公开(公告)号：US12109201B2

公开(公告)日：2024-10-08

申请号：US17843028

申请日：2022-06-17

申请人： Ovid Therapeutics, Inc.

发明人： Matthew During

IPC分类号： A61K31/437 ,  A61K9/00 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/197 ,  A61K31/27 ,  A61K31/325 ,  A61K31/36 ,  A61K31/4015 ,  A61K31/4166 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/433 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/513 ,  A61K31/515 ,  A61K31/53 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/5517 ,  A61K31/57 ,  A61K31/7048 ,  A61K45/06

CPC分类号： A61K31/437 ,  A61K9/0019 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/197 ,  A61K31/27 ,  A61K31/325 ,  A61K31/36 ,  A61K31/4015 ,  A61K31/4166 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/433 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/513 ,  A61K31/515 ,  A61K31/53 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/5517 ,  A61K31/57 ,  A61K31/7048 ,  A61K45/06 ,  A61K31/437 ,  A61K2300/00 ,  A61K31/57 ,  A61K2300/00 ,  A61K31/5517 ,  A61K2300/00 ,  A61K31/5513 ,  A61K2300/00 ,  A61K31/44 ,  A61K31/04 ,  A61K2300/00 ,  A61K2300/00 ,  A61K31/27 ,  A61K2300/00 ,  A61K31/433 ,  A61K2300/00 ,  A61K31/55 ,  A61K2300/00 ,  A61K31/4015 ,  A61K2300/00 ,  A61K31/195 ,  A61K2300/00 ,  A61K31/165 ,  A61K2300/00 ,  A61K31/53 ,  A61K2300/00 ,  A61K31/444 ,  A61K2300/00 ,  A61K31/515 ,  A61K2300/00 ,  A61K31/4166 ,  A61K2300/00 ,  A61K31/4192 ,  A61K2300/00 ,  A61K31/19 ,  A61K2300/00 ,  A61K31/513 ,  A61K2300/00 ,  A61K31/36 ,  A61K2300/00 ,  A61K31/4535 ,  A61K2300/00 ,  A61K31/7048 ,  A61K2300/00 ,  A61K31/197 ,  A61K2300/00 ,  A61K31/423 ,  A61K2300/00 ,  A61K31/136 ,  A61K2300/00

摘要： Use of allosteric modulators and/or gaboxadol for the treatment of epileptic disorders in a subject in need thereof.

公开(公告)号：US12070456B2

公开(公告)日：2024-08-27

申请号：US17515706

申请日：2021-11-01

申请人： The Hospital for Sick Children

发明人： Nicola Jones ,  Laura MacDougall ,  Mariana Capurro

IPC分类号： A61K31/445 ,  A61K31/18 ,  A61K31/4535 ,  A61K31/4709 ,  A61K45/06

CPC分类号： A61K31/4709 ,  A61K31/18 ,  A61K31/4535 ,  A61K45/06

摘要： A method for treating and/or preventing VacA+ H. pylori infection and a disorder associated with VacA+ H. pylori infection is provided. The method comprises the administration of TRPML agonists such as ML-SA1, SF-22, SF-51, MK6-83 and their derivatives.

公开(公告)号：US20240239775A1

公开(公告)日：2024-07-18

申请号：US18555470

申请日：2022-04-18

申请人： QINGDAO RUIJI MEDICAL TECHNOLOGY CO., LTD.

发明人： Ning JIAO ,  Xiaodong DOU ,  Tongyu HUO ,  Lingyu SU ,  Xinyi ZHAO ,  Yingjie HUANG ,  Yameng LIU

IPC分类号： C07D409/14 ,  A61K31/438 ,  A61K31/4535 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/551 ,  A61P35/00 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D471/10 ,  C07D487/08

CPC分类号： C07D409/14 ,  A61K31/438 ,  A61K31/4535 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/551 ,  A61P35/00 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D471/10 ,  C07D487/08

摘要： The present invention relates to a compound capable of being used as an FXR regulator, a pharmaceutically acceptable salt or ester, a stereoisomer, a tautomer, a geometric isomer, a prodrug, a hydrate, a solvate or a crystalline form thereof, a metabolite form of same, or any combination or mixture of same, and also relates to a preparation method therefor, a pharmaceutical composition thereof and the use thereof.

公开(公告)号：US12023348B2

公开(公告)日：2024-07-02

申请号：US15569407

申请日：2016-04-26

申请人： The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center

发明人： Ofer Sarig ,  Eli Sprecher

IPC分类号： A61K31/704 ,  A61K31/122 ,  A61K31/137 ,  A61K31/167 ,  A61K31/277 ,  A61K31/365 ,  A61K31/366 ,  A61K31/37 ,  A61K31/404 ,  A61K31/423 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4402 ,  A61K31/4453 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4738 ,  A61K31/4741 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/498 ,  A61K31/53 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/566 ,  A61K31/58 ,  A61K31/688 ,  A61K45/06 ,  A61P17/00 ,  A61P17/06

CPC分类号： A61K31/704 ,  A61K31/122 ,  A61K31/137 ,  A61K31/167 ,  A61K31/277 ,  A61K31/365 ,  A61K31/366 ,  A61K31/37 ,  A61K31/404 ,  A61K31/423 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4402 ,  A61K31/4453 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4738 ,  A61K31/4741 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/498 ,  A61K31/53 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/566 ,  A61K31/58 ,  A61K31/688 ,  A61K45/06 ,  A61P17/00 ,  A61P17/06

摘要： A method of treating an inflammation or a hyperproliferative disease in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of:



a compound represented by Formula I:








or a pharmaceutically acceptable salt thereof,



a compound represented by Formula II:










and a compound represented by Formula III:








wherein the variables in Formulae I, II and III are as defined in the specification.

公开(公告)号：US11951080B2

公开(公告)日：2024-04-09

申请号：US18066694

申请日：2022-12-15

申请人： Duke University

发明人： Suzanne E. Wardell ,  Erik R. Nelson ,  Donald P. McDonnell

IPC分类号： A61K31/137 ,  A61K9/00 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  A61P35/00 ,  C07C217/78 ,  C07C217/84

CPC分类号： A61K31/137 ,  A61K9/0019 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  C07C217/78 ,  C07C217/84 ,  A61K2121/00 ,  A61P35/00 ,  A61K31/137 ,  A61K2300/00 ,  A61K31/138 ,  A61K2300/00 ,  A61K31/4535 ,  A61K2300/00 ,  A61K31/4196 ,  A61K2300/00 ,  A61K31/5685 ,  A61K2300/00 ,  A61K31/40 ,  A61K2300/00 ,  A61K31/565 ,  A61K2300/00

摘要： Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.

公开(公告)号：US20240033259A1

公开(公告)日：2024-02-01

申请号：US18019959

申请日：2021-08-06

申请人： SEN-JAM PHARMACEUTICAL LLC

发明人： Jacqueline M. IVERSEN ,  Thomas A. DAHL

IPC分类号： A61K31/4535 ,  A61K31/405 ,  A61K31/192 ,  A61P31/14

CPC分类号： A61K31/4535 ,  A61K31/405 ,  A61K31/192 ,  A61P31/14

摘要： The present disclosure relates to methods and compositions for treating or preventing a beta-coronavirus infection, or for inhibiting symptoms of a disease caused by a beta coronavirus infection in a subject, including SARS-CoV-2 and COVID-19. In various embodiments, the composition and methods involve a combination of a non-steroidal anti-inflammatory drug (NSAID) and ketotifen. In exemplary embodiments, naproxen and/or indomethacin are combined with ketotifen for therapy in a single unit dose or separate compositions, and the combination is surprisingly and unexpectedly effective to reduce SARS-CoV-2 viral load and treat COVID-19.

公开(公告)号：US20230404994A1

公开(公告)日：2023-12-21

申请号：US17860246

申请日：2022-07-08

申请人： The University of Newcastle

发明人： Roger Smith ,  Kaushik Maiti

IPC分类号： A61K31/473 ,  A61P15/00 ,  A61K31/4436 ,  A61K31/4535 ,  C12Q1/26 ,  C12Q1/6883

CPC分类号： A61K31/473 ,  A61P15/00 ,  A61K31/4436 ,  A61K31/4535 ,  C12Q1/26 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

摘要： Provided herein are methods of detecting or determining aging and/or oxidative damage in tissue, including placental tissue, skin, kidney and brain tissue. One embodiment provides a method for detecting or determining aging in body tissue, comprising measuring one or more markers of aldehyde oxidase 1 (AOX1) expression or activity in a biological sample, wherein the level of AOX1 expression or activity, or of the one or more markers, is indicative of aging in the tissue. Also provided herein are methods of treating a disease or condition associated with ageing or oxidative damage in one or more cells or tissues, comprising administering to a subject in need thereof an inhibitor of AOX1.

公开(公告)号：US11806336B2

公开(公告)日：2023-11-07

申请号：US18296532

申请日：2023-04-06

申请人： Ovid Therapeutics Inc.

发明人： Matthew During

IPC分类号： A61K31/437 ,  A61K31/57 ,  A61K31/5513 ,  A61K31/325 ,  A61K31/44 ,  A61K31/433 ,  A61K31/55 ,  A61K31/4015 ,  A61K31/195 ,  A61K31/165 ,  A61K31/53 ,  A61K31/444 ,  A61K31/515 ,  A61K31/4166 ,  A61K31/197 ,  A61K9/00 ,  A61K45/06 ,  A61K31/19 ,  A61K31/27 ,  A61K31/36 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/4535 ,  A61K31/513 ,  A61K31/5517 ,  A61K31/7048

CPC分类号： A61K31/437 ,  A61K9/0019 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/197 ,  A61K31/27 ,  A61K31/325 ,  A61K31/36 ,  A61K31/4015 ,  A61K31/4166 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/433 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/513 ,  A61K31/515 ,  A61K31/53 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/5517 ,  A61K31/57 ,  A61K31/7048 ,  A61K45/06 ,  A61K31/437 ,  A61K2300/00 ,  A61K31/57 ,  A61K2300/00 ,  A61K31/5517 ,  A61K2300/00 ,  A61K31/5513 ,  A61K2300/00 ,  A61K31/44 ,  A61K2300/00 ,  A61K31/27 ,  A61K2300/00 ,  A61K31/433 ,  A61K2300/00 ,  A61K31/55 ,  A61K2300/00 ,  A61K31/4015 ,  A61K2300/00 ,  A61K31/195 ,  A61K2300/00 ,  A61K31/165 ,  A61K2300/00 ,  A61K31/53 ,  A61K2300/00 ,  A61K31/444 ,  A61K2300/00 ,  A61K31/515 ,  A61K2300/00 ,  A61K31/4166 ,  A61K2300/00 ,  A61K31/4192 ,  A61K2300/00 ,  A61K31/19 ,  A61K2300/00 ,  A61K31/513 ,  A61K2300/00 ,  A61K31/36 ,  A61K2300/00 ,  A61K31/4535 ,  A61K2300/00 ,  A61K31/7048 ,  A61K2300/00 ,  A61K31/197 ,  A61K2300/00 ,  A61K31/423 ,  A61K2300/00 ,  A61K31/136 ,  A61K2300/00

摘要： Use of allosteric modulators and/or gaboxadol for the treatment of epileptic disorders in a subject in need thereof.

公开(公告)号：US11779552B2

公开(公告)日：2023-10-10

申请号：US17558731

申请日：2021-12-22

申请人： Duke University

发明人： Suzanne E. Wardell ,  Erik R. Nelson ,  Donald P McDonnell

IPC分类号： A61K31/137 ,  A61K9/00 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  C07C217/78 ,  C07C217/84

CPC分类号： A61K31/137 ,  A61K9/0019 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  C07C217/78 ,  C07C217/84 ,  A61K2121/00 ,  A61K31/137 ,  A61K2300/00 ,  A61K31/138 ,  A61K2300/00 ,  A61K31/4535 ,  A61K2300/00 ,  A61K31/4196 ,  A61K2300/00 ,  A61K31/5685 ,  A61K2300/00 ,  A61K31/40 ,  A61K2300/00 ,  A61K31/565 ,  A61K2300/00

摘要： Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.

公开(公告)号：US20230270733A1

公开(公告)日：2023-08-31

申请号：US18006582

申请日：2021-07-30

申请人： PHAROS IBIO CO., LTD. ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Tae Bo SIM ,  Seung Hye CHOI ,  Han Na CHO ,  Nam Kyoung KIM ,  Woo Young HUR ,  Chi Man SONG ,  Ky Youb NAM ,  Jeong Hyeok YOON

IPC分类号： A61K31/4535 ,  A23L33/10 ,  A61P35/00

CPC分类号： A61K31/4535 ,  A23L33/10 ,  A61P35/00

摘要： The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of gastrointestinal stromal tumor. The 2,3,5-substituted thiophene compound exhibits high inhibitory activity against the growth of gastrointestinal stromal tumor, and thus may be effectively used for the prevention, amelioration or treatment of gastrointestinal stromal tumor.