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公开(公告)号：US12220404B2
公开(公告)日：2025-02-11
申请号：US16932352
申请日：2020-07-17
Applicant: East Carolina University
Inventor： Stefan Clemens , Perrine Lallemand
IPC: A01N37/00 , A01N25/00 , A01N37/12 , A01N37/44 , A61K31/215 , A61K31/24 , A61K31/381 , A61K31/40 , A61K31/428 , A61K31/48 , A61K31/485 , A61K31/5383 , A61K31/55 , A61K45/06 , A61P43/00 , A61K9/00
Abstract: The present invention provides methods of treating Restless Legs Syndrome (RLS) including administering to a subject an effective amount of a dopamine D1 receptor antagonist. Compositions and kits useful for treating RLS are also provided.
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公开(公告)号：US12138247B2
公开(公告)日：2024-11-12
申请号：US18600431
申请日：2024-03-08
Applicant: BioXcel Therapeutics, Inc.
Inventor： Vasukumar Kakumanu , David Christian Hanley , Frank Yocca , Chetan Dalpatbhai Lathia , Lavanya Rajachandran , Robert Risinger
IPC: A01N37/00 , A01N25/00 , A01N37/12 , A01N37/44 , A61K9/00 , A61K31/215 , A61K31/24 , A61K31/4174 , A61K47/38 , A61P25/18 , A61P25/20
Abstract: Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.
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公开(公告)号：US12133912B2
公开(公告)日：2024-11-05
申请号：US18528684
申请日：2023-12-04
Applicant: Slayback Pharma LLC.
Inventor： Ashish Anilrao Dubewar , Amit Anil Charkha , Sumitra Ashokkumar Pillai , Pradeep Kumar Kare , Kumar Swamy Ummiti , Shanker Mamidi , Mayur Anshiram Adhav
IPC: A01N37/00 , A01N25/00 , A01N37/12 , A01N37/44 , A61K9/00 , A61K31/215 , A61K31/221 , A61K31/225 , A61K31/24 , A61K47/10 , A61K47/12 , A61K47/18
Abstract: The present invention relates to injectable pharmaceutical compositions comprising therapeutically effective amount of succinylcholine chloride, one or more pharmaceutically acceptable aqueous solvents, and one or more stabilizing agents selected from aliphatic polyols; lower alkyl alcohols; amino acids having at least one additional amino, carboxyl or hydroxyl group; amino alcohols; and aliphatic dicarboxylic acids having at least one hydroxyl or amino group, or α-β unsaturation. The compositions are stable at room temperature for at least 30 days. Methods of manufacturing the injectable pharmaceutical compositions are also provided. The composition may be provided in a sealed container, e.g., an ampoule, vial and pre-filled syringe, and are suitable for subcutaneous, intravenous or intramuscular administration as an adjunct to general anesthesia, to facilitate tracheal intubation, and/or to provide skeletal muscle relaxation during surgery or mechanical ventilation.
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公开(公告)号：US20240358013A1
公开(公告)日：2024-10-31
申请号：US18767160
申请日：2024-07-09
Applicant: Kannar Earth Science, Ltd.
Inventor： Samuel L. Cloete , Ahsan Habib , Heather Lewis
CPC classification number: A01N25/10 , A01C1/06 , A01N37/44 , A01N43/08 , A01N43/16 , A01N43/78 , A01P21/00
Abstract: Dry seed flow lubricant compositions are provided for improving seed appearance and flowability. The lubricant compositions include about 5% to about 100% by weight cellulose-based polymer in place of commonly used lubricants such as talc, graphite, or plant protein powder. Advantages of the lubricant compositions include that they are non-toxic, microplastic free, and biodegradable to provide a carbon source for plant growth and have an increased shelf life relative to plant oils that can become rancid over time. In addition, seed performance compositions are provided that reduce days to germination, increase germination rate, and/or increase plant growth. The seed performance compositions counteract negative effects on plant growth that can occur from seed treatment with pesticides. Dry compositions are also provided that include a combination of a seed flow lubricant and a seed performance additive to improve seed flowability and improve seed germination and growth.
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公开(公告)号：US12121028B2
公开(公告)日：2024-10-22
申请号：US17303367
申请日：2021-05-27
Applicant: The Texas A&M University System
Inventor： Kranthi Mandadi , Manikandan Ramasamy , Prakash Niraula , Sonia Irigoyen
Abstract: Applicants have developed novel methods and compositions for treating, preventing or ameliorating the effects plant phytopathogen infestation in plants, including of Candidatus liberibacter spp. the causal agents of citrus greening and potato zebrachip disease. Novel compositions include one or more active agents of aminocaproic acid, carbinoxamine maleate, chloroxylenol, chlorpropamide, cinoxacin, duartin, and cyclopentolate hydrochloride as well as their derivatives, or salt/acid forms thereof. Methods of preventing disease development and infestation by plant pathogens are disclosed as well as methods of making, using and producing such compositions.
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公开(公告)号：US20240315242A1
公开(公告)日：2024-09-26
申请号：US18576595
申请日：2022-06-28
Applicant: LG Chem, Ltd.
Inventor： Leehyeon Baek , JI Seok Lee , Hyungsam Choi , Seonjung Jung , Soonhee Kang , Haesung Yun , Yoon Hyung Hur
IPC: A01N37/44 , A01P1/00 , C07C219/06
CPC classification number: A01N37/44 , A01P1/00 , C07C219/06
Abstract: Provided is a novel compound, more particularly, a novel compound of Chemical Formula 1 exhibiting an excellent antibacterial property while having a polymerizable functional group to prepare an antibacterial polymer,
wherein all the variables are described herein.
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公开(公告)号：US20240298639A1
公开(公告)日：2024-09-12
申请号：US18268312
申请日：2021-04-12
Applicant: ZHEJIANG UNIVERSITY , ZHEJIANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD. , JIANGSU PESTICIDE RESEARCH INSTITUTE CO., LTD.
Inventor： ZHONGHUA MA , NINGJIE WU , HONGLEI WANG , YUN CHEN , TIANMING XU , YANG CAO
IPC: A01N37/44 , A01P3/00 , C07C253/30 , C07C255/43
CPC classification number: A01N37/44 , A01P3/00 , C07C253/30 , C07C255/43
Abstract: The present invention discloses a 2-cyanoacrylate compound and use thereof in controlling a fungal disease of a crop, and belongs to the field of fungicides. The 2-cyanoacrylate compound has a structural formula shown in a formula (I), has excellent fungicidal activity, particularly has a very highly fungicidal activity on Fusarium species, and is suitable for controlling a fungal disease of a crop. Therefore, the compound may be used for preparing a fungicide in the fields of agriculture, horticulture, and the like, and is highly efficient, low in toxicity, and environmentally friendly.
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公开(公告)号：US12042486B2
公开(公告)日：2024-07-23
申请号：US17293941
申请日：2019-06-13
Applicant: YUNNAN HAOPY PHARMACEUTICALS LTD
Inventor： Xianguo Liu , Biao Li , Qiongfen Wu
IPC: A01N37/00 , A01N25/00 , A01N37/12 , A01N37/44 , A61K9/00 , A61K9/08 , A61K9/20 , A61K9/28 , A61K9/48 , A61K9/70 , A61K31/215 , A61K31/24 , A61K31/439 , A61K47/02 , A61K47/44 , A61P17/04
CPC classification number: A61K31/439 , A61K9/0019 , A61K9/08 , A61K9/2013 , A61K9/2059 , A61K9/28 , A61K9/4858 , A61K9/4866 , A61K9/4891 , A61K9/7053 , A61K47/02 , A61K47/44 , A61P17/04
Abstract: The present disclosure belongs to the field of pharmaceuticals. Disclosed is a use of bulleyaconitine A in treating pruritus or a secondary lesion thereof, especially pruritus induced by histamine and/or chloroquine.
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公开(公告)号：US20240225003A1
公开(公告)日：2024-07-11
申请号：US18615183
申请日：2024-03-25
Applicant: The Texas A&M University System
Inventor： Kranthi Mandadi , Manikandan Ramasamy , Prakash Niraula , Sonia Irigoyen
Abstract: Applicants have developed novel methods and compositions for treating, preventing or ameliorating the effects plant phytopathogen infestation in plants, including of Candidatus Liberibacter spp. the causal agents of citrus greening and potato zebrachip disease. Novel compositions include one or more active agents of aminocaproic acid, carbinoxamine maleate, chloroxylenol, chlorpropamide, cinoxacin, duartin, and cyclopentolate hydrochloride as well as their derivatives, or salt/acid forms thereof. Methods of preventing disease development and infestation by plant pathogens are disclosed as well as methods of making, using and producing such compositions.
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10.发明公开
公开(公告)号：US20240196893A1
公开(公告)日：2024-06-20
申请号：US18556474
申请日：2021-04-26
Applicant: UNIVERSIDADE DO PORTO , UNIVERSIDADE DO MINHO
Inventor： David Alexandre MICAEL PEREIRA , Maria DO SAMEIRO TORRES GONÇALVES , António Belmiro GIL SILVA FORTES , Elisabete Maria DOS SANTOS CASTANHEIRA COUTINHO , Renato Joel BARROS PEREIRA
IPC: A01N37/44 , A01P7/04 , C07C229/56 , C07C229/60
CPC classification number: A01N37/44 , A01P7/04 , C07C229/56 , C07C229/60
Abstract: The present application relates to a compound of Formula (I) and its analogues, which are obtained by chemical synthesis. The disclosed compounds are suitable to be used as insecticides by killing insect cells in a selective fashion, namely by not being toxic to human cells. These compounds are different from existing insecticide solutions given their potency, selectivity and non-toxicity for human cells, and mechanism of action via caspase activation.
