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公开(公告)号：US12075785B2
公开(公告)日：2024-09-03
申请号：US17834252
申请日：2022-06-07
申请人： Pro Farm Group, Inc.
发明人： Ratnakar N. Asolkar , Marja Koivunen , Pamela G. Marrone , Ana Lucia Cordova-Kreylos , Huazhang Huang
IPC分类号： A01N43/16 , A01N43/76 , A01N43/86 , A01N43/90 , A01N57/20 , A01N63/20 , C07D263/32 , C07D263/34 , C07D309/14 , C07D407/06 , C07D413/04 , C07D413/06 , C07D493/10 , C07D498/14 , C07D513/04 , C12N1/20 , C12P17/04 , C12P17/06 , C12P17/14 , C12P17/16 , C12P17/18 , A01N43/00 , C12N1/00 , C12R1/00 , C12R1/01
CPC分类号： A01N63/20 , A01N43/16 , A01N43/76 , A01N43/86 , A01N43/90 , A01N57/20 , C07D263/32 , C07D263/34 , C07D309/14 , C07D407/06 , C07D413/04 , C07D413/06 , C07D493/10 , C07D498/14 , C07D513/04 , C12N1/20 , C12N1/205 , C12P17/04 , C12P17/06 , C12P17/14 , C12P17/16 , C12P17/18 , A01N43/00 , C12N1/00 , C12R2001/00 , C12R2001/01 , A01N63/20 , A01N43/16 , A01N43/74 , A01N43/76 , A01N43/90
摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.
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公开(公告)号：US20230193332A1
公开(公告)日：2023-06-22
申请号：US17883115
申请日：2022-08-08
发明人： Ryan M. Summers , Shelby Mills , Meredith Mock
CPC分类号： C12P17/14 , C12N9/0071 , C12Y114/00
摘要： The present disclosure relates to mutant enzymes and bacterial strains constructed to produce paraxanthine and 7-methylxanthine from caffeine and methods for the manufacture and use thereof.
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公开(公告)号：US11643673B2
公开(公告)日：2023-05-09
申请号：US16473874
申请日：2017-12-21
申请人： Arkema France
发明人： Georges Fremy , Arnaud Masselin
IPC分类号： C07D277/16 , C07D279/06 , C12P17/14
CPC分类号： C12P17/14 , C07D277/16 , C07D279/06
摘要： Provided is a process for synthesizing a functionalized cyclic dithiocarbamate.
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公开(公告)号：US11382331B2
公开(公告)日：2022-07-12
申请号：US16449871
申请日：2019-06-24
发明人： Ratnakar Asolkar , Marja Koivunen , Pamela G. Marrone , Ana Lucia Cordova-Kreylos , Huazhang Huang
IPC分类号： A01N63/20 , A01N43/00 , A01N43/16 , A01N43/76 , A01N43/86 , A01N43/90 , C12N1/20 , C12P17/06 , C12P17/14 , C12P17/16 , C07D309/14 , C07D407/06 , C07D413/04 , C07D413/06 , C07D263/32 , C07D263/34 , C07D493/10 , C07D498/14 , C07D513/04 , C12P17/04 , C12N1/00 , C12R1/01 , C12R1/00
摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.
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公开(公告)号：US11174290B2
公开(公告)日：2021-11-16
申请号：US16529342
申请日：2019-08-01
发明人： Aaron J. Peoples , Dallas Hughes , Losee Lucy Ling , William Millett , Anthony Nitti , Amy Spoering , Victoria Alexandra Steadman , Jean-Yves Christophe Chiva , Linos Lazarides , Michael Kenyon Jones , Karine Gaelle Poullennec , Kim Lewis , Slava Epstein
摘要： The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders.
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6.发明申请公开(公告)号：US20200288715A1
公开(公告)日：2020-09-17
申请号：US16892871
申请日：2020-06-04
发明人： Ratnakar Asolkar , Marja Koivunen , Pamela G. Marrone , Ana-Lucia Cordova Kreylos , Huazhang Huang
IPC分类号： A01N43/76 , A01N43/16 , A01N43/90 , A01N43/86 , C12P17/06 , C12P17/14 , C12P17/16 , C12R1/01 , C12N1/20 , A01N63/10 , A01N63/00 , C07D309/14 , C07D407/06 , C07D413/04 , C07D413/06 , C07D263/32 , C07D263/34 , C07D493/10 , C07D498/14 , C07D513/04 , C12P17/04
摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.
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公开(公告)号：US10414800B2
公开(公告)日：2019-09-17
申请号：US15183031
申请日：2016-06-15
发明人： Aaron J. Peoples , Dallas Hughes , Losee Lucy Ling , William Millett , Anthony Nitti , Amy Spoering , Victoria Alexandra Steadman , Jean-Yves Christophe Chiva , Linos Lazarides , Michael Kenyon Jones , Karine Gaelle Poullennec , Kim Lewis , Slava Epstein
摘要： The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders.
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公开(公告)号：US09994520B2
公开(公告)日：2018-06-12
申请号：US15179086
申请日：2016-06-10
IPC分类号： C07D205/08 , C12P17/10 , C12P17/14 , C07C229/22 , C07D263/26 , C12N9/20
CPC分类号： C07D205/08 , C07C229/22 , C07D263/26 , C12N9/20 , C12P17/10 , C12P17/14 , Y02P20/55
摘要： The present invention provides an enzymatic process for the preparation of (S)-5-(4-Fluoro-phenyl)-5-hydroxy-Imorpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)-5-morpholin-4-yl-pentane-1,5-dione by using a suitable enzyme or by the resolution of (R, S)-5-(4-Fluoro-phenyl)-5-hydroxy-1 morpholin-4-yl-pentan-1-one by using an enzyme. The present invention also provides process for the preparation of Ezetimibe comprising the steps of a) protecting the compound (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1 morpholin-4-yl-pentan-1-one with hydroxy protecting group b) hydrolyzing the obtained compound c) condensing with a chiral auxiliary d) reacting with an protected imine compound e) converting to alkyl ester f) cyclizing and g) deprotecting to obtain Ezetimibe.
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公开(公告)号：US20170137832A1
公开(公告)日：2017-05-18
申请号：US15127645
申请日：2015-03-20
发明人： Simon BOECKER , Dirk STORM , Vera MEYER , Lennart RICHTER , Sophia ZOBEL , Franziska WANKA , Roderich SUESSMUTH , Agnes MUEHLENWEG
摘要： A method for obtaining at least one microbial secondary metabolite or a derivative thereof, the method includes the step of heterologous expression of at least one synthetase of the secondary metabolite in at least one filamentous fungus. Also disclosed is an expression cassette, a plasmid vector including the expression cassette, an expression host, novel cyclodepsipeptides and a chimeric cyclodepsipeptide synthetase.
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公开(公告)号：US20160289718A1
公开(公告)日：2016-10-06
申请号：US15175779
申请日：2016-06-07
发明人： Rene Trussardi , Hans Iding
IPC分类号： C12P17/14 , C12P13/00 , C07D265/30 , C12P7/02
CPC分类号： C12P17/14 , C07D265/30 , C12P7/02 , C12P7/22 , C12P13/008 , Y02P20/55
摘要： The invention relates to a novel process for the preparation of chiral 2-(4-aminophenyl) morpholines of the formula wherein R1 is hydrogen an amino protecting group. The chiral 2-(4-aminophenyl) morpholines of the formula I are key intermediates for the preparation of compounds that have a good affinity to the trace amine associated receptors (TAARs).
摘要翻译： 式I的手性2-（4-氨基苯基）吗啉是制备与微量胺相关受体（TAAR）具有良好亲和力的化合物的关键中间体。
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