公开(公告)号：US20230242808A1

公开(公告)日：2023-08-03

申请号：US17768762

申请日：2020-10-14

Applicant: TOKUYAMA CORPORATION

Inventor： Masayuki MIYAZAKI ,  Junji TAKENAKA ,  Srinivas VENU ,  Junji MOMODA ,  Katsuhiro MORI

IPC: C09K9/02 ,  C09D4/06 ,  C09D7/63 ,  C07D497/10 ,  C07D311/96 ,  C07F7/08 ,  G02B1/04 ,  G02B1/10 ,  G02B5/23

CPC classification number: C09K9/02 ,  C09D4/06 ,  C09D7/63 ,  C07D497/10 ,  C07D311/96 ,  C07F7/0812 ,  G02B1/041 ,  G02B1/10 ,  G02B5/23 ,  C09K2211/1018 ,  C08K5/46

Abstract: A photochromic compound of the present invention comprises at least two monovalent photochromic basic structure groups PC including a T-type photochromic moiety, the photochromic basic structure groups being bonded to an organic group having a non-SO aromatic ring containing neither a sulfur atom nor an oxygen atom.

公开(公告)号：US11634414B2

公开(公告)日：2023-04-25

申请号：US16633538

申请日：2018-08-02

Applicant: LG CHEM, LTD.

Inventor： Seongmi Cho ,  Wanpyo Hong ,  Dong Hoon Lee ,  Jungoh Huh ,  Min Woo Jung ,  Jungha Lee

IPC: C07D311/96 ,  C07D335/04 ,  C07D407/14 ,  C07D409/14 ,  H01L51/00 ,  C07D491/048 ,  C07D487/04 ,  C07D495/04 ,  H01L51/50

Abstract: Provided is a hetero-cyclic compound of Chemical Formula 1: and an organic light emitting device comprising the same.

公开(公告)号：US20220242815A1

公开(公告)日：2022-08-04

申请号：US17560997

申请日：2021-12-23

Applicant: The Broad Institute, Inc. ,  Instituto Carlos Slim de la Salud, A.C. ,  The Brigham and Women's Hospital, Inc.

Inventor： Brian T. Chamberlain ,  David Kornfilt ,  Florence F. Wagner ,  Maria Alimova ,  Anna Greka ,  Joseph Growney

IPC: C07C211/38 ,  A61P13/12 ,  C07D311/96 ,  C07C217/52 ,  C07C209/22 ,  C07D295/185 ,  C07C215/44 ,  C07C229/50

Abstract: The present disclosure relates to compositions and methods related to bicyclo[2.2.1] heptanamine-containing compounds and salts.

公开(公告)号：US20220002552A1

公开(公告)日：2022-01-06

申请号：US17469792

申请日：2021-09-08

Applicant: BIOLEGEND, INC.

Inventor： Xinshe Xu ,  Jing Wang

IPC: C09B69/10 ,  C08G81/00 ,  C07C25/22 ,  C07C237/04 ,  C07D235/02 ,  C07D311/96 ,  C07D211/18 ,  C09B57/00 ,  C07C35/50 ,  C07C211/60 ,  G01N21/64

Abstract: The present invention provides fluorescent polyfluorene polymers or macromers with unique optical properties that are stable. The polymeric fluorophores are useful in various bioassays formats. The inventive polymers are useful in assays relying on fluorescence resonance energy transfer (FRET) mechanisms where two fluorophores are used.

公开(公告)号：US20210228547A1

公开(公告)日：2021-07-29

申请号：US17058973

申请日：2019-07-08

Applicant: UCB Biopharma SRL

Inventor： Gareth Neil Brace ,  Daniel Christopher Brookings ,  Gregory Foulkes ,  Fabien Claude Lecomte

IPC: A61K31/422 ,  C07D413/12 ,  C07D405/12 ,  C07D491/107 ,  C07D493/10 ,  C07D311/96 ,  C07D491/20 ,  C07D405/14 ,  A61K31/4155 ,  A61K31/427 ,  A61K31/407 ,  A61K31/4245 ,  A61K31/352 ,  A61K31/437

Abstract: A series of substituted spirocyclic indane derivatives of Formula (I), and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20210114998A1

公开(公告)日：2021-04-22

申请号：US16762245

申请日：2019-03-08

Applicant: LG CHEM, LTD.

Inventor： Dong Uk HEO ,  Jin Joo KIM ,  Dong Hoon LEE ,  Jungoh HUH ,  Yongbum CHA ,  Wanpyo HONG

IPC: C07D251/24 ,  C07D311/96 ,  C07D335/10 ,  H01L51/00

Abstract: Provided is a compound of Chemical Formula 1: wherein X is O or S; L1 and L2 each independently is a direct bond or a substituted or unsubstituted arylene group; X1 is N or CR1, X2 is N or CR2, X3 is N or CR3, and at least two of X1 to X3 are N; R1 to R3 each independently is hydrogen, deuterium, or a substituted or unsubstituted alkyl, aryl or heteroaryl group; Ar1 and Ar2 each independently is hydrogen, deuterium, or a substituted or unsubstituted alkyl, aryl or heteroaryl group; positions at which is substituted with are asymmetric; m1, m2, n1 and n2 each independently is 0 or 1; and m1+m2 is 1, and n1+n2 is 1, and an organic light emitting device comprising the same.

公开(公告)号：US10968232B2

公开(公告)日：2021-04-06

申请号：US16465156

申请日：2017-12-15

Applicant: Merck Sharp & Dohme Corp.

Inventor： Michael Miller ,  Harry R. Chobanian ,  Shuwen He ,  Jinsong Hao ,  Barbara Pio ,  Yan Guo ,  Dong Xiao

IPC: C07D491/107 ,  A61P3/10 ,  C07D311/96 ,  C07D405/12

Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

公开(公告)号：US10696686B2

公开(公告)日：2020-06-30

申请号：US14894698

申请日：2014-05-29

Applicant: Syngenta Limited

Inventor： Janice Black ,  James Nicholas Scutt ,  Louisa Whalley ,  Nigel James Willets

IPC: C07D493/08 ,  A01N43/16 ,  C07D309/32 ,  C07D311/96 ,  C07C49/753 ,  A01N43/18 ,  C07C323/22 ,  A01N43/40 ,  C07D307/42 ,  A01N35/06 ,  A01N37/02 ,  A01N37/10 ,  A01N47/06 ,  C07C49/577 ,  C07C69/24 ,  C07C69/78 ,  C07C69/96 ,  C07C381/14 ,  A01N43/90 ,  C07C49/517

Abstract: The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R1 is fluorine or bromine; R2 is ethynyl, C1-C3alkoxy, C1-C3haloalkoxy, or C1-C3alkoxy-C1-C3alkoxy-; and Q is a pyran-3,5-dione-4-yl, a thiopyran-3,5-dione-4-yl, a piperidine-3,5-dione-4-yl, a cyclopentane-1,3-dione-2-yl, a cyclohexane-1,3, 5-trione-2-yl, a cyclohexane-1,3-dione-2-yl, or a cycloheptane-1,3-dione-2-yl, or a derivative thereof (e.g. a fused such as fused bicyclic derivative, and/or a spirocyclic derivative), or an enol ketone tautomer derivative thereof, wherein Q is further defined herein; and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. Preferably, X is methyl; and/or R1 is fluorine; and/or R2 is —O—R2A, wherein R2A is methyl, ethyl, trifluoromethyl, difluoromethyl, trifluoroethyl, or —CH2CH2OCH3. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the weeds and/or to the plants and/or to the locus thereof.

公开(公告)号：US10351706B2

公开(公告)日：2019-07-16

申请号：US15756734

申请日：2016-08-30

Applicant: East China University of Science and Technology

Inventor： Youjun Yang ,  Xinran Li ,  Zuhai Lei ,  Yi Li

IPC: C07D491/22 ,  C07D311/96 ,  C09K11/06 ,  C09B11/10 ,  C07D491/20 ,  C09B11/24 ,  C09B23/01

Abstract: The invention relates to a near-infrared fluorescent dye and use thereof, and particularly relates to compounds represented by following Formulae A, B and C, wherein each group in the Formulae is described in the specification. Further provided are a dye composition comprising the compound represented by Formula A or Formula B, and a preparation method of the compound represented by Formula A or Formula B. The compound has a maximum absorption wavelength of 880 nm, considerably exceeding maximum absorption wavelengths of the majority of small-molecule near-infrared fluorescent dyes in the prior art. Moreover, the structure thereof does not aggregate even if the concentration thereof is excessively high, thereby having considerably high chemical stability and light stability.

公开(公告)号：US20190071405A1

公开(公告)日：2019-03-07

申请号：US16181864

申请日：2018-11-06

Applicant: AUTIFONY THERAPEUTICS LIMITED

Inventor： Agostino Marasco ,  Giuseppe Alvaro ,  Anne Dècor ,  Dieter Hamprecht ,  Paolo Dambruoso ,  Simona Tommasi

IPC: C07D249/12 ,  C07C255/37 ,  C07C43/225 ,  C07C255/46 ,  C07C43/313 ,  C07D307/87 ,  C07D401/04 ,  C07D311/96 ,  C07D311/76 ,  C07D311/04 ,  C07D307/94 ,  C07D405/14 ,  C07C255/48 ,  C07C43/29

Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.