公开(公告)号：US20230399302A1

公开(公告)日：2023-12-14

申请号：US18034439

申请日：2021-10-29

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

发明人： Justin M. Lopchuk ,  Zachary P. SHULTZ ,  Thomas SCATTOLIN

IPC分类号： C07D239/38 ,  C07D405/04 ,  C07D403/04 ,  C07D405/12 ,  C07D401/12 ,  C07D417/06 ,  C07D409/04 ,  C07D411/04 ,  C07D417/04 ,  C07D239/30 ,  C07D239/42 ,  C07D471/04 ,  C07D241/12 ,  C07D213/34 ,  C07D213/803 ,  C07D213/80 ,  C07D213/61 ,  C07D215/12 ,  C07D487/04 ,  C07D473/00 ,  C07D495/04 ,  C07D277/64

CPC分类号： C07D239/38 ,  C07D405/04 ,  C07D403/04 ,  C07D405/12 ,  C07D401/12 ,  C07D417/06 ,  C07D409/04 ,  C07D411/04 ,  C07D417/04 ,  C07D239/30 ,  C07D239/42 ,  C07D471/04 ,  C07D241/12 ,  C07D213/34 ,  C07D213/803 ,  C07D213/80 ,  C07D213/61 ,  C07D215/12 ,  C07D487/04 ,  C07D473/00 ,  C07D495/04 ,  C07D277/64

摘要： The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.

公开(公告)号：US11691986B2

公开(公告)日：2023-07-04

申请号：US17558390

申请日：2021-12-21

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Ulrich Lücking ,  Daniel Hog ,  Clara Christ ,  Ulrike Sack ,  Franziska Siegel ,  Philip Lienau ,  Nicolas Werbeck

IPC分类号： C07D213/61 ,  C07D498/18 ,  C07D239/30 ,  C07D498/08

CPC分类号： C07D498/18 ,  C07D213/61 ,  C07D239/30 ,  C07D498/08

摘要： The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

公开(公告)号：US20180134681A1

公开(公告)日：2018-05-17

申请号：US15871552

申请日：2018-01-15

申请人： MITSUI CHEMICALS, INC.

发明人： Kei Yoshida ,  Takeo Wakita ,  Hiroyuki Katsuta ,  Akiyoshi Kai ,  Yutaka Chiba ,  Kiyoshi Takahashi ,  Hiroko Kato ,  Nobuyuki Kawahara ,  Michikazu Nomura ,  Hidenori Daido ,  Junji Maki ,  Shinichi Banba

IPC分类号： C07D333/38 ,  C07D317/46 ,  C07D213/64 ,  C07D239/28 ,  C07D261/18 ,  C07D307/85 ,  C07C237/48 ,  A01N43/60 ,  A01N37/22 ,  C07D207/416 ,  C07C327/48 ,  C07C323/42 ,  C07C317/40 ,  C07C237/42 ,  A01N43/80 ,  A01N43/78 ,  A01N43/58 ,  A01N43/56 ,  A01N43/54 ,  A01N43/42 ,  A01N43/40 ,  A01N43/30 ,  A01N43/16 ,  A01N43/12 ,  A01N43/10 ,  A01N43/08 ,  A01N37/44 ,  C07D333/68 ,  C07D317/62 ,  C07D309/28 ,  C07D309/08 ,  C07D307/84 ,  C07D307/68 ,  C07D307/24 ,  C07D277/56 ,  C07D275/03 ,  C07D263/34 ,  C07D241/24 ,  C07D239/30 ,  C07D231/16 ,  C07D231/14 ,  C07D215/52 ,  C07D213/89 ,  C07D213/82 ,  C07D213/81 ,  C07D213/73 ,  C07D207/34

CPC分类号： C07D333/38 ,  A01N37/22 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/78 ,  A01N43/80 ,  C07C237/42 ,  C07C237/48 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/34 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/28 ,  C07D239/30 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D307/85 ,  C07D309/08 ,  C07D309/28 ,  C07D317/46 ,  C07D317/62 ,  C07D333/68

摘要： An object of the present invention is to provide a compound represented by Formula (1): wherein A1, A2, A3 and A4 each represent a carbon atom, a nitrogen atom or an oxidized nitrogen atom; R1 and R2 each represent a hydrogen atom, an optionally substituted alkyl group or an optionally substituted C1-C4 alkylcarbonyl group; G1 and G2 each represent an oxygen atom or a sulfur atom; X, which may be identical or different each other, represents a hydrogen atom, a halogen atom, a C1-C3 alkyl group or a trifluoromethyl group; n is an integer of 0 to 4; and Q1 represents an optionally substituted phenyl group, an optionally substituted naphthyl group or an optionally substituted heterocyclic group; Q2 represents a phenyl group or heterocyclic group having one or more substituents, at least one of the substituent being any of a C1-C4 haloalkoxy group, a C2-C6 perfluoroalkyl group, a C1-C6 perfluoroalkylthio group, a C1-C6 perfluoroalkylsulfinyl group and a C1-C6 perfluoroalkylsulfonyl group, an insecticide comprising the compound as the active ingredient, and a process for preparation thereof.

公开(公告)号：US09969743B2

公开(公告)日：2018-05-15

申请号：US15463051

申请日：2017-03-20

申请人： Southern Research Institute

发明人： Subramaniam Ananthan

IPC分类号： C07D487/04 ,  C07D295/15 ,  C07D239/42 ,  C07D215/46 ,  C07D213/14 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D215/38 ,  C07D295/215 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D211/60 ,  C07D213/14 ,  C07D215/06 ,  C07D215/38 ,  C07D215/46 ,  C07D239/26 ,  C07D239/30 ,  C07D239/42 ,  C07D239/74 ,  C07D295/033 ,  C07D295/13 ,  C07D295/215 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04

摘要： Provided are compounds represented by the formula: In which: Y is an unbranched, saturated or unsaturated hydrocarbon chain with 2-5 hydrocarbon atoms R1=aryl R2=NR3R4 wherein R3 and R4 together form a heterocycle or R2=4-substitutedcyclohexyl, 1-substitutedpiperidine-4-yl or imidazo(1,2-a)azine-2-yl when Y is as defined above and R1 is a heterocycle other than benzothiophene pharmaceutically acceptable salts thereof, deuterated forms thereof, isomers thereof, solvates thereof, and mixtures thereof. The compounds can be used for treating a patient suffering from a condition that is capable of treatment with a partial agonist or antagonist of the dopamine D2/D3 receptors. The compounds are especially useful for patients suffering from schizophrenia, depressions, neurodegenerative diseases such as Parkinson's, dyskinesias, substance abuse and relapse to substance abuse and addiction to substances such as cocaine, methamphetamine, nicotine and alcohol, glaucoma, cognitive disorders, restless leg syndrome, attention deficit hyperactivity disorders, hyperprolactinemia, autism, motor disturbances such as akathisia, rigor, dystonias as well as various disorders of the urinary tract and other neurologic disorders. Also provided are processes for the preparation of compounds of the present disclosure.

公开(公告)号：US20180086723A1

公开(公告)日：2018-03-29

申请号：US15828163

申请日：2017-11-30

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  The United States Government as Represented by the Department of Veterans Affairs

发明人： Raju Reddy

IPC分类号： C07D241/20 ,  C07D241/18 ,  C07D241/16 ,  C07D241/12 ,  C07D239/52 ,  C07D239/26 ,  C07D239/42 ,  C07D239/38 ,  C07D239/34 ,  C07D239/30 ,  C07D239/47

CPC分类号： C07D241/20 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D241/12 ,  C07D241/16 ,  C07D241/18

摘要： Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: X1-L-X2 wherein L is a linking moiety comprising an enone; and X1 and X2 are each independently an optionally-substituted N-heterocycle. Also disclosed are method for treating pulmonary conditions and other organ or system conditions with the compounds.

公开(公告)号：US09920026B2

公开(公告)日：2018-03-20

申请号：US14854627

申请日：2015-09-15

申请人： MITSUI CHEMICALS, INC.

发明人： Kei Yoshida ,  Takeo Wakita ,  Hiroyuki Katsuta ,  Akiyoshi Kai ,  Yutaka Chiba ,  Kiyoshi Takahashi ,  Hiroko Kato ,  Nobuyuki Kawahara ,  Michikazu Nomura ,  Hidenori Daido ,  Junji Maki ,  Shinichi Banba

IPC分类号： C07C237/42 ,  C07D333/38 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/78 ,  A01N43/80 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/30 ,  C07D241/24 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D309/08 ,  C07D309/28 ,  C07D317/62 ,  C07D333/68 ,  A01N37/22 ,  A01N43/60 ,  C07C237/48 ,  C07D207/34 ,  C07D239/28 ,  C07D261/18 ,  C07D307/85 ,  C07D317/46

CPC分类号： C07D333/38 ,  A01N37/22 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/78 ,  A01N43/80 ,  C07C237/42 ,  C07C237/48 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/34 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/28 ,  C07D239/30 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D307/85 ,  C07D309/08 ,  C07D309/28 ,  C07D317/46 ,  C07D317/62 ,  C07D333/68

摘要： A compound represented by Formula (1): The compound can be used as insecticides.

公开(公告)号：US09868721B2

公开(公告)日：2018-01-16

申请号：US15297272

申请日：2016-10-19

申请人： AMGEN INC.

发明人： Ning Chen ,  Xiaoqi Chen ,  Yinhong Chen ,  Alan C. Cheng ,  Richard V. Connors ,  Jeffrey Deignan ,  Paul John Dransfield ,  Xiaohui Du ,  Zice Fu ,  Julie Anne Heath ,  Daniel B. Horne ,  Jonathan Houze ,  Matthew R. Kaller ,  Aarif Yusuf Khakoo ,  David John Kopecky ,  Su-Jen Lai ,  Zhihua Ma ,  Lawrence R. McGee ,  Julio C. Medina ,  Jeffrey T. Mihalic ,  Nobuko Nishimura ,  Steven H. Olson ,  Vatee Pattaropong ,  Gayathri Swaminath ,  Xiaodong Wang ,  Kevin Yang ,  Wen-Chen Yeh ,  Mikkel V. Debenedetto ,  Robert P. Farrell ,  Simon J. Hedley ,  Ted C. Judd ,  Frank Kayser

IPC分类号： C07D401/14 ,  C07D401/04 ,  C07D413/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K45/06 ,  C07B57/00 ,  C07B59/00 ,  C07D211/54 ,  C07D213/71 ,  C07D213/82 ,  C07D239/26 ,  C07D239/30 ,  C07D241/12 ,  C07D241/24 ,  C07D249/08 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D401/12 ,  A61K31/695 ,  C07F7/08 ,  A61K31/437 ,  C07C311/13 ,  C07D213/61 ,  C07D239/34 ,  C07D241/18 ,  C07D295/16

CPC分类号： A61K31/506 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/513 ,  A61K31/695 ,  A61K45/06 ,  C07B57/00 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/07 ,  C07C311/13 ,  C07D211/54 ,  C07D213/61 ,  C07D213/71 ,  C07D213/82 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D241/24 ,  C07D249/08 ,  C07D295/16 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F7/08

摘要： Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

公开(公告)号：US09845310B2

公开(公告)日：2017-12-19

申请号：US15298748

申请日：2016-10-20

申请人： AMGEN INC.

发明人： Ning Chen ,  Xiaoqi Chen ,  Alan C. Cheng ,  Richard V. Connors ,  Jeffrey Deignan ,  Paul John Dransfield ,  Xiaohui Du ,  Zice Fu ,  Julie Anne Heath ,  Daniel B. Horne ,  Jonathan Houze ,  Matthew R. Kaller ,  David John Kopecky ,  Su-Jen Lai ,  Zhihua Ma ,  Lawrence R. McGee ,  Julio C. Medina ,  Jeffrey T. Mihalic ,  Nobuko Nishimura ,  Steven H. Olson ,  Vatee Pattaropong ,  Xiaodong Wang ,  Kevin Yang ,  Mikkel V. Debenedetto ,  Simon J. Hedley

IPC分类号： A61K31/4439 ,  C07D239/30 ,  C07D401/14 ,  C07D401/04 ,  C07D413/04 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K45/06 ,  C07B57/00 ,  C07B59/00 ,  C07D211/54 ,  C07D213/71 ,  C07D213/82 ,  C07D239/26 ,  C07D241/12 ,  C07D241/24 ,  C07D249/08 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D401/12 ,  A61K31/695 ,  C07F7/08 ,  A61K31/437 ,  C07C311/13 ,  C07D213/61 ,  C07D239/34 ,  C07D241/18 ,  C07D295/16

CPC分类号： A61K31/506 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/513 ,  A61K31/695 ,  A61K45/06 ,  C07B57/00 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/07 ,  C07C311/13 ,  C07D211/54 ,  C07D213/61 ,  C07D213/71 ,  C07D213/82 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D241/24 ,  C07D249/08 ,  C07D295/16 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F7/08

摘要： Compounds of Formula VII, salts thereof, tautomers thereof, and salts of the tautomers are useful intermediates in the synthesis of agonists of the APJ Receptor. Compounds of Formula VII have the following structure: where the definitions of the variables are provided herein.

公开(公告)号：US09732100B2

公开(公告)日：2017-08-15

申请号：US14766160

申请日：2014-02-11

申请人： BAYER CROPSCIENCE AKTIENGESELLSCHAFT

发明人： Mark James Ford ,  Marc Mosrin

IPC分类号： C07D239/30 ,  C07F3/06 ,  C07F3/02

CPC分类号： C07F3/06 ,  C07D239/30 ,  C07F3/02

摘要： The present invention relates to a process for preparing alkaline earth metal-complexed metal bisamides of the formula (I) from metal monoamides of the formula (II). The present invention further relates to a process for preparing alkaline earth metal monoamides of the formula (II-AE), to novel LiCl-free alkaline earth metal monoamides of the formula (II-AE-L), and to the use of these alkaline earth metal monoamides for metallation of aromatics, heteroaromatics, alkenes, alkynes and other organic compounds having activated C—H bonds.

公开(公告)号：US20170166549A1

公开(公告)日：2017-06-15

申请号：US15323260

申请日：2015-06-30

申请人： BAYER CROPSCIENCE AKTIENGESELLSCHAFT

发明人： MARC MOSRIN ,  Harald JAKOBI ,  Hansjoerg DIETRICH ,  Elmar GATZWEILER ,  Christopher Hugh ROSINGER ,  Dirk SCHMUTZLER

IPC分类号： C07D333/28 ,  A01N43/40 ,  C07D213/57 ,  C07D239/30 ,  A01N43/54 ,  C07D239/26 ,  C07D237/08 ,  A01N43/58 ,  C07D237/12 ,  C07D241/12 ,  A01N43/60 ,  C07D241/16 ,  C07D333/24 ,  A01N43/10 ,  C07D307/54 ,  A01N43/08 ,  C07D307/56 ,  C07D263/32 ,  A01N43/76 ,  C07D263/34 ,  C07D277/30 ,  A01N43/78 ,  C07D277/32 ,  C07D233/64 ,  A01N43/50 ,  C07D233/68 ,  C07D231/12 ,  A01N43/48 ,  C07D231/16 ,  C07D251/20 ,  A01N43/66 ,  C07D253/04 ,  A01N43/707 ,  C07D253/065 ,  C07D253/07 ,  C07D253/075 ,  C07D213/61

CPC分类号： C07D333/28 ,  A01N43/08 ,  A01N43/10 ,  A01N43/40 ,  A01N43/48 ,  A01N43/50 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  A01N43/66 ,  A01N43/707 ,  A01N43/76 ,  A01N43/78 ,  C07D213/57 ,  C07D213/61 ,  C07D231/12 ,  C07D231/16 ,  C07D233/64 ,  C07D233/68 ,  C07D237/08 ,  C07D237/12 ,  C07D239/26 ,  C07D239/30 ,  C07D241/12 ,  C07D241/16 ,  C07D251/20 ,  C07D253/04 ,  C07D253/065 ,  C07D253/07 ,  C07D253/075 ,  C07D263/32 ,  C07D263/34 ,  C07D277/30 ,  C07D277/32 ,  C07D307/54 ,  C07D307/56 ,  C07D333/24

摘要： Primarily, the present invention relates to compounds of the formula (I) defined below and to their use as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants. The present invention also relates to herbicidal or plant growth-regulating compositions comprising one or more compounds of the formula (I). Moreover, the present invention relates to processes for preparing the compounds of the formula (I).