公开(公告)号：US11926608B2

公开(公告)日：2024-03-12

申请号：US17249524

申请日：2021-03-04

申请人： NANJING UNIVERSITY ,  NANJING QUANKAI RESEARCH INSTITUTE OF BIOMATERIALS CO., LTD.

发明人： Wei Jiang ,  Yunbiao Qi ,  Ping Sun ,  Wei Huang ,  Aimin Li ,  Quanxing Zhang

IPC分类号： C07D319/12 ,  B01D1/22 ,  B01D3/14 ,  B01D5/00 ,  B01J4/00 ,  B01J19/00 ,  B01J19/24 ,  C08G63/91

CPC分类号： C07D319/12 ,  B01D1/22 ,  B01D3/143 ,  B01D5/006 ,  B01D5/0075 ,  B01D5/009 ,  B01J4/001 ,  B01J19/0013 ,  B01J19/245 ,  C08G63/912 ,  B01J2219/0004 ,  B01J2219/00081 ,  B01J2219/00085

摘要： The invention discloses a synthesis method and device for rapidly producing lactide at high yield. The method comprises: adding a single component of lactic acid or two components of lactic acid and catalyst, passing the mixture through a mixer to enter an oligomer preparation system, increasing a residence time through bottom circulation, synthesizing oligomeric lactic acid, and passing a gas-phase component through a rectification system. With the adoption of the device, the lactide is capable of being efficiently synthesized, crude lactide with a yield of 94% to 98% is capable of being obtained.

公开(公告)号：US20180312484A1

公开(公告)日：2018-11-01

申请号：US15772833

申请日：2016-11-03

申请人： Mylan Laboratories Limited

发明人： Sureshbabu Jayachandra ,  Vipin Kumar Kaushik ,  Vijaya Krishna RAVI ,  Vikas Chandra Dev ,  Saiprasad Kottolla ,  Potla Venkata Srinivasa Rao ,  Srinivas Vakiti ,  Chaitanya Muggu ,  Subramanyam Dandala

IPC分类号： C07D307/33 ,  C07D319/12

CPC分类号： C07D307/33 ,  C07D307/20 ,  C07D319/12

摘要： A process for the preparation of intermediates 9, useful in the synthesis of sofosbuvir, as well as intermediates of formula [12] are disclosed herein.

公开(公告)号：US20180155313A1

公开(公告)日：2018-06-07

申请号：US15570244

申请日：2016-04-28

申请人： PURAC BIOCHEM BV

发明人： Johannes Jeichienus DE VRIES ,  Ana Isabel CAVACO MORAO ,  Andre Banier DE HAAN

IPC分类号： C07D319/12 ,  B01D3/34 ,  B01D3/42 ,  B01J19/00

CPC分类号： C07D319/12 ,  B01D3/34 ,  B01D3/42 ,  B01J19/0013 ,  B01J19/0066 ,  B01J2219/00033 ,  B01J2219/00051 ,  B01J2219/00166

摘要： A method and a device for manufacturing lactide, whereby crude lactide, being prepared by means of depolymerization of lactic acid oligomers, is purified by means of a distillation step. The prepared crude lactide is maintained for a period of at least 5 hours in a reaction vessel at a temperature between 97° C. and 200° C. prior to the distillation step. Keeping the lactide during a period of time in a reaction vessel leads to a decrease of the lactic acid content and an increase of the lactic acid oligomer concentration, so that the resulting crude lactide can be more efficiently purified during subsequent distillation. A pre-distilling step gives additional advantages.

公开(公告)号：US20180057476A1

公开(公告)日：2018-03-01

申请号：US15804874

申请日：2017-11-06

申请人： FUTERRO S.A.

发明人： Christian Penu ,  Benjamine Belloncle

IPC分类号： C07D319/12 ,  B01J27/24 ,  B01J31/02 ,  B01J31/04 ,  B01J31/26 ,  C08G18/42 ,  B01J23/02 ,  C04B16/06 ,  C09D167/04

CPC分类号： C07D319/12 ,  B01J23/02 ,  B01J27/24 ,  B01J31/0267 ,  B01J31/0274 ,  B01J31/04 ,  B01J31/26 ,  B01J2231/52 ,  B01J2531/002 ,  B01J2531/004 ,  B01J2531/007 ,  C04B16/0683 ,  C08G18/428 ,  C09D167/04

摘要： Process for increasingly producing D-Lactide and meso lactide by depolymerizing by back biting polylactide (PLA) said process which comprises: (i) Depolymerizing polylactide into its corresponding dimeric cyclic esters by heating the polylactide in the presence of a catalyst system comprising a catalyst and a co-catalyst in a reaction zone at temperature and pressure at which the polylactide is molten; (ii) Forming a vapor product stream from the reaction zone; (iii) Removing the vapor product stream and optionally condense it; (iv) Recovering, either together or separately meso-lactide, D-lactide and L-lactide.

公开(公告)号：US09862700B2

公开(公告)日：2018-01-09

申请号：US15399189

申请日：2017-01-05

申请人： Total Research & Technology Feluy

发明人： Bert Sels ,  Michiel Dusselier

IPC分类号： C07D241/08 ,  C07D319/12 ,  C07D313/04 ,  C07D223/08 ,  C07D223/10

CPC分类号： C07D319/12 ,  C07D223/08 ,  C07D223/10 ,  C07D313/04

摘要： The invention relates to a process for preparing a cyclic ester or a cyclic amide, comprising the step of: contacting at least one hydroxycarboxylic acid and/or at least one amino-carboxylic acid; or an ester, or salt thereof; wherein said hydroxycarboxylic acid is a 2-hydroxycarboxylic acid, or a 6-hydroxycarboxylic acid; and wherein said amino carboxylic acid is a 2-amino-carboxylic acid or a 6-amino-carboxylic acid; with at least one acidic zeolite comprising: two or three interconnected and non-parallel channel systems, wherein at least one of said channel systems comprises 10-or more-membered ring channels; and a framework Si/X2 ratio of at least 24 as measured by NMR; or three interconnected and non-parallel channel systems, wherein at least two of said channel systems comprise 10-or more-membered ring channels; and a framework Si/X2 ratio of at least 6 as measured by NMR; wherein each X is Al or B, and wherein the process is performed at a pressure between 0.5 and 20 bar.

公开(公告)号：US09708287B2

公开(公告)日：2017-07-18

申请号：US14872419

申请日：2015-10-01

申请人： Cayman Chemical Company Incorporated

发明人： Mitchell A. deLong ,  Kalla Lynn Kvalnes ,  Raymond Boissy

IPC分类号： C07D335/02 ,  C07D309/10 ,  A61K8/49 ,  A61K8/69 ,  C07D309/12 ,  A61Q19/02 ,  A61K8/60 ,  C07D215/227 ,  C07D311/94 ,  C07D313/04 ,  C07D313/18 ,  C07D333/32 ,  C07D333/64 ,  C07D493/04 ,  C07H15/203 ,  C07D311/02 ,  C07D215/22 ,  C07D319/12 ,  C07D333/48 ,  C07D307/20 ,  A61K8/33

CPC分类号： C07D335/02 ,  A61K8/33 ,  A61K8/4926 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/4986 ,  A61K8/602 ,  A61K8/69 ,  A61K2800/591 ,  A61Q19/02 ,  C07D215/22 ,  C07D215/227 ,  C07D307/20 ,  C07D309/10 ,  C07D309/12 ,  C07D311/02 ,  C07D311/94 ,  C07D313/04 ,  C07D313/18 ,  C07D319/12 ,  C07D333/32 ,  C07D333/48 ,  C07D333/64 ,  C07D493/04 ,  C07H15/203

摘要： Compounds that function, alone or in combination, as inhibitors of pigmentation for the improvement of mammalian skin are described herein. Specifically, the compounds of the present disclosure, namely chiral, non-racemic compounds, function as pigment formation inhibitors thereof to beautify skin and discourage the production of melanins. One or more products, consumer and otherwise, comprising the chiral, non-racemic compounds are disclosed herein. Methods of employing both the compounds of the present disclosure and the products incorporating the present compounds are also disclosed herein.

公开(公告)号：US09655879B2

公开(公告)日：2017-05-23

申请号：US14934386

申请日：2015-11-06

申请人： EA Pharma Co., Ltd.

发明人： Takahiro Koshiba ,  Munetaka Tokumasu ,  Taisuke Ichimaru ,  Koji Ohsumi ,  Tadakiyo Nakagawa ,  Tatsuhiro Yamada ,  Kayo Matsumoto ,  Tamotsu Suzuki

IPC分类号： A61K31/38 ,  A61K31/381 ,  C07D333/38 ,  C07D409/06 ,  C07D409/12 ,  C07D333/40 ,  C07D319/12 ,  A61K31/19 ,  A61K31/396 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4436 ,  A61K31/4535 ,  A61K31/4725 ,  A61K38/05

CPC分类号： A61K31/381 ,  A61K31/19 ,  A61K31/396 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4436 ,  A61K31/4535 ,  A61K31/4725 ,  A61K38/05 ,  C07D319/12 ,  C07D333/38 ,  C07D333/40 ,  C07D409/06 ,  C07D409/12

摘要： Compounds represented by the following formula (I); wherein each symbol is as defined in the specification, are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

公开(公告)号：US09630942B2

公开(公告)日：2017-04-25

申请号：US14782627

申请日：2013-08-17

申请人： Nanjing University

发明人： Hong Li ,  Quanxing Zhang ,  Na Cheng ,  Tianrong Zhang ,  Wei Jiang ,  Wei Huang ,  Bingcai Pan

IPC分类号： C07D319/12 ,  B01J31/02

CPC分类号： C07D319/12 ,  B01J31/0208 ,  B01J31/0241 ,  B01J31/0271 ,  B01J2231/34

摘要： A technological method for synthesizing optically pure L-/D-lactide by using a biogenic guanidine catalysis method. The method of the present invention comprises: by using biogenic guanidine creatinine (CR) as a catalyst and L-/D-lactic acid (90% of mass content) as a raw material, synthesizing optically pure L-/D-lactide by using a reactive reduced pressure distillation catalysis method. The method of the present invention has advantages that the used catalyst is biogenic guanidine creatinine and free of toxicity, metal, and cytotoxicity; the synthesized lactide is high in optical purity (the specific rotation of the L-lactide [α]25D=−276˜−280, and the specific rotation of the D-lactide [α]25D=280), and does not contain any metal; the amount of the catalyst used in reaction is low, the technological process is simplified (a process for rectifying and purifying a crude lactide product by using a conventional method is avoided); and the technological method is simple and convenient to operate and easy in industrial implementation.

公开(公告)号：US09284294B2

公开(公告)日：2016-03-15

申请号：US13763135

申请日：2013-02-08

申请人： Novus International Inc.

发明人： Graciela B. Arhancet ,  Matthew Mahoney ,  Xiaojun Wang ,  Rangarani Karnati

IPC分类号： A61K31/765 ,  A23D9/013 ,  C07C315/00 ,  C07D319/12 ,  C08G75/02 ,  C08G67/00 ,  C08G63/688 ,  C08G63/85 ,  C08L67/04 ,  C07D265/33 ,  A23K1/18 ,  A23K1/16

CPC分类号： C07D319/12 ,  A23K20/10 ,  A23K50/10 ,  A23K50/75 ,  C07D265/33 ,  C08G63/6882 ,  C08G63/85 ,  C08G67/00 ,  C08G75/02 ,  C08L67/00 ,  C08L67/04

摘要： The invention relates to functionalized polymers including homopolymers and copolymers and their uses in industrial applications and in agricultural applications. In particular, the homopolymers and copolymers may be, for example, used in polymer blends, used as nutritives and in feed compositions, and used in combination with a pharmaceutical or nutritive.

摘要翻译： 本发明涉及包括均聚物和共聚物在内的官能化聚合物及其在工业应用和农业应用中的用途。 特别地，均聚物和共聚物可以例如用于聚合物共混物，用作营养物质和饲料组合物中，并与药物或营养物质组合使用。

公开(公告)号：US20160060454A1

公开(公告)日：2016-03-03

申请号：US14937416

申请日：2015-11-10

申请人： Novus International Inc.

发明人： Graciela B. Arhancet ,  Matthew Mahoney ,  Xiaojun Wang ,  Rangarani Karnati

IPC分类号： C08L67/04 ,  A23K1/16 ,  A23K1/18

CPC分类号： C07D319/12 ,  A23K20/10 ,  A23K50/10 ,  A23K50/75 ,  C07D265/33 ,  C08G63/6882 ,  C08G63/85 ,  C08G67/00 ,  C08G75/02 ,  C08L67/00 ,  C08L67/04

摘要： The invention relates to functionalized polymers including homopolymers and copolymers and their uses in industrial applications and in agricultural applications. In particular, the homopolymers and copolymers may be, for example, used in polymer blends, used as nutritives and in feed compositions, and used in combination with a pharmaceutical or nutritive.