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公开(公告)号：US20240327334A1
公开(公告)日：2024-10-03
申请号：US18390287
申请日：2023-12-20
发明人： Xuri GAO , Bin WANG , Hui CAO , Jiajun ZHANG , Yuk Ming SIU , Jiang LONG , Wei LI , Matthew C. RHODES , Xuechao XING , Jianming YU , Scott MITCHELL , Yat Sun OR
IPC分类号： C07C233/56 , A61K31/166 , A61K31/277 , A61K31/337 , A61K31/365 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/403 , A61K31/415 , A61K31/4152 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/4402 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/662 , A61P31/14 , C07C243/30 , C07C255/46 , C07C255/66 , C07D205/04 , C07D207/16 , C07D209/52 , C07D209/56 , C07D213/40 , C07D215/12 , C07D231/08 , C07D231/12 , C07D231/56 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D263/34 , C07D265/02 , C07D277/28 , C07D295/185 , C07D305/08 , C07D307/58 , C07D333/20 , C07D333/24 , C07D401/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D417/14 , C07F9/40
CPC分类号： C07C233/56 , A61K31/166 , A61K31/277 , A61K31/337 , A61K31/365 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/403 , A61K31/415 , A61K31/4152 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/4402 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/662 , A61P31/14 , C07C243/30 , C07C255/46 , C07C255/66 , C07D205/04 , C07D207/16 , C07D209/52 , C07D209/56 , C07D213/40 , C07D215/12 , C07D231/08 , C07D231/12 , C07D231/56 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D263/34 , C07D265/02 , C07D277/28 , C07D295/185 , C07D305/08 , C07D307/58 , C07D333/20 , C07D333/24 , C07D401/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D417/14 , C07F9/4015
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof:
which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US12075785B2
公开(公告)日：2024-09-03
申请号：US17834252
申请日：2022-06-07
申请人： Pro Farm Group, Inc.
发明人： Ratnakar N. Asolkar , Marja Koivunen , Pamela G. Marrone , Ana Lucia Cordova-Kreylos , Huazhang Huang
IPC分类号： A01N43/16 , A01N43/76 , A01N43/86 , A01N43/90 , A01N57/20 , A01N63/20 , C07D263/32 , C07D263/34 , C07D309/14 , C07D407/06 , C07D413/04 , C07D413/06 , C07D493/10 , C07D498/14 , C07D513/04 , C12N1/20 , C12P17/04 , C12P17/06 , C12P17/14 , C12P17/16 , C12P17/18 , A01N43/00 , C12N1/00 , C12R1/00 , C12R1/01
CPC分类号： A01N63/20 , A01N43/16 , A01N43/76 , A01N43/86 , A01N43/90 , A01N57/20 , C07D263/32 , C07D263/34 , C07D309/14 , C07D407/06 , C07D413/04 , C07D413/06 , C07D493/10 , C07D498/14 , C07D513/04 , C12N1/20 , C12N1/205 , C12P17/04 , C12P17/06 , C12P17/14 , C12P17/16 , C12P17/18 , A01N43/00 , C12N1/00 , C12R2001/00 , C12R2001/01 , A01N63/20 , A01N43/16 , A01N43/74 , A01N43/76 , A01N43/90
摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.
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公开(公告)号：US20230357221A1
公开(公告)日：2023-11-09
申请号：US18343319
申请日：2023-06-28
发明人： Yves GAREAU , Stéphane GINGRAS , Yves CHANTIGNY , Gaoqiang YANG , Guy SAUVAGEAU , Irène BACCELLI , Anne MARINIER
IPC分类号： C07D417/12 , C07D249/04 , C07D263/32 , C07D263/34 , C07D277/24 , C07D413/12 , G01N33/50
CPC分类号： C07D417/12 , C07D249/04 , C07D263/32 , C07D263/34 , C07D277/24 , C07D413/12 , G01N33/5011
摘要： Heterocyclic compounds of Formula I:
and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly cancers sensitive to mitochondrial activity inhibition and increased reactive oxygen species (ROS) levels, is also disclosed. Such cancers include acute myeloid leukemia (AML), preferably AML characterized by certain features, such as high level of expression of one or more Homeobox (HOX)-network genes, high and/or low expression of specific genes, the presence of one or more cytogenetic or molecular risk factors such as intermediate cytogenetic risk, Normal Karyotype (NK), mutated NPM1, mutated CEBPA, mutated FLT3, mutated DNMT3A, mutated TET2, mutated IDH1, mutated IDH2, mutated RUNX1, mutated WT1, mutated SRSF2, intermediate cytogenetic risk with abnormal karyotype (intern(abnK)), trisomy 8 (+8) and/or abnormal chromosome (5/7), and/or a high leukemic stem cell (LSC) frequency.-
公开(公告)号：US11760754B2
公开(公告)日：2023-09-19
申请号：US16761210
申请日：2018-11-02
发明人： Yves Gareau , Stéphane Gingras , Yves Chantigny , Gaoqiang Yang , Guy Sauvageau , Irène Baccelli , Anne Marinier
IPC分类号： C07D413/12 , C07D263/32 , C07D263/34 , C07D417/12 , A61K31/421 , A61K31/427 , A61K31/4439 , A61K31/501 , A61K31/506 , A61P35/02 , C07D249/04 , C07D277/24 , G01N33/50
CPC分类号： C07D417/12 , C07D249/04 , C07D263/32 , C07D263/34 , C07D277/24 , C07D413/12 , G01N33/5011
摘要： Heterocyclic compounds of Formula (I) and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly cancers sensitive to mitochondrial activity inhibition and increased reactive oxygen species (ROS) levels, is also disclosed. Such cancers include acute myeloid leukemia (AML), preferably AML characterized by certain features, such as high level of expression of one or more Homeobox (HOX)-network genes, high and/or low expression of specific genes, the presence of one or more cytogenetic or molecular risk factors such as intermediate cytogenetic risk, Normal Karyotype (A/K), mutated NPM1, mutated CEBPA, mutated FLT3, mutated DNMT3A, mutated TET2, mutated IDH1, mutated IDH2, mutated RUNX1, mutated WT1, mutated SRSF2, intermediate cytogenetic risk with abnormal karyotype (intern(abnK)), trisomy 8 (+8) and/or abnormal chromosome (5/7), and/or a high leukemic stem cell (LSC) frequency.
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公开(公告)号：US11760742B2
公开(公告)日：2023-09-19
申请号：US17208474
申请日：2021-03-22
发明人： Kei Yoshida , Takeo Wakita , Hiroyuki Katsuta , Akiyoshi Kai , Yutaka Chiba , Kiyoshi Takahashi , Hiroko Kato , Nobuyuki Kawahara , Michikazu Nomura , Hidenori Daido , Junji Maki , Shinichi Banba
IPC分类号： C07C237/42 , C07D333/38 , A01N37/44 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/16 , A01N43/30 , A01N43/42 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/78 , A01N43/80 , C07C317/40 , C07C323/42 , C07C327/48 , C07D207/416 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/52 , C07D231/14 , C07D231/16 , C07D239/30 , C07D241/24 , C07D263/34 , C07D275/03 , C07D277/56 , C07D307/24 , C07D307/68 , C07D307/84 , C07D309/08 , C07D309/28 , C07D317/62 , C07D333/68 , A01N43/40 , A01N37/22 , A01N43/60 , C07C237/48 , C07D207/34 , C07D239/28 , C07D261/18 , C07D307/85 , C07D317/46
CPC分类号： C07D333/38 , A01N37/22 , A01N37/44 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/16 , A01N43/30 , A01N43/40 , A01N43/42 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/78 , A01N43/80 , C07C237/42 , C07C237/48 , C07C317/40 , C07C323/42 , C07C327/48 , C07D207/34 , C07D207/416 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/52 , C07D231/14 , C07D231/16 , C07D239/28 , C07D239/30 , C07D241/24 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D307/24 , C07D307/68 , C07D307/84 , C07D307/85 , C07D309/08 , C07D309/28 , C07D317/46 , C07D317/62 , C07D333/68
摘要： A compound represented by Formula (1):
The compound can be used as insecticides.-
6.发明申请公开(公告)号：US20180161313A1
公开(公告)日：2018-06-14
申请号：US15580991
申请日：2016-06-06
IPC分类号： A61K31/4184 , A61K31/445 , A61K31/40 , A61K31/4196 , A61K31/4025 , A61K31/538 , A61K31/165 , A61K31/5415 , A61K31/4709 , A61K31/4178 , A61K31/405 , A61K31/433 , A61K31/5377 , A61K31/47 , A61K31/423 , A61K31/4439 , A61K31/4965 , A61K31/501 , A61K31/444 , A61K31/4245 , A61K31/496 , A61K31/4525 , A61K31/541 , A61K31/341 , A61K31/519 , A61K31/437 , A61K31/506 , A61P35/00 , G01N33/50
CPC分类号： A61K31/4184 , A61K31/165 , A61K31/167 , A61K31/341 , A61K31/40 , A61K31/4025 , A61K31/405 , A61K31/4164 , A61K31/4178 , A61K31/4196 , A61K31/423 , A61K31/4245 , A61K31/433 , A61K31/437 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4525 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/50 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K45/06 , A61P35/00 , C07C233/87 , C07C237/00 , C07C237/52 , C07D207/337 , C07D209/08 , C07D209/42 , C07D211/34 , C07D215/48 , C07D217/06 , C07D233/60 , C07D235/10 , C07D235/12 , C07D235/16 , C07D235/28 , C07D249/12 , C07D263/34 , C07D265/36 , C07D279/02 , C07D295/108 , C07D307/54 , C07D317/60 , C07D401/06 , C07D403/06 , C07D403/14 , C07D405/06 , C07D409/14 , C07D413/06 , C07D417/12 , C07D487/04 , G01N33/5011 , G01N2333/4703 , A61K2300/00
摘要： The present invention includes compositions and methods for inhibiting MCL-1, including novel inhibitors of MCL-1, and compositions and methods for treating a subject with cancer that is refractory to one or more MAPK pathway protein inhibitors.
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公开(公告)号：US09957248B2
公开(公告)日：2018-05-01
申请号：US15323260
申请日：2015-06-30
发明人： Marc Mosrin , Harald Jakobi , Hansjoerg Dietrich , Elmar Gatzweiler , Christopher Hugh Rosinger , Dirk Schmutzler
IPC分类号： A01N43/08 , A01N43/10 , A01N43/40 , A01N43/48 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/66 , A01N43/707 , A01N43/76 , A01N43/78 , C07D333/28 , C07D333/24 , C07D213/57 , C07D213/61 , C07D231/12 , C07D231/16 , C07D233/64 , C07D233/68 , C07D237/08 , C07D237/12 , C07D239/26 , C07D239/30 , C07D241/12 , C07D241/16 , C07D251/20 , C07D253/04 , C07D253/065 , C07D253/07 , C07D253/075 , C07D263/32 , C07D263/34 , C07D277/30 , C07D277/32 , C07D307/54 , C07D307/56
CPC分类号： C07D333/28 , A01N43/08 , A01N43/10 , A01N43/40 , A01N43/48 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/66 , A01N43/707 , A01N43/76 , A01N43/78 , C07D213/57 , C07D213/61 , C07D231/12 , C07D231/16 , C07D233/64 , C07D233/68 , C07D237/08 , C07D237/12 , C07D239/26 , C07D239/30 , C07D241/12 , C07D241/16 , C07D251/20 , C07D253/04 , C07D253/065 , C07D253/07 , C07D253/075 , C07D263/32 , C07D263/34 , C07D277/30 , C07D277/32 , C07D307/54 , C07D307/56 , C07D333/24
摘要： Primarily, the present invention relates to compounds of the formula (I) defined below and to their use as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants. The present invention also relates to herbicidal or plant growth-regulating compositions comprising one or more compounds of the formula (I). Moreover, the present invention relates to processes for preparing the compounds of the formula (I).
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公开(公告)号：US20180105503A1
公开(公告)日：2018-04-19
申请号：US15689168
申请日：2017-08-29
发明人： Melissa Fleury , Roland Gendron , Adam D. Hughes , Jane Schmidt
IPC分类号： C07D261/18 , A61K45/06 , A61K31/42
CPC分类号： C07D261/18 , A01N47/16 , A61K31/4196 , A61K31/42 , A61K31/4355 , A61K31/437 , A61K45/06 , A61K47/55 , A61K47/6895 , C07D213/81 , C07D237/04 , C07D237/24 , C07D239/28 , C07D241/24 , C07D249/04 , C07D249/10 , C07D249/18 , C07D263/34 , C07D307/68 , C07D333/38 , C07D401/06 , C07D471/04 , C07D487/04 , C07D498/04 , C09K15/30
摘要： In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, X, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
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公开(公告)号：US20180057486A1
公开(公告)日：2018-03-01
申请号：US15687697
申请日：2017-08-28
申请人： Incyte Corporation
发明人： Liangxing Wu , Fenglei Zhang , Song Mei , Wenqing Yao
IPC分类号： C07D417/14 , C07D417/06 , C07D277/56 , C07D401/06 , C07D233/90 , C07D231/14 , C07D405/12 , C07D403/12 , C07D263/34
CPC分类号： C07D417/14 , C07D231/14 , C07D233/90 , C07D263/34 , C07D277/56 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/06
摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
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公开(公告)号：US09856266B2
公开(公告)日：2018-01-02
申请号：US15349872
申请日：2016-11-11
IPC分类号： C07D295/192 , C07D413/06 , C07D417/06 , C07D417/04 , C07D403/04 , C07D405/06 , C07D295/112 , C07D277/56 , C07D417/12 , C07D239/38 , C07D249/06 , C07D207/16 , C07D307/68 , C07D239/26 , C07D487/08 , C07D207/14 , C07D207/08 , C07D213/74 , C07D295/108 , C07D401/12 , C07D213/38 , C07D211/26 , C07D211/58 , C07D401/04 , C07D295/26 , C07D295/32 , C07D277/12 , C07D263/34 , C07D409/12 , C07D333/38 , C07D277/18
CPC分类号： C07D487/08 , C07C59/74 , C07C65/30 , C07C69/738 , C07C235/78 , C07C235/84 , C07D207/08 , C07D207/14 , C07D207/16 , C07D211/26 , C07D211/58 , C07D211/62 , C07D211/66 , C07D211/98 , C07D213/36 , C07D213/38 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/26 , C07D239/38 , C07D249/06 , C07D263/34 , C07D277/12 , C07D277/18 , C07D277/42 , C07D277/56 , C07D295/108 , C07D295/112 , C07D295/185 , C07D295/192 , C07D295/26 , C07D295/32 , C07D307/68 , C07D333/38 , C07D333/40 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要： The invention provides compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
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