ,  Chouaib Tahtaoui

IPC: A61K31/167 ,  A61K31/63 ,  A61P33/10

Abstract: The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of clorsulon.

公开(公告)号：US11938103B2

公开(公告)日：2024-03-26

申请号：US17281914

申请日：2019-09-30

Applicant: Elanco Tiergesundheit AG

Inventor： Sarah George ,  Peter Rolfe ,  Chouaib Tahtaoui

IPC: A61K31/167 ,  A61K31/63 ,  A61P33/10

CPC classification number: A61K31/167 ,  A61K31/63 ,  A61P33/10

Abstract: The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of clorsulon.

公开(公告)号：US10464889B2

公开(公告)日：2019-11-05

申请号：US16037396

申请日：2018-07-17

Applicant: ELANCO Tiergesundheit AG

Inventor： Noelle Gauvry ,  Chouaib Tahtaoui

IPC: C07C311/08 ,  C07D277/62 ,  C07D213/61 ,  C07D213/84 ,  C07D231/12 ,  C07D231/20 ,  C07D231/56 ,  C07C307/10 ,  C07D333/24 ,  C07D333/28 ,  C07C311/10 ,  C07C311/14 ,  C07C311/21 ,  C07C311/29 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D249/12 ,  C07D277/30 ,  C07D277/64 ,  C07D279/12 ,  C07D295/155 ,  C07D295/185 ,  C07D295/26 ,  C07D213/26 ,  C07D213/64 ,  C07D213/65 ,  C07C311/09 ,  C07C235/56 ,  C07F5/02 ,  C07F7/08 ,  C07D209/08 ,  C07D213/56 ,  C07D215/06 ,  C07D237/26 ,  C07D249/08 ,  C07D263/50 ,  C07D275/03 ,  C07D277/46 ,  C07D277/54 ,  C07D277/56 ,  C07D277/60 ,  C07D285/135 ,  C07D309/06 ,  C07D317/66 ,  C07D333/78 ,  C07D487/04

Abstract: The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

公开(公告)号：US10370375B2

公开(公告)日：2019-08-06

申请号：US16055560

申请日：2018-08-06

Applicant: Elanco Tiergesundheit AG

Inventor： Noelle Gauvry ,  Chouaib Tahtaoui ,  Pascal Furet ,  Pierre Ducray

IPC: C07D471/14 ,  C07D239/46 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  C07D239/42 ,  C07D239/48

Abstract: The invention relates to a compound of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful as therapeutic agent for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis. Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, inflammatory bowel diseases, Crohn's disease, Alzheimer's disease, leukemia, osteoarthritis, control of pruritus, chronic respiratory disease or keratoconjunctivitis in mammals.

公开(公告)号：US20190142795A1

公开(公告)日：2019-05-16

申请号：US16099590

申请日：2017-05-03

Applicant: Elanco Tiergesundheit AG

Inventor： Chouaib Tahtaoui

IPC: A61K31/381 ,  A23K50/80 ,  A23K20/137

CPC classification number: A61K31/381 ,  A01N43/80 ,  A23K20/137 ,  A23K50/80

Abstract: The present invention provides a dihydroisoxazole of formula: or a salt thereof, for use in the control of sea lice in fish.

公开(公告)号：US10059709B2

公开(公告)日：2018-08-28

申请号：US15119800

申请日：2015-03-25

Applicant: Elanco Tiergesundheit AG

Inventor： Noelle Gauvry ,  Chouaib Tahtaoui ,  Pascal Furet ,  Pierre Ducray

IPC: C07D471/14 ,  C07D239/46 ,  C07D471/04 ,  A61K31/44 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  C07D239/42 ,  C07D239/48

CPC classification number: C07D471/14 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04

Abstract: The invention relates to a compound of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful as therapeutic agent for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, inflammatory bowel diseases, Crohn's disease, Alzheimer's disease, leukemia, osteoarthritis, control of pruritus, chronic respiratory disease or keratoconjunctivitis in mammals.

公开(公告)号：US20220064160A1

公开(公告)日：2022-03-03

申请号：US17415323

申请日：2019-12-13

Applicant: Elanco Tiergesundheit AG

Inventor： Chouaib Tahtaoui ,  Denise Rageot ,  Francois Pautrat ,  Pierre Ducray

IPC: C07D471/04 ,  C07D495/04 ,  C07D493/04 ,  C07D405/12 ,  C07D311/68 ,  A61P33/10

Abstract: The present invention provides compounds of formula (I): which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.

公开(公告)号：US10537549B2

公开(公告)日：2020-01-21

申请号：US16099590

申请日：2017-05-03

Applicant: Elanco Tiergesundheit AG

Inventor： Chouaib Tahtaoui

IPC: A61K31/381 ,  A23K50/80 ,  A23K20/137 ,  A01N43/80

Abstract: The present invention provides a dihydroisoxazole of formula: or a salt thereof, for use in the control of sea lice in fish.