公开(公告)号：US20250008960A1

公开(公告)日：2025-01-09

申请号：US18802256

申请日：2024-08-13

Applicant: CORTEVA AGRISCIENCE LLC

Inventor： RONALD J. HEEMSTRA ,  RONALD ROSS, JR. ,  KYLE A. DEKORVER ,  KAITLYN GRAY ,  DANIEL I. KNUEPPEL ,  PETER VEDNOR ,  TIMOTHY P. MARTIN ,  JOSEPH D. ECKELBARGER ,  JOHN F. DAEUBLE, SR. ,  RICKY HUNTER ,  DAVID A. DEMETER ,  TONY K. TRULLINGER ,  ERICH W. BAUM ,  ZOLTAN L. BENKO ,  NAKYEN CHOY ,  GARY D. CROUSE ,  FANGZHENG LI ,  JEFFREY NISSEN ,  MONICA B. OLSON ,  MICHELLE RIENER ,  THOMAS C. SPARKS ,  FRANK J. WESSELS ,  MAURICE C. YAP

IPC: A01N53/00 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C237/22 ,  C07C237/42 ,  C07C255/29 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07C271/28 ,  C07C271/66 ,  C07C311/08 ,  C07C311/46 ,  C07C317/14 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07D207/10 ,  C07D207/273 ,  C07D207/452 ,  C07D209/49 ,  C07D213/56 ,  C07D213/75 ,  C07D213/81 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07D215/38 ,  C07D231/12 ,  C07D231/56 ,  C07D233/36 ,  C07D233/80 ,  C07D235/30 ,  C07D241/20 ,  C07D249/08 ,  C07D253/07 ,  C07D261/12 ,  C07D263/26 ,  C07D277/30 ,  C07D277/36 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D307/33 ,  C07D307/52 ,  C07D309/14 ,  C07D331/04 ,  C07D333/36 ,  C07D333/48 ,  C07D333/60 ,  C07D487/04

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US20240415851A1

公开(公告)日：2024-12-19

申请号：US18605319

申请日：2024-03-14

Applicant: The University of Chicago ,  The United States of America, as Represented by the Secretary, Department of Health and Human ,  President and Fellows of Harvard College ,  IIT Research Institute ,  Beth Israel Deaconess Medical Center, Inc.

Inventor： Julian SOLWAY ,  Nickolai DULIN ,  Marsha ROSNER ,  Gokhan MUTLU ,  Diane LUCI ,  David MALONEY ,  Chan Young PARK ,  Jeffrey FREDBERG ,  David MCCORMICK ,  Ramaswamy KRISHNAN

IPC: A61K31/635 ,  A61K31/18 ,  A61K31/63 ,  A61P35/04 ,  C07C311/16 ,  C07C311/21 ,  C07D207/48 ,  C07D211/34 ,  C07D211/96 ,  C07D239/42 ,  C07D241/04 ,  C07D265/30 ,  C07D277/52 ,  C07D279/12 ,  C07D295/13 ,  C07D295/26 ,  C07D309/14 ,  C07D401/12 ,  C07D471/04 ,  C07D487/08 ,  C07D491/113

Abstract: Disclosed herein is a class of molecules termed remodilins that inhibit serum response factor (SRF). By inhibiting SRF, a number of downstream pathways can be targeted. The remodilins can be used to treat glaucoma, inhibit tumor cell growth, inhibit tumor metastasis, inhibit hypoxia-induced response, and/or reduce cellular metabolism.

公开(公告)号：US12162864B2

公开(公告)日：2024-12-10

申请号：US17280628

申请日：2019-09-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shinobu Sasaki ,  Yasutomi Asano ,  Hironobu Maezaki ,  Ayumu Sato ,  Kazuaki Takami ,  Masaki Seto ,  Haruhi Ando ,  Shuji Kitamura ,  Steve L. Swann

IPC: C07D405/14 ,  A61K9/00 ,  A61K9/20 ,  A61P1/10 ,  C07D309/14 ,  C07D407/12 ,  C07D407/14

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20240360075A1

公开(公告)日：2024-10-31

申请号：US18640931

申请日：2024-04-19

Applicant: ALCON INC.

Inventor： Heeren M. Gordhan ,  Mitchell A. deLong ,  Jill M. Sturdivant ,  David Archer Ellis ,  Cynthia L. Lichorowic

IPC: C07C233/60 ,  A61K9/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/175 ,  A61K31/192 ,  A61K31/27 ,  A61K31/277 ,  A61K31/337 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/4465 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/69 ,  A61K47/12 ,  A61K47/18 ,  A61K47/38 ,  C07C231/02 ,  C07C233/58 ,  C07C233/59 ,  C07C233/62 ,  C07C233/63 ,  C07C235/14 ,  C07C235/56 ,  C07C237/24 ,  C07C271/20 ,  C07C271/24 ,  C07C279/22 ,  C07C315/04 ,  C07C317/30 ,  C07D205/04 ,  C07D207/09 ,  C07D209/54 ,  C07D211/58 ,  C07D213/75 ,  C07D213/79 ,  C07D231/40 ,  C07D239/42 ,  C07D263/04 ,  C07D263/56 ,  C07D265/36 ,  C07D275/03 ,  C07D277/46 ,  C07D295/088 ,  C07D295/135 ,  C07D295/32 ,  C07D305/06 ,  C07D305/08 ,  C07D305/14 ,  C07D307/22 ,  C07D307/94 ,  C07D309/14 ,  C07D311/58 ,  C07D335/02 ,  C07F5/02

CPC classification number: C07C233/60 ,  A61K9/0048 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/175 ,  A61K31/192 ,  A61K31/27 ,  A61K31/277 ,  A61K31/337 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/4465 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/69 ,  A61K47/12 ,  A61K47/183 ,  A61K47/186 ,  A61K47/38 ,  C07C231/02 ,  C07C233/58 ,  C07C233/59 ,  C07C233/62 ,  C07C233/63 ,  C07C235/14 ,  C07C235/56 ,  C07C237/24 ,  C07C271/20 ,  C07C271/24 ,  C07C279/22 ,  C07C315/04 ,  C07C317/30 ,  C07D205/04 ,  C07D207/09 ,  C07D209/54 ,  C07D211/58 ,  C07D213/75 ,  C07D213/79 ,  C07D231/40 ,  C07D239/42 ,  C07D263/04 ,  C07D263/56 ,  C07D265/36 ,  C07D275/03 ,  C07D277/46 ,  C07D295/088 ,  C07D295/135 ,  C07D295/32 ,  C07D305/06 ,  C07D305/08 ,  C07D305/14 ,  C07D307/22 ,  C07D307/94 ,  C07D309/14 ,  C07D311/58 ,  C07D335/02 ,  C07F5/025 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/18 ,  C07C2602/38 ,  C07C2602/42 ,  C07C2602/50

Abstract: Described herein are modified monoterpene TRPM8 activating compounds. In particular, provided herein are compounds that affect the function of ion channels in a cell, and are useful as therapeutic agents or with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and conditions including inflammatory eye diseases such as uveitis, cardiovascular diseases, inflammatory diseases, and diseases characterized by abnormal growth, such as cancers.

公开(公告)号：US12060339B2

公开(公告)日：2024-08-13

申请号：US17631212

申请日：2021-07-28

Applicant: Vivozon Inc.

Inventor： Dae Kyu Choi ,  Hyo Jin Kim ,  Mi Seon Bae ,  Jin Choi ,  Hyun Jin Heo ,  Yong Seok Lee ,  Geon Ho Lee ,  Mi Yon Shim ,  Jin Sun Park ,  Han Mi Lee

IPC: C07D295/135 ,  A61P25/04 ,  C07C233/66 ,  C07C233/70 ,  C07C233/72 ,  C07C233/78 ,  C07C233/86 ,  C07C237/34 ,  C07D213/40 ,  C07D213/56 ,  C07D305/06 ,  C07D307/14 ,  C07D309/06 ,  C07D309/14 ,  C07D319/12

CPC classification number: C07D295/135 ,  A61P25/04 ,  C07C233/66 ,  C07C233/70 ,  C07C233/72 ,  C07C233/78 ,  C07C233/86 ,  C07C237/34 ,  C07D213/40 ,  C07D213/56 ,  C07D305/06 ,  C07D307/14 ,  C07D309/06 ,  C07D309/14 ,  C07D319/12

Abstract: Disclosed are a dual modulator of mGluR5 and 5-HT2AR (5-HT2A receptor), and use thereof. More specifically, disclosed are a compound which acts as modulator of mGluR5 and an antagonist of 5-HT2AR at the same time, and use thereof as therapeutic agent for pain.

公开(公告)号：US20240174611A1

公开(公告)日：2024-05-30

申请号：US18273476

申请日：2022-02-07

Applicant: Rappta Therapeutics Oy

Inventor： George L. Trainor ,  Maria Obdulia Rabal Gracia ,  Laura Fourmois ,  Olga Gherbovet ,  Frederic Cachoux

IPC: C07D211/96 ,  C07C311/29 ,  C07D205/04 ,  C07D205/12 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D209/52 ,  C07D211/28 ,  C07D211/56 ,  C07D211/58 ,  C07D211/76 ,  C07D231/56 ,  C07D261/10 ,  C07D309/14 ,  C07D311/68 ,  C07D311/96 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D451/04

CPC classification number: C07D211/96 ,  C07C311/29 ,  C07D205/04 ,  C07D205/12 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D209/52 ,  C07D211/28 ,  C07D211/56 ,  C07D211/58 ,  C07D211/76 ,  C07D231/56 ,  C07D261/10 ,  C07D309/14 ,  C07D311/68 ,  C07D311/96 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D451/04 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/74

Abstract: The present disclosure relates in part to chemical modulators of protein phosphatase 2A (PP2A). The compounds of the present disclosure are useful in treating, preventing, and/or ameliorating cancer, diabetes, autoimmune disease, solid organ transplant rejection, graft vs host disease, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease, abdominal aortic aneurysm, chronic liver disease, heart failure, neurodegenerative disease, and cardiac hypertrophy.

公开(公告)号：US11917999B2

公开(公告)日：2024-03-05

申请号：US17499014

申请日：2021-10-12

Applicant: PRO FARM GROUP, INC.

Inventor： Ratnakar Asolkar ,  Marja Koivunen ,  Pamela G. Marrone ,  Ana Lucia Cordova-Kreylos ,  Huazhang Huang

IPC: A01N63/20 ,  A01N25/12 ,  A01N25/14 ,  C07D263/32 ,  C07D263/34 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12N1/20

CPC classification number: A01N63/20 ,  A01N25/12 ,  A01N25/14 ,  C07D263/32 ,  C07D263/34 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  A01N63/10 ,  A01N25/00 ,  A01N63/20 ,  A01N25/00

Abstract: Provided is the use of or compositions or formulations comprising Burkholderia species, filtrate, supernatant, extract, pesticidally active compound or metabolite derived therefrom as an insecticide, particularly against infestation of Corn Rootworm larvae, and/or as crop yield enhancer.

公开(公告)号：US20230322675A1

公开(公告)日：2023-10-12

申请号：US18322492

申请日：2023-05-23

Applicant: Lhotse Bio, Inc.

Inventor： Wei Huang ,  Hui Lei ,  Zhongmiao Xu ,  Haizhen Zhang ,  Qiong Zhang

IPC: C07D211/66 ,  C07C229/18 ,  C07C229/28 ,  C07D309/14 ,  C07D317/54 ,  C07D317/58 ,  C07C61/39 ,  C07D407/12

CPC classification number: C07D211/66 ,  C07C229/18 ,  C07C229/28 ,  C07D309/14 ,  C07D317/54 ,  C07D317/58 ,  C07C61/39 ,  C07D407/12 ,  C07C2602/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08

Abstract: The present disclosure provides LPA antagonists, as well as pharmaceutical compositions comprising the compounds disclosed herein. Also provided are methods for treating LPA-associated diseases, disorders, and conditions.

公开(公告)号：US11779592B2

公开(公告)日：2023-10-10

申请号：US16639027

申请日：2018-08-14

Applicant: University of North Texas Health Science Center

Inventor： Yu-Chieh Wang ,  Victor J. T. Lin ,  Ashwini Zolekar ,  Kyle A. Emmitte ,  Nigam M. Mishra ,  Jin Liu

IPC: A61K31/7105 ,  A61P35/00 ,  C07D309/14 ,  C12N15/113 ,  A61K45/06

CPC classification number: A61K31/7105 ,  A61P35/00 ,  C07D309/14 ,  C12N15/1137 ,  A61K45/06 ,  C12Y305/01052

Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula (I): wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.

公开(公告)号：US20230286904A1

公开(公告)日：2023-09-14

申请号：US18013431

申请日：2021-07-02

Applicant: BRIDGENE BIOSCIENCES, INC.

Inventor： Chao ZHANG ,  Michael J. BISHOP ,  Hang CHEN ,  Ping CAO

IPC: C07C233/25 ,  A61K45/06 ,  C07C233/27 ,  C07C251/42 ,  C07D333/32 ,  C07D333/36 ,  C07D213/643 ,  C07D311/68 ,  C07D215/38 ,  C07D213/64 ,  C07D261/08 ,  C07D231/12 ,  C07D231/54 ,  C07D261/20 ,  C07D271/06 ,  C07D249/06 ,  C07D309/14 ,  C07D261/12 ,  C07D217/24 ,  C07D213/40 ,  C07D237/08 ,  C07D275/02 ,  C07D205/04 ,  C07C233/23

CPC classification number: C07C233/25 ,  A61K45/06 ,  C07C233/23 ,  C07C233/27 ,  C07C251/42 ,  C07D205/04 ,  C07D213/40 ,  C07D213/64 ,  C07D213/643 ,  C07D215/38 ,  C07D217/24 ,  C07D231/12 ,  C07D231/54 ,  C07D237/08 ,  C07D249/06 ,  C07D261/08 ,  C07D261/12 ,  C07D261/20 ,  C07D271/06 ,  C07D275/02 ,  C07D309/14 ,  C07D311/68 ,  C07D333/32 ,  C07D333/36 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2602/50

Abstract: Disclosed herein are synthesis and use of covalent inhibitors selective for Transcriptional Enhancer Factor TEF-1 (TEAD1), which can be used for treatment of cancers such as glioblastoma, gastric cancer, colorectal cancer, pancreatic ductal adenocarcinoma (PDAC), and malignant pleural mesothelioma (MPM). Further disclosed herein are pharmaceutical compositions including the TEAD1 inhibitor and methods of treating cancers using the same.