公开(公告)号：US20240197654A1

公开(公告)日：2024-06-20

申请号：US18594233

申请日：2024-03-04

Applicant: Duke University

Inventor： Suzanne E. Wardell ,  Erik R. Nelson ,  Donald P. McDonnell

IPC: A61K31/137 ,  A61K9/00 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  A61P35/00 ,  C07C217/78 ,  C07C217/84

CPC classification number: A61K31/137 ,  A61K9/0019 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  C07C217/78 ,  C07C217/84 ,  A61K2121/00 ,  A61P35/00

Abstract: Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.

公开(公告)号：US4438128A

公开(公告)日：1984-03-20

申请号：US273543

申请日：1981-06-15

Applicant: Fritz Wiedemann ,  Wolfgang Kampe ,  Karl Dietmann ,  Gisbert Sponer

Inventor： Fritz Wiedemann ,  Wolfgang Kampe ,  Karl Dietmann ,  Gisbert Sponer

IPC: A61K31/38 ,  A61K31/045 ,  A61K31/135 ,  A61K31/138 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/47 ,  A61K31/472 ,  A61K31/473 ,  A61K31/495 ,  A61K31/498 ,  A61K31/50 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P9/00 ,  A61P9/04 ,  C07C217/32 ,  C07C217/72 ,  C07C217/78 ,  C07C219/06 ,  C07C219/08 ,  C07C219/14 ,  C07D209/48 ,  C07D213/74 ,  C07D215/46 ,  C07D217/22 ,  C07D219/12 ,  C07D231/06 ,  C07D231/20 ,  C07D231/32 ,  C07D231/38 ,  C07D231/46 ,  C07D231/52 ,  C07D231/56 ,  C07D237/20 ,  C07D239/42 ,  C07D239/54 ,  C07D239/545 ,  C07D239/557 ,  C07D239/56 ,  C07D239/84 ,  C07D239/95 ,  C07D241/44 ,  C07D249/18 ,  C07D333/36 ,  C07D473/16 ,  C07D473/32 ,  C07D473/34 ,  C07D487/00 ,  C07D487/04 ,  C07D231/54

CPC classification number: C07D473/16 ,  C07D209/48 ,  C07D213/74 ,  C07D215/46 ,  C07D217/22 ,  C07D219/12 ,  C07D231/06 ,  C07D231/20 ,  C07D231/32 ,  C07D231/38 ,  C07D231/52 ,  C07D231/56 ,  C07D237/20 ,  C07D239/42 ,  C07D239/545 ,  C07D239/557 ,  C07D239/56 ,  C07D239/84 ,  C07D239/95 ,  C07D333/36 ,  C07D473/34 ,  C07D487/04

Abstract: The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are hydrogen or halogen atoms or lower alkyl, cyano, carboxamido, hydroxyl, lower acyloxy, lower alkoxy, lower alkenyloxy or aryl lower alkoxy radicals, R.sub.5 and R.sub.6, which may be the same or different, are hydrogen atoms or lower alkyl radicals, X is a straight or branched alkylene chain containing 2 to 6 carbon atoms, A is a mono-, bi- or tricyclic heteroaromatic or hydroheteroaromatic radical or, when at least one of the symbols R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is other than a hydrogen atom, may also be a phenyl radical, with the proviso that when A is a uracil-6-yl radical, the 5-position of the uracil moiety does not contain a hydrogen atom, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11, which may be the same or different, are mono- or divalent substituents selected from hydrogen, halogen, nitro, hydroxylamino, amino, lower acylamino, lower alkylamino, di-(lower alkyl)-amino, hydroxyethylamino, di-(hydroxyethyl)-amino, hydroxyl, lower alkoxy, allyloxy, methoxy lower alkoxy, cyano, carboxamido, carboxy, lower alkoxycarbonyl, hydroxymethyl, lower alkoxymethyl, halomethyl, aminomethyl, lower acylaminomethyl, di-(lower alkyl)-aminomethyl, pyrrolidinomethyl, piperidinomethyl, di-(hydroxyethyl)-aminomethyl, morpholinomethyl, piperazinomethyl, 4-lower acylpiperazinomethyl, 4-lower alkylpiperazinomethyl, lower alkyl, lower alkenyl, 2-cyanoethyl, 2-(lower alkoxycarbonyl)-ethyl, 2-carboxyethyl, 2-hydroxyethyl, phenyl lower alkyl and phenyl, the phenyl radicals being optionally substituted with 1 or 2 hydroxyl or methoxy radicals, or from oxygen or sulphur; the optically-active forms and the racemic mixtures thereof, and the pharmacologically compatible salts thereof.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.

公开(公告)号：US20200368184A1

公开(公告)日：2020-11-26

申请号：US16986492

申请日：2020-08-06

Applicant: Duke University

Inventor： Suzanne E. Wardell ,  Erik R. Nelson ,  Donald P. McDonnell

IPC: A61K31/137 ,  A61K45/06 ,  A61K31/136 ,  C07C217/78 ,  C07C217/84 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/565 ,  A61K31/5685 ,  A61K31/4535 ,  A61K9/00

Abstract: Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.

公开(公告)号：US10420734B2

公开(公告)日：2019-09-24

申请号：US15129197

申请日：2015-03-28

Applicant: Duke University

Inventor： Suzanne E. Wardell ,  Erik R. Nelson ,  Donald P. McDonnell

IPC: A61K31/137 ,  A61K45/06 ,  A61K31/136 ,  C07C217/78 ,  C07C217/84 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K9/00

Abstract: Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.

公开(公告)号：US10071066B2

公开(公告)日：2018-09-11

申请号：US15214187

申请日：2016-07-19

Applicant: Duke University

Inventor： Suzanne E. Wardell ,  Erik R. Nelson ,  Donald P. McDonnell

IPC: A61K31/136 ,  A61K31/137 ,  A61K31/138 ,  A61K45/06 ,  C07C217/78 ,  C07C217/84 ,  A61K9/00 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685

Abstract: Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.

公开(公告)号：US5780625A

公开(公告)日：1998-07-14

申请号：US756222

申请日：1996-11-25

Applicant: Suruliappa Gowper Jeganathan ,  Christophe Bulliard

Inventor： Suruliappa Gowper Jeganathan ,  Christophe Bulliard

IPC: C07C217/78 ,  C07C217/84 ,  C07C219/34 ,  C07C233/25 ,  C07C235/48 ,  C07C317/18 ,  C07C323/11 ,  C07D263/46 ,  C07D285/125 ,  C07D295/08 ,  C07D295/096 ,  C07D487/04 ,  C07F9/6574 ,  G03C7/30 ,  G03C7/392 ,  C07D265/30 ,  C07D279/12

CPC classification number: C07D295/096 ,  C07C217/84 ,  C07F9/65744 ,  G03C7/301 ,  G03C7/3924

Abstract: A description is given of novel O-phenol-substituted aminophenol derivatives of the formula ##STR1## in which the symbols are as defined in claim 1, which can be used in particular as stabilizers for magenta couplers in color-photographic recording materials.

Abstract translation: 描述了新颖的式“IMAGE”的O-苯酚取代的氨基苯酚衍生物，其中符号如权利要求1所定义，其可以特别用作彩色照相记录材料中品红色成色剂的稳定剂。

公开(公告)号：US5650534A

公开(公告)日：1997-07-22

申请号：US519228

申请日：1995-08-25

Applicant: Stephen Kelly ,  Klaus Schmitt

Inventor： Stephen Kelly ,  Klaus Schmitt

IPC: G02F1/13 ,  C07C69/773 ,  C07C69/86 ,  C07C69/92 ,  C07C69/94 ,  C07C217/78 ,  C07C235/06 ,  C07C255/49 ,  C07D239/26 ,  C07D239/34 ,  C08F20/10 ,  C08F20/18 ,  C08F20/30 ,  C09K19/20 ,  C09K19/34 ,  C09K19/38 ,  C09K19/42 ,  C07C69/76 ,  C07C69/90

CPC classification number: C09K19/3857 ,  C07C69/92 ,  C08F20/30 ,  C09K19/2028

Abstract: The present invention is concerned with optically active, ferroelectric, smectic, photo-cross linkable compounds of the formula ##STR1## wherein A.sup.1 and A.sup.2 may both signify residues of the formula ##STR2## and be the same or different, while A.sup.3 may signify a residue of the formula ##STR3## as well as liquid crystalline mixtures which contain such compounds and their use in the cross-linked state in optical components.

Abstract translation: 本发明涉及下式的光学活性的，铁电的，近晶的，可光交联的可光交联的化合物，其中A 1和A 2可以都表示式I​​I的残基并且相同或不同，而A3可以 表示式“IMAGE”III的残基以及含有这些化合物的液晶混合物及其在光学组分中的交联状态。

公开(公告)号：US4507488A

公开(公告)日：1985-03-26

申请号：US483788

申请日：1983-04-11

Applicant: Fritz Wiedemann ,  Ewald Rieger

Inventor： Fritz Wiedemann ,  Ewald Rieger

IPC: A61K31/38 ,  A61K31/045 ,  A61K31/135 ,  A61K31/138 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/47 ,  A61K31/472 ,  A61K31/473 ,  A61K31/495 ,  A61K31/498 ,  A61K31/50 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P9/00 ,  A61P9/04 ,  C07C217/32 ,  C07C217/72 ,  C07C217/78 ,  C07C219/06 ,  C07C219/08 ,  C07C219/14 ,  C07D209/48 ,  C07D213/74 ,  C07D215/46 ,  C07D217/22 ,  C07D219/12 ,  C07D231/06 ,  C07D231/20 ,  C07D231/32 ,  C07D231/38 ,  C07D231/46 ,  C07D231/52 ,  C07D231/56 ,  C07D237/20 ,  C07D239/42 ,  C07D239/54 ,  C07D239/545 ,  C07D239/557 ,  C07D239/56 ,  C07D239/84 ,  C07D239/95 ,  C07D241/44 ,  C07D249/18 ,  C07D333/36 ,  C07D473/16 ,  C07D473/32 ,  C07D473/34 ,  C07D487/00 ,  C07D487/04

CPC classification number: C07D473/16 ,  C07D209/48 ,  C07D213/74 ,  C07D215/46 ,  C07D217/22 ,  C07D219/12 ,  C07D231/06 ,  C07D231/20 ,  C07D231/32 ,  C07D231/38 ,  C07D231/52 ,  C07D231/56 ,  C07D237/20 ,  C07D239/42 ,  C07D239/545 ,  C07D239/557 ,  C07D239/56 ,  C07D239/84 ,  C07D239/95 ,  C07D333/36 ,  C07D473/34 ,  C07D487/04

Abstract: New N-heteroarylalkylenediamine ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen, an alkyl radical containing up to 6 carbon atoms, or a benzyl radical,X is an alkylene radical containing 2 to 6 carbon atoms,A is a mono- or bicyclic heteroaromatic radical, which can be partly hydrogenated, with the proviso that it contains 2 or 3 adjacent ring heteroatoms, whereby the bound ring heteroatoms can be an oxygen atom and a nitrogen atom or 2 or 3 nitrogen atoms, andR.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 each independently is hydrogen, or an alkyl radical containing up to 6 carbon atoms, which can be substituted by hydroxyl, carbamyl, nitrile or carboxyl, an alkenyl radical containing 2 to 6 carbon atoms, a phenyl or carbamyl radical or one of the divalent substituents oxygen or sulphur,or a salt thereof. The compounds are intermediates in the synthesis of cardioactive compounds.

Abstract translation: 新的N-杂芳基亚烷基二胺其中R 1和R 2各自独立地是氢，含有至多6个碳原子的烷基或苄基，X是含有2至6个碳原子的亚烷基，A是单环或双环 杂芳族基团，其可部分氢化，条件是其含有2或3个相邻的环杂原子，其中结合的环杂原子可以是氧原子和氮原子或2或3个氮原子，并且R 3，R 4，R 5， R6和R7各自独立地是氢或含有至多6个碳原子的烷基，其可以被羟基，氨基甲酰基，腈或羧基取代，含有2-6个碳原子的烯基，苯基或氨基甲酰基或其中之一 二价取代基为氧或硫，或其盐。 这些化合物是合成心脏活性化合物的中间体。

公开(公告)号：US20230398085A1

公开(公告)日：2023-12-14

申请号：US18457567

申请日：2023-08-29

Applicant: Duke University

Inventor： Suzanne E. Wardell ,  Erik R. Nelson ,  Donald P. McDonnell

IPC: A61K31/137 ,  A61K9/00 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  C07C217/78 ,  C07C217/84

CPC classification number: A61K31/137 ,  A61K9/0019 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  C07C217/78 ,  C07C217/84 ,  A61K2121/00

Abstract: Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.

公开(公告)号：US11274213B2

公开(公告)日：2022-03-15

申请号：US16491386

申请日：2018-09-14

Applicant: LG Chem, Ltd.

Inventor： Hyeonah Shin ,  Sungkyoung Kang ,  Kwanghyun Kim ,  Jaesoon Bae ,  Jaechol Lee ,  Jae Hak Jeong ,  Chung Whan Lee ,  Hyungil Park

IPC: H01L51/50 ,  C09D4/00 ,  H01L51/00 ,  H01L51/56 ,  C07C217/78

Abstract: The present specification relates to a compound represented by Chemical Formula 1, a coating composition comprising the compound represented by Chemical Formula 1, an organic light emitting device using the same, and a method for manufacturing the same.